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Review

Ganciclovir ophthalmic gel 0.15% for the treatment of acute herpetic keratitis: background, effectiveness, tolerability, safety, and future applications

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Pages 665-681 | Published online: 20 Aug 2014

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Ting Yu, Rong-Mei Peng, Ge-Ge Xiao, Li-Na Feng & Jing Hong. (2020) Clinical Evaluation of Intravitreal Injection of Ganciclovir in Refractory Corneal Endotheliitis. Ocular Immunology and Inflammation 28:2, pages 270-280.
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Souska Zandi, Bahram Bodaghi & Justus G. Garweg. (2018) Review for Disease of the Year: Treatment of Viral Anterior Uveitis: A Perspective. Ocular Immunology and Inflammation 26:7, pages 1135-1142.
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Lina Zhu, Junping Ao & Peiling Li. (2015) A novel in situ gel base of deacetylase gellan gum for sustained ophthalmic drug delivery of ketotifen: in vitro and in vivo evaluation. Drug Design, Development and Therapy 9, pages 3943-3949.
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Antonia Reyes, Mónica A. Farías, Nicolás Corrales, Eduardo Tognarelli & Pablo A. González. 2022. Encyclopedia of Infection and Immunity. Encyclopedia of Infection and Immunity 12 36 .
Angela H. Y. Wong, Wee Nie Kua, Alvin L. Young & Kelvin H. Wan. (2021) Management of cytomegalovirus corneal endotheliitis. Eye and Vision 8:1.
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Manisha Pandey, Hira Choudhury, Azila Abdul-Aziz, Subrat Kumar Bhattamisra, Bapi Gorain, Jocelyn Sziou Ting Su, Choo Leey Tan, Woon Yee Chin & Khar Yee Yip. (2020) Advancement on Sustained Antiviral Ocular Drug Delivery for Herpes Simplex Virus Keratitis: Recent Update on Potential Investigation. Pharmaceutics 13:1, pages 1.
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G. Ch. Zaynutdinova. (2019) Мodern Approaches to the Treatment and Prevention of Recurrent of Ophthalmic Herpes. Review. Ophthalmology in Russia 16:1S, pages 12-20.
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Aseel Mahmood Ibrahim Al-Mashahedah, Rupinder Kaur Kanwar & Jagat Rakesh Kanwar. (2019) Utility of nanomedicine targeting scar-forming myofibroblasts to attenuate corneal scarring and haze. Nanomedicine 14:8, pages 1049-1072.
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Pooja Maharjan, Kwan Hyung Cho, Anjila Maharjan, Meong Cheol Shin, Cheol Moon & Kyoung Ah Min. (2018) Pharmaceutical challenges and perspectives in developing ophthalmic drug formulations. Journal of Pharmaceutical Investigation 49:2, pages 215-228.
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Mehdi Roozbahani & Kristin M. Hammersmith. (2018) Management of herpes simplex virus epithelial keratitis. Current Opinion in Ophthalmology 29:4, pages 360-364.
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Tanja Kalezic, Mostafa Mazen, Eric Kuklinski & Penny Asbell. (2018) Herpetic eye disease study. Current Opinion in Ophthalmology 29:4, pages 340-346.
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Ling Wang, Lin Ye, Gaobin Wei, Yu Chen, Lina Ye, Xiaoting Wu, Zhihong Zeng, Yuan Wang, Guogan Yin, Xiang Long & Hui Li. (2018) Conditional reprogrammed human limbal epithelial cells represent a novel in vitro cell model for drug responses. Biochemical and Biophysical Research Communications 499:4, pages 735-742.
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Aseel Al-Mashahedah, Rupinder Kaur Kanwar & Jagat Rakesh Kanwar. 2018. Drug Delivery for the Retina and Posterior Segment Disease. Drug Delivery for the Retina and Posterior Segment Disease 169 194 .
Nishant G. Soni, Angelique Pillar, Jordan Margo & Bennie H. Jeng. 2018. Ocular Surface Disease. Ocular Surface Disease 221 231 .
Venkateswara Prasad Padala & Venkata Satyanarayana Bokka. (2017) A CLINICAL STUDY OF OCULAR COMPLICATIONS OF HIV. Journal of Evidence Based Medicine and Healthcare 4:95, pages 5969-5973.
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Ariana Austin, Tom Lietman & Jennifer Rose-Nussbaumer. (2017) Update on the Management of Infectious Keratitis. Ophthalmology 124:11, pages 1678-1689.
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Narumon Keorochana & Raveewan Choontanom. (2017) Efficacy and safety of an extemporaneous preparation of 2% ganciclovir eye drops in CMV anterior uveitis. BMJ Open Ophthalmology 2:1, pages e000061.
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Manuel Alejandro Garza León & Marisol Huichapa. (2017) Medical Management of Herpes Simplex Keratitis. Highlights of Ophthalmology 45:4ENG, pages 15-25.
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Simon Wandel, Beat Neuenschwander, Christian Röver & Tim Friede. (2017) Using phase II data for the analysis of phase III studies: An application in rare diseases. Clinical Trials 14:3, pages 277-285.
Crossref
Yuhua Weng, Juan Liu, Shubin Jin, Weisheng Guo, Xingjie Liang & Zhongbo Hu. (2017) Nanotechnology-based strategies for treatment of ocular disease. Acta Pharmaceutica Sinica B 7:3, pages 281-291.
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Anna Ligasová, Petr Konečný, Ivo Frydrych & Karel Koberna. (2017) Cell cycle profiling by image and flow cytometry: The optimised protocol for the detection of replicational activity using 5-Bromo-2′-deoxyuridine, low concentration of hydrochloric acid and exonuclease III. PLOS ONE 12:4, pages e0175880.
Crossref
Michael Tsatsos, Cheryl MacGregor, Ioannis Athanasiadis, Marilita M Moschos, Parwez Hossain & David Anderson. (2016) Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents. Clinical & Experimental Ophthalmology 44:9, pages 824-837.
Crossref
Sara M. Thomasy & David J. Maggs. (2016) A review of antiviral drugs and other compounds with activity against feline herpesvirus type 1. Veterinary Ophthalmology 19, pages 119-130.
Crossref
Sutasinee Boonsopon, Armin Maghsoudlou, Ninani E. Kombo & C. Stephen Foster. (2015) A Therapeutic Trial of Valganciclovir in Patients with Uveitis and Positive Epstein-Barr virus Early Antigen D IgG Titers. European Journal of Ophthalmology 26:1, pages 30-35.
Crossref
Mitchell B. Strominger. 2016. The Infected Eye. The Infected Eye 177 196 .
Kirk R Wilhelmus. (2015) Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Cochrane Database of Systematic Reviews.
Crossref