Advanced search
Publication Cover
International Journal of Nanomedicine Volume 1, 2006 - Issue 4
Submit an article Journal homepage
110
Views
55
CrossRef citations to date
0
Altmetric
Original Research

Chitosan-DNA nanoparticles delivered by intrabiliary infusion enhance liver-targeted gene delivery

Hui Dai1 Tissue and Therapeutic Engineering Lab, Division of Johns Hopkins in Singapore, Singapore;;2 Department of Hepatobiliary Surgery, Xijing Hospital, the Fourth Military Medical University, Xian, P. R. China;;4 Department of Biomedical Engineering, Duke University, Durham, NC, USA;
,
Xuan Jiang5 Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA
,
Geoffrey CY Tan1 Tissue and Therapeutic Engineering Lab, Division of Johns Hopkins in Singapore, Singapore;
,
Yong Chen2 Department of Hepatobiliary Surgery, Xijing Hospital, the Fourth Military Medical University, Xian, P. R. China;
,
Michael Torbenson3 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA;
,
Kam W Leong1 Tissue and Therapeutic Engineering Lab, Division of Johns Hopkins in Singapore, Singapore;;4 Department of Biomedical Engineering, Duke University, Durham, NC, USA;
&
Hai-Quan Mao1 Tissue and Therapeutic Engineering Lab, Division of Johns Hopkins in Singapore, Singapore;;5 Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USACorrespondence[email protected] [email protected]
 show all
Pages 507-522 | Published online: 09 Oct 2022

Citations (55)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Dariush Semnani, Elham Naghashzargar, Mehdi Hadjianfar, Fahimeh Dehghan Manshadi, Sajjad Mohammadi, Saeed Karbasi & Farshid Effaty. (2017) Evaluation of PCL/chitosan electrospun nanofibers for liver tissue engineering. International Journal of Polymeric Materials and Polymeric Biomaterials 66:3, pages 149-157.
Read now
Yu-Shiang Peng, Po-Liang Lai, Sydney Peng, His-Chin Wu, Siang Yu, Tsan-Yun Tseng, Li-Fang Wang & I-Ming Chu. (2014) Glial cell line-derived neurotrophic factor gene delivery via a polyethylene imine grafted chitosan carrier. International Journal of Nanomedicine 9, pages 3163-3174.
Read now
Roberto Molinaro, Joy Wolfram, Cinzia Federico, Felisa Cilurzo, Luisa Di Marzio, Cinzia A Ventura, Maria Carafa, Christian Celia & Massimo Fresta. (2013) Polyethylenimine and chitosan carriers for the delivery of RNA interference effectors. Expert Opinion on Drug Delivery 10:12, pages 1653-1668.
Read now
Atul Pathak, Suresh P Vyas & Kailash C Gupta. (2008) Nano-vectors for efficient liver specific gene transfer. International Journal of Nanomedicine 3:1, pages 31-49.
Read now

Articles from other publishers (51)

Seokhwan Chung, Chan Mi Lee & Miqin Zhang. (2023) Advances in nanoparticle-based mRNA delivery for liver cancer and liver-associated infectious diseases. Nanoscale Horizons 8:1, pages 10-28.
Crossref
Tatjana Chan, Hiu Man Grisch-Chan, Philipp Schmierer, Ulrike Subotic, Nicole Rimann, Tanja Scherer, Udo Hetzel, Matthias Bozza, Richard Harbottle, James A. Williams, Barbara Steblaj, Simone K. Ringer, Johannes Häberle, Xaver Sidler & Beat Thöny. (2022) Delivery of non-viral naked DNA vectors to liver in small weaned pigs by hydrodynamic retrograde intrabiliary injection. Molecular Therapy - Methods & Clinical Development 24, pages 268-279.
Crossref
Neha S. Raut, Divya Zambre, Milind J. Umekar & Sanjay J. Dhoble. 2022. Photophysics and Nanophysics in Therapeutics. Photophysics and Nanophysics in Therapeutics 431 442 .
Manoj Trivedi & Sanjay Kumar. 2022. Chitosan-Based Nanocomposite Materials. Chitosan-Based Nanocomposite Materials 121 144 .
Esmaeel Mohammadi Pargoo, Mohammad Reza Aghasadeghi, Kazem Parivar, Mehri Nikbin, Pooneh Rahimi & Mehdi Shafiee Ardestani. (2021) Lamivudine‐conjugated and efavirenz‐loaded G2 dendrimers: Novel anti‐retroviral nano drug delivery systems. IET Nanobiotechnology 15:7, pages 627-637.
Crossref
Udisha Singh, Vinod Morya, Bhaskar Datta, Chinmay Ghoroi & Dhiraj Bhatia. (2021) Stimuli Responsive, Programmable DNA Nanodevices for Biomedical Applications. Frontiers in Chemistry 9.
