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Review

Update on the management of chronic eczema: new approaches and emerging treatment options

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Pages 99-117 | Published online: 28 Jul 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Taylor Edwards, Nupur U. Patel, Amy Blake, Samantha Prabakaran, Danielle Reimer, Steven R. Feldman & Lindsay C. Strowd. (2018) Insights into future therapeutics for atopic dermatitis. Expert Opinion on Pharmacotherapy 19:3, pages 265-278.
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Siao Pei Tan, Simon B Brown, Christopher EM Griffiths, Richard B Weller & Neil K Gibbs. (2017) Feeding filaggrin: effects of l-histidine supplementation in atopic dermatitis. Clinical, Cosmetic and Investigational Dermatology 10, pages 403-411.
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Sherman X. Gu, Anthony L. Zhang, Meaghan E. Coyle, Dacan Chen & Charlie C. Xue. (2017) Chinese herbal medicine for atopic eczema: an overview of clinical evidence. Journal of Dermatological Treatment 28:3, pages 246-250.
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Jonathan I. Silverberg, Diane B. Nelson & Gil Yosipovitch. (2016) Addressing treatment challenges in atopic dermatitis with novel topical therapies. Journal of Dermatological Treatment 27:6, pages 568-576.
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Articles from other publishers (38)

Sakeena Fatima, Tazeen Abbas, Maggi A. Refat, John E. Harris, Henry W. Lim, Iltefat H. Hamzavi & Tasneem F. Mohammad. (2022) Systemic therapies in vitiligo: a review. International Journal of Dermatology 62:3, pages 279-289.
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Sarika Wairkar, Dhrumi Patel & Abhinav Singh. (2022) Nanostructured lipid carrier based dermal gel of cyclosporine for atopic dermatitis-in vitro and in vivo evaluation. Journal of Drug Delivery Science and Technology 72, pages 103365.
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Ilke Kildaci, Yasemin Budama-Kilinc, Serda Kecel-Gunduz & Ebru Altuntas. (2021) Linseed Oil Nanoemulsions for treatment of Atopic Dermatitis disease: Formulation, characterization, in vitro and in silico evaluations. Journal of Drug Delivery Science and Technology 64, pages 102652.
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Kyle Fahrbach, Jialu Tarpey, Evelien Bergrath Washington, Rachel Hughes, Howard Thom, Maureen P. Neary, Amy Cha, Robert Gerber & Joseph C. Cappelleri. (2020) Crisaborole Ointment, 2%, for Treatment of Patients with Mild-to-Moderate Atopic Dermatitis: Systematic Literature Review and Network Meta-Analysis. Dermatology and Therapy 10:4, pages 681-694.
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Si Yeon Jo, Mi Hye Kim, Haesu Lee, Sun Haeng Lee & Woong Mo Yang. (2020) Ameliorative and Synergic Effects of Derma-H, a New Herbal Formula, on Allergic Contact Dermatitis. Frontiers in Pharmacology 11.
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Silke B. Lohan, Siavash Saeidpour, Miriam Colombo, Sven Staufenbiel, Michael Unbehauen, Amanuel Wolde-Kidan, Roland R. Netz, Roland Bodmeier, Rainer Haag, Christian Teutloff, Robert Bittl & Martina C. Meinke. (2020) Nanocrystals for Improved Drug Delivery of Dexamethasone in Skin Investigated by EPR Spectroscopy. Pharmaceutics 12:5, pages 400.
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Wei Xu, Yan Li, Mei Ju, Wei Lai, Xueyan Lu, Huijuan Shi, Weimin Shi, Heng Gu & Linfeng Li. (2020) A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Compound Glycyrrhizin Capsules Combined with a Topical Corticosteroid in Adults with Chronic Eczema. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-9.
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Akmal H. Sabri, Jane Ogilvie, Khuriah Abdulhamid, Volha Shpadaruk, John McKenna, Joel Segal, David J. Scurr & Maria Marlow. (2019) Expanding the applications of microneedles in dermatology. European Journal of Pharmaceutics and Biopharmaceutics 140, pages 121-140.
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Su-Jin Kang, Eun-Heui Jo, Geum-Jin Yang, Yu-Hwa Shim, Ji-Eun Hong & Min-Cheol Park. (2019) Efficacy and safety of Soshiho-tang in patients with atopic dermatitis and gastrointestinal disorders. Medicine 98:18, pages e15479.
