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Review

Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer’s disease: A systematic review and meta-analysis

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Pages 211-225 | Published online: 19 Oct 2022

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Ömer Şahin, Ümmühan Özmen Özdemir, Nurgül Seferoğlu, Şevki Adem & Zeynel Seferoğlu. (2022) Synthesis, characterization, molecular docking and in vitro screening of new metal complexes with coumarin Schiff base as anticholine esterase and antipancreatic cholesterol esterase agents. Journal of Biomolecular Structure and Dynamics 40:10, pages 4460-4474.
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Hecheng Wang, Yu Zong, Yanshuo Han, Jing Zhao, Hongqun Liu & Yong Liu. (2022) Compared of efficacy and safety of high-dose donepezil vs standard-dose donepezil among elderly patients with Alzheimer’s disease: a systematic review and meta-analysis. Expert Opinion on Drug Safety 21:3, pages 407-415.
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Sirasa Ruangritchankul, Prawat Chantharit, Sahaphume Srisuma & Leonard C Gray. (2021) Adverse Drug Reactions of Acetylcholinesterase Inhibitors in Older People Living with Dementia: A Comprehensive Literature Review. Therapeutics and Clinical Risk Management 17, pages 927-949.
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Naoki Yuda, Miyuki Tanaka, Koji Yamauchi, Fumiaki Abe, Izumi Kakiuchi, Kyoko Kiyosawa, Mitsunaga Miyasaka, Naoki Sakane & Masahiko Nakamura. (2020) Effect of the Casein-Derived Peptide Met-Lys-Pro on Cognitive Function in Community-Dwelling Adults Without Dementia: A Randomized, Double-Blind, Placebo-Controlled Trial. Clinical Interventions in Aging 15, pages 743-754.
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Mohammed Saeed Alawi, Talal Ahmed Awad, Magdi Awadalla Mohamed, Asaad Khalid, Esraa M. O. Ismail, Fatima Alfatih, Sehrish Naz & Zaheer UL-Haq. (2020) Insights into the molecular basis of acetylcholinesterase inhibition by xanthones: an integrative in silico and in vitro approach. Molecular Simulation 46:4, pages 253-261.
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Andrea Haake, Kevin Nguyen, Lauren Friedman, Binu Chakkamparambil & George T Grossberg. (2020) An update on the utility and safety of cholinesterase inhibitors for the treatment of Alzheimer’s disease. Expert Opinion on Drug Safety 19:2, pages 147-157.
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Saikat Ghosh, Rohan Lalani, Vivek Patel, Subhas Bhowmick & Ambikanandan Misra. (2019) Surface engineered liposomal delivery of therapeutics across the blood brain barrier: recent advances, challenges and opportunities. Expert Opinion on Drug Delivery 16:12, pages 1287-1311.
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Callum Ross, Mark Taylor, Nigel Fullwood & David Allsop. (2018) Liposome delivery systems for the treatment of Alzheimer’s disease. International Journal of Nanomedicine 13, pages 8507-8522.
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Amanda Calhoun, Christian King, Rita Khoury & George T. Grossberg. (2018) An evaluation of memantine ER + donepezil for the treatment of Alzheimer’s disease. Expert Opinion on Pharmacotherapy 19:15, pages 1711-1717.
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Jinghong Liang, Jiayu Li, Ruixia Jia, Yingquan Wang, Rongkun Wu, Hongbo Zhang, Lei Hang & Yong Xu. (2018) Identification of the optimal cognitive drugs among Alzheimer’s disease: a Bayesian meta-analytic review. Clinical Interventions in Aging 13, pages 2061-2073.
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Kunmeng Liu, Hui-Heng Lin, Rongbiao Pi, Shinghung Mak, Yifan Han & Yuanjia Hu. (2018) Research and development of anti-Alzheimer’s disease drugs: an update from the perspective of technology flows. Expert Opinion on Therapeutic Patents 28:4, pages 341-350.
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Kazuhito Ohsawa, Fumiya Nakamura, Naoto Uchida, Seiichi Mizuno & Hidehiko Yokogoshi. (2018) Lactobacillus helveticus-fermented milk containing lactononadecapeptide (NIPPLTQTPVVVPPFLQPE) improves cognitive function in healthy middle-aged adults: a randomised, double-blind, placebo-controlled trial. International Journal of Food Sciences and Nutrition 69:3, pages 369-376.
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Kazuhito Ohsawa, Naoto Uchida, Kohji Ohki & Hidehiko Yokogoshi. (2018) Identification of peptides present in sour milk whey that ameliorate scopolamine-induced memory impairment in mice. International Journal of Food Sciences and Nutrition 69:1, pages 33-45.
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Rosanna Caliandro, Alessandro Pesaresi, Luca Cariati, Antonio Procopio, Manuela Oliverio & Doriano Lamba. (2018) Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 794-803.
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Govindarajan Karthivashan, Palanivel Ganesan, Shin-Young Park, Joon-Soo Kim & Dong-Kug Choi. (2018) Therapeutic strategies and nano-drug delivery applications in management of ageing Alzheimer’s disease. Drug Delivery 25:1, pages 307-320.
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Ryoko Nakagawa, Takashi Ohnishi, Hisanori Kobayashi, Toshio Yamaoka, Tsutomu Yajima, Ai Tanimura, Toshiya Kato & Kazutake Yoshizawa. (2017) Long-term effect of galantamine on cognitive function in patients with Alzheimer’s disease versus a simulated disease trajectory: an observational study in the clinical setting. Neuropsychiatric Disease and Treatment 13, pages 1115-1124.
