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Review

Update on subcutaneous methotrexate for inflammatory arthritis and psoriasis

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Pages 105-116 | Published online: 09 Jan 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Yanyan Zhang, Zhaoju Gao, Shushu Chao, Wenjuan Lu & Pingping Zhang. (2022) Transdermal delivery of inflammatory factors regulated drugs for rheumatoid arthritis. Drug Delivery 29:1, pages 1934-1950.
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Leena Chularojanamontri, Chanisada Wongpraparut, Narumol Silpa-Archa, Chayada Chaiyabutr, Chutipon Pruksaeakanan, Anchalika Klinniyom, Sarawut Junnu & Chatchawan Srisawat. (2022) Patient-ready syringes containing 25 mg/mL methotrexate can be kept at temperature ranging from 4 °C to 37 °C for up to 12 weeks for use in psoriatic and rheumatologic conditions. Journal of Dermatological Treatment 33:2, pages 1023-1028.
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Fang Wei, Qiuyue Wang, Hang Liu, Xuejing Yang, Wenyu Cao, Weiman Zhao, Yingying Li, Lijie Zheng, Tao Ma & Qingqing Wang. (2022) High Efficacy Combined Microneedles Array with Methotrexate Nanocrystals for Effective Anti-Rheumatoid Arthritis. International Journal of Nanomedicine 17, pages 2397-2412.
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Jesús Tornero Molina, Juan Carlos López Robledillo & Núria Casamira Ruiz. (2021) Potential Benefits of the Self-Administration of Subcutaneous Methotrexate with Autoinjector Devices for Patients: A Review. Drug, Healthcare and Patient Safety 13, pages 81-94.
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Arash Maleki, Jordan A. Ueberroth, Marisa Walsh, Frances Foster, Peter Y. Chang, Stephen D. Anesi & Charles Stephen Foster. (2021) Combination of Intravenous Methotrexate and Methylprednisolone Therapy in the Treatment of Severe Ocular Inflammatory Diseases. Ocular Immunology and Inflammation 29:7-8, pages 1559-1563.
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Marija Gvoic, Sasa Vukmirovic, Hani Al-Salami, Armin Mooranian, Momir Mikov & Karmen Stankov. (2021) Bile acids as novel enhancers of CNS targeting antitumor drugs: a comprehensive review. Pharmaceutical Development and Technology 26:6, pages 617-633.
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Sandra M. Quezada, Leon P. McLean & Raymond K. Cross. (2018) Adverse events in IBD therapy: the 2018 update. Expert Review of Gastroenterology & Hepatology 12:12, pages 1183-1191.
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Articles from other publishers (27)

