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Review

Safinamide in the management of patients with Parkinson’s disease not stabilized on levodopa: a review of the current clinical evidence

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Pages 1737-1745 | Published online: 18 Sep 2018

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Nbaa Masood & Joohi Jimenez-Shahed. (2023) Effective Management of “OFF” Episodes in Parkinson’s Disease: Emerging Treatment Strategies and Unmet Clinical Needs. Neuropsychiatric Disease and Treatment 19, pages 247-266.
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Pedro Ayuso, Félix Javier Jiménez-Jiménez, Javier Gómez-Tabales, Hortensia Alonso-Navarro, Elena García-Martín & José A. G. Agúndez. (2023) An update on the pharmacogenetic considerations when prescribing dopamine receptor agonists for Parkinson’s disease. Expert Opinion on Drug Metabolism & Toxicology 19:7, pages 447-460.
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Edoardo Bianchini, Michela Sforza, Domiziana Rinaldi, Marika Alborghetti, Lanfranco De Carolis, Francesco Della Gatta & Francesco E. Pontieri. (2021) Switch from rasagiline to safinamide in fluctuating Parkinson’s disease patients: a retrospective, pilot study. Neurological Research 43:11, pages 950-954.
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Jens Hagenow, Stefanie Hagenow, Kathrin Grau, Mohammad Khanfar, Lena Hefke, Ewgenij Proschak & Holger Stark. (2020) Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs. Drug Design, Development and Therapy 14, pages 371-393.
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Yuanyuan Zhang, Zewen Li, Hui Tang, Wenjie Ren, Xin Gao, Yangjian Sun, Qiu Xiang Zhao, Fanye Wang & Junhong Liu. (2020) Development and optimization of levodopa and benzylhydrazine orally disintegrating tablets by direct compression and response surface methodology. Drug Development and Industrial Pharmacy 46:1, pages 42-49.
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Paolo Guglielmi, Simone Carradori, Alessandra Ammazzalorso & Daniela Secci. (2019) Novel approaches to the discovery of selective human monoamine oxidase-B inhibitors: is there room for improvement?. Expert Opinion on Drug Discovery 14:10, pages 995-1035.
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Danielle S. Shpiner, Sagari Bette, Daniel G. Di Luca & Jason Margolesky. (2019) CVT-301 for the treatment of Parkinson’s disease. Expert Review of Neurotherapeutics 19:7, pages 603-611.
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Heba M. El-Sayed, Hisham Ezzat Abdellatef, Amr M. Mahmoud, Hassan A.M. Hendawy, Omar M El-Abassy & Hany Ibrahim. (2023) Safinamide detection based on Prussian blue analogue modified Solid-contact potentiometric sensor. Microchemical Journal 191, pages 108829.
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Heba M. El-Sayed, Hisham Ezzat Abdellatef, Hassan A.M. Hendawy, Omar M El-Abassy & Hany Ibrahim. (2023) DoE-enhanced development and validation of eco-friendly RP-HPLC method for analysis of safinamide and its precursor impurity: QbD approach. Microchemical Journal 190, pages 108730.
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Heba M El-Sayed, Omar M El-Abassy, Hisham Ezzat Abdellatef, Hassan A M Hendawy & Hany Ibrahim. (2023) Green Spectrophotometric Platforms for Resolving Overlapped Spectral Signals of Recently Approved Antiparkinsonian Drug (Safinamide) in the Presence of Its Synthetic Precursor (4-Hydroxybenzaldehyde): Applying Ecological Appraisal and Comparative Statistical Studies. Journal of AOAC INTERNATIONAL 106:1, pages 26-33.
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Heba M El-sayed, Ahmed M. Abdel-Raoof, Hisham Ezzat Abdellatef, Hassan A.M. Hendawy, Omar M El-Abassy & Hany Ibrahim. (2022) Versatile eco-friendly electrochemical sensor based on chromium-doped zinc oxide nanoparticles for determination of safinamide aided by green assessment criteria. Microchemical Journal 182, pages 107900.
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Kaiyue Liu, Shiqi Zhou, Jie Zhou, Ruxue Bo, Xiaoyu Wang, Tong Xu, Yuhe Yuan & Bailing Xu. (2022) Discovery of 3, 6-disubstituted isobenzofuran-1(3H)-ones as novel inhibitors of monoamine oxidases. Bioorganic & Medicinal Chemistry Letters 67, pages 128748.
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Eoin Mulroy & Kailash P. Bhatia. 2022. Non-Motor Parkinson's Disease. Non-Motor Parkinson's Disease 241 251 .
Danielle Larson & Tanya Simuni. (2022) New dopaminergic therapies for PD motor complications. Neuropharmacology 204, pages 108869.
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Fabrizio Gardoni. 2022. Glutamate and Neuropsychiatric Disorders. Glutamate and Neuropsychiatric Disorders 313 336 .
Neha Hanna Daniel, Ananya Aravind & Poonam Thakur. (2021) Are ion channels potential therapeutic targets for Parkinson’s disease?. NeuroToxicology 87, pages 243-257.
