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Review

Management of hyperuricemia in gout: focus on febuxostat

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Pages 7-18 | Published online: 05 Jan 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Yanfen Niu, Wei Lu, Lihui Gao, Hua Lin, Xu Liu & Ling Li. (2012) Reducing effect of mangiferin on serum uric acid levels in mice. Pharmaceutical Biology 50:9, pages 1177-1182.
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Mattheus K Reinders & Tim L Th A Jansen. (2010) New advances in the treatment of gout: review of pegloticase. Therapeutics and Clinical Risk Management 6, pages 543-550.
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Articles from other publishers (33)

Aya Y. Rashad, Hoda G. Daabees, Mohamed Elagawany, Mohamed Shahin, Ahmed E. Abdel Moneim & Sherif A.F. Rostom. (2023) Towards the Development of Dual Hypouricemic and Anti-inflammatory Candidates: Design, Synthesis, Stability Studies and Biological Evaluation of Some Mutual Ester Prodrugs of Febuxostat-NSAIDs. Bioorganic Chemistry 135, pages 106502.
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Sk Manirul Haque, Habibur Rahman, Nafisur Rahman, Syed Najmul Hejaz Azmi, Omar Ashwaq, Saikh M Wabaidur, Masoom Raza Siddiqui & Mahboob Alam. (2023) Application of Box–Behnken design combined response surface methodology to optimize HPLC and spectrophotometric techniques for quantifying febuxostat in pharmaceutical formulations and spiked wastewater samples. Microchemical Journal 184, pages 108191.
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Mahima Jyothi, Hussien Ahmed Khamees, Shashank M. Patil, Ramith Ramu & Shaukath Ara Khanum. (2022) Microwave-Assisted Synthesis, Characterization, Docking Studies and Molecular Dynamic of Some Novel Phenyl Thiazole Analogs as Xanthine Oxidase Inhibitor. Journal of the Iranian Chemical Society 19:9, pages 3919-3933.
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Aya Y. Rashad, Shaymaa E. Kassab, Hoda G. Daabees, Ahmed E. Abdel Moneim & Sherif A.F. Rostom. (2021) Febuxostat-based amides and some derived heterocycles targeting xanthine oxidase and COX inhibition. Synthesis, in vitro and in vivo biological evaluation, molecular modeling and in silico ADMET studies. Bioorganic Chemistry 113, pages 104948.
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Yuan-Yuan Huang, Zhuang Ye, San-Wei Gu, Zhen-Yu Jiang & Ling Zhao. (2020) The efficacy and tolerability of febuxostat treatment in a cohort of Chinese Han population with history of gout. Journal of International Medical Research 48:5, pages 030006052090295.
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Yuyang Huang, Jiongfeng Huang, Cheng Luo, Li’an Chen & Bingsheng Huang. (2020) Treatment of atypical gouty arthritis of the hip using total hip arthroplasty. Medicine 99:44, pages e23027.
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Bing Yan, Dongmei Liu, Jie Zhu & Xiaoling Pang. (2019) The effects of hyperuricemia on the differentiation and proliferation of osteoblasts and vascular smooth muscle cells are implicated in the elevated risk of osteopenia and vascular calcification in gout: An in vivo and in vitro analysis. Journal of Cellular Biochemistry 120:12, pages 19660-19672.
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В. В. Черненко, В. Й. Савчук, Н. І. Желтовська, Д. В. Черненко & Ю. М. Бондаренко. (2019) Current Possibilities in the Correction of Hyperuricemia in Patients with Urolithiasis and Uric Acid Hypercrystallization. Health of Man 0:3, pages 70-74.
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Yu-Xue Hou, Shi-Wei Sun, Yang Liu, Yan Li, Xiao-Hong Liu, Wei Wang, Shuang Zhang & Wei Wang. (2019) An Improved Method for the Synthesis of Butein Using SOCl2/EtOH as Catalyst and Deciphering Its Inhibition Mechanism on Xanthine Oxidase. Molecules 24:10, pages 1948.
