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Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence

Pages 403-414 | Published online: 18 Oct 2022

Keep up to date with the latest research on this topic with citation updates for this article.

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Roni M. Joentausta, Aino Siltari, Antti Rannikko & Teemu J. Murtola. (2023) Incidence of erectile dysfunction treatment after radical prostatectomy by Statin use in Finnish Nationwide Cohort Study. Scandinavian Journal of Urology 57:1-6, pages 53-59.
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Pawan Kumar, Deepak Sheokand, Annu Grewal, Vandana Saini & Ajit Kumar. (2023) Clinical side-effects based drug repositioning for anti-epileptic activity. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-12.
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Anne A. Adeyanju, Omolola R. Oyenihi, Oluwafemi O. Oguntibeju & Oreoluwa Ojomu. (2023) Sildenafil aggravates adriamycin-induced testicular toxicity in rats; a preliminary investigation. Drug and Chemical Toxicology 46:2, pages 219-225.
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Sheyda Ranjbar, Seyed Afshin Seyednejad, Shekoufeh Nikfar, Roja Rahimi & Mohammad Abdollahi. (2019) How can we develop better antispasmodics for irritable bowel syndrome?. Expert Opinion on Drug Discovery 14:6, pages 549-562.
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Carmen Gil, Nuria E Campillo, Daniel I Perez & Ana Martinez. (2008) PDE7 inhibitors as new drugs for neurological and inflammatory disorders. Expert Opinion on Therapeutic Patents 18:10, pages 1127-1139.
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Christopher Perry, Jeffery B. Budweg, Andrew P. Stein, Jonathan Harder, Shishir Gupta, Alex J. Nusbickel, Madeline Smoot, Keval Patel & David E. Winchester. (2023) Assessment of Cardiovascular Risk for Noncardiac and Nonsurgical Activities. The American Journal of Medicine 136:4, pages 350-354.
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Faheem Ahmed, In Suk Kang, Kyung Hwan Kim, Arun Asif, Chethikkattuveli Salih Abdul Rahim, Anupama Samantasinghar, Fida Hussain Memon & Kyung Hyun Choi. (2023) Drug repurposing for viral cancers: A paradigm of machine learning, deep learning, and virtual screening‐based approaches. Journal of Medical Virology 95:4.
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Flavia Ramos Glina & Sidney Glina. (2022) Organic or psychological? It does matter!. International braz j urol 48:3, pages 579-582.
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Mikołaj Kamiński, Michał Kulecki, Paweł Lachowski, Dominika Kasprzak, Ania Kulczycka, Maria Kozłowska, Daria Klause, Aleksandra Uruska, Mateusz Michalski & Dorota Zozulińska-Ziółkiewicz. (2022) Erectile Dysfunction in Individuals with Type 1 Diabetes is Associated with Long-term Metabolic Control and Diabetic Complications: A Cross-Sectional Study. International Journal of Angiology 31:02, pages 097-106.
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Sirikan Rojanasarot, Samir K. Bhattacharyya & Arthur L. Burnett. (2022) Cost of Lost Productivity Due to Erectile Dysfunction and Impact of Employer Benefit Exclusion of Penile Prosthesis Implantation Treatment. Journal of Occupational & Environmental Medicine 64:5, pages 403-408.
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Abdulrahman Alwhaibi, Sary Alsanea, Ziyad Alrabiah, Fars K. Alanazi, Badraddin M. Al-Hadiya & Hisham S. Abou-Auda. (2021) Pharmacokinetic profile of sildenafil citrate in healthy Middle Eastern Males: Comparison with other ethnicities. Saudi Pharmaceutical Journal 29:12, pages 1498-1505.
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Marwa H. El-Wakil, Marwa Ahmed Meheissen & Marwa M. Abu-Serie. (2021) Nitrofurazone repurposing towards design and synthesis of novel apoptotic-dependent anticancer and antimicrobial agents: Biological evaluation, kinetic studies and molecular modeling. Bioorganic Chemistry 113, pages 104971.
