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Original Research

Impact of hypoglycemia on patients with type 2 diabetes mellitus and their quality of life, work productivity, and medication adherence

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Pages 683-692 | Published online: 08 May 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Rohit Kedia, Supriya Kulkarni, Meredith Ross & Vijay Shivaswamy. (2016) Spotlight on empagliflozin/metformin fixed-dose combination for the treatment of type 2 diabetes: a systematic review. Patient Preference and Adherence 10, pages 1999-2006.
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William H Polonsky & Robert R Henry. (2016) Poor medication adherence in type 2 diabetes: recognizing the scope of the problem and its key contributors. Patient Preference and Adherence 10, pages 1299-1307.
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Catherine M Kuecker & Eva M Vivian. (2016) Patient considerations in type 2 diabetes – role of combination dapagliflozin–metformin XR. Diabetes, Metabolic Syndrome and Obesity 9, pages 25-35.
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Yuji Liguori, Katsuhito Murase & Misako Hamamura. (2016) Differences between patient and physician opinions on adherence to medication for hypertension and diabetes mellitus. Current Medical Research and Opinion 32:9, pages 1539-1545.
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Joshua W Fleming, Laurie W Fleming & Courtney S Davis. (2015) Fixed-dose combinations in type 2 diabetes – role of the canagliflozin metformin combination. Diabetes, Metabolic Syndrome and Obesity 8, pages 287-294.
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Frank Lavernia, Pamela Kushner, Dace Trence, Donna Rice, George Dailey & Louis Kuritzky. (2015) Recognizing and minimizing hypoglycemia: The need for individualized care. Postgraduate Medicine 127:8, pages 801-807.
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Ravi Kant, Mc Anto Antony, David Geurkink, Nathan Gilreath, Lakshya Chandra, Elizabeth Zipprer, Kashif M. Munir, Rashmi Chandra, Veronica G. Parker & Vipin Verma. (2022) Real-time continuous glucose monitoring improves glycemic control and reduces hypoglycemia: Real-world data. Primary Care Diabetes 16:6, pages 786-790.
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Muaz Mubashir, Mazhar Ahmed, Hassan Atique, Ahmed Wassan, Mehdi Naqvi & Muneeb Ullah. (2022) Randomized Clinical Trial on Efficacy of Empagliflozin Versus Sitagliptin, In Addition to Metformin in Type 2 Diabetic Patients. Cureus.
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Anthonia I. Okurumeh, Oluwaseyi A. Akpor, Olutoyin E. Okeya & Oghenerobor B. Akpor. (2022) Type 2 diabetes mellitus patients’ lived experience at a tertiary hospital in Ekiti State, Nigeria. Scientific Reports 12:1.
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Uffe Søholm, Melanie Broadley, Natalie Zaremba, Patrick Divilly, Giesje Nefs, Zeinab Mahmoudi, Bastiaan de Galan, Ulrik Pedersen-Bjergaard, Alan Brennan, Daniel John Pollard, Rory J McCrimmon, Stephanie A. Amiel, Christel Hendrieckx, Jane Speight, Pratik Choudhary & Frans Pouwer. (2022) Investigating the day-to-day impact of hypoglycaemia in adults with type 1 or type 2 diabetes: design and validation protocol of the Hypo-METRICS application. BMJ Open 12:2, pages e051651.
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Takahiro Mori, Tomohisa Nagata, Masako Nagata, Kenji Fujimoto, Yoshihisa Fujino & Koji Mori. (2021) Diabetes severity measured by treatment control status and number of anti-diabetic drugs affects presenteeism among workers with type 2 diabetes. BMC Public Health 21:1.
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António Lopes, Fátima Roque, Sandra Morgado, Cristina Dinis, Maria Teresa Herdeiro & Manuel Morgado. (2021) Behavioral Sciences in the Optimization of Pharmacological and Non-Pharmacological Therapy for Type 2 Diabetes. Behavioral Sciences 11:11, pages 153.
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Eddie M. Mulenga & Lawrence Mvula. (2021) Prescribing Patterns of Antidiabetic in Patients with Type 2 Diabetes Mellitus at Levy and Chilenje Hospitals in Zambia. European Journal of Basic Medical Sciences 11:3, pages 30-37.
