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Review

Current perspectives on the optimal management of infantile hemangioma

Peter GrzesikDepartment of Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA

June K WuDepartment of Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USACorrespondence[email protected]

Pages 107-116 | Published online: 06 Dec 2017

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Besiana P. Beqo, Paolo Gasparella, Christina Flucher, Stephan Spendel, Franz Quehenberger & Emir Q. Haxhija. (2023) Indications for surgical resection of complicated infantile hemangiomas in the β-blocker’s era: a single-institution experience from a retrospective cohort study. International Journal of Surgery 109:4, pages 829-840.
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Bin Xie, Xiongming Zhou & Jiaxuan Qiu. (2022) Identification of novel potential biomarkers in infantile hemangioma via weighted gene co-expression network analysis. BMC Pediatrics 22:1.
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Chen‐xi Li, Hong Li, Yu‐chuan Zhou, Zhong‐cheng Gong & Bin Ling. (2022) Application of topical betaxolol to cure superficial infantile hemangioma: A pilot study. Pediatrics International 64:1.
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Zhe Shen, Diekuo Zhang, Guo Li, Donghai Huang, Yuanzheng Qiu, Changning Xie, Xin Zhang, Xingwei Wang & Yong Liu. (2021) Clinical Characteristics, Classification, and Management of Adult Nasopharyngolaryngeal Hemangioma. The Laryngoscope 131:12, pages 2724-2728.
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Zhe Liu, Sha Lv, Shuang Wang, Sheng-Ming Qu, Gui-Yun Zhang, Yi-Tong Lin, Lei Yang & Fu-Qiu Li. (2021) Itraconazole therapy for infant hemangioma: Two case reports. World Journal of Clinical Cases 9:28, pages 8579-8586.
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Hüseyin ÖZLÜ, İbrahim İlker ÇETİN & Derya ÖZYÖRÜK. (2021) Hemanjiyomu Nedeniyle Propranolol Tedavisi Verilen Çocuklarda Tek Lokalizasyon veya Çoklu Lokalizasyon ile Prognoz Arasındaki İlişkinin Değerlendirilmesi. Turkish Journal of Pediatric Disease, pages 1-7.
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V. Vivcharuk & V. Davydenko. (2021) INFLUENCE OF AGE AND MORPHOLOGICAL FEATURES ON THE CLINICAL MANIFESTATIONS AND TREATMENT EFFICACY OF HEMANGIOMAS IN CHILDREN. Inter Collegas 8:1, pages 22-29.
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Alexander K.C. Leung, Joseph M. Lam, Kin F. Leong & Kam L. Hon. (2021) Infantile Hemangioma: An Updated Review. Current Pediatric Reviews 17:1, pages 55-69.
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V. P. Vivcharuk, M. L. Kochina & O. G. Firsov. (2021) Model of Predicting the Effectiveness of Hemangioma Treatment in Children. Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6:1, pages 194-202.
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Viktoriia Vivcharuk. (2020) PARTICULARITIES OF THE COURSE AND TREATMENT HEMANGIOMAS OF DIFFERENT MORPHOLOGICAL TYPES IN CHILDREN AND THEIR ASSOCIATION WITH SOLUBLE FORMS OF FAS AND FASL. ScienceRise:6, pages 59-67.
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Junbo Qiao, Junjie Lin, Dexin Zhang, Junhua Li, Changkuan Chen, Hongye Yu, Xiaodi Li & Bin Fang. (2020) Efficacy of Combined Topical Timolol and Oral Propranolol for Treating Infantile Hemangioma: A Meta-Analysis of Randomized Controlled Trials. Frontiers in Pharmacology 11.
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Laura Tiemann & Sarrah Hein. (2020) Infantile Hemangioma: A Review of Current Pharmacotherapy Treatment and Practice Pearls. The Journal of Pediatric Pharmacology and Therapeutics 25:7, pages 586-599.
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Jin-Wei Zhang, Shu-Yue Yin, De-Kai Zhou, Jie-Xin Wen, Hui Gao, Lu Chen & Zhao-Xia Wang. (2020) Quantitative Evaluation of Percutaneous Local Drug Perfusion Against Refractory Infantile Hemangioma via 3-D Power Doppler Angiography. Ultrasound in Medicine & Biology 46:3, pages 610-619.
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Il'ya Diomidov, Yuliya Mandra, Sergey Chernyad'ev, N. Gegalina, Ekaterina Mandra, Olga Schneider, Margarita Shimova, Yulia Dimitrova & Yuriy Boldyrev. (2020) IMPROVEMENT OF APPROACHES TO TREATMENT OF CHILDREN WITH SUPERFICIAL INFANTILE HEMANGIOMAS OF THE HEAD AND NECK USING HIGH-ENERGY LASERS. Actual problems in dentistry 15:4, pages 131-139.
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Francesco Moccia. 2020. Calcium Signaling. Calcium Signaling 1013 1030 .

Fang Yong, Lin Juan, Wei Jinhuan, Yao Haohua, Chen Wei, Mo Jiacong, Luo Junhang & Wang Wenwei. (2019) Urethral cavernous hemangioma: a highly misdiagnosed disease (a case report of two patients and literature review). BMC Urology 19:1.
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Vishal R Kaley, E Oliver Aregullin, Bennett P Samuel & Joseph J Vettukattil. (2019) Trends in the off‐label use of β‐blockers in pediatric patients. Pediatrics International 61:11, pages 1071-1080.
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Su Jung Park, Woo Beom Shin, Sam Ath Huon, Hyang Joo Ryu & Jin Sook Yoon. (2019) Surgical Treatment of Infantile Hemangioma Involuted With Fatty Degeneration. Ophthalmic Plastic & Reconstructive Surgery 35:4, pages 409-411.
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Nicole Harter & Anthony J. Mancini. (2019) Diagnosis and Management of Infantile Hemangiomas in the Neonate. Pediatric Clinics of North America 66:2, pages 437-459.
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Bin Sun, Changxian Dong, Hongzhao Lei, Yubin Gong, Miaomiao Li, Yuanfang Zhang, Hongyu Zhang & Longlong Sun. (2019) Knockdown of inhibitor of differentiation 1 suppresses proliferation and induces apoptosis by inactivating PI3K/Akt/mTOR signaling in hemangioma-derived endothelial cells. Biomedicine & Pharmacotherapy 111, pages 236-243.
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Woosun Choi & Young Bae Choi. (2018) Splenic embolization for a giant splenic hemangioma in a child: a case report. BMC Pediatrics 18:1.
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Bin Sun, Changxian Dong, Hongzhao Lei, Yubin Gong, Miaomiao Li, Yuanfang Zhang, Hongyu Zhang & Longlong Sun. (2018) Propranolol inhibits proliferation and invasion of hemangioma-derived endothelial cells by suppressing the DLL4/Notch1/Akt pathway. Chemico-Biological Interactions 294, pages 28-33.
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Zhewei Fei, Mingke Qiu, Xianqin Qi, Yuxin Dai, Shuqing Wang, Zhiwei Quan, Yingbin Liu & Jingmin Ou. (2018) MicroRNA‑424 suppresses the proliferation of hemangioma‑derived endothelial cells by targeting VEGFR‑2. Molecular Medicine Reports.
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Milton Waner & M. O Teresa. 2018. Evidence-Based Management of Head and Neck Vascular Anomalies. Evidence-Based Management of Head and Neck Vascular Anomalies 121 129 .

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