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Review

Intranasal fentanyl for pain control: current status with a focus on patient considerations

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Pages 157-164 | Published online: 18 Mar 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Alain Tanguay, Johann Lebon, Denise Hébert & François Bégin. (2020) Intranasal Fentanyl versus Subcutaneous Fentanyl for Pain Management in Prehospital Patients with Acute Pain: A Retrospective Analysis. Prehospital Emergency Care 24:6, pages 760-768.
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Marianne Gausche-Hill, Kathleen M. Brown, Zoë J. Oliver, Comilla Sasson, Peter S. Dayan, Nicholas M. Eschmann, Tasmeen S. Weik, Benjamin J. Lawner, Ritu Sahni, Yngve Falck-Ytter, Joseph L. Wright, Knox Todd & Eddy S. Lang. (2014) An Evidence-based Guideline for Prehospital Analgesia in Trauma. Prehospital Emergency Care 18:sup1, pages 25-34.
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Articles from other publishers (34)

Sossio Serra, Michele Domenico Spampinato, Alessandro Riccardi, Mario Guarino, Rita Pavasini, Andrea Fabbri & Fabio De Iaco. (2023) Intranasal Fentanyl for Acute Pain Management in Children, Adults and Elderly Patients in the Prehospital Emergency Service and in the Emergency Department: A Systematic Review. Journal of Clinical Medicine 12:7, pages 2609.
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Felipe C. Braga, Tiago O. Ramos, Timothy J. Brocksom & Kleber T. de Oliveira. (2022) Synthesis of Fentanyl under Continuous Photoflow Conditions. Organic Letters 24:45, pages 8331-8336.
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Tierra V. Lynch, Peter W. Callas, Timothy D. Peterson & Sarah M. Schlein. (2022) Intranasal Fentanyl for On-the-Hill Analgesia by Ski Patrol. Wilderness & Environmental Medicine 33:3, pages 296-303.
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Laurentine Maljean, Gaëtan Gavazzi, Prudence Gibert, Armance Grevy, Marion Payen, Nabil Zerhouni, Théophile Tiffet, Jean-Luc Cracowski, Nathalie Mitha, Caroline Maindet, Magalie Baudrant, Pierrick Bedouch & Sabine Drevet. (2022) Tolerance of Fentanyl Pectin Nasal Spray for Procedural Pain in Geriatric Patients. Journal of the American Medical Directors Association 23:6, pages 1005-1010.
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Anders Johansson, Anders Svensson & Jonas Wihlborg. (2021) Pain management with methoxyflurane (Penthrox®) in Swedish ambulance care – An observational pilot study. International Emergency Nursing 59, pages 101076.
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Srinivas R. Banala, Osama K. Khattab, Valda D. Page, Carla L. Warneke, Knox H. Todd & Sai-Ching Jim Yeung. (2020) Intranasal fentanyl spray versus intravenous opioids for the treatment of severe pain in patients with cancer in the emergency department setting: A randomized controlled trial. PLOS ONE 15:7, pages e0235461.
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Rita Ambrus, Péter Gieszinger, Róbert Gáspár, Anita Sztojkov-Ivanov, Eszter Ducza, Árpád Márki, Tamás Janáky, Ferenc Tömösi, Gábor Kecskeméti, Piroska Szabó-Révész & Csilla Bartos. (2020) Investigation of the Absorption of Nanosized lamotrigine Containing Nasal Powder via the Nasal Cavity. Molecules 25:5, pages 1065.
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A. KURZOVÁ, J. MÁLEK, L. HESS, M. JAČEK & J. SLÍVA. (2019) Non-Traditional Administration of Remifentanil in an Experimental Setting. Physiological Research, pages S97-S103.
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Seyed Ebrahim Alavi, Peter J. Cabot & Peter M. Moyle. (2019) Glucagon-Like Peptide-1 Receptor Agonists and Strategies To Improve Their Efficiency. Molecular Pharmaceutics 16:6, pages 2278-2295.
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Joanna Brząkała & Wojciech Leppert. (2019) The role of rapid onset fentanyl products in the management of breakthrough pain in cancer patients. Pharmacological Reports 71:3, pages 438-442.
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Michelle Seiler, Georg Staubli & Markus A. Landolt. (2019) Combined nitrous oxide 70% with intranasal fentanyl for procedural analgosedation in children: a prospective, randomised, double-blind, placebo-controlled trial. Emergency Medicine Journal 36:3, pages 142-147.
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Anuradha Setlur & Howard Friedland. (2018) Treatment of pain with intranasal fentanyl in pediatric patients in an acute care setting: a systematic review. Pain Management 8:5, pages 341-352.
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Mohsen Saidinejad. (2018) The Patient-Centered Emergency Department. Advances in Pediatrics 65:1, pages 105-120.
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Kwan-Sub Kim, Nam-Kyung Yeo, Seong-Su Kim, Woong-Sub Park, Su-Hyun Kwak, Sang-Hyeon Cho, Gyu-Wan Sung, Hae-Sook Kim, Sang-Wook Yi & Hae Jun Cho. (2018) Effect of Fentanyl Nasal Packing Treatment on Patients With Acute Postoperative Pain After Nasal Operation: A Randomized Double-Blind Controlled Trial. Annals of Otology, Rhinology & Laryngology 127:5, pages 297-305.
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Csilla Bartos, Rita Ambrus, Anita Kovács, Róbert Gáspár, Anita Sztojkov-Ivanov, Árpád Márki, Tamás Janáky, Ferenc Tömösi, Gábor Kecskeméti & Piroska Szabó-Révész. (2018) Investigation of Absorption Routes of Meloxicam and Its Salt Form from Intranasal Delivery Systems. Molecules 23:4, pages 784.