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Marc Evans, Angharad R. Morgan & Stephen C. Bain. (2021) One Hundred Years of Insulin: Value Beyond Price in Type 2 Diabetes Mellitus. Diabetes Therapy 12:6, pages 1593-1604.
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NesmaAli Ibrahim. (2021) Frequency and predictors of hypoglycemia in Type 2 diabetes: A population-based study. Journal of Diabetology 12:2, pages 157.
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Ejiofor Ugwu, Ekenechukwu Young & Marcellinus Nkpozi. (2020) Diabetes care knowledge and practice among primary care physicians in Southeast Nigeria: a cross-sectional study. BMC Family Practice 21:1.
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Susan Cornell. (2020) A review of GLP‐1 receptor agonists in type 2 diabetes: A focus on the mechanism of action of once‐weekly agents. Journal of Clinical Pharmacy and Therapeutics 45:S1, pages 17-27.
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Takahiro Mori, Tomohisa Nagata, Masako Nagata, Makoto Otani, Yoshihisa Fujino & Koji Mori. (2020) The Impact of Diabetes Status on Presenteeism in Japan. Journal of Occupational & Environmental Medicine 62:8, pages 654-661.
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Ides M. Colin, Kathy Alexandre, Jacques Bruhwyler, André Scheen & Ann Verhaegen. (2020) Patient-Reported Outcomes with Insulin Glargine 300 U/mL in People with Type 2 Diabetes: The MAGE Multicenter Observational Study. Diabetes Therapy 11:8, pages 1835-1847.
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Cheli Melzer Cohen, Tamar Banon, Varda Shalev & Gabriel Chodick. (2020) The effectiveness of insulin glargine 300 U/mL among type 2 diabetes patients: Analysis of a real‐world data in Israel. Endocrinology, Diabetes & Metabolism 3:3.
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Mei‐Chuan Huang, Chich‐Hsiu Hung, Chung‐Yuan Chen, Wei‐Wen Hung & Hsiu‐Ling Liang. (2020) Factors associated with quality of life in patients with diabetic hypoglycaemia. Journal of Clinical Nursing 29:9-10, pages 1704-1711.
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Jason Gordon, Lee Beresford‐Hulme, Hayley Bennett, Amarjeet Tank, Christopher Edmonds & Phil McEwan. (2020) Relationship between hypoglycaemia, body mass index and quality of life among patients with type 1 diabetes: Observations from the DEPICT clinical trial programme. Diabetes, Obesity and Metabolism 22:5, pages 857-865.
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Yonghyun Nam, Dong-gi Lee, Sunjoo Bang, Ju Han Kim, Jae-Hoon Kim & Hyunjung Shin. (2019) The translational network for metabolic disease – from protein interaction to disease co-occurrence. BMC Bioinformatics 20:1.
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Fatima Al Sayah, Roseanne O. Yeung & Jeffrey A. Johnson. (2019) Association of Depressive Symptoms and Diabetes Distress With Severe Hypoglycemia in Adults With Type 2 Diabetes. Canadian Journal of Diabetes 43:5, pages 316-321.
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Fang L. Zhou, Charlie Nicholls, Lin Xie, Yuexi Wang, Neel Vaidya & Luigi F. Meneghini. (2019) Hypoglycaemia and treatment patterns among insulin‐treated patients with type 2 diabetes who switched to insulin glargine 300 units/mL versus other basal insulin in a real‐world setting. Endocrinology, Diabetes & Metabolism 2:3.
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Ulrik Pedersen‐Bjergaard, Saud Alsifri, Ronnie Aronson, Maja Cigrovski Berković, Gagik Galstyan, Helge Gydesen, Jesper Barner Lekdorf, Bernhard Ludvik, Erik Moberg, Ambady Ramachandran & Kamlesh Khunti. (2019) Comparison of the HAT study, the largest global hypoglycaemia study to date, with similar large real‐world studies. Diabetes, Obesity and Metabolism 21:4, pages 844-853.
