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Therapeutics and Clinical Risk Management Volume 11, 2015 - Issue
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Original Research

A randomized crossover study comparing trehalose/hyaluronate eyedrops and standard treatment: patient satisfaction in the treatment of dry eye syndrome

Juan Carlos Pinto-Bonilla1 Department of Corneal, Refractive, and Cataract Surgery, European Ophthalmological Institute, Clínica Baviera, Pamplona, Navarra, SpainCorrespondence[email protected]
,
Alberto del Olmo-Jimeno2 Optometry Department, European Ophthalmological Institute, Clínica Baviera, Pamplona, Navarra, Spain
,
Fernando Llovet-Osuna3 Department of Refractive and Cataract Surgery, European Ophthalmological Institute, Clínica Baviera, Madrid, Madrid, Spain
&
Emiliano Hernández-Galilea4 Ophthalmology Department, Hospital Clínico Universitario de Salamanca, Universidad de Salamanca, Salamanca, Salamanca, Spain
Pages 595-603 | Published online: 13 Apr 2015

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David A Semp, Danielle Beeson, Amy L Sheppard, Debarun Dutta & James S Wolffsohn. (2023) Artificial Tears: A Systematic Review. Clinical Optometry 15, pages 9-27.
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Emine Sen, Ufuk Elgin, Osman Ozen & Fikriye Gozde Ozturk. (2021) The Efficacy and Safety of Trehalose in Primary Trabeculectomy with Mitomycin C: A Report of Early Findings. Clinical Ophthalmology 15, pages 2301-2306.
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Renee Garofalo, Carolina Kunnen, Rekha Rangarajan, Venkiteshwar Manoj & Howard Ketelson. (2021) Relieving the symptoms of dry eye disease: update on lubricating eye drops containing hydroxypropyl-guar. Clinical and Experimental Optometry 104:8, pages 826-834.
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Rosa Longo, Anna Avesani, Giulia Dalla Mura, Daniele Dell’Orco, Stefano Manfredini & Giacomo Panozzo. (2021) Clinical improvement of ocular surface parameters in dry eye patients following treatment with urea/crosslinked-hyaluronate eyedrops correlates with the secretion of MUC-4. Expert Review of Ophthalmology 16:6, pages 497-504.
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Chiara Fariselli, Giuseppe Giannaccare, Michela Fresina & Piera Versura. (2018) Trehalose/hyaluronate eyedrop effects on ocular surface inflammatory markers and mucin expression in dry eye patients. Clinical Ophthalmology 12, pages 1293-1300.
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Antonio J Mateo Orobia, Paula Casas Pascual, José Á Cristóbal Bescós, Diana Perez García, Carlos Peiro Embid, M Ángeles del Buey Sayas, Valentyna Korobko Kulikova & Noelia Lafuente Ojeda. (2017) Effects of 3% trehalose as an adjuvant treatment after LASIK. Clinical Ophthalmology 11, pages 347-353.
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Nariman Nassiri, Yasaira Rodriguez Torres, Zachary Meyer, Michael A. Beyer, Gautham Vellaichamy, Amar S. Dhaliwal, Neil Chungfat & Frank S. Hwang. (2017) Current and emerging therapy of dry eye disease. Part A: pharmacological modalities. Expert Review of Ophthalmology 12:4, pages 269-297.
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Marcella Nebbioso, Valeria Fameli, Magda Gharbiya, Marta Sacchetti, Anna Maria Zicari & Alessandro Lambiase. (2016) Investigational drugs in dry eye disease. Expert Opinion on Investigational Drugs 25:12, pages 1437-1446.
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Articles from other publishers (10)

Francisco Pastor-Pascual, Rafael Pastor-Pascual, Patricia Gálvez-Perez, Rosa Dolz-Marco & Roberto Gallego-Pinazo. (2022) Use of Artificial Tears in Patients Undergoing Treatment with Anti-VEGF Intravitreal Injections. Clinical Ophthalmology Volume 16, pages 3959-3972.
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Meilin Chen, Peng Yu, Chuanbei Ao, Miao Zhang, Jiaqi Xing, Chunmei Ding, Jing Xie & Jianshu Li. (2022) Ethanol-Induced Responsive Behavior of Natural Polysaccharide Hydrogels. Industrial & Engineering Chemistry Research 61:35, pages 13145-13153.
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Ajaz Ahmed & Debaraj Mukherjee. (2022) Stereoselective Construction of Orthogonally Protected, N–O Interlinked Disaccharide Mimetics Using N-Substituted β-Aminooxy Donors. The Journal of Organic Chemistry 87:8, pages 5125-5135.
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Anthony M. Buckley, Ines B. Moura, Norie Arai, William Spittal, Emma Clark, Yoshihiro Nishida, Hannah C. Harris, Karen Bentley, Georgina Davis, Dapeng Wang, Suparna Mitra, Takanobu Higashiyama & Mark H. Wilcox. (2021) Trehalose-Induced Remodelling of the Human Microbiota Affects Clostridioides difficile Infection Outcome in an In Vitro Colonic Model: A Pilot Study. Frontiers in Cellular and Infection Microbiology 11.
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Hakika ERDOGAN & Orkun MUHSİNOGLU. (2021) Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery. Black Sea Journal of Health Science 4:1, pages 17-21.
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Nianxuan Wu, Liangbo Chen, Dan Yan, Meng Zhou, Chunyi Shao, Yang Lu, Qinke Yao, Hao Sun & Yao Fu. (2020) Trehalose attenuates TGF-β1-induced fibrosis of hSCFs by activating autophagy. Molecular and Cellular Biochemistry 470:1-2, pages 175-188.
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Jarmo Laihia & Kai Kaarniranta. (2020) Trehalose for Ocular Surface Health. Biomolecules 10:5, pages 809.
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Natallia Dubashynskaya, Daria Poshina, Sergei Raik, Arto Urtti & Yury A. Skorik. (2019) Polysaccharides in Ocular Drug Delivery. Pharmaceutics 12:1, pages 22.
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Victor J. Drew, Ching-Li Tseng, Jerard Seghatchian & Thierry Burnouf. (2018) Reflections on Dry Eye Syndrome Treatment: Therapeutic Role of Blood Products. Frontiers in Medicine 5.
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Sergey Yu Astakhov & Natalia V Tkachenko. (2016) Trehalose efficacy in dry eye syndrome treatment after phacoemulsification. Ophthalmology Reports 9:4, pages 79-89.
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