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Original Research

RETRACTED ARTICLE: Kanglaite reverses multidrug resistance of HCC by inducing apoptosis and cell cycle arrest via PI3K/AKT pathway

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Pages 983-996 | Published online: 26 Feb 2018

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Mahshid Deldar Abad Paskeh, Fatemeh Ghadyani, Mehrdad Hashemi, Alireza Abbaspour, Amirhossein Zabolian, Salar Javanshir, Mehrnaz Razzazan, Sepideh Mirzaei, Maliheh Entezari, Mohammad Ali Shekhi Beig Goharrizi, Shokooh Salimimoghadam, Amir Reza Aref, Alireza Kalbasi, Romina Rajabi, Mohsen Rashidi, Afshin Taheriazam & Gautam Sethi. (2023) Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges. Pharmacological Research 187, pages 106553.
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Yi Sun, Peishi Jiang, Hongjie Yang, Zhichun Zhang, Yuanda Zhou, Peng Li, Qingsheng Zeng & Xipeng Zhang. (2022) Network Pharmacology-Based Analysis of the Potential Biological Mechanisms of Coix Seed against Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-11.
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Zhihui Zhang, Yulin Kuang, Kui Ma, Yan Li, Xiaoming Liu, Yuru Shi & Xu Wu. (2022) Gclc overexpression inhibits apoptosis of bone marrow mesenchymal stem cells through the PI3K/AKT/Foxo1 pathway to alleviate inflammation in acute lung injury. International Immunopharmacology 110, pages 109017.
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Cuncun Lu, Shuilin Wu, Lixin Ke, Fumei Liu, Wenru Shang, Xiuxiu Deng, Yanli Huang, Qiang Zhang, Xin Cui, Alexios-Fotios A. Mentis, Yanming Xie & Zhifei Wang. (2022) Kanglaite (Coix Seed Extract) as Adjunctive Therapy in Cancer: Evidence Mapping Overview Based on Systematic Reviews With Meta-Analyses. Frontiers in Pharmacology 13.
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Maomao Tang, Yuzhe Huang, Xiao Liang, Yaotian Tao, Ning He, Zhenbao Li, Jian Guo & Shuangying Gui. (2022) Sorafenib-Loaded PLGA-TPGS Nanosystems Enhance Hepatocellular Carcinoma Therapy Through Reversing P-Glycoprotein-Mediated Multidrug Resistance. AAPS PharmSciTech 23:5.
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Jian Yang, Ying Liu, Shengnan Lu, Xuejia Sun, Yue Yin, Kaifeng Wang & Shi Liu. (2022) Coix seed oil regulates mitochondrial functional damage to induce apoptosis of human pancreatic cancer cells via the PTEN/PI3K/AKT signaling pathway. Molecular Biology Reports 49:7, pages 5897-5909.
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Chunlei Ni, Bailiang Li, Yangyue Ding, Yue Wu, Qiuye Wang, Jiarong Wang & Jianjun Cheng. (2021) Anti-Cancer Properties of Coix Seed Oil against HT-29 Colon Cells through Regulation of the PI3K/AKT Signaling Pathway. Foods 10:11, pages 2833.
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Guanghui Zhu, Xinmiao Wang, Jie Li, Ying Zhang, Ruike Gao, Xiaoxiao Zhang, Bowen Xu, Jiaqi Hu, Minghao Dai & Jiayang Chen. (2021) Evaluation of Efficacy and Safety for Kanglaite Injection in the Control of the Malignant Pleural Effusions via Thoracic Perfusion: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Frontiers in Pharmacology 12.
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Chang-liang Yao, Jian-qing Zhang, Jia-yuan Li, Wen-long Wei, Shi-fei Wu & De-an Guo. (2021) Traditional Chinese medicine (TCM) as a source of new anticancer drugs. Natural Product Reports 38:9, pages 1618-1633.
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M. Ganesan, G. Kanimozhi, B. Pradhapsingh, Haseeb A. Khan, Abdullah S. Alhomida, Aishah Ekhzaimy, GR Brindha & N. Rajendra Prasad. (2021) Phytochemicals reverse P-glycoprotein mediated multidrug resistance via signal transduction pathways. Biomedicine & Pharmacotherapy 139, pages 111632.
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Chen Chen, Qi-di Ai & Yu-hui Wei. (2021) Kanglaite enhances the efficacy of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-κB pathway and regulating transporter mediated drug efflux. Journal of Ethnopharmacology 264, pages 113388.
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Ting Fang, Yi-Xin Jiang, Long Chen, Ling Huang, Xin-Hui Tian, Yu-Dong Zhou, Dale G. Nagle & Dan-Dan Zhang. (2020) Coix Seed Oil Exerts an Anti–Triple-Negative Breast Cancer Effect by Disrupting miR-205/S1PR1 Axis. Frontiers in Pharmacology 11.
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Weili Mao, Yihua Fan, Chao ChengXingyu YuanTian Lan, Kaili Mao & Jun Wang. (2020) Efficacy and safety of Kanglaite injection combined with chemotherapy for colorectal cancer. Medicine 99:39, pages e22357.
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Rui Liu, Youwen Chen, Guangzhi Liu, Chenxi Li, Yurong Song, Zhiwen Cao, Wen Li, Jinghong Hu, Cheng Lu & Yuanyan Liu. (2020) PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers. Cell Death & Disease 11:9.