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Paras P Vakharia & Jonathan I Silverberg. (2019) New and emerging therapies for paediatric atopic dermatitis. The Lancet Child & Adolescent Health 3:5, pages 343-353.
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Sara Burr. (2019) Assessment and management of eczema in adults in the community setting. British Journal of Community Nursing 24:3, pages 110-115.
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Susan Mayor. (2019) Translating Evidence to Practice: From Clinical Research to Real-World Experience. EMJ Dermatology, pages 2-12.
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Meihua Zhou & Hongfeng Sui. (2018) Effect of total glucosides of paeony on the changes of IL-4 and ICAM-1 levels in eczema mouse model serum. Experimental and Therapeutic Medicine.
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Janna Frombach, Silke B. Lohan, Davina Lemm, Paul Gruner, Julia Hasler, Sebastian Ahlberg, Ulrike Blume-Peytavi, Michael Unbehauen, Rainer Haag, Martina C. Meinke & Annika Vogt. (2018) Protease-mediated Inflammation: An In Vitro Human Keratinocyte-based Screening Tool for Anti-inflammatory Drug Nanocarrier Systems . Zeitschrift für Physikalische Chemie 232:5-6, pages 919-933.
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Dasom Shin, Won Choi & Hyunsu Bae. (2018) Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor. Toxins 10:4, pages 146.
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Ilja Ovsiy, Vladimir Riabov, Ioannis Manousaridis, Julia Michel, Kondaiah Moganti, Shuiping Yin, Tengfei Liu, Carsten Sticht, Elisabeth Kremmer, Martin C. Harmsen, Sergij Goerdt, Alexei Gratchev & Julia Kzhyshkowska. (2017) IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration. Scientific Reports 7:1.
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Younghee Yun, Youme Ko, Jin-Hyang Ahn, Bo-Hyoung Jang, Kyuseok Kim, Seong-Gyu Ko & Inhwa Choi. (2017) Topical application of Jaungo in atopic dermatitis patients: study protocol for a randomized, controlled trial. Trials 18:1.
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Shirin Abbasi, Mohammad Kamalinejad, Delara Babaie, SeyedMohammad Shams, Zahra Sadr, Mehdi Gheysari, Vahid Reza Askari & Hassan Rakhshandeh. (2017) A new topical treatment of atopic dermatitis in pediatric patients based on Ficus carica L. (Fig): A randomized, placebo-controlled clinical trial. Complementary Therapies in Medicine 35, pages 85-91.
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Paras P. Vakharia & Jonathan I. Silverberg. (2017) Monoclonal Antibodies for Atopic Dermatitis: Progress and Potential. BioDrugs 31:5, pages 409-422.
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Lisa M. Sedger, Charani Ranasinghe, Michael F. McDermott & Parisa Asvadi. 2017. Immunotherapy - Myths, Reality, Ideas, Future. Immunotherapy - Myths, Reality, Ideas, Future.
Jun Yang, Yong-Ai Xiong, Shi-Ji Xiao & Ying-Shu Xu. (2017) Anti-inflammatory Effects of Saxifrage Cream in Hapten-induced Chronic Dermatitis-eczema in Mice. Chinese Herbal Medicines 9:2, pages 176-182.
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Y. Thandar, A. Gray, J. Botha & A. Mosam. (2016) Topical herbal medicines for atopic eczema: a systematic review of randomized controlled trials. British Journal of Dermatology 176:2, pages 330-343.
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Amy S. Paller, Wynnis L. Tom, Mark G. Lebwohl, Robin L. Blumenthal, Mark Boguniewicz, Robert S. Call, Lawrence F. Eichenfield, Douglass W. Forsha, William C. Rees, Eric L. Simpson, Mary C. Spellman, Linda F. Stein Gold, Andrea L. Zaenglein, Matilda H. Hughes, Lee T. Zane & Adelaide A. Hebert. (2016) Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults. Journal of the American Academy of Dermatology 75:3, pages 494-503.e6.
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Chang Taek Oh, Tae-Rin Kwon, Joon Seok, Eun Ja Choi, Soon Re Kim, Yu-Jin Jang, Seog Kyun Mun, Chan Woong Kim, Sungeun Lee, Jongmin Lee, Myeung Nam Kim, Sun Young Choi & Beom Joon Kim. (2016) Effect of a 308-nm excimer laser on atopic dermatitis-like skin lesions in NC/Nga mice. Lasers in Surgery and Medicine 48:6, pages 629-637.
