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Therapeutics and Clinical Risk Management Volume 12, 2016 - Issue
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Original Research

Patients’ safety: is there a systemic release of gentamicin by gentamicin-coated tibia nails in clinical use?

Arash Moghaddam1 HTRG – Heidelberg Traume Research Group Center for Orthopedics, Trauma and Spinal Cord Injury, University Hospital Heidelberg, Heidelberg, GermanyCorrespondence[email protected]
,
Viola Graeser1 HTRG – Heidelberg Traume Research Group Center for Orthopedics, Trauma and Spinal Cord Injury, University Hospital Heidelberg, Heidelberg, Germany
,
Fabian Westhauser1 HTRG – Heidelberg Traume Research Group Center for Orthopedics, Trauma and Spinal Cord Injury, University Hospital Heidelberg, Heidelberg, Germany
,
Ulrike Dapunt1 HTRG – Heidelberg Traume Research Group Center for Orthopedics, Trauma and Spinal Cord Injury, University Hospital Heidelberg, Heidelberg, Germany
,
Till Kamradt1 HTRG – Heidelberg Traume Research Group Center for Orthopedics, Trauma and Spinal Cord Injury, University Hospital Heidelberg, Heidelberg, Germany
,
Stefan M Woerner2 Department of Internal Medicine and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany
&
Gerhard Schmidmaier1 HTRG – Heidelberg Traume Research Group Center for Orthopedics, Trauma and Spinal Cord Injury, University Hospital Heidelberg, Heidelberg, Germany
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Pages 1387-1393 | Published online: 07 Sep 2016

Citations (23)

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Lars Helbig, Maren Bechberger, Riyadh Aldeeri, Adriana Ivanova, Patrick Haubruck, Matthias Miska, Gerhard Schmidmaier & Georg W Omlor. (2018) Initial peri- and postoperative antibiotic treatment of infected nonunions: results from 212 consecutive patients after mean follow-up of 34 months. Therapeutics and Clinical Risk Management 14, pages 59-67.
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Articles from other publishers (22)