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Bruno Guerci, Neha Chanan, Simarjeet Kaur, Juan Guillermo Jasso-Mosqueda & Elisheva Lew. (2019) Lack of Treatment Persistence and Treatment Nonadherence as Barriers to Glycaemic Control in Patients with Type 2 Diabetes. Diabetes Therapy 10:2, pages 437-449.
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Yasuo Terauchi, Asuka Ozaki, Xiahong Zhao, Cheryl Teoh, Dena Jaffe, Yuki Tajima & Yujin Shuto. (2019) Humanistic and economic burden of cardiovascular disease related comorbidities and hypoglycaemia among patients with type 2 diabetes in Japan. Diabetes Research and Clinical Practice 149, pages 115-125.
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Koji Mori, Takahiro Mori, Tomohisa Nagata, Masako Nagata, Mahoko Iwasaki, Hiroki Sakai, Koki Kimura & Natsumi Shinzato. (2019) Factors of occurrence and improvement methods of presenteeism attributed to diabetes: A systematic review. Journal of Occupational Health 61:1, pages 36-53.
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Domingo Orozco-Beltrán, Sara Artola, Margarida Jansà, Martin Lopez de la Torre-Casares & Eva Fuster. (2018) Impact of hypoglycemic episodes on health-related quality of life of type-2 diabetes mellitus patients: development and validation of a specific QoLHYPO© questionnaire. Health and Quality of Life Outcomes 16:1.
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Anthony CannonYehuda HandelsmanMichael HeileMichael Shannon. (2018) Burden of Illness in Type 2 Diabetes Mellitus. Journal of Managed Care & Specialty Pharmacy 24:9-a Suppl, pages S5-S13.
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Annaswamy Raji, Jianmin Long, Raymond L. H. Lam, Edward A. O’Neill & Samuel S. Engel. (2018) Efficacy and Safety of Sitagliptin in Hispanic/Latino Patients with Type 2 Diabetes: A Pooled Analysis from Ten Randomized, Placebo-Controlled Phase 3 Clinical Trials. Diabetes Therapy 9:4, pages 1581-1589.
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Wenying Yang, Jianhua Ma, Yiming Li, Yanbing Li, Zhiguang Zhou, Jae Hyeon Kim, June Zhao & Agata Ptaszynska. (2018) Dapagliflozin as add-on therapy in Asian patients with type 2 diabetes inadequately controlled on insulin with or without oral antihyperglycemic drugs: A randomized controlled trial. Journal of Diabetes 10:7, pages 589-599.
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Simon J. Fisher, Xingyue Huang, Manjiri Pawaskar, Edward A. Witt, Swapnil Rajpathak, R. Ravi Shankar & Silvio E. Inzucchi. (2018) Hypoglycemia in type 2 diabetes: understanding patients’ and physicians’ knowledge and experience. Endocrine 60:3, pages 435-444.
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Manjiri Pawaskar, Kristy Iglay, Edward A. Witt, Samuel S. Engel & Swapnil Rajpathak. (2018) Impact of the severity of hypoglycemia on health - Related quality of life, productivity, resource use, and costs among US patients with type 2 diabetes. Journal of Diabetes and its Complications 32:5, pages 451-457.
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Manjiri Pawaskar, Edward A. Witt, Samuel S. Engel, Swapnil N. Rajpathak & Kristy Iglay. (2018) Severity of hypoglycaemia and health-related quality of life, work productivity and healthcare costs in patients with type 2 diabetes in Europe. Endocrinology, Diabetes & Metabolism 1:2, pages e00011.
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Yoon Jeong Choi & Arlene M. Smaldone. (2017) Factors Associated With Medication Engagement Among Older Adults With Diabetes: Systematic Review and Meta-Analysis. The Diabetes Educator 44:1, pages 15-30.
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M.M.J. Zanders, H.R. Haak, M.P.P. van Herk-Sukel, R.M.C. Herings, L.V. van de Poll-Franse & J.A. Johnson. (2018) Changes in glucose-lowering drug use before and after cancer diagnosis in patients with diabetes. Diabetes & Metabolism 44:1, pages 22-29.