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Chung-Yang YenChing-Liang Hsieh. (2016) Therapeutic Effect of Tzu-Yun Ointment on Patients with Atopic Dermatitis: A Preliminary, Randomized, Controlled, Open-Label Study . The Journal of Alternative and Complementary Medicine 22:3, pages 237-243.
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Andrés Tirado-Sánchez, Victoria de la Fuente-García & Rosa María Ponce-Olivera. (2016) Off-label uses of etanercept in dermatology. Revista Médica del Hospital General de México 79:1, pages 26-32.
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Sherman X. Gu, Anthony L. Zhang, Meaghan E. Coyle, Xiumei Mo, George B. Lenon, Noel E. Cranswick, DaCan Chen & Charlie C. Xue. (2015) Chinese herbal medicine granules (PTQX) for children with moderate to severe atopic eczema: study protocol for a randomised controlled trial. Trials 16:1.
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Boshu Ru, Kimberly Harris & Lixia Yao. (2015) A Content Analysis of Patient-Reported Medication Outcomes on Social Media. A Content Analysis of Patient-Reported Medication Outcomes on Social Media.
Andrea Montes-Torres, Mar Llamas-Velasco, Alejandra Pérez-Plaza, Guillermo Solano-López & Javier Sánchez-Pérez. (2015) Biological Treatments in Atopic Dermatitis. Journal of Clinical Medicine 4:4, pages 593-613.
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Seul Ji Lee, Sung-il Woo, Soo Hyun Ahn, Dong Kyu Lim, Ji Yeon Hong, Jeong Hill Park, Johan Lim, Mi-kyeong Kim & Sung Won Kwon. (2014) Functional interpretation of metabolomics data as a new method for predicting long-term side effects: treatment of atopic dermatitis in infants. Scientific Reports 4:1.
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Tae-Rin Kwon, Seog Kyun Mun, Chang Taek Oh, Hyuckki Hong, Yeon Shik Choi, Bong-Jun Kim & Beom Joon Kim. (2014) Therapeutic Effects of Full Spectrum Light on the Development of Atopic Dermatitis-like Lesions in NC/Nga Mice. Photochemistry and Photobiology, pages n/a-n/a.
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Ami Oizumi, Hitoshi Nakayama, Nozomu Okino, Chihiro Iwahara, Katsunari Kina, Ryo Matsumoto, Hideoki Ogawa, Kenji Takamori, Makoto Ito, Yasushi Suga & Kazuhisa Iwabuchi. (2014) Pseudomonas-Derived Ceramidase Induces Production of Inflammatory Mediators from Human Keratinocytes via Sphingosine-1-Phosphate. PLoS ONE 9:2, pages e89402.
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Ming Zhang, Yang Wu, Ye Yuan, ESheng Zhou, Jan Sundell, YueXia Sun & Xu Yang. (2013) Effects of home environment and lifestyles on prevalence of atopic eczema among children in Wuhan area of China. Chinese Science Bulletin 58:34, pages 4217-4222.
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O R KATUNINA, V V CHIKIN, L F ZNAMENSKAYA & L A INOYATOVA. (2013) Role of neuromediators in the development of skin inflammation in patients with atopic dermatitis. Vestnik dermatologii i venerologii 89:5, pages 91-101.
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G. Garnacho-Saucedo, R. Salido-Vallejo & J.C. Moreno-Giménez. (2013) Atopic Dermatitis: Update and Proposed Management Algorithm. Actas Dermo-Sifiliográficas (English Edition) 104:1, pages 4-16.
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G. Garnacho-Saucedo, R. Salido-Vallejo & J.C. Moreno-Giménez. (2013) Actualización en dermatitis atópica. Propuesta de algoritmo de actuación. Actas Dermo-Sifiliográficas 104:1, pages 4-16.
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E E Varlamov, T V Vinogradova, A A Chuslyaeva, T S Okuneva & A N Pampura. (2012) BIOMARKERS ALLERGIC INFLAMATION AND SEVERITY OF ATOPIC DERMATITIS AT CHILDREN. Russian Journal of Allergy 9:5, pages 31-35.
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Chagit Adler-Cohen, Tali Czarnowicki, Jacob Dreiher, Thomas Ruzicka, Arieh Ingber & Marco Harari. (2012) Climatotherapy at the Dead Sea. Dermatitis 23:2, pages 75-80.
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