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Expert Opinion

Monotherapy for partial epilepsy: focus on levetiracetam

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Pages 33-38 | Published online: 08 Feb 2008

Keep up to date with the latest research on this topic with citation updates for this article.

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Laura Mumoli, Caterina Palleria, Sara Gasparini, Rita Citraro, Angelo Labate, Edoardo Ferlazzo, Antonio Gambardella, Giovambattista De Sarro & Emilio Russo. (2015) Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures. Drug Design, Development and Therapy 9, pages 5719-5725.
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Sujeeve Sanmugabatham, Tarun Bastiampillai, Rohan Dhillon & Montaha Khan. (2009) Levetiracetam-induced psychosis. Australian and New Zealand Journal of Psychiatry 43:10, pages 977-979.
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Articles from other publishers (32)

John Agbo, Zainab G. Ibrahim, Shehu Y. Magaji, Yahkub Babatunde Mutalub, Philemon Paul Mshelia & Daniel H. Mhyha. (2023) Therapeutic efficacy of voltage-gated sodium channel inhibitors in epilepsy. Acta Epileptologica 5:1.
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Valerija Lamouret, Christoph Kurth, Tassanai Intravooth & Bernhard J. Steinhoff. (2020) Is the anticonvulsant activity of levetiracetam dose-dependent?. Seizure 83, pages 197-202.
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Gashirai K Mbizvo, Bharath Chandrasekar, Sarah J Nevitt, Pete Dixon, Jane L Hutton & Anthony G Marson. (2020) Levetiracetam add-on for drug-resistant focal epilepsy. Cochrane Database of Systematic Reviews 2020:6.
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Angelo Labate, Maria Eugenia Caligiuri, Francesco Fortunato, Edoardo Ferlazzo, Umberto Aguglia & Antonio Gambardella. (2020) Late drug‐resistance in mild MTLE: Can it be influenced by preexisting white matter alterations?. Epilepsia 61:5, pages 924-934.
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Jeyakumar M, Kavitha A & Jeyanthi Arulneyam. (2019) Effect of Levetiracetam Monotherapy on Serum Cortisol Levels - A Descriptive Study. Journal of Evolution of Medical and Dental Sciences 8:49, pages 3649-3652.
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Sudhir Chandra Sarangi, Nivendeep Kaur & Manjari Tripathi. (2019) Assessment of psychiatric and behavioral adverse effects of antiepileptic drugs monotherapy: Could they have a neuroendocrine correlation in persons with epilepsy?. Epilepsy & Behavior 100, pages 106439.
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Kevin S. O’Connell, Nathaniel W. McGregor, Anil Malhotra, Todd Lencz, Robin Emsley & Louise Warnich. (2018) Variation within voltage-gated calcium channel genes and antipsychotic treatment response in a South African first episode schizophrenia cohort. The Pharmacogenomics Journal 19:1, pages 109-114.
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Raghavendra Kumar Gunda, Prasada Rao Manchineni, Chaikam Gopi Reddy, Kurapati Divya, Duddu Alekhya & Ekula Jyoshna. (2019) Formulation development and in vitro evaluation of oral disintegrating tablets for newer anticonvulsant agent. Journal of Analytical & Pharmaceutical Research 8:2, pages 85-89.
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Tony Wu, Siew-Na Lim, Jing-Jane Tsai, Yao-Chung Chuang, Chin-Wei Huang, Chun-Chieh Lin, Chang-Hung Hsu, Hong-Chung Fung & Chih-Hong Lee. (2018) A randomized, double-blind, double-dummy, multicenter trial comparing the efficacy and safety of extended- and immediate-release levetiracetam in people with partial epilepsy. Seizure 62, pages 84-90.
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Guray Koc, Selda Keskin Guler, Omer Karadas, Tahir Yoldas & Zeki Gokcil. (2018) Fetal safety of levetiracetam use during pregnancy. Acta Neurologica Belgica 118:3, pages 503-508.
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M. Trimboli, E. Russo, L. Mumoli, G. Tripepi, F. Fortunato, G. Mastroianni, F. Abate, G. De Sarro, A. Gambardella & A. Labate. (2018) Brand-to-generic levetiracetam switching: a 4-year prospective observational real-life study. European Journal of Neurology 25:4, pages 666-671.
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Raluca Luchian, Emil Vinţeler, Cosmina Chiş, Mihai Vasilescu, Nicolae Leopold, João P. Prates Ramalho & Vasile Chiş. (2017) Conformational Preference and Spectroscopical Characteristics of the Active Pharmaceutical Ingredient Levetiracetam. Journal of Pharmaceutical Sciences 106:12, pages 3564-3573.
