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OncoTargets and Therapy Volume 12, 2019 - Issue
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Original Research

Apiosporamide, A 4-hydroxy-2-pyridone Alkaloid, Induces Apoptosis Via PI3K/Akt Signaling Pathway In Osteosarcoma Cells

Yuying Zhang1 Department of Biotechnology, School of Biological Science and Technology, University of Jinan, Jinan 250022, People’s Republic of China
,
Qianqian Zhang1 Department of Biotechnology, School of Biological Science and Technology, University of Jinan, Jinan 250022, People’s Republic of China
,
Jie Bao1 Department of Biotechnology, School of Biological Science and Technology, University of Jinan, Jinan 250022, People’s Republic of China
,
Jintian Huang2 Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, People’s Republic of China
&
Hua Zhang1 Department of Biotechnology, School of Biological Science and Technology, University of Jinan, Jinan 250022, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-5959-6473
ORCID Icon
Pages 8611-8620 | Published online: 21 Oct 2019

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Ahmed A. Fadda, Reham A. Ghanem, Hatem E. Gaffer, Mohamed M. Waly & Eman H. Tawfik. (2023) Synthesis, Antimicrobial Evaluation, and Molecular Docking of New Azole, Azine, Thiazole, and Chromene Derivatives. Polycyclic Aromatic Compounds 43:4, pages 3429-3449.
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Articles from other publishers (11)

Shilpa A. Verekar, Manish K. Gupta & Sunil Kumar Deshmukh. 2023. Fungi and Fungal Products in Human Welfare and Biotechnology. Fungi and Fungal Products in Human Welfare and Biotechnology 257 287 .
Dimitris Kalaitzakis, Artemis Bosveli, Tamsyn Montagnon & Georgios Vassilikogiannakis. (2022) Sequential Visible Light‐Induced Reactions Using Different Photocatalysts: Transformation of Furans into 2‐Pyridones via γ‐Lactams Using a New Ring Expansion Reaction. Chemistry – A European Journal 28:17.
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Sarita Sangwan, Neelam Yadav, Ravi Kumar, Sonu Chauhan, Vidhi Dhanda, Pooja Walia & Anil Duhan. (2022) A score years’ update in the synthesis and biological evaluation of medicinally important 2-pyridones. European Journal of Medicinal Chemistry 232, pages 114199.
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Shuo Li, Ruirong Guo, Zhibin Peng, Bingxuan Quan, Yuhang Hu, Yiwen Wang & Yansong Wang. (2021) NPR3, transcriptionally regulated by POU2F1, inhibits osteosarcoma cell growth through blocking the PI3K/AKT pathway. Cellular Signalling 86, pages 110074.
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Sivanna Chithanna & Ding-Yah Yang. (2021) Construction of 2-pyridones via oxidative cyclization of enamides: access to Pechmann dye derivatives . Organic & Biomolecular Chemistry 19:7, pages 1565-1574.
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Katrina L. Forrestall, Darcy E. Burley, Meghan K. Cash, Ian R. Pottie & Sultan Darvesh. (2021) 2-Pyridone natural products as inhibitors of SARS-CoV-2 main protease. Chemico-Biological Interactions 335, pages 109348.
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Yuying Zhang, Mengru Li, Qianqian Zhang, Zhaoyang Wang, Xiuxiu Li, Jie Bao & Hua Zhang. (2021) Arthpyrone L, a New Pyridone Alkaloid from a Deep‐Sea Arthrinium sp., Inhibits Proliferation of MG63 Osteosarcoma Cells by Inducing G0/G1 Arrest and Apoptosis . Chemistry & Biodiversity 18:2.
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Xiaohui Pan, Jingxue Tan, Xiaokun Weng, Rui Du, Yuqing Jiang, Yiping Weng, Dong Zhou & Yifei Shen. (2021) ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 Pathway. BioMed Research International 2021, pages 1-10.
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Shanyong ZhangLei DingFeng GaoHongwu Fan. (2020) Long non-coding RNA DSCAM-AS1 upregulates USP47 expression through sponging miR-101-3p to accelerate osteosarcoma progression . Biochemistry and Cell Biology 98:5, pages 600-611.
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Mengmeng Zhang, Hanyang Lan, Nan Li, Qidi Zhong, Hao Zhu, Chunyan Liu & Hongwu Zhao. (2020) Photocatalyst-Free Singlet Oxygen-Induced Oxygenation: A Strategy for the Preparation of 5-Cyano-2-pyridones Driven by Blue-Light Irradiation. The Journal of Organic Chemistry 85:12, pages 8279-8286.
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Yong Zhang, Qiuyan Weng, Jinming Han & Jianming Chen. (2019) Alantolactone suppresses human osteosarcoma through the PI3K/AKT signaling pathway. Molecular Medicine Reports.
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