Crossref
Laura Nicolle, Jens Casper, Melanie Willimann, Céline M. A. Journot, Pascal Detampel, Tomaž Einfalt, Hiu Man Grisch-Chan, Beat Thöny, Sandrine Gerber-Lemaire & Jörg Huwyler. (2021) Development of Covalent Chitosan-Polyethylenimine Derivatives as Gene Delivery Vehicle: Synthesis, Characterization, and Evaluation. International Journal of Molecular Sciences 22:8, pages 3828.
Crossref
Guojun Chen, Yiping Zhu, Xiao Liang, Xianfa Wang, Weihua Yu, Junping Guo, Linghua Zhu & Rui Ma. (2020) The Effect of Lecithins Coupled Decorin Nanoliposomes on Treatment of Carbon Tetrachloride-Induced Liver Fibrosis. BioMed Research International 2020, pages 1-10.
Crossref
Yuhang Cai & Yakov Lapitsky. (2020) Biomolecular uptake effects on chitosan/tripolyphosphate micro- and nanoparticle stability. Colloids and Surfaces B: Biointerfaces 193, pages 111081.
Crossref
Chenguang Dai, Min Wang, Lili Zhao, Chunfang Xu, Jin Huang & Zhining Fan. (2020) Liver gene transfection by retrograde intrabiliary infusion facilitated by temporary biliary obstruction. The Journal of Gene Medicine 22:1.
Crossref
Toheed Ahmed, Aimen Saleem, Pothu Ramyakrishna, Boddula Rajender, Tahsin Gulzar, Anish Khan & Abdullah M. Asiri. 2019. Nanostructured Polymer Composites for Biomedical Applications. Nanostructured Polymer Composites for Biomedical Applications 167 188 .
Vrantika Chaudhary, Sumit Jangra & Neelam R. Yadav. (2018) Nanotechnology based approaches for detection and delivery of microRNA in healthcare and crop protection. Journal of Nanobiotechnology 16:1.
Crossref
Zhaohui Tang, Chaoliang He, Huayu Tian, Jianxun Ding, Benjamin S. Hsiao, Benjamin Chu & Xuesi Chen. (2016) Polymeric nanostructured materials for biomedical applications. Progress in Polymer Science 60, pages 86-128.
Crossref
Faithful Makita-Chingombe, Hilliard L. Kutscher, Sara L. DiTursi, Gene D. Morse & Charles C. Maponga. (2016) Poly(lactic-co-glycolic) Acid-Chitosan Dual Loaded Nanoparticles for Antiretroviral Nanoformulations. Journal of Drug Delivery 2016, pages 1-10.
Crossref
Saadet Özgümüş, Mehmet Koray GÖk & Serhat Pabuccuoğlu. 2015. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 1735 1749 .
Sunaina Surana, Avinash R. Shenoy & Yamuna Krishnan. (2015) Designing DNA nanodevices for compatibility with the immune system of higher organisms. Nature Nanotechnology 10:9, pages 741-747.
Crossref
Marya Ahmed & Ravin Narain. (2015) Carbohydrate-based materials for targeted delivery of drugs and genes to the liver. Nanomedicine 10:14, pages 2263-2288.
Crossref
Joydeep Dutta. 2015. Polysaccharides. Polysaccharides 1029 1063 .
Anisha A. D’Souza, Vishvesh M. Joshi & Padma V. Devarajan. 2015. Targeted Drug Delivery : Concepts and Design. Targeted Drug Delivery : Concepts and Design 197 238 .
Joydeep Dutta. 2021. Polysaccharides. Polysaccharides 1 30 .
Bo Xiao, Xiaoyu Wang, Zhiye Qiu, Jun Ma, Lei Zhou, Ying Wan & Shengmin Zhang. (2012) A dual‐functionally modified chitosan derivative for efficient liver‐targeted gene delivery. Journal of Biomedical Materials Research Part A 101A:7, pages 1888-1897.
Crossref
Huayu Tian, Jie Chen & Xuesi Chen. (2013) Nanoparticles for Gene Delivery. Small 9:12, pages 2034-2044.
Crossref
Balakrishnan Chakrapani NarmadaYuzhan KangLakshmi VenkatramanQiwen PengRashidah Binte SakbanBramasta NugrahaXuan JiangRalph M. BuntePeter T.C. SoLisa Tucker-KelloggHai-Quan MaoHanry Yu. (2013) Hepatic Stellate Cell–Targeted Delivery of Hepatocyte Growth Factor Transgene via Bile Duct Infusion Enhances Its Expression at Fibrotic Foci to Regress Dimethylnitrosamine-Induced Liver Fibrosis. Human Gene Therapy 24:5, pages 508-519.
