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Review

Memantine: a review of studies into its safety and efficacy in treating Alzheimer’s disease and other dementias

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Pages 367-377 | Published online: 28 Sep 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (11)

Fei Zhou, Bao-Feng Liu, Can Wang, Jie Zhang, Guo-Ming Dong, Hong-Tao Jin, Bai-Ping Ma & Xiao-Ming Zhong. (2022) Acute toxicity, 28-day repeated-dose toxicity and toxicokinetic study of timosaponin BII in beagle dogs. Journal of Asian Natural Products Research 24:9, pages 860-876.
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Arthur G Roberts & Morgan E Gibbs. (2018) Mechanisms and the clinical relevance of complex drug–drug interactions. Clinical Pharmacology: Advances and Applications 10, pages 123-134.
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Sıla Gülbağ, Duygu Yılmaz Usta, Hazal E. Gültekin, Ayşe N. Oktay, Özden Demirtaş, Alptuğ Karaküçük & Nevin Çelebi. (2018) New perspective to develop memantine orally disintegrating tablet formulations: SeDeM expert system. Pharmaceutical Development and Technology 23:5, pages 512-519.
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Jerry J Flores, Yang Zhang, Damon W Klebe, Tim Lekic, Weiling Fu & John H Zhang. (2014) Small molecule inhibitors in the treatment of cerebral ischemia. Expert Opinion on Pharmacotherapy 15:5, pages 659-680.
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Francesco Patti. (2012) Treatment of cognitive impairment in patients with multiple sclerosis. Expert Opinion on Investigational Drugs 21:11, pages 1679-1699.
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Indrapal Singh & George T Grossberg. (2011) Critical appraisal and role of memantine extended-release in the management of Alzheimer’s disease. Degenerative Neurological and Neuromuscular Disease 1, pages 9-13.
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Daphne Lo & George T Grossberg. (2011) Use of memantine for the treatment of dementia. Expert Review of Neurotherapeutics 11:10, pages 1359-1370.
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Cesare Mancuso, Raffaella Siciliano, Eugenio Barone, David Allan Butterfield & Paolo Preziosi. (2011) Pharmacologists and Alzheimer disease therapy: to boldly go where no scientist has gone before. Expert Opinion on Investigational Drugs 20:9, pages 1243-1261.
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Nathan Herrmann, Abby Li & Krista Lanctôt. (2011) Memantine in dementia: a review of the current evidence. Expert Opinion on Pharmacotherapy 12:5, pages 787-800.
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Nazem Bassil, Papan Thaipisuttikul & George T Grossberg. (2010) Memantine ER, a once-daily formulation for the treatment of Alzheimer's disease. Expert Opinion on Pharmacotherapy 11:10, pages 1765-1771.
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Articles from other publishers (21)