Ramkumar Katturajan & Sabina Evan Prince. (2023) L-carnitine and Zinc supplementation impedes intestinal damage in methotrexate-treated adjuvant-induced arthritis rats: Reinstating enterocyte proliferation and trace elements. Journal of Trace Elements in Medicine and Biology 78, pages 127188.
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Yezan M. Salamoun, Kishore Polireddy, Yu Kyoung Cho & Ryan Sol Funk. (2022) Metabolomic Profiling of Red Blood Cells to Identify Molecular Markers of Methotrexate Response in the Collagen Induced Arthritis Mouse Model. Future Pharmacology 2:4, pages 625-641.
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Y. Han, Z.Y. Jin, D.S. Zhang, B.B. Hu, Z.Q. Li, Y.S. Jing & S.G. Sun. (2022) Application of polymers in promoting transdermal absorption. Materials Today Chemistry 26, pages 101204.
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Huaiji Wang, Zihan Zhao, Chenghao Wu, Xiaowen Tong, Yuling Shi & Shunjie Chen. (2022) Microneedle Patch Delivery of Methotrexate-Loaded Albumin Nanoparticles to Immune Cells Achieves a Potent Antipsoriatic Effect. International Journal of Nanomedicine Volume 17, pages 3841-3851.
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Ana Socorro Rodríguez‐Báez, Ana Patricia Huerta‐García, Susanna Edith Medellín‐Garibay, Cristian Jazmín Rodríguez‐Pinal, Marco Ulises Martínez‐Martínez, David Herrera‐Van Oostdam, Carlos Abud‐Mendoza, Silvia Romano‐Moreno & Rosa del Carmen Milán‐Segovia. (2022) Disease activity and therapeutic drug monitoring of polyglutamates of methotrexate after daily or weekly administration of low‐dose methotrexate in patients recently diagnosed with rheumatoid arthritis. Basic & Clinical Pharmacology & Toxicology 130:6, pages 644-654.
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Charoen Choonhakarn, Suteeraporn Chaowattanapanit, Narachai Julanon & Panita Limpawattana. (2022) Comparison of the clinical efficacy of subcutaneous vs. oral administration of methotrexate in patients with psoriasis vulgaris: a randomized controlled trial. Clinical and Experimental Dermatology 47:5, pages 942-948.
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Iveta Merćep, Nikolina Friščić, Dominik Strikić & Željko Reiner. (2022) Advantages and Disadvantages of Inclisiran: A Small Interfering Ribonucleic Acid Molecule Targeting PCSK9—A Narrative Review. Cardiovascular Therapeutics 2022, pages 1-6.
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Yezan M. Salamoun, Kishore Polireddy, Yu Kyoung Cho, Matthew R. Medcalf & Ryan S. Funk. (2021) Methotrexate Disposition, Anti-Folate Activity, and Metabolomic Profiling to Identify Molecular Markers of Disease Activity and Drug Response in the Collagen-Induced Arthritis Mouse Model. Metabolites 12:1, pages 24.
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Chaoxiong Wu, Jiale Cheng, Wei Li, Lingzhi Yang, Haifeng Dong & Xueji Zhang. (2021) Programmable Polymeric Microneedles for Combined Chemotherapy and Antioxidative Treatment of Rheumatoid Arthritis. ACS Applied Materials & Interfaces 13:46, pages 55559-55568.
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Lobna Abdel Salam, Amal Q. Aldarwesh & Hatem H. Eleishi. (2021) Whole exome sequencing (WES) of methotrexate response/adverse event profile in rheumatoid arthritis patients. The Egyptian Rheumatologist 43:4, pages 287-291.
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Sonali S. Bharate. (2021) Modulation of biopharmaceutical properties of acidic drugs using cationic counterions: A critical analysis of FDA-approved pharmaceutical salts. International Journal of Pharmaceutics 607, pages 120993.
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Emad Molaei, Ali Molaei, Farshad Abedi, A. Wallace Hayes & Gholamreza Karimi. (2021) Nephroprotective activity of natural products against chemical toxicants: The role of Nrf2/ARE signaling pathway. Food Science & Nutrition 9:6, pages 3362-3384.
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T. V. Korotaeva, E. Yu. Loginova, E. E. Gubar, Yu. L. Korsakova, M. V. Sedunova, I. N. Pristavsky, I. N. Kushnir, I. F. Umnova & S. S. Kudishina. (2021) Achievement of minimal disease activity in psoriatic arthritis according to the time of administration of synthetic disease-modifying antirheumatic drugs, a comparative analysis of the efficacy of oral and subcutaneous methotrexate. Data from the All-Russian Psoriatic Arthritis Registry. Modern Rheumatology Journal 15:1, pages 27-31.
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Jeffrey P. Callen & Carol L. Kulp-Shorten. 2021. Comprehensive Dermatologic Drug Therapy. Comprehensive Dermatologic Drug Therapy 156 168.e5 .
Erin Boh, Andrew Joselow & Brittany Stumpf. 2021. Advances in Psoriasis. Advances in Psoriasis 103 118 .
Manar Amanouil Said, Liana Soido Teixeira e Silva, Aline Maria de Oliveira Rocha, Gustavo Guimarães Barreto Alves, Daniela Gerent Petry Piotto, Claudio Arnaldo Len & Maria Teresa Terreri. (2020) Adverse drug reactions associated with treatment in patients with chronic rheumatic diseases in childhood: a retrospective real life review of a single center cohort. Advances in Rheumatology 60:1.
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Ismaiel A. Tekko, Andi Dian Permana, Lalitkumar Vora, Taher Hatahet, Helen O. McCarthy & Ryan F. Donnelly. (2020) Localised and sustained intradermal delivery of methotrexate using nanocrystal-loaded microneedle arrays: Potential for enhanced treatment of psoriasis. European Journal of Pharmaceutical Sciences 152, pages 105469.
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Ismaiel A. Tekko, Gaoyun Chen, Juan Domínguez-Robles, Raghu Raj Singh Thakur, Iman M.N. Hamdan, Lalitkumar Vora, Eneko Larrañeta, James C. McElnay, Helen O. McCarthy, Madeleine Rooney & Ryan F. Donnelly. (2020) Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based hydrogel-forming microneedle arrays for enhanced and sustained transdermal delivery of methotrexate. International Journal of Pharmaceutics 586, pages 119580.
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Deepak M. W. Balak, Sascha Gerdes, Aurora Parodi & Laura Salgado-Boquete. (2020) Long-term Safety of Oral Systemic Therapies for Psoriasis: A Comprehensive Review of the Literature. Dermatology and Therapy 10:4, pages 589-613.
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. (2020) Modify treatment for atopic dermatitis when patient response to dupilumab is partial or non-durable. Drugs & Therapy Perspectives 36:5, pages 186-189.
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Eve Lebas, Corinne Chapelier, Pascale Quatresooz, Laurence Seidel & A.F. Nikkels. (2020) Exploratory Assessment of Oxygen Flow–Assisted Cutaneous Administration of Methotrexate for Superficial Basal Cell Carcinoma, Mycosis Fungoides, and Extramammary Paget Disease. Journal of Investigative Dermatology 140:3, pages 583-592.
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Krzysztof Dyrbuś, Mariusz Gąsior, Peter Penson, Kausik K. Ray & Maciej Banach. (2020) Inclisiran—New hope in the management of lipid disorders?. Journal of Clinical Lipidology 14:1, pages 16-27.
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Dawn Homer. (2019) Using video‐based training for button‐free auto‐injection of subcutaneous methotrexate: A pilot study. Musculoskeletal Care 17:3, pages 247-279.
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Aleksi J. Hendricks, Peter A. Lio & Vivian Y. Shi. (2019) Management Recommendations for Dupilumab Partial and Non-durable Responders in Atopic Dermatitis. American Journal of Clinical Dermatology 20:4, pages 565-569.
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Rakesh K. Singh, Leon van Haandel, Paul Kiptoo, Mara L. Becker, Teruna J. Siahaan & Ryan S. Funk. (2019) Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model. European Journal of Pharmacology 853, pages 264-274.
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Rahul Bodkhe, Baskar Balakrishnan & Veena Taneja. (2019) The role of microbiome in rheumatoid arthritis treatment. Therapeutic Advances in Musculoskeletal Disease 11, pages 1759720X1984463.
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Gloria C. Higgins. (2018) Complications of Treatments for Pediatric Rheumatic Diseases. Pediatric Clinics of North America 65:4, pages 827-854.
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