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Review

Intravenous ibuprofen: the first injectable product for the treatment of pain and fever

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Pages 67-79 | Published online: 25 May 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Mandeep Kaur, Pramodkumar P. Gupta, Anmol Jain, Gurmeet Kaur, Amandeep Kaur & Manisha Bansal. (2023) Investigating multifaceted action of ibuprofen derivatives towards cox isozymes and interleukin-6 (IL-6) site correlating with various target sites. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-14.
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Ahmad Mahdian-Shakib, Mohammad Sadegh Hashemzadeh, Ali Anissian, Mona Oraei & Abbas Mirshafiey. (2022) Evaluation of the acute and 28-day sub-acute intravenous toxicity of α-l-guluronic acid (ALG; G2013) in mice. Drug and Chemical Toxicology 45:1, pages 151-160.
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Lisa Miles, Jessica Hall, Bartosz Jenner, Richard Addis & Simon Hutchings. (2018) Predicting rapid analgesic onset of ibuprofen salts compared with ibuprofen acid: Tlag, Tlow, Tmed, and a novel parameter, TmaxRef. Current Medical Research and Opinion 34:8, pages 1483-1490.
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Jie Luo & Su Min. (2017) Postoperative pain management in the postanesthesia care unit: an update. Journal of Pain Research 10, pages 2687-2698.
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Articles from other publishers (33)

