1,011
Views
34
CrossRef citations to date
0
Altmetric
Review

The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents

, &
Pages 125-143 | Published online: 27 Sep 2022

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Wanxia Liang, Yaqi Lan, Chengyu Chen, Mingyue Song, Jie Xiao, Qingrong Huang, Yong Cao, Chi-Tang Ho & Muwen Lu. (2023) Modulating effects of capsaicin on glucose homeostasis and the underlying mechanism. Critical Reviews in Food Science and Nutrition 63:19, pages 3634-3652.
Read now
Arif Mermer, Serpil Demirci & Gizem Tatar. (2022) Synthesis of novel pancreatic lipase inhibitors: Biological investigation and in silico studies. Journal of Biomolecular Structure and Dynamics 40:2, pages 931-940.
Read now
Christo J. F. Muller, Christiaan J. Malherbe, Nireshni Chellan, Kazumi Yagasaki, Yutaka Miura & Elizabeth Joubert. (2018) Potential of rooibos, its major C-glucosyl flavonoids, and Z-2-(β-D-glucopyranosyloxy)-3-phenylpropenoic acid in prevention of metabolic syndrome. Critical Reviews in Food Science and Nutrition 58:2, pages 227-246.
Read now
Zenghao Yan, Minmin Su, Wenjun Pan, Weiwei Su & Yonggang Wang. (2017) A simple method for extraction and purification of pedunculoside from the dried barks of Ilex rotunda and its inhibitory effect on pancreatic lipase in vitro. Separation Science and Technology 52:18, pages 2878-2887.
Read now
Srishti Shukla, Dommati Anand Kumar, Sanga Venkata Anusha & Ashok Kumar Tiwari. (2016) Antihyperglucolipidaemic and anticarbonyl stress properties in green, yellow and red sweet bell peppers (Capsicum annuum L.). Natural Product Research 30:5, pages 583-589.
Read now
Floirendo P. Flores, Rakesh K. Singh & Fanbin Kong. (2016) Anthocyanin extraction, microencapsulation, and release properties during in vitro digestion. Food Reviews International 32:1, pages 46-67.
Read now
Shilpa Chaudhary, Tarun Garg, R. S. R. Murthy, Goutam Rath & Amit K. Goyal. (2014) Recent approaches of lipid-based delivery system for lymphatic targeting via oral route. Journal of Drug Targeting 22:10, pages 871-882.
Read now

Articles from other publishers (26)