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Alper Yenigun, Sinan Yilmaz, Remzi Dogan, Seda Sezen Goktas, Muhittin Calim & Orhan Ozturan. (2018) Demonstration of analgesic effect of intranasal ketamine and intranasal fentanyl for postoperative pain after pediatric tonsillectomy. International Journal of Pediatric Otorhinolaryngology 104, pages 182-185.
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Pierre Ellis. (2017) What is the most appropriate out-of-hospital opioid for adults with traumatic pain?. Journal of Paramedic Practice 9:12, pages 528-535.
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Sylvie Le MaySamina AliAmy C. PlintBenoit MâsseGina NetoMarie-Christine AuclairAmy L. DrendelAriane BallardChristelle KhadraEdith Villeneuve, Stefan Parent, Patrick J. McGrath, Grégoire LeclairSerge Gouin. (2017) Oral Analgesics Utilization for Children With Musculoskeletal Injury (OUCH Trial): An RCT. Pediatrics 140:5.
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KS Chew & AH Shaharudin. (2017) An open-label randomised controlled trial on the efficacy of adding intranasal fentanyl to intravenous tramadol in patients with moderate to severe pain following acute musculoskeletal injuries. Singapore Medical Journal 58:10, pages 601-605.
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Julie-Anne Fleet, Meril Jones & Ingrid Belan. (2017) Taking the alternative route: Women's experience of intranasal fentanyl, subcutaneous fentanyl or intramuscular pethidine for labour analgesia. Midwifery 53, pages 15-19.
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Daniel S. Tsze, Maria Ieni, Daniel B. Fenster, John Babineau, Joshua Kriger, Bruce Levin & Peter S. Dayan. (2017) Optimal Volume of Administration of Intranasal Midazolam in Children: A Randomized Clinical Trial. Annals of Emergency Medicine 69:5, pages 600-609.
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Muralikrishnan Angamuthu & S. Narasimha Murthy. 2017. Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement 123 137 .
Csilla Bartos, Rita Ambrus, Péter Sipos, Mária Budai-Szűcs, Erzsébet Csányi, Róbert Gáspár, Árpád Márki, Adrienn B. Seres, Anita Sztojkov-Ivanov, Tamás Horváth & Piroska Szabó-Révész. (2015) Study of sodium hyaluronate-based intranasal formulations containing micro- or nanosized meloxicam particles. International Journal of Pharmaceutics 491:1-2, pages 198-207.
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Antonio Paredes Mogollo. (2015) Importancia de la vía nasal para la administración de opioides. Medicina Paliativa 22, pages 33-45.
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Vicente Tormo Ferrero. (2015) Vías de administración de fentanilo para el tratamiento del dolor irruptivo oncológico. Medicina Paliativa 22, pages 27-32.
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Sebastiano Mercadante, Renato Vellucci, Arturo Cuomo, Claudio Adile, Andrea Cortegiani, Alessandro Valle, Patrizia Villari & Alessandra Casuccio. (2014) Long-term efficacy and tolerability of intranasal fentanyl in the treatment of breakthrough cancer pain. Supportive Care in Cancer 23:5, pages 1349-1354.
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Joseph V. PergolizziJrJrRobert TaylorJrJr & Robert B. Raffa. (2015) Intranasal Ketorolac as Part of a Multimodal Approach to Postoperative Pain. Pain Practice 15:4, pages 378-388.
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Andis Graudins, Robert Meek, Dianna Egerton-Warburton, Ed Oakley & Robert Seith. (2015) The PICHFORK (Pain in Children Fentanyl or Ketamine) Trial: A Randomized Controlled Trial Comparing Intranasal Ketamine and Fentanyl for the Relief of Moderate to Severe Pain in Children With Limb Injuries. Annals of Emergency Medicine 65:3, pages 248-254.e1.
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Ana Fortuna, Gilberto Alves, Ana Serralheiro, Joana Sousa & Amílcar Falcão. (2014) Intranasal delivery of systemic-acting drugs: Small-molecules and biomacromolecules. European Journal of Pharmaceutics and Biopharmaceutics 88:1, pages 8-27.
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Fiona Yeaman, Robert Meek, Diana Egerton-Warburton, Pamela Rosengarten & Andis Graudins. (2014) Sub-dissociative-dose intranasal ketamine for moderate to severe pain in adult emergency department patients. Emergency Medicine Australasia 26:3, pages 237-242.
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Agata Gierlotka, Jacek Kozakiewicz, Artur Pakosz & Jadwiga Pyszkowska. (2014) Leczenie przeciwbólowe pacjentów z nowotworami głowy i szyi. Polski Przegląd Otorynolaryngologiczny 3:2, pages 80-83.
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Helmar Bornemann-Cimenti, Mischa Wejbora, Istvan S. Szilagyi & Andreas Sandner-Kiesling. (2013) Fentanyl for the Treatment of Tumor-Related Breakthrough Pain. Deutsches Ärzteblatt international.
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Jennifer M. Belavic. (2012) Annual drug update. The Nurse Practitioner 37:2, pages 14-23.
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Claudia F. ClavijoRachael Rzasa LynnUwe ChristiansJeffrey L. Galinkin. (2012) Intranasal Fentanyl for Breakthrough Pain Control. Clinical Medicine Insights: Therapeutics 4, pages CMT.S7298.
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