Hua Li, Daofeng Wang, Wupeng Zhang, Gaoxiang Xu, Cheng Xu, Wanheng Liu & Jiantao Li. (2023) Potential side effects of antibacterial coatings in orthopaedic implants: A systematic review of clinical studies. Frontiers in Bioengineering and Biotechnology 11.
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Yannik Kalbas, Felix Klingebiel & Hans-Christoph Pape. (2022) Antibiotic coated nails: Rationale, development, indications and outcomes. Journal of Orthopaedic Surgery 30:3, pages 102255362211185.
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Suman Medda & Joseph R. Hsu. (2022) Simplified Antibiotic-Coated Plating for Infected Nonunion, Fracture-Related Infection, and Single-Stage Prophylactic Fixation. Journal of Orthopaedic Trauma 36:6, pages e255-e259.
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Nike Walter, Daniel Popp, Viola Freigang, Michael Nerlich, Volker Alt & Markus Rupp. (2021) Treatment of severely open tibial fractures, non-unions, and fracture-related infections with a gentamicin-coated tibial nail—clinical outcomes including quality of life analysis and psychological ICD-10-based symptom rating. Journal of Orthopaedic Surgery and Research 16:1.
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Tommaso Greco, Luigi Cianni, Chiara Polichetti, Michele Inverso, Giulio Maccauro & Carlo Perisano. (2021) Uncoated vs. Antibiotic-Coated Tibia Nail in Open Diaphyseal Tibial Fracture (42 according to AO Classification): A Single Center Experience. BioMed Research International 2021, pages 1-9.
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Daniele De Meo, Giancarlo Ceccarelli, Giancarlo Iaiani, Federico Lo Torto, Diego Ribuffo, Pietro Persiani & Ciro Villani. (2021) Clinical Application of Antibacterial Hydrogel and Coating in Orthopaedic and Traumatology Surgery. Gels 7:3, pages 126.
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Abhishek Tiwari, Prince Sharma, Bhagyashree Vishwamitra & Gaurav Singh. (2021) Review on Surface Treatment for Implant Infection via Gentamicin and Antibiotic Releasing Coatings. Coatings 11:8, pages 1006.
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D. Franz, M. Raschke, P.V. Giannoudis, M. Leliveld, W.J. Metsemakers, M.H.J. Verhofstad, J.A. Craig, J. Shore, A. Smith, C. Muehlendyck, M. Kerstan & T. Fuchs. (2021) Use of antibiotic coated intramedullary nails in open tibia fractures: A European medical resource use and cost-effectiveness analysis. Injury 52:7, pages 1951-1958.
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Dina A. Mosselhy, Mhd Assad, Tarja Sironen & Mady Elbahri. (2021) Nanotheranostics: A Possible Solution for Drug-Resistant Staphylococcus aureus and their Biofilms?. Nanomaterials 11:1, pages 82.
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Preetam Guha Ray, Ragavi Rajasekaran, Trina Roy, Abir Dutta, Baisakhee Saha, Hema Bora, Subrata K. Das & Santanu Dhara. 2021. Regenerated Organs. Regenerated Organs 39 80 .
Daniele De Meo, Federico M. Cannari, Luisa Petriello, Pietro Persiani & Ciro Villani. (2020) Gentamicin-Coated Tibia Nail in Fractures and Nonunion to Reduce Fracture-Related Infections: A Systematic Review. Molecules 25:22, pages 5471.
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Giovanni Vicenti, Davide Bizzoca, Domenico Cotugno, Massimiliano Carrozzo, Flavia Riefoli, Francesco Rifino, Vito Belviso, Rossella Elia, Giuseppe Solarino & Biagio Moretti. (2020) The use of a gentamicin-coated titanium nail, combined with RIA system, in the management of non-unions of open tibial fractures: A single centre prospective study. Injury 51, pages S86-S91.
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Sara Ferraris, Sergio Perero, Piero Costa, G. Gautier di Confiengo, Andrea Cochis, Lia Rimondini, Fabian Renaux, Enrica Vernè, Monica Ferraris & Silvia Spriano. (2020) Antibacterial inorganic coatings on metallic surfaces for temporary fixation devices. Applied Surface Science 508, pages 144707.
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Zachary Mallon, Jason Provus & Gavin Lee. (2020) Removing a Retained Antibiotic Cement Nail from a Tibia. JBJS Case Connector 10:4, pages e20.00106-e20.00106.
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Andrei Bogdan Stoian, Ioana Demetrescu & Daniela Ionita. (2020) Nanotubes and nano pores with chitosan construct on TiZr serving as drug reservoir. Colloids and Surfaces B: Biointerfaces 185, pages 110535.
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Arash Moghaddam, Johanna Weis, Patrick Haubruck, Tim Friedrich Raven, Ayoub Addali & Gerhard Schmidmaier. (2019) Evaluation of the clinical use of the ETN PROtect® in non-union therapy. Injury 50, pages 32-39.
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Vaishali Pawar, Upendra Bulbake, Wahid Khan & Rohit Srivastava. (2019) Chitosan sponges as a sustained release carrier system for the prophylaxis of orthopedic implant-associated infections. International Journal of Biological Macromolecules 134, pages 100-112.
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Alberto Jorge-Mora, Samer Amhaz-Escanlar, Sabela Fernandez-Pose, Adrián García-Iglesias, Fermín Mandia-Mancebo, Eloi Franco-Trepat, María Guillán-Fresco & Jesús Pino-Minguez. (2019) Commercially available antibiotic-laden PMMA-covered locking nails for the treatment of fracture-related infections - A retrospective case analysis of 10 cases. Journal of Bone and Joint Infection 4:4, pages 155-162.
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. (2019) Cefuroxime. Reactions Weekly 1754:1, pages 95-95.
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Chenhao Pan, Zubin Zhou & Xiaowei Yu. (2018) Coatings as the useful drug delivery system for the prevention of implant-related infections. Journal of Orthopaedic Surgery and Research 13:1.
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G. Schmidmaier, M. Kerstan, P. Schwabe, N. Südkamp & M. Raschke. (2017) Clinical experiences in the use of a gentamicin-coated titanium nail in tibia fractures. Injury 48:10, pages 2235-2241.
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Patrick Haubruck & Gerhard Schmidmaier. (2017) Infektanfälligkeit und Verhalten von StahlSusceptibility to infections and behavior of stainless steel. Der Unfallchirurg 120:2, pages 110-115.
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