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Himika Wasan, Devendra Singh, Balu Joshi, Uma Sharma, A. K. Dinda & K. H. Reeta. (2021) Post Stroke Safinamide Treatment Attenuates Neurological Damage by Modulating Autophagy and Apoptosis in Experimental Model of Stroke in Rats. Molecular Neurobiology 58:12, pages 6121-6135.
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Serene Ho & Adrian Wong. (2021) Perioperative management considerations in patients taking prescribed psychoactive medications (including those for depression and Parkinson's disease). Current Opinion in Anaesthesiology 34:5, pages 582-589.
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P. Pérez-Torre, J.L. López-Sendón, V. Mañanes Barral, I. Parees, S. Fanjul-Arbós, E. Monreal, A. Alonso-Canovas & J.C. Martínez Castrillo. (2021) Concomitant treatment with safinamide and antidepressant drugs: Safety data from real clinical practice. Neurología.
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Luminita Crisan, Daniela Istrate, Alina Bora & Liliana Pacureanu. (2020) Virtual screening and drug repurposing experiments to identify potential novel selective MAO-B inhibitors for Parkinson’s disease treatment. Molecular Diversity 25:3, pages 1775-1794.
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Domiziana Rinaldi, Edoardo Bianchini, Michela Sforza, Marika Alborghetti, Silvia Galli, Marco Salvetti, Morena Giovannelli & Francesco E. Pontieri. (2020) The tolerability, safety and efficacy of safinamide in elderly Parkinson’s disease patients: a retrospective study. Aging Clinical and Experimental Research 33:6, pages 1689-1692.
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Violina Kakoty, Sarathlal K C, Sunil Kumar Dubey, Chih Hao Yang, Prashant Kesharwani & Rajeev Taliyan. (2021) The gut-brain connection in the pathogenicity of Parkinson disease: Putative role of autophagy. Neuroscience Letters 753, pages 135865.
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Donald J. AbrahamOla A.M. Ghoneim & Raymond G. Booth. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 46 .
Sara Silva, António J. Almeida & Nuno Vale. (2021) Importance of Nanoparticles for the Delivery of Antiparkinsonian Drugs. Pharmaceutics 13:4, pages 508.
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Himika Wasan, Devendra Singh & Reeta KH. (2021) Safinamide in neurological disorders and beyond: Evidence from preclinical and clinical studies. Brain Research Bulletin 168, pages 165-177.
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Jacopo Troisi, Annamaria Landolfi, Pierpaolo Cavallo, Francesca Marciano, Paolo Barone & Marianna Amboni. 2021. 107 149 .
Begum E. Aksoz & Erkan Aksoz. (2020) Vital Role of Monoamine Oxidases and Cholinesterases in Central Nervous System Drug Research: A Sharp Dissection of the Pathophysiology. Combinatorial Chemistry & High Throughput Screening 23:9, pages 877-886.
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Falaq Naz & Yasir Hasan Siddique. (2020) Role of Genes and Treatments for Parkinson’s Disease. The Open Biology Journal 8:1, pages 47-65.
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V.K.D. Krishnaswamy, Phaniendra Alugoju & Latha Periyasamy. (2020) Multifaceted targeting of neurodegeneration with bioactive molecules of saffron (Crocus sativus): An insilco evidence-based hypothesis. Medical Hypotheses 143, pages 109872.
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Michelle Ann C. Sy & Hubert H. Fernandez. (2020) Pharmacological Treatment of Early Motor Manifestations of Parkinson Disease (PD). Neurotherapeutics 17:4, pages 1331-1338.
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Pablo Duarte, Antonio Cuadrado & Rafael León. 2021. Reactive Oxygen Species. Reactive Oxygen Species 229 259 .
Zhipeng Wang, Ge Gao, Chunli Duan & Hui Yang. (2019) Progress of immunotherapy of anti-α-synuclein in Parkinson’s disease. Biomedicine & Pharmacotherapy 115, pages 108843.
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Vikram S. Sawant, Hyeri Park, Soo Yoon Baek, Jieon Lee, Ji Won Choi, Ki Duk Park, Kyung Il Choi, Jihye Seong, Sanghee Lee & Hyunah Choo. (2019) Benzoxazoles as Selective Monoamine Oxidase B (MAO‐B) Inhibitors. Bulletin of the Korean Chemical Society 40:5, pages 457-460.
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Marios G. Krokidis. (2019) Identification of biomarkers associated with Parkinson’s disease by gene expression profiling studies and bioinformatics analysis. AIMS Neuroscience 6:4, pages 333-345.
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Moussa B. H. Youdim. (2018) Monoamine oxidase inhibitors, and iron chelators in depressive illness and neurodegenerative diseases. Journal of Neural Transmission 125:11, pages 1719-1733.
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