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Original Research

Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer

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Pages 3531-3543 | Published online: 17 Jul 2017

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Aiman Mushtaq, Prithvi Singh, Gulnaz Tabassum, Taj Mohammad, Md Imtaiyaz Hassan, Mansoor Ali Syed & Ravins Dohare. (2023) Unravelling hub genes as potential therapeutic targets in lung cancer using integrated transcriptomic meta-analysis and in silico approach. Journal of Biomolecular Structure and Dynamics 41:18, pages 9089-9102.
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Yu-Chia Chen, I-shu Chen, Guan-Jin Huang, Chi-hsiang Kang, Kuo-Chiang Wang, Min-Jen Tsao & Hung-Wei Pan. (2018) Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells. OncoTargets and Therapy 11, pages 1601-1616.
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Articles from other publishers (26)

Diaaidden Alwadi, Quentin Felty, Changwon Yoo, Deodutta Roy & Alok Deoraj. (2023) Endocrine Disrupting Chemicals Influence Hub Genes Associated with Aggressive Prostate Cancer. International Journal of Molecular Sciences 24:4, pages 3191.
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Wenji Li, Wei Xu, Kai Sun, Fujun Wang, Tin Wui Wong & Ah‐Ng Kong. (2022) Identification of novel biomarkers in prostate cancer diagnosis and prognosis. Journal of Biochemical and Molecular Toxicology 36:9.
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Yijing He, Lei Peng, Jia Li, Qiao Li, Yajie Chu, Qixin Lin, Rong Rui & Shiqiang Ju. (2022) TPX2 deficiency leads to spindle abnormity and meiotic impairment in porcine oocytes. Theriogenology 187, pages 164-172.
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Ziwei Wei, Dunsheng Han, Cong Zhang, Shiyu Wang, Jinke Liu, Fan Chao, Zhenyu Song & Gang Chen. (2022) Deep Learning-Based Multi-Omics Integration Robustly Predicts Relapse in Prostate Cancer. Frontiers in Oncology 12.
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Baisheng Sun, Yin Long, Ling Xiao, Jiazhi Wang, Qian Yi, Dali Tong & Ke Li. (2022) Target Protein for Xklp2 Functions as Coactivator of Androgen Receptor and Promotes the Proliferation of Prostate Carcinoma Cells. Journal of Oncology 2022, pages 1-10.
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Daojun Lv, Xiangkun Wu, Xi Chen, Shuxin Yang, Wenzhe Chen, Ming Wang, Yongda Liu, Di Gu & Guohua Zeng. (2021) A novel immune-related gene-based prognostic signature to predict biochemical recurrence in patients with prostate cancer after radical prostatectomy. Cancer Immunology, Immunotherapy 70:12, pages 3587-3602.
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Qiang Su, Zhenyu Liu, Chi Chen, Han Gao, Yongbei Zhu, Liusu Wang, Meiqing Pan, Jiangang Liu, Xin Yang & Jie Tian. (2021) Gene signatures predict biochemical recurrence‐free survival in primary prostate cancer patients after radical therapy. Cancer Medicine 10:18, pages 6492-6502.
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Rone A. De Grandis, Katia M. Oliveira, Adriana P. M. Guedes, Patrick W. S. dos Santos, Alexandre F. Aissa, Alzir A. Batista & Fernando R. Pavan. (2021) A Novel Ruthenium(II) Complex With Lapachol Induces G2/M Phase Arrest Through Aurora-B Kinase Down-Regulation and ROS-Mediated Apoptosis in Human Prostate Adenocarcinoma Cells. Frontiers in Oncology 11.
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Hongqing Zhou, Mingsheng Liu, Tao Shao, Pingbo Xie, Shaojie Zhu, Wei Wang, Qiong Miao, Jiaxi Peng & Peng Zhang. (2021) TPX2 Enhanced the Activation of the HGF/ETS-1 Pathway and Increased the Invasion of Endocrine-Independent Prostate Carcinoma Cells. Frontiers in Oncology 11.
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Boya Zhang, Mingpeng Zhang, Qi Li, Yanjie Yang, Zhiqun Shang & Jun Luo. (2021) TPX2 mediates prostate cancer epithelial-mesenchymal transition through CDK1 regulated phosphorylation of ERK/GSK3β/SNAIL pathway. Biochemical and Biophysical Research Communications 546, pages 1-6.
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Enchong Zhang, Fujisawa Shiori, Oscar YongNan Mu, Jieqian He, Yuntian Ge, Hongliang Wu, Mo Zhang & Yongsheng Song. (2021) Establishment of Novel DNA Methylation-Based Prostate Cancer Subtypes and a Risk-Predicting Eight-Gene Signature. Frontiers in Cell and Developmental Biology 9.