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Dou Dou, Ze-yu Zhang, Zhi-yuan Wu, Xu-dong Qiu & Xiang-gen Zhong. (2020) Aidi Injection, Compound Kushen Injection, or Kanglaite Injection: Which Is the Best Partner with Systemic Chemotherapy for Patients with HCC? A Network Meta-Analysis. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-11.
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Daorui Hou, Liangjun Yang, Jian XiongLu Xiong. (2020) Efficacy and safety of Kanglaite injection for gastric cancer. Medicine 99:32, pages e21619.
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Xiang Zhang, Songna Yin & Ke Ma. (2020) Bioinformatics analysis of different candidate genes involved in hepatocellular carcinoma induced by HepG2 cells or tumor cells of patients. Journal of International Medical Research 48:6, pages 030006052093211.
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Qi Song, Jie ZhangQibiao WuGuoping Li & Elaine Lai-Han Leung. (2020) Kanglaite injection plus fluorouracil-based chemotherapy on the reduction of adverse effects and improvement of clinical effectiveness in patients with advanced malignant tumors of the digestive tract. Medicine 99:17, pages e19480.
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Xiaoming Huang, Jue Wang, Wanjun Lin, Na Zhang, Jingjing Du, Ze Long, You Yang, Bowen Zheng, Fangfang Zhong, Qibiao Wu & Wenzhe Ma. (2020) Kanglaite injection plus platinum-based chemotherapy for stage III/IV non-small cell lung cancer: A meta-analysis of 27 RCTs. Phytomedicine 67, pages 153154.
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Qiying Yi, Yang Liu, Min Cao, Jianing Liu, Qin Xiang, Guo Tan, Huatang Zhang, Guoqi Lai & Yajun Xie. (2020) Transcriptional analysis and differentially expressed gene screening of spontaneous liver tumors in CBA/CaJ mice. Gene 725, pages 144159.
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Mengfei Guo, Ding Qu, Yue Qin, Yunyan Chen, Yuping Liu, Mengmeng Huang & Yan Chen. (2019) Transferrin-Functionalized Microemulsions Coloaded with Coix Seed Oil and Tripterine Deeply Penetrate To Improve Cervical Cancer Therapy. Molecular Pharmaceutics 16:12, pages 4826-4835.
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Jingjing Liu, Xueni Liu, Jing Ma, Ke Li & Chao Xu. (2019) The clinical efficacy and safety of kanglaite adjuvant therapy in the treatment of advanced hepatocellular carcinoma: A PRISMA-compliant meta-analysis. Bioscience Reports 39:11.
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Qian, Xiong, Feng, Wu, Zhang, Chen & Gu. (2019) Coix Seed Extract Enhances the Anti-Pancreatic Cancer Efficacy of Gemcitabine through Regulating ABCB1- and ABCG2-Mediated Drug Efflux: A Bioluminescent Pharmacokinetic and Pharmacodynamic Study. International Journal of Molecular Sciences 20:21, pages 5250.
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Xiang Ji, Xing Wei, Jie Qian, Xuejun Mo, Guoyin Kai, Faliang An & Yanhua Lu. (2019) 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone induced apoptosis and G1 cell cycle arrest through PI3K/AKT pathway in BEL-7402/5-FU cells. Food and Chemical Toxicology 131, pages 110533.
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Jianling Liu, Lingbo Yu & Wei Ding. (2019) Efficacy and safety of Kanglaite injection combined with radiochemotherapy in the treatment of advanced pancreatic cancer. Medicine 98:32, pages e16656.
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Yafang Pan, Yu Zhang, Wenwen Liu, Yan Huang, Xianjuan Shen, Rongrong Jing, Jiang Pu, Xudong Wang, Shaoqing Ju, Hui Cong & Hongmei Chen. (2019) LncRNA H19 overexpression induces bortezomib resistance in multiple myeloma by targeting MCL-1 via miR-29b-3p. Cell Death & Disease 10:2.
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Jia-yin Hou, Hua-yu Wu, Rong-quan He, Peng Lin, Yi-wu Dang & Gang Chen. (2019) Clinical and prognostic value of chaperonin containing T-complex 1 subunit 3 in hepatocellular carcinoma: A Study based on microarray and RNA-sequencing with 4272 cases. Pathology - Research and Practice 215:1, pages 177-194.
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Fuhai Hui, Xiaochun Qin, Qiao Zhang, Ruolan Li, Mingyue Liu, Tianshu Ren, Mingyi Zhao & Qingchun Zhao. (2019) Alpinia oxyphylla oil induces apoptosis of hepatocellular carcinoma cells via PI3K/Akt pathway in vitro and in vivo. Biomedicine & Pharmacotherapy 109, pages 2365-2374.
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Xin Gao, Yinyi Chen, Mei Chen, Shunlan Wang, Xiaohong Wen & Shufang Zhang. (2018) Identification of key candidate genes and biological pathways in bladder cancer. PeerJ 6, pages e6036.
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