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Mohammed Murtadha, Mohamed Ahmed Raslan, Sarah Farid Fahmy & Nagwa Ali Sabri. (2021) Changes in the Pharmacokinetics and Pharmacodynamics of Sildenafil in Cigarette and Cannabis Smokers. Pharmaceutics 13:6, pages 876.
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Manohara Dhulappa Jalageri, Akshatha Nagaraja & Yashoda Malgar Puttaiahgowda. (2021) Piperazine based antimicrobial polymers: a review. RSC Advances 11:25, pages 15213-15230.
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Tsukasa Narukawa, Jintetsu Soh, Noriyuki Kanemitsu, Shunji Harikai, Atsuko Fujihara & Osamu Ukimura. (2020) Efficacy of testosterone replacement therapy plus alternate‐day tadalafil for patients with late‐onset hypogonadism: An open‐label, randomized, crossover study. International Journal of Urology 28:4, pages 376-381.
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Priti Jain, Shreyans K. Jain & Munendra Jain. (2021) Harnessing Drug Repurposing for Exploration of New Diseases: An Insight to Strategies and Case Studies. Current Molecular Medicine 21:2, pages 111-132.
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Harish Kumar, Kushal Kumar Bansal & Anju Goyal. (2020) Synthetic Methods and Antimicrobial Perspective of Pyrazole Derivatives: An Insight. Anti-Infective Agents 18:3, pages 207-223.
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Nan Lu, Jin-ling Huo, Shuai Wang, Xiao-Han Yuan & Hong-Min Liu. (2020) Drug repurposing: Discovery of troxipide analogs as potent antitumor agents. European Journal of Medicinal Chemistry 202, pages 112471.
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Emma Mitidieri, Giuseppe Cirino, Roberta d’Emmanuele di Villa Bianca & Raffaella Sorrentino. (2020) Pharmacology and perspectives in erectile dysfunction in man. Pharmacology & Therapeutics 208, pages 107493.
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Vineela Parvathaneni, Nishant S. Kulkarni, Aaron Muth & Vivek Gupta. (2019) Drug repurposing: a promising tool to accelerate the drug discovery process. Drug Discovery Today 24:10, pages 2076-2085.
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Nicolai Egholt Munk, Jakob Schöllhammer Knudsen, Simon Comerma-Steffensen & Ulf Simonsen. (2019) Systematic Review of Oral Combination Therapy for Erectile Dysfunction When Phosphodiesterase Type 5 Inhibitor Monotherapy Fails. Sexual Medicine Reviews 7:3, pages 430-441.
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Victor Hugo Gonçalves-Rizzi, José Sérgio Possomato-Vieira, Regina Aparecida Nascimento, Mayara Caldeira-Dias & Carlos Alan Dias-Junior. (2018) Maternal hypertension and feto-placental growth restriction is reversed by sildenafil: Evidence of independent effects of circulating nitric oxide levels. European Journal of Pharmacology 822, pages 119-127.
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Xiao-Gang Chen, Fu Hua, Shou-Guo Wang, Yong- Yi Xu & Hai-Tao Yue. (2017) Phosphodiesterase inhibitor ameliorates neuronal injury in spinal cord ischemia/reperfusion injured rat model. Biomedicine & Pharmacotherapy 93, pages 1213-1219.
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Khaled S. Abdelkawy, Ahmed M. Donia, R. Brigg Turner & Fawzy Elbarbry. (2016) Effects of Lemon and Seville Orange Juices on the Pharmacokinetic Properties of Sildenafil in Healthy Subjects. Drugs in R&D 16:3, pages 271-278.
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Yufeng Bai & Ruihua An. (2015) Resveratrol and sildenafil synergistically improve diabetes-associated erectile dysfunction in streptozotocin-induced diabetic rats. Life Sciences 135, pages 43-48.
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Ibrahim A. Abdel-Hamid, Mohamed A. Abo-Aly & Moustafa A. Elsaied. (2014) Nonresponse to phosphodiesterase 5 inhibitors in erectile dysfunction. Part 1. Human Andrology 4:2, pages 23-29.