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Nicolaas C. Schaper, Annie Nikolajsen, Anna Sandberg, Sarah Buchs & Mette Bøgelund. (2017) Timing of Insulin Injections, Adherence, and Glycemic Control in a Multinational Sample of People with Type 2 Diabetes: A Cross-Sectional Analysis. Diabetes Therapy 8:6, pages 1319-1329.
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Tim Holbrook, Yuexin Tang, Romita Das, R. Ravi Shankar, Kaan Tunceli, Jean Williams, Larry Radican, Sarah E. Holden, Chris Ll. Morgan, James Piercy & Craig J. Currie. (2017) Direct medical costs of severe hypoglycaemic events in patients with type 2 diabetes in England: A retrospective database study. International Journal of Clinical Practice 71:6, pages e12958.
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Kate Van Brunt, Riccardo Pedersini, Jillian Rooney & Sheila M. Corrigan. (2017) Behaviours, thoughts and perceptions around mealtime insulin usage and wastage among people with type 1 and type 2 diabetes mellitus: A cross-sectional survey study. Diabetes Research and Clinical Practice 126, pages 30-42.
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Dilek Büyükkaya Besen, Hamdiye Arda Sürücü & Cansu Koşar. (2016) Self-reported frequency, severity of, and awareness of hypoglycemia in type 2 diabetes patients in Turkey. PeerJ 4, pages e2700.
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Deborah Young-Hyman, Mary de Groot, Felicia Hill-Briggs, Jeffrey S. Gonzalez, Korey Hood & Mark Peyrot. (2016) Psychosocial Care for People With Diabetes: A Position Statement of the American Diabetes Association. Diabetes Care 39:12, pages 2126-2140.
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Freddy Goldberg Eliaschewitz & Tânia Barreto. (2016) Concepts and clinical use of ultra-long basal insulin. Diabetology & Metabolic Syndrome 8:1.
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Nadine Kuniss, Guido Kramer, Nicolle Müller, Christof Kloos, Gunter Wolf & Ulrich Alfons Müller. (2016) History of mild hypoglycaemia does not affect the prevalence of diabetes-related distress in people with diabetes. Acta Diabetologica 53:5, pages 833-838.
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C. Victor Spain, Jonathon J. Wright, Rebecca M. Hahn, Ashley Wivel & Alan A. Martin. (2016) Self-reported Barriers to Adherence and Persistence to Treatment With Injectable Medications for Type 2 Diabetes. Clinical Therapeutics 38:7, pages 1653-1664.e1.
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G. Veronese, G. Marchesini, G. Forlani, S. Saragoni, L. Degli Esposti, E. Centis & A. Fabbri. (2016) Costs associated with emergency care and hospitalization for severe hypoglycemia. Nutrition, Metabolism and Cardiovascular Diseases 26:4, pages 345-351.
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Richa Redhu Gehlaut, Godwin Y. Dogbey, Frank L. Schwartz, Cynthia R. Marling & Jay H. Shubrook. (2015) Hypoglycemia in Type 2 Diabetes - More Common Than You Think. Journal of Diabetes Science and Technology 9:5, pages 999-1005.
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Marjolein M. J. Zanders, Harm R. Haak, Myrthe P. P. van Herk-Sukel, Lonneke V. van de Poll-Franse & Jeffrey A. Johnson. (2015) Impact of cancer on adherence to glucose-lowering drug treatment in individuals with diabetes. Diabetologia 58:5, pages 951-960.
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Ralph A. DeFronzo, Andrew Lewin, Sanjay PatelDacheng Liu, Renee Kaste, Hans J. Woerle & Uli C. Broedl. (2015) Combination of Empagliflozin and Linagliptin as Second-Line Therapy in Subjects With Type 2 Diabetes Inadequately Controlled on Metformin. Diabetes Care 38:3, pages 384-393.
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P. Vellanki & G.E. Umpierrez. (2015) Iatrogenic hypoglycemia and quality of life in patients with type 2 diabetes mellitus. Revista Clínica Española 215:2, pages 104-106.
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Jae-Seung YunSeung-Hyun Ko. (2015) Avoiding or coping with severe hypoglycemia in patients with type 2 diabetes. The Korean Journal of Internal Medicine 30:1, pages 6.
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