Loghman Firoozpour, Faraz Kazemzadeh Arasi, Mahsa Toolabi, Setareh Moghimi, Maryam Armandeh, Farzaneh Salmani, Roya Pakrad, Hadis Firuzpour, Mahtab Ghasemi Dogaheh, Seyed Esmaeil Sadat Ebrahimi, Shima H.M.E. Ketabforoosh, Saeed Karima & Alireza Foroumadi. (2023) Design, synthesis and α-glucosidase inhibition study of novel pyridazin-based derivatives. Medicinal Chemistry Research 32:4, pages 713-722.
Crossref
Emmanuel Anyachukwu Irondi, Yunus Temitayo Imam & Emmanuel Oladipo Ajani. (2022) Physicochemical, antioxidant and starch-digesting enzymes inhibitory properties of pearl millet and sweet detar gluten-free flour blends, and sensory qualities of their breads. Frontiers in Food Science and Technology 2.
Crossref
Vikram Kumar, Desh Deepak Singh, Sudarshan Singh Lakhawat, Nusrath Yasmeen, Aishwarya Pandey & Rajeev K. Singla. (2022) Biogenic Phytochemicals Modulating Obesity: From Molecular Mechanism to Preventive and Therapeutic Approaches. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-20.
Crossref
Jonh A. M. Santos, Cláudia L. A. A. Santos, João R. Freitas Filho, Paulo H. Menezes & Juliano C. R. Freitas. (2021) Polyacetylene Glycosides: Isolation, Biological Activities and Synthesis. The Chemical Record 22:1.
Crossref
Navjot Kaur, Vanktesh Kumar, Surendra Kumar Nayak, Pankaj Wadhwa, Paranjit Kaur & Sanjeev Kumar Sahu. (2021) Alpha‐amylase as molecular target for treatment of diabetes mellitus: A comprehensive review. Chemical Biology & Drug Design 98:4, pages 539-560.
Crossref
Hao Suo, Mohammad Rezaul Islam Shishir, Jianbo Xiao, Mingfu Wang, Feng Chen & Ka-Wing Cheng. (2021) Red Wine High-Molecular-Weight Polyphenolic Complex: An Emerging Modulator of Human Metabolic Disease Risk and Gut Microbiota. Journal of Agricultural and Food Chemistry 69:37, pages 10907-10919.
Crossref
Muhammad Nawaz, Muhammad Taha, Faiza Qureshi, Nisar Ullah, Manikandan Selvaraj, Sumaira Shahzad, Sridevi Chigurupati, Abdul Waheed & Fadiah Ammar Almutairi. (2020) Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives. BMC Chemistry 14:1.
Crossref
Xin Yi Chu, Shi Zhen Yang, Meng Qing Zhu, Dan Yang Zhang, Xiao Chen Shi, Bo Xia, Ye Yuan, Min Liu & Jiang Wei Wu. (2020) Isorhapontigenin Improves Diabetes in Mice via Regulating the Activity and Stability of PPARγ in Adipocytes. Journal of Agricultural and Food Chemistry 68:13, pages 3976-3985.
Crossref
Morena Gabriele, Francesca Sparvoli, Roberto Bollini, Valter Lubrano, Vincenzo Longo & Laura Pucci. (2019) The Impact of Sourdough Fermentation on Non‐Nutritive Compounds and Antioxidant Activities of Flours from Different Phaseolus Vulgaris L. Genotypes . Journal of Food Science 84:7, pages 1929-1936.
Crossref
Wanyu Wang, Jiao Li, Huizhen Zhang, Xiaokai Wang, Jianming Fan & Xiaofeng Zhang. (2019) Phenolic compounds and bioactivity evaluation of aqueous and methanol extracts of Allium mongolicum Regel . Food Science & Nutrition 7:2, pages 779-787.
Crossref
Shiow‐Ying Chiou, Jia‐Ying Lai, Jie‐Ann Liao, Jih‐Min Sung & Sheng‐Dun Lin. (2018) In vitro inhibition of lipase, α‐amylase, α‐glucosidase, and angiotensin‐converting enzyme by defatted rice bran extracts of red‐pericarp rice mutant. Cereal Chemistry 95:1, pages 167-176.
Crossref
Laura Brooks CroneEmily BeattyRyan G. MoranMatthew ButawanRichard J. Bloomer. (2016) Impact of Meal Ingestion Rate and Caffeine Coingestion on Postprandial Lipemia and Oxidative Stress Following High-Fat Meal Consumption. Journal of Caffeine Research 6:3, pages 108-116.
Crossref
Stephen M. Boue, Kim W. Daigle, Ming-Hsuan Chen, Heping Cao & Mark L. Heiman. (2016) Antidiabetic Potential of Purple and Red Rice ( Oryza sativa L.) Bran Extracts . Journal of Agricultural and Food Chemistry 64:26, pages 5345-5353.
