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OncoTargets and Therapy Volume 10, 2017 - Issue
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Original Research

Comparison of a mouse and a novel human scFv-SNAP-auristatin F drug conjugate with potent activity against EGFR-overexpressing human solid tumor cells

Mira Woitok1 Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Aachen, Germany;2 Institute of Molecular Biotechnology (Biology VII), RWTH Aachen University, Aachen, GermanyCorrespondence[email protected]
,
Diana Klose1 Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Aachen, Germany
,
Stefano Di Fiore1 Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Aachen, Germany
,
Wolfgang Richter3 Tube Pharmaceuticals GmbH, Vienna, Austria
,
Christoph Stein1 Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Aachen, Germany
,
Gerrit Gresch1 Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Aachen, Germany
,
Elena Grieger1 Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Aachen, Germany
,
Stefan Barth1 Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Aachen, Germany
,
Rainer Fischer1 Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Aachen, Germany;2 Institute of Molecular Biotechnology (Biology VII), RWTH Aachen University, Aachen, Germany
,
Katharina Kolberg1 Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Aachen, Germany
&
Judith Niesen1 Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Aachen, Germany
 show all
Pages 3313-3327 | Published online: 06 Jul 2017

Citations (17)

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Mahendra P. Deonarain & Gokhan Yahioglu. (2021) Current strategies for the discovery and bioconjugation of smaller, targetable drug conjugates tailored for solid tumor therapy. Expert Opinion on Drug Discovery 16:6, pages 613-624.
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Articles from other publishers (16)

Allan M. Huysamen, Olaolu E. Fadeyi, Grace Mayuni, Dennis M. Dogbey, Neelakshi Mungra, Fleury A. N. Biteghe, Natasha Hardcastle, Dharanidharan Ramamurthy, Olusiji A. Akinrinmade, Krupa Naran, Susan Cooper, Dirk Lang, Wolfgang Richter, Roger Hunter & Stefan Barth. (2023) Click Chemistry-Generated Auristatin F–Linker–Benzylguanine for a SNAP-Tag-Based Recombinant Antibody–Drug Conjugate Demonstrating Selective Cytotoxicity toward EGFR-Overexpressing Tumor Cells. ACS Omega 8:4, pages 4026-4037.
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Chaoyu Zhang, Wenjie Sheng, Marwah Al-Rawe, T. M. Mohiuddin, Marcus Niebert, Felix Zeppernick, Ivo Meihold-Heerlein & Ahmad Fawzi Hussain. (2022) EpCAM- and EGFR-Specific Antibody Drug Conjugates for Triple-Negative Breast Cancer Treatment. International Journal of Molecular Sciences 23:11, pages 6122.
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V. T. AnjaliFeroze Kaliyadan. (2022) Immunotherapy in skin cancers - A narrative review. Journal of Skin and Sexually Transmitted Diseases 4, pages 11-18.
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Md. Mahbub Hasan, Mark Laws, Peiqin Jin & Khondaker Miraz Rahman. (2022) Factors influencing the choice of monoclonal antibodies for antibody–drug conjugates. Drug Discovery Today 27:1, pages 354-361.
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Zhefu Dai, Xiao-Nan Zhang, Qinqin Cheng, Fan Fei, Tianling Hou, Jiawei Li, Alireza Abdolvahabi, Junji Watanabe, Hua Pei, Goar Smbatyan, Jianming Xie, Heinz-Josef Lenz, Stan G. Louie & Yong Zhang. (2021) Site-specific antibody-drug conjugates with variable drug-to-antibody-ratios for AML therapy. Journal of Controlled Release 336, pages 433-442.
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Donald J. AbrahamL. Nathan Tumey. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 39 .
M. Knödler & J.F. Buyel. (2021) Plant-made immunotoxin building blocks: A roadmap for producing therapeutic antibody-toxin fusions. Biotechnology Advances 47, pages 107683.
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Suresh Madheswaran, Neelakshi Mungra, Fleury A.N. Biteghe, Jean De la Croix Ndong, Afolake T. Arowolo, Henry A. Adeola, Dharanidharan Ramamurthy, Krupa Naran, Nonhlanhla P. Khumalo & Stefan Barth. (2020) Antibody-Based Targeted Interventions for the Diagnosis and Treatment of Skin Cancers. Anti-Cancer Agents in Medicinal Chemistry 21:2, pages 162-186.
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Mahendra P Deonarain & Quinn Xue. (2020) Tackling solid tumour therapy with small-format drug conjugates. Antibody Therapeutics 3:4, pages 237-245.
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Fleury Augustin Nsole Biteghe, Neelakshi Mungra, Nyangone Ekome Toung Chalomie, Jean De La Croix Ndong, Jean Engohang-Ndong, Guillaume Vignaux, Eden Padayachee, Krupa Naran & Stefan Barth. (2020) Advances in epidermal growth factor receptor specific immunotherapy: lessons to be learned from armed antibodies. Oncotarget 11:38, pages 3531-3557.
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Fleury Augustin Nsole Biteghe, Nyangone Ekome Toung Chalomie, Neelakshi Mungra, Guillaume Vignaux, Nan Gao, Aurelia Vergeade, Ambrose Okem, Krupa Naran, Jean De La Croix Ndong & Stefan Barth. (2020) Antibody-Based Immunotherapy: Alternative Approaches for the Treatment of Metastatic Melanoma. Biomedicines 8:9, pages 327.
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Zhefu Dai, Xiao-Nan Zhang, Fariborz NasertorabiQinqin ChengJiawei LiBenjamin B. Katz, Goar Smbatyan, Hua PeiStan G. Louie, Heinz-Josef LenzRaymond C. Stevens & Yong Zhang. (2020) Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases. Science Advances 6:23.
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Nagavendra Kommineni, Palpandi Pandi, Naveen Chella, Abraham J. Domb & Wahid Khan. (2019) Antibody drug conjugates: Development, characterization, and regulatory considerations. Polymers for Advanced Technologies 31:6, pages 1177-1193.
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L. Nathan Tumey. 2020. Antibody-Drug Conjugates. Antibody-Drug Conjugates 1 22 .
Eden Rebecca Padayachee, Henry Ademola Adeola, Jennifer Catherine Van Wyk, Fleury Augustine Nsole Biteghe, Shivan Chetty, Nonhlanhla Patience Khumalo & Stefan Barth. (2019) Applications of SNAP-tag technology in skin cancer therapy. Health Science Reports 2:2, pages e103.
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Mahendra P. Deonarain. (2018) Miniaturised ‘antibody’-drug conjugates for solid tumours?. Drug Discovery Today: Technologies 30, pages 47-53.
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