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Research and Reports in Tropical Medicine Volume 3, 2012 - Issue

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Original Research

Monitoring the use of nifurtimox-eflornithine combination therapy (NECT) in the treatment of second stage gambiense human African trypanosomiasis

Jose R Franco1 World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, Geneva, Switzerland, [email protected]Correspondence[email protected]

Pere P Simarro1 World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, Geneva, Switzerland, [email protected]

Abdoulaye Diarra2 World Health Organization, Regional Office for Africa, Brazzaville, Congo

Jose A Ruiz-Postigo3 World Health Organization, Communicable Disease Control, Control of Tropical Diseases and Zoonoses Regional Office for the Eastern Mediterranean, Cairo, Egypt

Mireille Samo1 World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, Geneva, Switzerland, [email protected]

Jean G Jannin1 World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, Geneva, Switzerland, [email protected]

Pages 93-101 | Published online: 24 Aug 2012

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Etedal Ahmed A. Ibrahim, Mohammed Gasm Elseed M. Elmahal, Khabab Abbasher Hussien Mohamed Ahmed, Elfatih A. Hasabo & Mohammed Eltahier Abdalla Omer. (2022) Unusual neurological presentation of second stage African trypanosomiasis in a young boy: a case report. BMC Pediatrics 22:1.
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Aboagye Kwarteng Dofuor, Emmanuel Kofi Kumatia, Jersley Didewurah Chirawurah & Frederick Ayertey. (2022) Antiplasmodial, Antitrypanosomal, and Cytotoxic Effects of Anthonotha macrophylla, Annickia polycarpa, Tieghemella heckelii, and Antrocaryon micraster Extracts. Advances in Pharmacological and Pharmaceutical Sciences 2022, pages 1-7.
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Carl Amilon, Mikael Boberg, Joel Tarning, Angela Äbelö, Michael Ashton & Rasmus Jansson-Löfmark. (2022) Population Pharmacodynamic Modeling of Eflornithine-Based Treatments Against Late-Stage Gambiense Human African Trypanosomiasis and Efficacy Predictions of L-eflornithine-Based Therapy. The AAPS Journal 24:3.
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Raquel Inocencio da Luz, Sara Tablado Alonso, Philippe Büscher, Paul Verlé, Anja De Weggheleire, Dieudonné Mumba Ngoyi, Pati Patient Pyana & Epco Hasker. (2022) Two-Year Follow-Up of Trypanosoma brucei gambiense Serology after Successful Treatment of Human African Trypanosomiasis: Results of Four Different Sero-Diagnostic Tests. Diagnostics 12:2, pages 246.
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Vittoria Lutje, Katrin Probyn, Jorge Seixas, Hanna Bergman & Gemma Villanueva. (2021) Chemotherapy for second-stage human African trypanosomiasis: drugs in use. Cochrane Database of Systematic Reviews 2021:12.
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Anna Kryshchyshyn, Danylo Kaminskyy, Philippe Grellier & Roman Lesyk. 2021. Azoles - Synthesis, Properties, Applications and Perspectives. Azoles - Synthesis, Properties, Applications and Perspectives.

Aboagye Kwarteng Dofuor, Frederick Ayertey, Peter Bolah, Georgina Isabella Djameh, Kwaku Kyeremeh, Mitsuko Ohashi, Laud Kenneth Okine & Theresa Manful Gwira. (2020) Isolation and Antitrypanosomal Characterization of Furoquinoline and Oxylipin from Zanthoxylum zanthoxyloides. Biomolecules 10:12, pages 1670.
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Vasiliki Pardali, Erofili Giannakopoulou, Dimitrios-Ilias Balourdas, Vassilios Myrianthopoulos, Martin C. Taylor, Marina Šekutor, Kata Mlinarić-Majerski, John M. Kelly & Grigoris Zoidis. (2020) Lipophilic Guanylhydrazone Analogues as Promising Trypanocidal Agents: An Extended SAR Study. Current Pharmaceutical Design 26:8, pages 838-866.
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Westley F. Tear, Seema Bag, Rosario Diaz-Gonzalez, Gloria Ceballos-Pérez, Domingo I. Rojas-Barros, Carlos Cordon-Obras, Guiomar Pérez-Moreno, Raquel García-Hernández, Maria Santos Martinez-Martinez, Luis Miguel Ruiz-Perez, Francisco Gamarro, Dolores Gonzalez Pacanowska, Conor R. Caffrey, Lori Ferrins, Pilar Manzano, Miguel Navarro & Michael P. Pollastri. (2019) Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5- b ]pyridazines for the Treatment of Human African Trypanosomiasis . Journal of Medicinal Chemistry 63:2, pages 756-783.
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Harry P. De Koning. (2020) The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History. Tropical Medicine and Infectious Disease 5:1, pages 14.
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Jean-Benoît Falisse, Erick Mwamba-Miaka & Alain Mpanya. (2020) Whose Elimination? Frontline Workers’ Perspectives on the Elimination of the Human African Trypanosomiasis and Its Anticipated Consequences. Tropical Medicine and Infectious Disease 5:1, pages 6.
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Dofuor, Kwain, Osei, Tetevi, Okine, Ohashi, Gwira & Kyeremeh. (2019) N-(Isobutyl)-3,4-methylenedioxy Cinnamoyl Amide. Molbank 2019:3, pages M1070.
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Dorota Olender, Justyna Żwawiak & Lucjusz Zaprutko. (2018) Multidirectional Efficacy of Biologically Active Nitro Compounds Included in Medicines. Pharmaceuticals 11:2, pages 54.
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Philippe Büscher, Giuliano Cecchi, Vincent Jamonneau & Gerardo Priotto. (2017) Human African trypanosomiasis. The Lancet 390:10110, pages 2397-2409.
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Danielle Légaré & Marc Ouellette. 2017. Antimicrobial Drug Resistance. Antimicrobial Drug Resistance 1409 1463 .

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Joshua B. Richardson, Benjamin Evans, Patient P. Pyana, Nick Van Reet, Mark Sistrom, Philippe Büscher, Serap Aksoy & Adalgisa Caccone. (2016) Whole genome sequencing shows sleeping sickness relapse is due to parasite regrowth and not reinfection. Evolutionary Applications 9:2, pages 381-393.
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Alain Buguet, Raymond Cespuglio & Bernard Bouteille. 2015. Sleep Medicine. Sleep Medicine 159 165 .

SAM ALSFORD, JOHN M. KELLY, NICOLA BAKER & DAVID HORN. (2013) Genetic dissection of drug resistance in trypanosomes. Parasitology 140:12, pages 1478-1491.
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Monitoring the use of nifurtimox-eflornithine combination therapy (NECT) in the treatment of second stage gambiense human African trypanosomiasis

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Monitoring the use of nifurtimox-eflornithine combination therapy (NECT) in the treatment of second stage gambiense human African trypanosomiasis

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