Sanghee Choi, Wang-Seob Shim, Jiyoung Yoon, Doowon Choi, Jinseong Lee, Soo-Heui Paik, Eun-Kyoung Chung & Kyung-Tae Lee. (2023) A Validated Chiral LC–MS/MS Method for the Enantioselective Determination of (S)-(+)- and (R)-(-)-Ibuprofen in Dog Plasma: Its Application to a Pharmacokinetic Study. Pharmaceutics 15:3, pages 824.
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Аlexei M. Ovechkin, Mikhail E. Politov & Sergey V. Sokologorskiy. (2022) Ibuprofen for intravenous administration: new possibilities for the use of NSAIDs in postoperative pain management. Regional Anesthesia and Acute Pain Management 16:2, pages 91-101.
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Gyeong Geon Lee, Joon Seong Park, Hyung Sun Kim, Dong Sup Yoon & Jin Hong Lim. (2022) Clinical effect of preoperative intravenous non-steroidal anti-inflammatory drugs on relief of postoperative pain in patients after laparoscopic cholecystectomy: Intravenous ibuprofen vs. intravenous ketorolac. Annals of Hepato-Biliary-Pancreatic Surgery 26:3, pages 251-256.
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Marigona BytyqiDriton ShabaniAdnan Bozalija. (2022) In vitro Pharmaceutical Quality Evaluation of different Ibuprofen tablet brands available on the Republic of Kosovo Market. Research Journal of Pharmacy and Technology, pages 3725-3730.
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Jun Kim, Bo-Bae Seo, Ki Hyun Hong, Sung Eun Kim, Young-Min Kim & Soo-Chang Song. (2022) Long-term anti-inflammatory effects of injectable celecoxib nanoparticle hydrogels for Achilles tendon regeneration. Acta Biomaterialia 144, pages 183-194.
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S. Akbas, A.S. Ozkan, M.A. Durak & S. Yologlu. (2021) Efficacy of Intravenous Paracetamol and Ibuprofen on Postoperative Pain and Morphine Consumption in Lumbar Disc Surgery: Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Neurochirurgie 67:6, pages 533-539.
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Su Yeon Kim, Sangseok Lee, Yeji Lee, Hyunho Kim & Kye-Min Kim. (2021) Effect of single dose preoperative intravenous ibuprofen on postoperative pain and opioid consumption: a systematic review and meta-analysis. Korean Journal of Anesthesiology 74:5, pages 409-421.
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McKenzie C Ferguson, Roman Schumann, Sean Gallagher & Ewan D McNicol. (2021) Single-dose intravenous ibuprofen for acute postoperative pain in adults. Cochrane Database of Systematic Reviews 2021:9.
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Ewan D McNicol, McKenzie C Ferguson & Roman Schumann. (2021) Single-dose intravenous ketorolac for acute postoperative pain in adults. Cochrane Database of Systematic Reviews 2021:5.
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Gizem Oncel, Atakan Yilmaz, Ramazan Sabirli, YesimKinaci Cimen, Mert Ozen, Murat Seyit, Ibrahim Turkcuer & Uzeyir Cimen. (2021) Comparative evaluation of the efficacy of intravenous paracetamol and ibuprofen on the treatment of tonsillopharyngitis with fever: A prospective, randomized controlled, double-blind clinical trial. Turkish Journal of Emergency Medicine 21:4, pages 177.
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Sercan Yalçınlı, Güçlü Selahattin Kıyan & Özge Can. (2020) Comparison of intravenous ibuprofen and paracetamol efficiency in soft tissue injuries: A randomized, double-blind study. The American Journal of Emergency Medicine 38:10, pages 2014-2018.
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Russell D. Weisz, Alexander A. Fokin, Vivian Lerner, Amy Flynt, Ines Macias-Perez, Leo Pavliv, Maggie Crawford & Ivan Puente. (2020) Intravenous Ibuprofen Reduces Opioid Consumption During the Initial 48 Hours After Injury in Orthopedic Trauma Patients. Journal of Orthopaedic Trauma 34:7, pages 341-347.
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Sheila Dakhel, Tiziano Ongaro, Baptiste Gouyou, Mattia Matasci, Alessandra Villa, Dario Neri & Samuele Cazzamalli. (2019) Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade. Oncotarget 10:62, pages 6678-6690.
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David W. Creighton, Amanda H. Kumar & Stuart A. Grant. (2019) Perioperative Multimodal Pain Management: an Evidence-Based Update. Current Anesthesiology Reports 9:3, pages 295-307.
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McKenzie C Ferguson, Roman Schumann, Sean Gallagher & Ewan D McNicol. (2019) Single-dose intravenous ibuprofen for acute postoperative pain in adults. Cochrane Database of Systematic Reviews.
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Ewan D McNicol, McKenzie C Ferguson, Sean Gallagher & Roman Schumann. (2019) Single-dose intravenous ketorolac for acute postoperative pain in adults. Cochrane Database of Systematic Reviews.
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Alberto A. Uribe, Fernando L. Arbona, David C. Flanigan, Christopher C. Kaeding, Marilly Palettas & Sergio D. Bergese. (2018) Comparing the Efficacy of IV Ibuprofen and Ketorolac in the Management of Postoperative Pain Following Arthroscopic Knee Surgery. A Randomized Double-Blind Active Comparator Pilot Study. Frontiers in Surgery 5.
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Ewan D McNicol, Emily Rowe & Tess E Cooper. (2018) Ketorolac for postoperative pain in children. Cochrane Database of Systematic Reviews.
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Donna-Ann Thomas, Praba Boominathan, Jyotsna Goswami, Sudipta Mukherjee & Nalini Vadivelu. (2018) Perioperative Management of Patients with Addiction to Opioid and Non-opioid Medications. Current Pain and Headache Reports 22:7.
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Prashant S. Korat & Pankaj P. Kapupara. (2017) Local infiltration of the surgical wound with levobupivacaine, ibuprofen, and epinephrine in postoperative pain: An experimental study. Biomedicine & Pharmacotherapy 96, pages 104-111.
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L.M. Torres & A. Martínez Ruiz. (2017) Inflammation and anesthesia, is there anything new?. Revista Española de Anestesiología y Reanimación (English Edition) 64:7, pages 365-368.
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L.M. Torres & A. Martínez Ruiz. (2017) Inflamación y anestesia, ¿hay algo nuevo?. Revista Española de Anestesiología y Reanimación 64:7, pages 365-368.
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Yali Shen, Feng Nan, Mei Li, Maozhi Liang, Ying Wang, Zhihui Chen & Zhu Luo. (2016) Pharmacokinetic Properties of Intravenous Ibuprofen in Healthy Chinese Volunteers. Clinical Drug Investigation 36:12, pages 1051-1058.
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Emily Rowe, Tess E Cooper & Ewan D McNicol. (2016) Ketorolac for postoperative pain in children. Cochrane Database of Systematic Reviews.
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Andrea Gago Martínez, Blanca Escontrela Rodriguez, Antonio Planas Roca & Alberto Martínez Ruiz. (2016) Intravenous Ibuprofen for Treatment of Post-Operative Pain: A Multicenter, Double Blind, Placebo-Controlled, Randomized Clinical Trial. PLOS ONE 11:5, pages e0154004.
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Jean-Pierre Pelletier, Johanne Martel-Pelletier, François Rannou & Cyrus Cooper. (2016) Efficacy and safety of oral NSAIDs and analgesics in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Seminars in Arthritis and Rheumatism 45:4, pages S22-S27.
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Alix Zuleta-Alarcón, Juan Fiorda-Díaz, Alberto Martínez Ruiz, Alfredo Abad Gurumeta & Luis M. Torres Morera. (2016) Ibuprofeno intravenoso: experiencia clínica en el tratamiento del dolor postoperatorio. Revista de la Sociedad Española del Dolor 23.
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Joseph D. Tobias. (2014) Acute Pain Management in Infants and Children—Part 1: Pain Pathways, Pain Assessment, and Outpatient Pain Management. Pediatric Annals 43:7.
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Delia Mihaela Iurea (Raţă), Marcel Popa, Jean-François Chailan, Bogdan Ionel Tamba, Ionut Tudorancea & Cătălina Anişoara Peptu. (2013) Ibuprofen-loaded chitosan/poly(maleic anhydride-alt-vinyl acetate) submicronic capsules for pain treatment. Journal of Bioactive and Compatible Polymers 28:4, pages 368-384.
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Georgia Charkoftaki, Aristides Dokoumetzidis, Georgia Valsami & Panos Macheras. (2012) Elucidating the Role of Dose in the Biopharmaceutics Classification of Drugs: The Concepts of Critical Dose, Effective In Vivo Solubility, and Dose-Dependent BCS. Pharmaceutical Research 29:11, pages 3188-3198.
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Howard S. Smith & Bryan Voss. (2012) Pharmacokinetics of Intravenous Ibuprofen. Drugs 72:3, pages 327-337.
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Peter B Kroll. (2012) Intravenous ibuprofen for postoperative pain. Pain Management 2:1, pages 47-54.
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John T. Promes, Karen Safcsak, Leo Pavliv, Bryan Voss & Amy Rock. (2011) A Prospective, Multicenter, Randomized, Double-Blind Trial of IV Ibuprofen for Treatment of Fever and Pain in Burn Patients. Journal of Burn Care & Research 32:1, pages 79-90.
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