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Original Research

Inhibition of EZH2 and EGFR produces a synergistic effect on cell apoptosis by increasing autophagy in gastric cancer cells

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Pages 8455-8463 | Published online: 29 Nov 2018

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Shanshan Liu, Guihong Rong, Xia Li, Lijun Geng, Zhineng Zeng, Dongxiang Jiang, Jun Yang & Yesheng Wei. (2020) Diosgenin and GSK126 Produce Synergistic Effects on Epithelial–Mesenchymal Transition in Gastric Cancer Cells by Mediating EZH2 via the Rho/ROCK Signaling Pathway. OncoTargets and Therapy 13, pages 5057-5067.
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Articles from other publishers (19)

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Qili Liao, Jie Yang, Shengfang Ge, Peiwei Chai, Jiayan Fan & Renbing Jia. (2023) Novel insights into histone lysine methyltransferases in cancer therapy: From epigenetic regulation to selective drugs. Journal of Pharmaceutical Analysis 13:2, pages 127-141.
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Feng Shu, Han Xiao, Qiu-Nuo Li, Xiao-Shuai Ren, Zhi-Gang Liu, Bo-Wen Hu, Hong-Sheng Wang, Hao Wang & Guan-Min Jiang. (2023) Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets. Signal Transduction and Targeted Therapy 8:1.
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Dong He, Tao Xin, Bo Pang, Jun Sun, Zi Hao Liu, Zhen Qin, Xiao Shuai Ji, Fan Yang, Yan Bang Wei, Zi Xiao Wang, Jia Jia Gao, Qi Pang & Qian Liu. (2022) A novel lncRNA MDHDH suppresses glioblastoma multiforme by acting as a scaffold for MDH2 and PSMA1 to regulate NAD+ metabolism and autophagy. Journal of Experimental & Clinical Cancer Research 41:1.
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Leonie Ratz, Chiara Brambillasca, Leandra Bartke, Maxim A. Huetzen, Jonas Goergens, Orsolya Leidecker, Ron D. Jachimowicz, Marieke van de Ven, Natalie Proost, Bjørn Siteur, Renske de Korte-Grimmerink, Peter Bouwman, Emilia M. Pulver, Roebi de Bruijn, Jörg Isensee, Tim Hucho, Gaurav Pandey, Maarten van Lohuizen, Peter Mallmann, Hans Christian Reinhardt, Jos Jonkers & Julian Puppe. (2022) Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer. Breast Cancer Research 24:1.
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Jinfeng Du, Qian Xu, Han Zhao, Xiyun Jia, Nan Ba, Fanghui Peng & Zisen Zhang. (2022) PI3K inhibitor 3-MA promotes the antiproliferative activity of esomeprazole in gastric cancer cells by downregulating EGFR via the PI3K/FOXO3a pathway. Biomedicine & Pharmacotherapy 148, pages 112665.
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Nannan HUANG, Dan YU, Junkai WU & Xiaowei DU. (2022) Diosgenin: an important natural pharmaceutical active ingredient. Food Science and Technology 42.
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Yang Li, Gaoxia Yang, Chengcan Yang, Pan Tang, Juncheng Chen, Jifa Zhang, Jie Liu & Liang Ouyang. (2021) Targeting Autophagy-Related Epigenetic Regulators for Cancer Drug Discovery. Journal of Medicinal Chemistry 64:16, pages 11798-11815.
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Oliver J. Pickering, Stella P. Breininger, Timothy J. Underwood & Zoë S. Walters. (2021) Histone Modifying Enzymes as Targets for Therapeutic Intervention in Oesophageal Adenocarcinoma. Cancers 13:16, pages 4084.
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Shuai Xue, Ming Ma, Songhua Bei, Fan Li, Chenqu Wu, Huanqing Li, Yanling Hu, Xiaohong Zhang, YanQing Qian, Zhe Qin, Jun Jiang & Li Feng. (2021) Identification and Validation of the Immune Regulator CXCR4 as a Novel Promising Target for Gastric Cancer. Frontiers in Immunology 12.
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Rui Huang & Shuyan Wu. 2021. Autophagy: Biology and Diseases. Autophagy: Biology and Diseases 311 332 .
Marie-Lisa Eich, Mohammad Athar, James E. FergusonIIIIII & Sooryanarayana Varambally. (2020) EZH2-Targeted Therapies in Cancer: Hype or a Reality. Cancer Research 80:24, pages 5449-5458.
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Ran Duan, Wenfang Du & Weijian Guo. (2020) EZH2: a novel target for cancer treatment. Journal of Hematology & Oncology 13:1.
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Elena Shramova, Galina Proshkina, Victoria Shipunova, Anastasia Ryabova, Roman Kamyshinsky, Andrey Konevega, Aleksey Schulga, Elena Konovalova, Georgij Telegin & Sergey Deyev. (2020) Dual Targeting of Cancer Cells with DARPin-Based Toxins for Overcoming Tumor Escape. Cancers 12:10, pages 3014.
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Marin Ishikawa, Hideyuki Hayashi, Naoya Sakamoto, Shinya Tanaka & Hiroshi Nishihara. (2019) Cancer gene profiling explores the possible precision medicine for diffuse-type gastric adenocarcinoma. Medical Oncology 37:1.
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Paul Peixoto, Céline Grandvallet, Jean-Paul Feugeas, Michaël Guittaut & Eric Hervouet. (2019) Epigenetic Control of Autophagy in Cancer Cells: A Key Process for Cancer-Related Phenotypes. Cells 8:12, pages 1656.
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Sung Hee Lim, Jason K. Sa, Dong Woo Lee, Jusun Kim, Seung Tae Kim, Se Hoon Park, Bosung Ku, Joon Oh Park, Young Suk Park, Hoyeong Lim, Won Ki Kang, Do-Hyun Nam & Jeeyun Lee. (2019) Systematic Evaluation of Gastric Tumor Cell Index and Two-Drug Combination Therapy via 3-Dimensional High-Throughput Drug Screening. Frontiers in Oncology 9.
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Shuang Cai, Yang Weng, Pengliang Liu & Feng Miao. (2019) Knockdown of ST7-AS1 inhibits migration, invasion, cell cycle progression and induces apoptosis of gastric cancer. Oncology Letters.
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Silvia Stacchiotti, Valentina Zuco, Monica Tortoreto, Denis Cominetti, Anna Maria Frezza, Stefano Percio, Valentina Indio, Marta Barisella, Valentina Monti, Silvia Brich, Annalisa Astolfi, Chiara Colombo, Sandro Pasquali, Marco Folini, Mrinal M. Gounder, Maria A. Pantaleo, Paola Collini, Angelo Paolo Dei Tos, Paolo Giovanni Casali, Alessandro Gronchi & Nadia Zaffaroni. (2019) Comparative Assessment of Antitumor Effects and Autophagy Induction as a Resistance Mechanism by Cytotoxics and EZH2 Inhibition in INI1-Negative Epithelioid Sarcoma Patient-Derived Xenograft. Cancers 11:7, pages 1015.
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