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Lichao Zhang, Sibo Wang, Mingzheng Yang, Ailong Shi, He Wang, Qi Guan, Kai Bao & Weige Zhang. (2019) Design, synthesis and bioevaluation of 3-oxo-6-aryl-2,3-dihydropyridazine-4-carbohydrazide derivatives as novel xanthine oxidase inhibitors. Bioorganic & Medicinal Chemistry 27:9, pages 1818-1823.
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Giuseppe Luna, Anton V. Dolzhenko & Ricardo L. Mancera. (2019) Inhibitors of Xanthine Oxidase: Scaffold Diversity and Structure‐Based Drug Design. ChemMedChem 14:7, pages 714-743.
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Anubha Srivastava, Sandeep S. Zode, Jaya Pandey, Karnica Srivastava, Poonam Tandon, Alejandro P. Ayala & Arvind K. Bansal. (2019) A novel approach to design febuxostat-salicylic acid eutectic system: evaluation and characterization. CrystEngComm 21:2, pages 310-320.
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В. М. Рудіченко & М. О. Кушнєрова. (2018) Atypical Gout Manifestations in General Practice–Family Medicine: Own Clinical Observations and Literature Data. Family Medicine 0:6, pages 26-29.
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İbrahim Evren Kıbrız, Mustafa Saçmacı, İsmail Yıldırım, Samir Abbas Ali Noma, Tuğba Taşkın Tok & Burhan Ateş. (2018) Xanthine oxidase inhibitory activity of new pyrrole carboxamide derivatives: In vitro and in silico studies . Archiv der Pharmazie 351:10, pages 1800165.
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S. Schlee, L. C. Bollheimer, T. Bertsch, C. C. Sieber & P. Härle. (2017) Crystal arthritides – gout and calcium pyrophosphate arthritisKristall-Arthritiden – Gicht und Kalziumpyrophosphat-Arthritis. Zeitschrift für Gerontologie und Geriatrie 51:6, pages 703-710.
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S. Schlee, L. C. Bollheimer, T. Bertsch, C. C. Sieber & P. Härle. (2017) Crystal arthritides – gout and calcium pyrophosphate arthritisKristall-Arthritiden – Gicht und Kalziumpyrophosphat-Arthritis. Zeitschrift für Gerontologie und Geriatrie 51:5, pages 579-584.
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S. Schlee, L. C. Bollheimer, T. Bertsch, C. C. Sieber & P. Härle. (2017) Crystal arthritides – gout and calcium pyrophosphate arthritisKristallarthritiden – Gicht und Kalziumpyrophosphat-Arthritis. Zeitschrift für Gerontologie und Geriatrie 51:4, pages 453-460.
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Heng Cheng, Dewen Yan, Xin Zuo, Junying Liu, Wenlan Liu & Youming Zhang. (2018) A retrospective investigation of HLA-B*5801 in hyperuricemia patients in a Han population of China. Pharmacogenetics and Genomics 28:5, pages 117-124.
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Md. Rahmat Ali, Suresh Kumar, Obaid Afzal, Nishtha Shalmali, Wazid Ali, Manju Sharma & Sandhya Bawa. (2017) 2-Benzamido-4-methylthiazole-5-carboxylic Acid Derivatives as Potential Xanthine Oxidase Inhibitors and Free Radical Scavengers. Archiv der Pharmazie 350:2, pages 1600313.
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Narisa Sulaiman, Ahmad Zaidi Othman, Nor Shuhaila Shahril, Anna Misyail Abdul Rashid & Mohamad Syafeeq Faeez Md Noh. (2017) Successful febuxostat desensitization in a patient with febuxostat hypersensitivity: A Malaysian experience. SAGE Open Medical Case Reports 5, pages 2050313X1774908.
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Žaklina Šmelcerović, Katarina Tomović, Denitsa Yancheva, Emiliya Cherneva, Gordana Kocić & Živomir Petronijević. (2016) XANTHINE OXIDASE INHIBITORY PROPERTIES AND IN SILICO STUDY OF THREE N-(α-BROMOACYL)-α-AMINO ESTERS. Acta Medica Medianae, pages 14-20.