Crossref
Lin Gao, Lisi Xie, Xiaojing Long, Zhiyong Wang, Cheng-Yi He, Zhi-Ying Chen, Lei Zhang, Xiang Nan, Hulong Lei, Xin Liu, Gang Liu, Jian Lu & Bensheng Qiu. (2013) Efficacy of MRI visible iron oxide nanoparticles in delivering minicircle DNA into liver via intrabiliary infusion. Biomaterials 34:14, pages 3688-3696.
Crossref
Xuan Jiang, Wei Qu, Deng Pan, Yong Ren, John-Michael Williford, Honggang Cui, Erik Luijten & Hai-Quan Mao. (2013) Plasmid-Templated Shape Control of Condensed DNA-Block Copolymer Nanoparticles. Advanced Materials 25:2, pages 227-232.
Crossref
Xuan Jiang, Yong Ren, John-Michael Williford, Zhiping Li & Hai-Quan Mao. 2013. Nanotechnology for Nucleic Acid Delivery. Nanotechnology for Nucleic Acid Delivery 275 284 .
Joydeep Dutta. 2013. Multifaceted Development and Application of Biopolymers for Biology, Biomedicine and Nanotechnology. Multifaceted Development and Application of Biopolymers for Biology, Biomedicine and Nanotechnology 87 134 .
J. Zhong & L. C. Dai. (2016) Targeting Liposomal Nanomedicine to Cancer Therapy. Technology in Cancer Research & Treatment 11:5, pages 475-481.
Crossref
Wei-Hsien Hsieh, Shwu-Fen Chang, Hui-Min Chen, Jeng-Hsien Chen & Jiahorng Liaw. (2012) Oral Gene Delivery with cyclo -( d -Trp-Tyr) Peptide Nanotubes . Molecular Pharmaceutics 9:5, pages 1231-1249.
Crossref
Michael T. Tseng, Xiaoqin Lu, Xiaoxian Duan, Sarita S. Hardas, Rukhsana Sultana, Peng Wu, Jason M. Unrine, Uschi Graham, D. Allan Butterfield, Eric A. Grulke & Robert A. Yokel. (2012) Alteration of hepatic structure and oxidative stress induced by intravenous nanoceria. Toxicology and Applied Pharmacology 260:2, pages 173-182.
Crossref
Paul Galvin, Damien Thompson, Katie B. Ryan, Anna McCarthy, Anne C. Moore, Conor S. Burke, Maya Dyson, Brian D. MacCraith, Yurii K. Gun’ko, Michelle T. Byrne, Yuri Volkov, Chris Keely, Enda Keehan, Michael Howe, Conor Duffy & Ronan MacLoughlin. (2011) Nanoparticle-based drug delivery: case studies for cancer and cardiovascular applications. Cellular and Molecular Life Sciences 69:3, pages 389-404.
Crossref
Alicia Fernandez-Fernandez, Romila Manchanda & Anthony J. McGoron. (2011) Theranostic Applications of Nanomaterials in Cancer: Drug Delivery, Image-Guided Therapy, and Multifunctional Platforms. Applied Biochemistry and Biotechnology 165:7-8, pages 1628-1651.
Crossref
Xinyun Zhai, Peng Sun, Yongfeng Luo, Chaonan Ma, Jun Xu & Wenguang Liu. (2011) Guanidinylation: A simple way to fabricate cell penetrating peptide analogue-modified chitosan vector for enhanced gene delivery. Journal of Applied Polymer Science 121:6, pages 3569-3578.
Crossref
Rajesh R Patil, Jianhua Yu, Sangeeta R Banerjee, Yong Ren, Derek Leong, Xuan Jiang, Martin Pomper, Benjamin Tsui, Dara L Kraitchman & Hai-Quan Mao. (2011) Probing In Vivo Trafficking of Polymer/DNA Micellar Nanoparticles Using SPECT/CT Imaging. Molecular Therapy 19:9, pages 1626-1635.
Crossref
M. Dash, F. Chiellini, R.M. Ottenbrite & E. Chiellini. (2011) Chitosan—A versatile semi-synthetic polymer in biomedical applications. Progress in Polymer Science 36:8, pages 981-1014.
Crossref
Hui DaiXuan JiangKam W. LeongHai-Quan Mao. (2011) Transient Depletion of Kupffer Cells Leads to Enhanced Transgene Expression in Rat Liver Following Retrograde Intrabiliary Infusion of Plasmid DNA and DNA Nanoparticles. Human Gene Therapy 22:7, pages 873-878.