Crossref
Diego Hernández-Saavedra, Iza F. Pérez-Ramírez, Minerva Ramos-Gómez, Sandra Mendoza-Díaz, Guadalupe Loarca-Piña & Rosalia Reynoso-Camacho. (2015) Phytochemical characterization and effect of Calendula officinalis, Hypericum perforatum, and Salvia officinalis infusions on obesity-associated cardiovascular risk. Medicinal Chemistry Research 25:1, pages 163-172.
Crossref
Akihiro Ogawa, Toshiya Kobayashi, Fumihiko Sakai, Yukio Kadooka & Yoshihiro Kawasaki. (2015) Lactobacillus gasseri SBT2055 suppresses fatty acid release through enlargement of fat emulsion size in vitro and promotes fecal fat excretion in healthy Japanese subjects. Lipids in Health and Disease 14:1.
Crossref
Kun Wei, Gang-Qiang Wang, Xue Bai, Yan-Fen Niu, He-Ping Chen, Chun-Nan Wen, Zheng-Hui Li, Ze-Jun Dong, Zhi-Li Zuo, Wen-Yong Xiong & Ji-Kai Liu. (2015) Structure-Based Optimization and Biological Evaluation of Pancreatic Lipase Inhibitors as Novel Potential Antiobesity Agents. Natural Products and Bioprospecting 5:3, pages 129-157.
Crossref
Debarshi Kar Mahapatra, Vivek Asati & Sanjay Kumar Bharti. (2015) Chalcones and their therapeutic targets for the management of diabetes: Structural and pharmacological perspectives. European Journal of Medicinal Chemistry 92, pages 839-865.
Crossref
Andrea Bellesia & Davide Tagliazucchi. (2014) Cocoa brew inhibits in vitro α-glucosidase activity: The role of polyphenols and high molecular weight compounds. Food Research International 63, pages 439-445.
Crossref
Yunfang Li, Yu Chen, Chuying Xiao, Dan Chen, Yuxiu Xiao & Zhinan Mei. (2014) Rapid screening and identification of α-amylase inhibitors from Garcinia xanthochymus using enzyme-immobilized magnetic nanoparticles coupled with HPLC and MS. Journal of Chromatography B 960, pages 166-173.
Crossref
Lorisa S. Teixeira, Arleilson S. Lima, Ana Paula A. Boleti, Adley A. N. Lima, Said T. Libório, Lucia de Paula, Maria Inês B. Oliveira, Everton F. Lima, Geison M. Costa, Flávio H. Reginatto & Emerson S. Lima. (2013) Effects of Passiflora nitida Kunth leaf extract on digestive enzymes and high caloric diet in rats. Journal of Natural Medicines 68:2, pages 316-325.
Crossref
Sujatha Jayaraj, Sukrutha Suresh & Ravi-Kumar Kadeppagari. (2013) Amylase inhibitors and their biomedical applications. Starch - Stärke 65:7-8, pages 535-542.
Crossref
Mizuho Handa, Toshihiro Murata, Kyoko Kobayashi, Erdenechimeg Selenge, Toshio Miyase, Javzan Batkhuu & Fumihiko Yoshizaki. (2013) Lipase inhibitory and LDL anti-oxidative triterpenes from Abies sibirica. Phytochemistry 86, pages 168-175.
Crossref
Wei Zhao, Vidya Iyer, Floirendo P. Flores, Erik Donhowe & Fanbin Kong. (2013) Microencapsulation of tannic acid for oral administration to inhibit carbohydrate digestion in the gastrointestinal tract. Food & Function 4:6, pages 899.
Crossref
Sedef Nehir El & Sebnem Simsek. (2012) Food Technological Applications for Optimal Nutrition: An Overview of Opportunities for the Food Industry. Comprehensive Reviews in Food Science and Food Safety 11:1, pages 2-12.
Crossref
Vincent Delorme, Rabeb Dhouib, Stéphane Canaan, Frédéric Fotiadu, Frédéric Carrière & Jean-François Cavalier. (2011) Effects of Surfactants on Lipase Structure, Activity, and Inhibition. Pharmaceutical Research 28:8, pages 1831-1842.
Crossref
Yun Jung BaeYoun-Kyung BakBumsik KimMin-Sun KimJin-Hee LeeMi-Kyung Sung. (2011) Coconut-derived D-xylose affects postprandial glucose and insulin responses in healthy individuals. Nutrition Research and Practice 5:6, pages 533.
Crossref