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OncoTargets and Therapy Volume 8, 2015 - Issue
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Original Research

Nimotuzumab enhances radiation sensitivity of NSCLC H292 cells in vitro by blocking epidermal growth factor receptor nuclear translocation and inhibiting radiation-induced DNA damage repair

Kai Teng1 Department of Thoracic Oncology, Cancer Center of Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China;2 Department of Radiation Oncology, Hainan Cancer Hospital, Haikou, Hainan, People’s Republic of China
,
Yong Zhang1 Department of Thoracic Oncology, Cancer Center of Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China
,
Xiaoyan Hu1 Department of Thoracic Oncology, Cancer Center of Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China
,
Yihui Ding1 Department of Thoracic Oncology, Cancer Center of Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China
,
Rui Gong1 Department of Thoracic Oncology, Cancer Center of Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China
&
Li Liu1 Department of Thoracic Oncology, Cancer Center of Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of ChinaCorrespondence[email protected]
Pages 809-818 | Published online: 13 Apr 2015

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ShishuKant Suman, Rashmi Priya & Mythili Kameswaran. (2020) Induction of different cellular arrest and molecular responses in low EGFR expressing A549 and high EGFR expressing A431 tumor cells treated with various doses of 177Lu-Nimotuzumab. International Journal of Radiation Biology 96:9, pages 1144-1156.
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Jianfeng Huang, Xiaopeng Yuan, Qingfeng Pang, Haowen Zhang, Jiahua Yu, Bo Yang, Leyuan Zhou, Fuzheng Zhang & Fenju Liu. (2018) Radiosensitivity enhancement by combined treatment of nimotuzumab and celecoxib on nasopharyngeal carcinoma cells. Drug Design, Development and Therapy 12, pages 2223-2231.
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Articles from other publishers (8)

Guifang Zhao, Liwen Feng, Ting Ye, Yanshen Liu, Li Fan, Chengzhi Ye & Jing Chen. (2023) Cetuximab enhances radiosensitivity of esophageal squamous cell carcinoma cells by G2 /M cycle arrest and DNA repair delay through inhibiting p‐EGFR and p‐ERK . Thoracic Cancer 14:22, pages 2127-2138.
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Xinyuan Xi, Fan Lei, Keliang Gao, Jingjing Li, Rihe Liu, Adam R. Karpf & Tatiana K. Bronich. (2023) Ligand-installed polymeric nanocarriers for combination chemotherapy of EGFR-positive ovarian cancer. Journal of Controlled Release 360, pages 872-887.
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Lili Wang, Hengzhao Zhuang, Xiaoyan Xu, Juying Zhou & Yang Jiao. (2023) Efficacy and survival analysis of nimotuzumab combined with concurrent chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma. Frontiers in Oncology 13.
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Chen Xue, Ganglei Li, Qiuxian Zheng, Xinyu Gu, Zhengyi Bao, Juan Lu & Lanjuan Li. (2022) The functional roles of the circRNA/Wnt axis in cancer. Molecular Cancer 21:1.
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Weiqiang Huang, Longshan Zhang, Mi Yang, Xixi Wu, Xiaoqing Wang, Wenqi Huang, Lu Yuan, Hua Pan, Yin Wang, Zici Wang, Yuting Wu, Jihong Huang, Huazhen Liang, Shaoqun Li, Liwei Liao, Laiyu Liu & Jian Guan. (2021) Cancer-associated fibroblasts promote the survival of irradiated nasopharyngeal carcinoma cells via the NF-κB pathway. Journal of Experimental & Clinical Cancer Research 40:1.
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Shuang Wang, Piaoyang Gao, Na Li, Ping Chen, Jinhan� Wang, Ningning He, Kaihua Ji, Liqing Du & Qiang Liu. (2018) Autocrine secretions enhance radioresistance in an exosome‑independent manner in NSCLC cells. International Journal of Oncology.
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Siyoung Ha, Jangho Jeong, Jiwon Oh, Sangmyung Rhee & Seung Wook Ham. (2017) A Small Organic Molecule Blocks EGFR Transport into the Nucleus by the Nonclassical Pathway Resulting in Repression of Cancer Invasion. ChemBioChem 19:2, pages 131-135.
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Kiran Mahajan & Nupam P. Mahajan. (2015) Cross talk of tyrosine kinases with the DNA damage signaling pathways. Nucleic Acids Research 43:22, pages 10588-10601.
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