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OncoTargets and Therapy Volume 10, 2017 - Issue
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Original Research

Downregulation of DEPTOR inhibits the proliferation, migration, and survival of osteosarcoma through PI3K/Akt/mTOR pathway

Binwu Hu1 Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
,
Xiao Lv1 Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
,
Feng Gao1 Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
,
Songfeng Chen2 Department of Orthopaedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
,
Shangyu Wang1 Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
,
Xiangcheng Qing1 Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
,
Jianxiang Liu1 Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
,
Baichuan Wang1 Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCorrespondence[email protected] [email protected]
&
Zengwu Shao1 Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCorrespondence[email protected] [email protected]
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Pages 4379-4391 | Published online: 08 Sep 2017

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Kun Ma, Chuan Zhang & Wuyin Li. (2020) RETRACTED ARTICLE: TGF-β is associated with poor prognosis and promotes osteosarcoma progression via PI3K/Akt pathway activation. Cell Cycle 19:18, pages 2327-2339.
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Yong Guan, Yajie He, Shaoping Lv, Xiaoqun Hou, Luo Li & Jianjun Song. (2019) Overexpression of HOXC10 promotes glioblastoma cell progression to a poor prognosis via the PI3K/AKT signalling pathway. Journal of Drug Targeting 27:1, pages 60-66.
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Binwu Hu, Deyao Shi, Xiao Lv, Fashuai Wu, Songfeng Chen & Zengwu Shao. (2018) Prognostic and clinicopathological significance of DEPTOR expression in cancer patients: a meta-analysis. OncoTargets and Therapy 11, pages 5083-5092.
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Articles from other publishers (15)

Mehrshad Sadria, Deokhwa Seo & Anita T. Layton. (2022) The mixed blessing of AMPK signaling in Cancer treatments. BMC Cancer 22:1.
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Zhongguang Wu, Xiaobo Zhang, Dongjie Chen, Zian Li, Xin Wu, Jianlong Wang & Youwen Deng. (2022) N6-Methyladenosine-Related LncRNAs Are Potential Remodeling Indicators in the Tumor Microenvironment and Prognostic Markers in Osteosarcoma. Frontiers in Immunology 12.
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Martina Raudenska, Jan Balvan & Michal Masarik. (2021) Crosstalk between autophagy inhibitors and endosome-related secretory pathways: a challenge for autophagy-based treatment of solid cancers. Molecular Cancer 20:1.
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Marcella Massimini, Mariarita Romanucci, Raffaella De Maria & Leonardo Della Salda. (2021) An Update on Molecular Pathways Regulating Vasculogenic Mimicry in Human Osteosarcoma and Their Role in Canine Oncology. Frontiers in Veterinary Science 8.
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Xian Wu, Ruiying Tong, Xiuli Chen, Xinying Jiang, Xiaoying He & Libing Ma. (2021) The miR-302s/367 Cluster Inhibits the Proliferation and Apoptosis in Sheep Fetal Fibroblasts via the Cell Cycle and PI3K-Akt Pathways. Mammalian Genome 32:3, pages 183-194.
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Elham Amjad, Solmaz Asnaashari & Babak Sokouti. (2020) Induction of mTOR signaling pathway in the progression of papillary thyroid cancer. Meta Gene 24, pages 100704.
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Min Ma, Cuiru Wang, Yue Ao, Nimantana He, Fei Hao, Hao Liang & Dongjun Liu. (2020) HOXC10 promotes proliferation and attenuates lipid accumulation of sheep bone marrow mesenchymal stem cells. Molecular and Cellular Probes 49, pages 101491.
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Jin Chen, Haidan Zhu, Qiumeng Liu, Deng Ning, Zhaoqi Zhang, Long Zhang, Jie Mo, Pengcheng Du, Xu Liu, Shasha Song, Yawei Fan, Huifang Liang, Jikui Liu, Bixiang Zhang & Xiaoping Chen. (2019) DEPTOR induces a partial epithelial-to-mesenchymal transition and metastasis via autocrine TGFβ1 signaling and is associated with poor prognosis in hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research 38:1.
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Wenbin Ding, Dajiang Wu, Fang Ji & Hao Zhang. (2019) Inhibition of long non‑coding RNA‑AWPPH decreases osteosarcoma cell proliferation, migration and invasion. Oncology Letters.
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Bruna H. Marcon, Patrícia Shigunov, Lucia Spangenberg, Isabela Tiemy Pereira, Alessandra Melo de Aguiar, Rocío Amorín, Carmen K. Rebelatto, Alejandro Correa & Bruno Dallagiovanna. (2019) Cell cycle genes are downregulated after adipogenic triggering in human adipose tissue-derived stem cells by regulation of mRNA abundance. Scientific Reports 9:1.
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Falguni Das, Nandini Ghosh-Choudhury, Doug Yoon Lee, Yves Gorin, Balakuntalam S. Kasinath & Goutam Ghosh Choudhury. (2018) Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression. PLOS ONE 13:11, pages e0207285.
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Qun-Qun Jiang & Wei-Bing Liu. (2018) Lycorine inhibits melanoma A375 cell growth and metastasis through the inactivation of the PI3K/AKT signaling pathway. médecine/sciences 34, pages 33-38.
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Yi Qin, Jichao� Ye, Fulan Zhao, Shaoyu Hu & Suwei Wang. (2018) TRIM2 regulates the development and metastasis of tumorous cells of osteosarcoma. International Journal of Oncology.
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Alexandre Caron, David M. BriscoeDenis RichardMathieu Laplante. (2018) DEPTOR at the Nexus of Cancer, Metabolism, and Immunity. Physiological Reviews 98:3, pages 1765-1803.
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Abhay P. Mishra, Bahare Salehi, Mehdi Sharifi-Rad, Raffaele Pezzani, Farzad Kobarfard, Javad Sharifi-Rad & Manisha Nigam. (2018) Programmed Cell Death, from a Cancer Perspective: An Overview. Molecular Diagnosis & Therapy 22:3, pages 281-295.
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