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Dana Mohammad, Parco Chan, Janelle Bradley, Krista Lanctôt & Nathan Herrmann. (2017) Acetylcholinesterase inhibitors for treating dementia symptoms - a safety evaluation. Expert Opinion on Drug Safety 16:9, pages 1009-1019.
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Débora B Vieira & Lionel F Gamarra. (2016) Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier. International Journal of Nanomedicine 11, pages 5381-5414.
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Victor V. Dotsenko, Elena A. Chigorina & Sergey G. Krivokolysko. (2016) 2,2,2-Trifluoroethyl-thiadiazines: a patent evaluation of WO2016023927. Expert Opinion on Therapeutic Patents 26:12, pages 1371-1376.
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Mehmet Koca, Kadir Ozden Yerdelen, Baris Anil, Zeynep Kasap, Handan Sevindik, Ibrahim Ozyurek, Gulsen Gunesacar & Kubra Turkaydin. (2016) Design, synthesis and biological activity of 1H-indene-2-carboxamides as multi-targeted anti-Alzheimer agents. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup2, pages 13-23.
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William James Deardorff & George T. Grossberg. (2016) Pharmacotherapeutic strategies in the treatment of severe Alzheimer’s disease. Expert Opinion on Pharmacotherapy 17:13, pages 1789-1800.
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Akhil Kumar, Sudeep Roy, Shubhandra Tripathi & Ashok Sharma. (2016) Molecular docking based virtual screening of natural compounds as potential BACE1 inhibitors: 3D QSAR pharmacophore mapping and molecular dynamics analysis. Journal of Biomolecular Structure and Dynamics 34:2, pages 239-249.
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Xiu-Zhen Zhang, Shao-Song Qian, Yue-Jie Zhang & Rui-Qi Wang. (2016) Salvia miltiorrhiza: A source for anti-Alzheimer’s disease drugs. Pharmaceutical Biology 54:1, pages 18-24.
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Kazuhito Ohsawa, Naoto Uchida, Kohji Ohki, Yasunori Nakamura & Hidehiko Yokogoshi. (2015) Lactobacillus helveticus–fermented milk improves learning and memory in mice. Nutritional Neuroscience 18:5, pages 232-240.
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William James Deardorff, Ahmad Shobassy & George T Grossberg. (2015) Safety and clinical effects of EVP-6124 in subjects with Alzheimer's disease currently or previously receiving an acetylcholinesterase inhibitor medication. Expert Review of Neurotherapeutics 15:1, pages 7-17.
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Alan G Wade, Mildred Farmer, Gil Harari, Naama Fund, Moshe Laudon, Tali Nir, Anat Frydman-Marom & Nava Zisapel. (2014) Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer’s disease: a 6-month, randomized, placebo-controlled, multicenter trial. Clinical Interventions in Aging 9, pages 947-961.
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Hamid Reza Amanatkar & George Thomas Grossberg. (2014) Transdermal rivastigmine in the treatment of Alzheimer’s disease: current and future directions. Expert Review of Neurotherapeutics 14:10, pages 1119-1125.
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Pamela E Potter. (2013) Curcumin: a natural substance with potential efficacy in Alzheimer’s disease. Journal of Experimental Pharmacology 5, pages 23-31.
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Mehrul Hasnain & W. Victor R. Vieweg. (2013) Weight Considerations in Psychotropic Drug Prescribing and Switching. Postgraduate Medicine 125:5, pages 117-129.
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Pier Luigi Scapicchio. (2013) Revisiting choline alphoscerate profile: a new, perspective, role in dementia?. International Journal of Neuroscience 123:7, pages 444-449.
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Bettina H. Bewernick & Thomas E. Schlaepfer. (2013) Chronic depression as a model disease for cerebral aging. Dialogues in Clinical Neuroscience 15:1, pages 77-85.
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Scott D Kuduk & Douglas C Beshore. (2012) Novel M1 allosteric ligands: a patent review. Expert Opinion on Therapeutic Patents 22:12, pages 1385-1398.
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Geoffrey A Kerchner, Maria Carmela Tartaglia & Adam L Boxer. (2011) Abhorring the vacuum: use of Alzheimer’s disease medications in frontotemporal dementia. Expert Review of Neurotherapeutics 11:5, pages 709-717.
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Stevan Pecic, Marie A. McAnuff & Wayne W. Harding. (2011) Nantenine as an acetylcholinesterase inhibitor: SAR, enzyme kinetics and molecular modeling investigations. Journal of Enzyme Inhibition and Medicinal Chemistry 26:1, pages 46-55.
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Geoffrey A Kerchner & Adam L Boxer. (2010) Bapineuzumab. Expert Opinion on Biological Therapy 10:7, pages 1121-1130.
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Ben Seltzer. (2010) Galantamine-ER for the treatment of mild-to-moderate Alzheimer’s disease. Clinical Interventions in Aging 5, pages 1-6.
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David Prvulovic, Harald Hampel & Johannes Pantel. (2010) Galantamine for Alzheimer's disease. Expert Opinion on Drug Metabolism & Toxicology 6:3, pages 345-354.
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