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Song Ou-Yang, Ji-Hong Liu & Qin-Zhang Wang. (2020) Expression patterns and a prognostic model of m 6 A-associated regulators in prostate adenocarcinoma . Biomarkers in Medicine 14:18, pages 1717-1731.
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Omeed Moaven, Jing Su, Guangxu Jin, Konstantinos I. Votanopoulos, Perry Shen, Christopher Mangieri, Stacey S. O’Neill, Kathleen C. Perry, Edward A. Levine & Lance D. Miller. (2020) Clinical Implications of Genetic Signatures in Appendiceal Cancer Patients with Incomplete Cytoreduction/HIPEC. Annals of Surgical Oncology 27:13, pages 5016-5023.
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Xiao Gu, Xiaocui Yao & Dengtao Liu. (2020) Up-regulation of microRNA-335-5p reduces inflammation via negative regulation of the TPX2-mediated AKT/GSK3β signaling pathway in a chronic rhinosinusitis mouse model. Cellular Signalling 70, pages 109596.
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Yutao Wang, Jianfeng Wang, Kexin Yan, Jiaxing Lin, Zhenhua Zheng & Jianbin Bi. (2020) Identification of core genes associated with prostate cancer progression and outcome via bioinformatics analysis in multiple databases. PeerJ 8, pages e8786.
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Yun Cai, Jie Mei, Zhuang Xiao, Bujie Xu, Xiaozheng Jiang, Yongjie Zhang & Yichao Zhu. (2019) Identification of five hub genes as monitoring biomarkers for breast cancer metastasis in silico. Hereditas 156:1.
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Mi-Xiao Hou, Ying-Lian Gao, Jin-Xing Liu, Junliang Shang, Rong Zhu & Sha-Sha Yuan. (2019) A new method for mining information of co-expression network based on multi-cancers integrated data. BMC Medical Genomics 12:S7.
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Wendy L. Johnston, Charles N. Catton & Carol J. Swallow. (2019) Unbiased data mining identifies cell cycle transcripts that predict non-indolent Gleason score 7 prostate cancer. BMC Urology 19:1.
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Weina Yang, Haiting Wan, Renfeng Shan, Wu Wen, Jianfeng Li, Daya Luo & Ren‐Hua Wan. (2019) The clinical significance and prognostic value of Xenopus kinesin‐like protein 2 expressions in human tumors: A systematic review and meta‐analysis. Journal of Cellular Physiology 234:9, pages 14991-14998.
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Lei Ding, Shuhong Zhang, Shijun Chen, Lixue Zheng & Lianxiang Xiao. (2018) Effect and mechanism of lentivirus‐mediated silencing of TPX2 gene on proliferation and apoptosis of human hepatoma cells . Journal of Cellular Biochemistry 120:5, pages 8352-8358.
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Shijie Wang, Yongyuan Chen & Ying Chai. (2018) Prognostic role of targeting protein for Xklp2 in solid tumors. Medicine 97:43, pages e13018.
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Jianing Tang, Deguang Kong, Qiuxia Cui, Kun Wang, Dan Zhang, Yan Gong & Gaosong Wu. (2018) Prognostic Genes of Breast Cancer Identified by Gene Co-expression Network Analysis. Frontiers in Oncology 8.
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Jun Zou, Rui‑Yan Huang, Fu‑Neng Jiang, De‑Xiong Chen, Cong Wang, Zhao‑Dong Han, Yu‑Xiang Liang & Wei‑De Zhong. (2018) Overexpression of TPX2 is associated with progression and prognosis of prostate cancer. Oncology Letters.
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Shuyun Ma, Xuan Rong, Fei Gao, Yang Yang & Lin Wei. (2018) TPX2 promotes cell proliferation and migration via PLK1 in OC. Cancer Biomarkers 22:3, pages 443-451.
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Jun Yi, Xiang Wei, Xinqiang Li, Lei Wan, Jiashou Dong & Rui Wang. (2018) A genome-wide comprehensive analysis of alterations in driver genes in non-small-cell lung cancer. Anti-Cancer Drugs 29:1, pages 10-18.
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Dawoon Jeong, Juyeon Ham, Sungbin Park, Seungyeon Lee, Hyunkyung Lee, Han-Sung Kang & Sun Jung Kim. (2017) MicroRNA-7-5p mediates the signaling of hepatocyte growth factor to suppress oncogenes in the MCF-10A mammary epithelial cell. Scientific Reports 7:1.
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