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Mohammad S. Rahnama'i, Stefan Ückert, Ramona Hohnen & Gommert A. van Koeveringe. (2013) The role of phosphodiesterases in bladder pathophysiology. Nature Reviews Urology 10:7, pages 414-424.
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Marija M. Janjic, Natasa J. Stojkov, Maja M. Bjelic, Aleksandar I. Mihajlovic, Silvana A. Andric & Tatjana S. Kostic. (2012) Transient Rise of Serum Testosterone Level after Single Sildenafil Treatment of Adult Male Rats. The Journal of Sexual Medicine 9:10, pages 2534-2543.
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Miriam Redondo, Juan G. Zarruk, Placido Ceballos, Daniel I. Pérez, Concepción Pérez, Ana Perez-Castillo, María A. Moro, José Brea, Cristina Val, María I. Cadavid, María I. Loza, Nuria E. Campillo, Ana Martínez & Carmen Gil. (2012) Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model. European Journal of Medicinal Chemistry 47, pages 175-185.
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K.-E. Andersson. (2011) Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction. Pharmacological Reviews 63:4, pages 811-859.
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Giovanni Corona, Nicola Mondaini, Andrea Ungar, Elisa Razzoli, Andrea Rossi & Ferdinando Fusco. (2011) Phosphodiesterase Type 5 (PDE5) Inhibitors in Erectile Dysfunction: The Proper Drug for the Proper Patient. The Journal of Sexual Medicine 8:12, pages 3418-3432.
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B Omar, E Banke, M Ekelund, S Frederiksen & E Degerman. (2011) Alterations in cyclic nucleotide phosphodiesterase activities in omental and subcutaneous adipose tissues in human obesity. Nutrition & Diabetes 1:8, pages e13-e13.
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Zhe Jin, Zhi-Chao Zhang, Ji-Hong Liu, Jun Lu, Yu-Xin Tang, Xiang-Zhou Sun, Wei-Dong Song, Bing Gao, Ying-Lu Guo & Zhong-Cheng Xin. (2011) An open, comparative, multicentre clinical study of combined oral therapy with sildenafil and doxazosin GITS for treating Chinese patients with erectile dysfunction and lower urinary tract symptoms secondary to benign prostatic hyperplasia. Asian Journal of Andrology 13:4, pages 630-635.
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Mugdha P Kulkarni, Bhakti S Shinde, Manoj Kumar V Chaudhari, Ganesh M Avhad, Shrikant V Pensalwar, B S V Prasad, Manoj Kumar M Deshpande & Richard A Rosenbloom. (2011) Efficacy and Safety of Two Polyherbal Combinations: E-MA-H and E-MA-HP in Male Sexual Dysfunction. American Journal of Therapeutics 18:2, pages 162-169.
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Erin R. McNamara & Craig F. Donatucci. 2011. Contemporary Treatment of Erectile Dysfunction. Contemporary Treatment of Erectile Dysfunction 93 106 .
Ilan Gruenwald, Ronit Leiba & Yoram Vardi. (2009) Effect of Sildenafil on Middle-Aged Sexually Active Males with No Erectile Complaints: A Randomized Placebo-Controlled Double-Blind Study. European Urology 55:4, pages 969-978.
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Valeria Panebianco, Alessandro Sciarra, Marcello Osimani, Danilo Lisi, Mauro Ciccariello, Stefano Salciccia, Vincenzo Gentile, Franco Di Silverio & Roberto Passariello. (2008) 2D and 3D T2-weighted MR sequences for the assessment of neurovascular bundle changes after nerve-sparing radical retropubic prostatectomy with erectile function correlation. European Radiology 19:1, pages 220-229.
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Kosmas I. Paraskevas, Nikolaos Bessias, Polyvios Pavlidis, Dimitrios Maras, Theofanis T. Papas, Christos D. Gekas & Vassilios Andrikopoulos. (2008) Erectile dysfunction in stroke patients: a multifactorial problem with important psychosocial consequences. International Urology and Nephrology 40:4, pages 1113-1114.
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