Crossref
Xuan Jiang, Derek Leong, Yong Ren, Zhiping Li, Michael S. Torbenson & Hai-Quan Mao. (2011) String-Like Micellar Nanoparticles Formed by Complexation of PEG-b-PPA and Plasmid DNA and Their Transfection Efficiency. Pharmaceutical Research 28:6, pages 1317-1327.
Crossref
Anumita Chaudhury & Surajit Das. (2010) Recent Advancement of Chitosan-Based Nanoparticles for Oral Controlled Delivery of Insulin and Other Therapeutic Agents. AAPS PharmSciTech 12:1, pages 10-20.
Crossref
Farzaneh Tajdini, Mohammad Ali Amini, Nastaran Nafissi-Varcheh & Mohammad Ali Faramarzi. (2010) Production, physiochemical and antimicrobial properties of fungal chitosan from Rhizomucor miehei and Mucor racemosus. International Journal of Biological Macromolecules 47:2, pages 180-183.
Crossref
R Jayakumar, K Chennazhi, S Nair, Tetsuya Furuike & Hiroshi Tamura. 2010. Chitin, Chitosan, Oligosaccharides and Their Derivatives. Chitin, Chitosan, Oligosaccharides and Their Derivatives 357 369 .
Christopher Chang. (2010) The immune effects of naturally occurring and synthetic nanoparticles. Journal of Autoimmunity 34:3, pages J234-J246.
Crossref
R. Jayakumar, K.P. Chennazhi, R.A.A. Muzzarelli, H. Tamura, S.V. Nair & N. Selvamurugan. (2010) Chitosan conjugated DNA nanoparticles in gene therapy. Carbohydrate Polymers 79:1, pages 1-8.
Crossref
Xi-Qin Ding, Alexander B. Quiambao, J. Browning Fitzgerald, Mark J. Cooper, Shannon M. Conley & Muna I. Naash. (2009) Ocular Delivery of Compacted DNA-Nanoparticles Does Not Elicit Toxicity in the Mouse Retina. PLoS ONE 4:10, pages e7410.
Crossref
Ana Helena Casé, Isadora Pfeifer Dalla Picola, Maria Elisabete Darbello Zaniquelli, Júlio Cesar Fernandes, Sebastião Roberto Taboga, Françoise M. Winnik & Marcio José Tiera. (2009) Physicochemical characterization of nanoparticles formed between DNA and phosphorylcholine substituted chitosans. Journal of Colloid and Interface Science 336:1, pages 125-133.
Crossref
Lin Peng, Xiangrong Cheng, Renxi Zhuo, Jing Lan, Yining Wang, Bin Shi & Siqun Li. (2009) Novel gene-activated matrix with embedded chitosan/plasmid DNA nanoparticles encoding PDGF for periodontal tissue engineering. Journal of Biomedical Materials Research Part A 90A:2, pages 564-576.
Crossref
Hunter H. Chen, Yi-Ping Ho, Xuan Jiang, Hai-Quan Mao, Tza-Huei Wang & Kam W. Leong. (2009) Simultaneous non-invasive analysis of DNA condensation and stability by two-step QD-FRET. Nano Today 4:2, pages 125-134.
Crossref
Yan Yang, Zehua Wang, Minfang Li & Shi Lu. (2009) Chitosan/pshRNA plasmid nanoparticles targeting MDR1 gene reverse paclitaxel resistance in ovarian cancer cells. Journal of Huazhong University of Science and Technology [Medical Sciences] 29:2, pages 239-242.
Crossref
Li-Cheng Dai, Xing Yao, Xiang Wang, Shu-Qiong Niu, Lin-Fu Zhou, Fang-Fang Fu, Shui-Xin Yang & Jin-Liang Ping. (2009) In vitro and in vivo suppression of hepatocellular carcinoma growth by midkine-antisense oligonucleotide-loaded nanoparticles. World Journal of Gastroenterology 15:16, pages 1966.
Crossref
Diego Velasco, Carlos Elvira & Julio San Román. (2007) New stimuli-responsive polymers derived from morpholine and pyrrolidine. Journal of Materials Science: Materials in Medicine 19:4, pages 1453-1458.
Crossref
Andrea Masotti, Federico Bordi, Giancarlo Ortaggi, Federica Marino & Cleofe Palocci. (2008) A novel method to obtain chitosan/DNA nanospheres and a study of their release properties. Nanotechnology 19:5, pages 055302.
Crossref
Xuan Jiang, Hui Dai, Chyan-Ying Ke, Xiao Mo, Michael S. Torbenson, Zhiping Li & Hai-Quan Mao. (2007) PEG-b-PPA/DNA micelles improve transgene expression in rat liver through intrabiliary infusion. Journal of Controlled Release 122:3, pages 297-304.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.