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Md Rahmat Ali, Suresh Kumar, Obaid Afzal, Nishtha Shalmali, Manju Sharma & Sandhya Bawa. (2016) Development of 2-(Substituted Benzylamino)-4-Methyl-1, 3-Thiazole-5-Carboxylic Acid Derivatives as Xanthine Oxidase Inhibitors and Free Radical Scavengers. Chemical Biology & Drug Design 87:4, pages 508-516.
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Isabel R. Orriss, Timothy R. Arnett, Jacob George & Miles D. Witham. (2016) Allopurinol and oxypurinol promote osteoblast differentiation and increase bone formation. Experimental Cell Research 342:2, pages 166-174.
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Ailong Shi, Defa Wang, He Wang, Yue Wu, Haiqiu Tian, Qi Guan, Kai Bao & Weige Zhang. (2016) Synthesis and bioevaluation of 2-phenyl-5-methyl-2H-1,2,3-triazole-4-carboxylic acid/carbohydrazide derivatives as potent xanthine oxidase inhibitors. RSC Advances 6:115, pages 114879-114888.
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M. J. Davies, A. Trujillo, U. Vijapurkar, C. V. Damaraju & G. Meininger. (2015) Effect of canagliflozin on serum uric acid in patients with type 2 diabetes mellitus. Diabetes, Obesity and Metabolism 17:4, pages 426-429.
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Qi Guan, Zengjin Cheng, Xiaoxue Ma, Lijie Wang, Dongjie Feng, Yuanhang Cui, Kai Bao, Lan Wu & Weige Zhang. (2014) Synthesis and bioevaluation of 2-phenyl-4-methyl-1,3-selenazole-5-carboxylic acids as potent xanthine oxidase inhibitors. European Journal of Medicinal Chemistry 85, pages 508-516.
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Da-Hua Shi, Wei Huang, Chao Li, Yu-Wei Liu & Shi-Fan Wang. (2014) Design, synthesis and molecular modeling of aloe-emodin derivatives as potent xanthine oxidase inhibitors. European Journal of Medicinal Chemistry 75, pages 289-296.
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MEI ZHANG, XIAOHUI DI, LIN XU, JUAN XU, YONGGE YANG, NAN JIANG, LIXUE SONG & XUETING XU. (2014) Pharmacokinetics and pharmacodynamics of febuxostat under fasting conditions in healthy individuals. Experimental and Therapeutic Medicine 7:2, pages 393-396.
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Peizhen Li, Yueli Tian, Honglin Zhai, Fangfang Deng, Meihong Xie & Xiaoyun Zhang. (2013) Study on the activity of non-purine xanthine oxidase inhibitor by 3D-QSAR modeling and molecular docking. Journal of Molecular Structure 1051, pages 56-65.
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Babasaheb P. Bandgar, Laxman K. Adsul, Hemant V. Chavan, Sadanand N. Shringare, Balaji L. Korbad, Shivkumar S. Jalde, Shrikant V. Lonikar, Shivraj H. Nile & Amol L. Shirfule. (2012) Synthesis, biological evaluation, and molecular docking of N-{3-[3-(9-methyl-9H-carbazol-3-yl)-acryloyl]-phenyl}-benzamide/amide derivatives as xanthine oxidase and tyrosinase inhibitors. Bioorganic & Medicinal Chemistry 20:18, pages 5649-5657.
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Silas W. Smith, Manfred Hauben & Jeffrey K. Aronson. (2012) Paradoxical and Bidirectional Drug Effects. Drug Safety, pages 1.
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Ignacio Garcia-Valladares, Tahir Khan & Luis R. Espinoza. (2011) Efficacy and safety of febuxostat in patients with hyperuricemia and gout. Therapeutic Advances in Musculoskeletal Disease 3:5, pages 245-253.
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Yanfen Niu, Huajie Zhu, Jia Liu, Huafang Fan, Ling Sun, Wei Lu, Xu Liu & Ling Li. (2011) 3,5,2′,4′-Tetrahydroxychalcone, a new non-purine xanthine oxidase inhibitor. Chemico-Biological Interactions 189:3, pages 161-166.
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