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Original Research

Methylnaltrexone for opioid-induced constipation: review and meta-analyses for objective plus subjective efficacy and safety outcomes

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Pages 401-412 | Published online: 11 Mar 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Richard L Rauck, Neal E Slatkin, Nancy Stambler & Robert J Israel. (2019) Safety of oral methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain. Journal of Pain Research 12, pages 139-150.
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Shilan Mozaffari, Shekoufeh Nikfar & Mohammad Abdollahi. (2018) Methylnaltrexone bromide for the treatment of opioid-induced constipation. Expert Opinion on Pharmacotherapy 19:10, pages 1127-1135.
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Articles from other publishers (23)

V. Andresen, G. Becker, T. Frieling, M. Goebel-Stengel, F. Gundling, A. Herold, M. Karaus, J. Keller, M. Kim, P. Klose, H. Krammer, M. E. Kreis, R. Kuhlbusch-Zicklam, J. Langhorst, P. Layer, R. Lenzen-Großimlinghaus, A. Madisch, H. Mönnikes, S. Müller-Lissner, D. Rubin, M. Schemann, J. Schwille-Kiuntke, A. Stengel, M. Storr, I. van der Voort, W. Voderholzer, T. Wedel, S. Wirz, H. Witzigmann & C. Pehl. (2022) Aktualisierte S2k-Leitlinie chronische Obstipation der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie & Motilität (DGNM) – April 2022 – AWMF-Registriernummer: 021–019. Zeitschrift für Gastroenterologie 60:10, pages 1528-1572.
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. 2022. Arzneimitteltherapie in der Palliativmedizin. Arzneimitteltherapie in der Palliativmedizin 511 774 .
Roberto De Giorgio, Furio Massimino Zucco, Giuseppe Chiarioni, Sebastiano Mercadante, Enrico Stefano Corazziari, Augusto Caraceni, Patrizio Odetti, Raffaele Giusti, Franco Marinangeli & Carmine Pinto. (2021) Management of Opioid-Induced Constipation and Bowel Dysfunction: Expert Opinion of an Italian Multidisciplinary Panel. Advances in Therapy 38:7, pages 3589-3621.
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Solomon S. Liao, Neal E. Slatkin & Nancy Stambler. (2021) The Influence of Age on Central Effects of Methylnaltrexone in Patients with Opioid-Induced Constipation. Drugs & Aging 38:6, pages 503-511.
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Ying-Ying Zhang, Rong Zhou & Wan-Jie Gu. (2021) Efficacy and Safety of Methylnaltrexone for the Treatment of Opioid-Induced Constipation: A Meta-analysis of Randomized Controlled Trials. Pain and Therapy 10:1, pages 165-179.
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A. Jaber, S. Hemmer, R. Klotz, T. Ferbert, C. Hensel, C. Eisner, Y. M. Ryang, P. Obid, K. Friedrich, W. Pepke & M. Akbar. (2020) Bowel dysfunction after elective spinal surgery: etiology, diagnostics and management based on the medical literature and experience in a university hospitalDarmfunktionsstörung nach elektiver Wirbelsäulenoperation: Ätiologie, Diagnostik und Management nach der aktuellen Literatur und den Erfahrungen in einem Universitätsklinikum. Der Orthopäde 50:6, pages 425-434.
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Nabil ALMouaalamy. (2021) Opioid-Induced Constipation in Advanced Cancer Patients. Cureus.
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Charles E. Argoff. (2020) Opioid-induced Constipation. The Clinical Journal of Pain 36:9, pages 716-722.
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Guillaume Gourcerol & Antoine Lemaire. (2020) Prise en charge de la constipation induite par les opioïdes : regards croisés d’un gastroentérologue et d’un médecin de la douleur. Douleurs : Évaluation - Diagnostic - Traitement 21:4, pages 147-154.
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Erlania do Carmo Freitas, Geslaney Reis da Silva, Rudval Souza da Silva, Rita Narriman Silva de Oliveira Boery & Maria Patricia Milagres. (2020) Opioid-induced constipation in palliative care: state of the art. Revista de Pesquisa Cuidado é Fundamental Online, pages 1116-1124.
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Bruce H Chamberlain, Michelle Rhiner, Neal E Slatkin, Nancy Stambler & Robert J Israel. (2020) Subcutaneous methylnaltrexone for opioid-induced constipation in advanced-illness patients with or without active cancer. Pain Management 10:2, pages 73-84.
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Kirbylee K. Nelson, Mark A. Schattner & Robin B. Mendelsohn. (2019) Methylnaltrexone is safe in cancer patients with peritoneal carcinomatosis. Scientific Reports 9:1.
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Adam D Farmer, Asbjørn M Drewes, Giuseppe Chiarioni, Roberto De Giorgio, Tony O'Brien, Bart Morlion & Jan Tack. (2019) Pathophysiology and management of opioid‐induced constipation: European expert consensus statement. United European Gastroenterology Journal 7:1, pages 7-20.
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John M. Streicher & Edward J. Bilsky. (2017) Peripherally Acting μ-Opioid Receptor Antagonists for the Treatment of Opioid-Related Side Effects: Mechanism of Action and Clinical Implications. Journal of Pharmacy Practice 31:6, pages 658-669.
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P.J. Larkin, N.I. Cherny, D. La Carpia, M. Guglielmo, C. Ostgathe, F. Scotté & C.I. Ripamonti. (2018) Diagnosis, assessment and management of constipation in advanced cancer: ESMO Clinical Practice Guidelines. Annals of Oncology 29, pages iv111-iv125.
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Adam D Farmer, Caroline Bruckner Holt, Thomas J Downes, Eugenio Ruggeri, Sara Del Vecchio & Roberto De Giorgio. (2018) Pathophysiology, diagnosis, and management of opioid-induced constipation. The Lancet Gastroenterology & Hepatology 3:3, pages 203-212.
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. 2018. Arzneimitteltherapie in der Palliativmedizin. Arzneimitteltherapie in der Palliativmedizin 447 696 .
Mellar P. Davis. 2018. The MASCC Textbook of Cancer Supportive Care and Survivorship. The MASCC Textbook of Cancer Supportive Care and Survivorship 17 35 .
Hong Yang & Tonghui Ma. (2017) Luminally Acting Agents for Constipation Treatment: A Review Based on Literatures and Patents. Frontiers in Pharmacology 8.
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J. Tack, H. Boardman, P. Layer, I. Schiefke, D. Jayne, C. Scarpignato, M. Fox, T. Frieling, P. Ducrotte, S. Hamdy, K. Gill, C. Ciriza de los Rios, R. Felt-Bersma, D. De Looze, V. Stanghellini, A. Mohr Drewes, M. Simrén, C. Pehl, T. Hoheisel, A. Leodolter, E. Rey, J. Dalrymple & A. Emmanuel. (2017) An expert consensus definition of failure of a treatment to provide adequate relief (F-PAR) for chronic constipation - an international Delphi survey. Alimentary Pharmacology & Therapeutics 45:3, pages 434-442.
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Kirby Welston & Dianne May. 2017. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions 373 387 .
Allen A. Lee & William L. Hasler. (2016) Opioids and GI Motility—Friend or Foe?. Current Treatment Options in Gastroenterology 14:4, pages 478-494.
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Wojciech Leppert & Jaroslaw Woron. (2016) The role of naloxegol in the management of opioid-induced bowel dysfunction. Therapeutic Advances in Gastroenterology 9:5, pages 736-746.
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