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OncoTargets and Therapy Volume 13, 2020 - Issue
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Original Research

Sinomenine Inhibits Non-Small Cell Lung Cancer via Downregulation of Hexokinases II-Mediated Aerobic Glycolysis

Wenbin Liu1 Department of Pathology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan410006, People’s Republic of China
,
Xinfang Yu2 Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio44195, USA
,
Li Zhou3 Department of Pathology, Xiangya Hospital of Central South University, Changsha, Hunan410008, People’s Republic of China
,
Jigang Li1 Department of Pathology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan410006, People’s Republic of China
,
Ming Li4 School of Stomatology, Hunan University of Chinese Medicine, Changsha, Hunan410208, People’s Republic of China;5 Changsha Stomatological Hospital, Hunan University of Chinese Medicine, Changsha, Hunan, 410004, People’s Republic of China
,
Wei Li6 Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan410013, People’s Republic of ChinaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-7267-6494
ORCID Icon &
Feng Gao7 Department of Ultrasonography, The Third Xiangya Hospital of Central South University, Changsha, Hunan410013, People’s Republic of China
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Pages 3209-3221 | Published online: 16 Apr 2020

Citations (18)

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Read on this site (2)

Xi Liu, Lei Chen & Tao Wang. (2023) Overcoming cisplatin resistance of human lung cancer by sinomenine through targeting the miR-200a-3p-GLS axis. Journal of Chemotherapy 35:4, pages 357-366.
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Xiang Gao, Hao-Nan Li, Peng-Ju Liu, Xiao-Kang Long, Xue-Hai Guo, Hui-Ming Hua & Da-Hong Li. Synthesis of sinomenine derivatives with potential anti-leukemia activity. Journal of Asian Natural Products Research 0:0, pages 1-17.
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Articles from other publishers (16)

Miao Yu, Miao Yu & Yubin Ji. (2024) Sinomenine: A Protential Biomaterial for Its Antitumor Effect in H22 Hepatoma-Bearing Mice and Its Mechanisms. Science of Advanced Materials 16:3, pages 385-395.
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Wen Hou, Lejun Huang, Hao Huang, Shenglan Liu, Wei Dai, Jianhong Tang, Xiangzhao Chen, Xiaolu Lu, Qisheng Zheng, Zhinuo Zhou, Ziyun Zhang & Jinxia Lan. (2024) Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review. Molecules 29:2, pages 540.
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Zhe Wang, Jinyou Li, LongFei Wang, Yaowei Liu, Wei Wang, JiaYao Chen, HuiJun Liang, Y. Q. Chen & ShengLong Zhu. (2024) FFAR4 activation inhibits lung adenocarcinoma via blocking respiratory chain complex assembly associated mitochondrial metabolism. Cellular & Molecular Biology Letters 29:1.
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Dan Li, Zhangfeng Zhong, Chung‐Nga Ko, Tiantian Tian & Chao Yang. (2023) From mundane to classic: Sinomenine as a multi‐therapeutic agent. British Journal of Pharmacology.
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Mohammad Mahboubi-Rabbani, Maryam Abbasi & Afshin Zarghi. (2023) Natural-Derived COX-2 Inhibitors as Anticancer Drugs: A Review of their Structural Diversity and Mechanism of Action. Anti-Cancer Agents in Medicinal Chemistry 23:1, pages 15-36.
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Chunmei Tan, Lanqing Li, Juanjuan Han, Kang Xu & Xianqiong Liu. (2022) A new strategy for osteoarthritis therapy: Inhibition of glycolysis. Frontiers in Pharmacology 13.
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Yuting Cui, Chuang Li, Feng Sang, Weiling Cao, Zhuo Qin & Peng Zhang. (2022) Natural products targeting glycolytic signaling pathways-an updated review on anti-cancer therapy. Frontiers in Pharmacology 13.
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Hongkui Chen, Min Zheng, Wenhui Zhang, Yuan Long, Yu Xu & Man Yuan. (2022) Research Status of Mouse Models for Non-Small-Cell Lung Cancer (NSCLC) and Antitumor Therapy of Traditional Chinese Medicine (TCM) in Mouse Models. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-13.
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Jing Zhang, Aomei Zhao, Xi Jia, Xinru Li, Yiqian Liang, Yan Liu, Xin Xie, Xijie Qu, Qi Wang, Yuemin Zhang, Rui Gao, Yan Yu & Aimin Yang. (2022) Sinomenine Hydrochloride Promotes TSHR-Dependent Redifferentiation in Papillary Thyroid Cancer. International Journal of Molecular Sciences 23:18, pages 10709.
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Fabrizio Fontana, Martina Anselmi & Patrizia Limonta. (2022) Exploiting the Metabolic Consequences of PTEN Loss and Akt/Hexokinase 2 Hyperactivation in Prostate Cancer: A New Role for δ-Tocotrienol. International Journal of Molecular Sciences 23:9, pages 5269.
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Wenjing Zhang, Cui Wang, Xiaomei Hu, Yanzhen Lian, Caili Ding & Liang Ming. (2022) Inhibition of LDHA suppresses cell proliferation and increases mitochondrial apoptosis via the JNK signaling pathway in cervical cancer cells. Oncology Reports 47:4.
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Na Chen, Yi-Shu Zhou, Li-Cui Wang & Jin-Bai Huang. (2022) Advances in metformin‑based metabolic therapy for non‑small cell lung cancer (Review). Oncology Reports 47:3.
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Anna Sebestyén, Titanilla Dankó, Dániel Sztankovics, Dorottya Moldvai, Regina Raffay, Catherine Cervi, Ildikó Krencz, Viktória Zsiros, András Jeney & Gábor Petővári. (2022) The role of metabolic ecosystem in cancer progression — metabolic plasticity and mTOR hyperactivity in tumor tissues. Cancer and Metastasis Reviews 40:4, pages 989-1033.
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Liyan Yang & Zhonglei Wang. (2021) Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer. Biomedicines 9:6, pages 689.
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Qi-Xing Yan, Yun Pan, Hai-Li Huang & Hui Zhao. (2021) Therapeutic Potential of Natural Products in Lung Cancer. International Journal of Pharmacology 17:5, pages 251-261.
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Ezequiel Monferrer, Isaac Vieco-Martí, Amparo López-Carrasco, Fernando Fariñas, Sergio Abanades, Luis de la Cruz-Merino, Rosa Noguera & Tomás Álvaro Naranjo. (2021) Metabolic Classification and Intervention Opportunities for Tumor Energy Dysfunction. Metabolites 11:5, pages 264.
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