Chencheng Ye. (2023) Mechanism and efficacy of drugs for Alzheimer's disease. Highlights in Science, Engineering and Technology 36, pages 786-791.
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Amanda Brignell, Catherine Marraffa, Katrina Williams & Tamara May. (2022) Memantine for autism spectrum disorder. Cochrane Database of Systematic Reviews 2022:8.
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Caitlyn J. Bartsch & Jacob C. Nordman. (2022) Promises and Pitfalls of NMDA Receptor Antagonists in Treating Violent Aggression. Frontiers in Behavioral Neuroscience 16.
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N. N. Koberskaya. (2022) Neuropsychiatric disorders correction in Alzheimer's disease. Neurology, Neuropsychiatry, Psychosomatics 14:3, pages 54-61.
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Mahdieh Anoush, Zeinab Pourmansouri, Rafi Javadi, Benyamin GhorbanPour, Ali Sharafi, Hamed Mohamadpour, Iraj jafari anarkooli & Sina Andalib. (2022) Clavulanic Acid: A Novel Potential Agent in Prevention and Treatment of Scopolamine-Induced Alzheimer’s Disease. ACS Omega 7:16, pages 13861-13869.
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Aylin Yaman & Hakan Yaman. 2022. NeuroPsychopharmacotherapy. NeuroPsychopharmacotherapy 2665 2675 .
Peyton H Terry, Kareem Seoudy, Meredith S Lee & Keri A Stevenson. (2021) Memantine for the Treatment of Behavioral Disturbance in Unspecified Major Neurocognitive Disorder. Cureus.
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Anya Jafari, Zahra Siavashpour & Mohammad Houshyari. (2021) An Updated Review on Memantine Efficacy in Reducing Cognitive Dysfunction of Whole-brain Irradiation for Adult Patients with Brain metastasis. International Journal of Cancer Management 14:4.
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Amanda Brignell, Chidambaram Prakash, Catherine Marraffa, Katrina Williams & Tamara May. (2021) Memantine for autism spectrum disorder. Cochrane Database of Systematic Reviews.
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A.N. Bogolepova, E.E. Vasenina, N.A. Gomzyakova, E.I. Gusev, N.G. Dudchenko, A.Yu. Emelin, N.M. Zalutskaya, R.I. Isaev, Yu.V. Kotovskaya, O.S. Levin, I.V. Litvinenko, V.Yu. Lobzin, M.Yu. Martynov, E.A. Mkhitaryan, G.N. Nikolay, E.I. Palchikova, O.N. Tkacheva, M.A. Cherdak, A.S. Chimagomedova & N.N. Yakhno. (2021) Clinical Guidelines for Cognitive Disorders in Elderly and Older Patients. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 121:10, pages 6.
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Aylin Yaman & Hakan Yaman. 2020. NeuroPsychopharmacotherapy. NeuroPsychopharmacotherapy 1 11 .
Jogender Mehla, Pooja Gupta, Monika Pahuja, Deepti Diwan & Diksha Diksha. (2020) Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment. Brain Sciences 10:12, pages 964.
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Veronika Prikhodko, Daria Chernyuk, Yurii Sysoev, Nikita Zernov, Sergey Okovityi & Elena Popugaeva. (2020) Potential Drug Candidates to Treat TRPC6 Channel Deficiencies in the Pathophysiology of Alzheimer’s Disease and Brain Ischemia. Cells 9:11, pages 2351.
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Yasuteru Inoue, Mitsuharu Ueda, Teruaki Masuda, Yohei Misumi, Taro Yamashita & Yukio Ando. (2019) Memantine, a Noncompetitive N-Methyl-d-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression. Molecular Neurobiology 56:12, pages 8573-8588.
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I. S. Preobrazhenskaya, D. Fantalis, S. A. Abdyshova & A. A. Kindarova. (2019) Non-drug therapies for cognitive impairment. Neurology, Neuropsychiatry, Psychosomatics 11:3S, pages 68-77.
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A. A. Naumenko & I. S. Preobrazhenskaya. (2018) Cognitive and motor training for patients with moderate cognitive impairment and mild dementia. Neurology, Neuropsychiatry, Psychosomatics 10:4, pages 81-87.
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Shahrina Alam, Kaelyn Skye Lingenfelter, Aaron M. Bender & Craig W. Lindsley. (2017) Classics in Chemical Neuroscience: Memantine. ACS Chemical Neuroscience 8:9, pages 1823-1829.
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Evan P. Lebois, Jason P. Schroeder, Thomas J. Esparza, Thomas M. Bridges, Craig W. Lindsley, P. Jeffrey Conn, David L. Brody, J. Scott Daniels & Allan I. Levey. (2017) Disease-Modifying Effects of M 1 Muscarinic Acetylcholine Receptor Activation in an Alzheimer’s Disease Mouse Model . ACS Chemical Neuroscience 8:6, pages 1177-1187.
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Kimberly D. Girling & Yu Tian Wang. (2016) Neuroprotective strategies for NMDAR-mediated excitotoxicity in Huntington’s Disease. Frontiers in Biology 11:6, pages 439-458.
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Theresa Lowinus, Tanima Bose, Stefan Busse, Mandy Busse, Dirk Reinhold, Burkhart Schraven & Ursula H.H. Bommhardt. (2016) Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness. Oncotarget 7:33, pages 53797-53807.
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Alla Guekht. 2016. Neuropsychiatric Symptoms of Epilepsy. Neuropsychiatric Symptoms of Epilepsy 235 254 .