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Case Report

Immune Checkpoint Inhibitor Therapy Achieved Complete Response for Drug-Sensitive EGFR/ALK Mutation-Negative Metastatic Pulmonary Large-Cell Neuroendocrine Carcinoma with High Tumor Mutation Burden: A Case Report

Xin Zhang1 The Department of Thoracic Surgery, The First Hospital of China Medical University, Shenyang110001, Liaoning Province, People’s Republic of China

Yanbin Sun1 The Department of Thoracic Surgery, The First Hospital of China Medical University, Shenyang110001, Liaoning Province, People’s Republic of China

https://orcid.org/0000-0003-4145-9515

Yuan Miao2 The Department of Pathology, The First Hospital of China Medical University, Shenyang110001, Liaoning Province, People’s Republic of China

https://orcid.org/0000-0001-7869-8099

Shun Xu1 The Department of Thoracic Surgery, The First Hospital of China Medical University, Shenyang110001, Liaoning Province, People’s Republic of ChinaCorrespondence[email protected]

Pages 8245-8250 | Published online: 19 Aug 2020

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Xiaoyun Chen, Yedong Huang, Fangrong Chen, Hui She & Xiangqi Chen. (2022) Risk factors and prognostic factors for pulmonary large cell neuroendocrine carcinoma with brain metastasis. Cancer Medicine 12:4, pages 4087-4099.
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Roberta Modica, Alessia Liccardi, Elio Benevento, Roberto Minotta, Giuseppe Cannavale & Annamaria Colao. 2023.

Wang Jianping, Liu Zipeng, Pan Tengfei & Zhang Song. (2022) A multiple detection method for distinguishing gene mutations based on melting curves of extended quenching probes. Heliyon 8:11, pages e11856.
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Naoki Kadota, Nobuo Hatakeyama, Hiroyuki Hino, Michihiro Kunishige, Yoshihiro Kondo, Yoshio Okano, Hisanori Machida, Keishi Naruse, Tsutomu Shinohara, Shoji Sakiyama, Fumitaka Ogushi & Eiji Takeuchi. (2021) Complete and durable response of pulmonary large‐cell neuroendocrine carcinoma to pembrolizumab. Cancer Reports 5:8.
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Sijia Zhang, Yu Xiao, Leichong Chen, Zhenyu Li, Yan Zong, Kuikui Zhu & Rui Meng. (2022) Endostar plus pembrolizumab combined with a platinum-based dual chemotherapy regime for advanced pulmonary large-cell neuroendocrine carcinoma as a first-line treatment: A case report. Open Life Sciences 17:1, pages 577-585.
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Masayo Yoshimura, Kurumi Seki, Andrey Bychkov & Junya Fukuoka. (2021) Molecular Pathology of Pulmonary Large Cell Neuroendocrine Carcinoma: Novel Concepts and Treatments. Frontiers in Oncology 11.
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Miriam Grazia Ferrara, Alessio Stefani, Michele Simbolo, Sara Pilotto, Maurizio Martini, Filippo Lococo, Emanuele Vita, Marco Chiappetta, Alessandra Cancellieri, Ettore D’Argento, Rocco Trisolini, Guido Rindi, Aldo Scarpa, Stefano Margaritora, Michele Milella, Giampaolo Tortora & Emilio Bria. (2021) Large Cell Neuro-Endocrine Carcinoma of the Lung: Current Treatment Options and Potential Future Opportunities. Frontiers in Oncology 11.
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Elizabeth Dudnik, Samuel Kareff, Mor Moskovitz, Chul Kim, Stephen V Liu, Anastasiya Lobachov, Teodor Gottfried, Damien Urban, Alona Zer, Ofer Rotem, Amir Onn, Mira Wollner & Jair Bar. (2021) Real-world survival outcomes with immune checkpoint inhibitors in large-cell neuroendocrine tumors of lung. Journal for ImmunoTherapy of Cancer 9:2, pages e001999.
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Yurie RAI, Hiroshi NISHIOKA & Takayuki HARA. (2021) Large Cell Neuroendocrine Carcinoma in the Sinonasal Cavity with Large Intracranial Extension Treated with Endonasal Endoscopic and Transcranial Combined Surgery: A Case Report. NMC Case Report Journal 8:1, pages 485-491.
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. (2020) Nivolumab. Reactions Weekly 1826:1, pages 254-254.
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Immune Checkpoint Inhibitor Therapy Achieved Complete Response for Drug-Sensitive EGFR/ALK Mutation-Negative Metastatic Pulmonary Large-Cell Neuroendocrine Carcinoma with High Tumor Mutation Burden: A Case Report

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Immune Checkpoint Inhibitor Therapy Achieved Complete Response for Drug-Sensitive EGFR/ALK Mutation-Negative Metastatic Pulmonary Large-Cell Neuroendocrine Carcinoma with High Tumor Mutation Burden: A Case Report

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