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Li-na Zhu, Deng Chen, Da Xu, Ge Tan, Hai-Jiao Wang & Ling Liu. (2017) Newer antiepileptic drugs compared to levetiracetam as adjunctive treatments for uncontrolled focal epilepsy: An indirect comparison. Seizure 51, pages 121-132.
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Bram Harmsen, Koen Robeyns, Johan Wouters & Tom Leyssens. (2017) A Study of Fasoracetam’s Solid State Forms: A Potential Anti-Alzheimer Pharmaceutical. Journal of Pharmaceutical Sciences 106:5, pages 1317-1321.
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Zahra Tolou-Ghamari. (2016) Levetiracetam (Keppra): Evidence-Based Polypharmacy in Two Patients With Epilepsy. Jundishapur Journal of Chronic Disease Care 5:2.
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Ayşe Kaçar Bayram, Mehmet Canpolat, Salih Levent Çınar, Fulya Tahan, Hakan Gumus, Sefer Kumandaş & Hüseyin Per. (2016) Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome Induced by Levetiracetam in a Pediatric Patient. The Journal of Emergency Medicine 50:2, pages e61-e66.
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Feten Béji, Sonia Taktouk, Jihène Ben Kraïem, Salem S. Al-Deyab & Hassen Amri. (2015) Two-Step Synthesis of Multifunctional γ-Lactams from γ-Lactone. Journal of Heterocyclic Chemistry 52:5, pages 1576-1579.
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Huda A.M. Omer & Muna A.M. Kutb. (2015) Chronic histopathological effects of levetiracetam on some internal organs of adult albino rats. Egyptian Journal of Forensic Sciences 5:2, pages 41-45.
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Jagriti Narang, Nidhi Chauhan, Nitesh Malhotra & C.S. Pundir. (2015) Nanocrystals of Zeolite Act as Enhanced Sensing Interface for Biosensing of Leviteracetum. Journal of Pharmaceutical Sciences 104:3, pages 1153-1159.
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Joanna Lee, Veronique Daniels, Zara A. Sands, Florence Lebon, Jiye Shi & Philip C. Biggin. (2015) Exploring the Interaction of SV2A with Racetams Using Homology Modelling, Molecular Dynamics and Site-Directed Mutagenesis. PLOS ONE 10:2, pages e0116589.
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Shahnaz Akhtar Chaudhry, Geert’t Jong & Gideon Koren. (2014) The fetal safety of Levetiracetam: A systematic review. Reproductive Toxicology 46, pages 40-45.
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Sheila A Lewis. (2014) Newer drug treatments for focal-onset epilepsy. British Journal of Neuroscience Nursing 10:1, pages 6-12.
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S. Renuga & S. Muthu. (2014) Molecular structure, normal coordinate analysis, harmonic vibrational frequencies, NBO, HOMO–LUMO analysis and detonation properties of (S)-2-(2-oxopyrrolidin-1-yl) butanamide by density functional methods. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 118, pages 702-715.
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Adriana Monserrath Orellana-Paucar, Tatiana Afrikanova, Joice Thomas, Yelaman K. Aibuldinov, Wim Dehaen, Peter A. M. de Witte & Camila V. Esguerra. (2013) Insights from Zebrafish and Mouse Models on the Activity and Safety of Ar-Turmerone as a Potential Drug Candidate for the Treatment of Epilepsy. PLoS ONE 8:12, pages e81634.
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Emilio Russo, Eugenio Donato di Paola, Pietro Gareri, Antonio Siniscalchi, Angelo Labate, Luca Gallelli, Rita Citraro & Giovambattista De Sarro. (2013) Pharmacodynamic potentiation of antiepileptic drugs’ effects by some HMG-CoA reductase inhibitors against audiogenic seizures in DBA/2 mice. Pharmacological Research 70:1, pages 1-12.
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Jounhong Ryan Cho, Dae Lim Koo, Eun Yeon Joo, So Mi Yoon, Eunji Ju, James Lee, Dae Young Kim & Seung Bong Hong. (2012) Effect of levetiracetam monotherapy on background EEG activity and cognition in drug-naïve epilepsy patients. Clinical Neurophysiology 123:5, pages 883-891.
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Andrew I. Geller, Wilawan Nopkhun, Marly N. Dows-Martinez & Dale C. Strasser. (2012) Polypharmacy and the Role of Physical Medicine and Rehabilitation. PM&R 4:3, pages 198-219.
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Jose de Leon. 2012. A Practitioner's Guide to Prescribing Antiepileptics and Mood Stabilizers for Adults with Intellectual Disabilities. A Practitioner's Guide to Prescribing Antiepileptics and Mood Stabilizers for Adults with Intellectual Disabilities 185 205 .
Antonella Gagliano, Irene Aricò, Tiziana Calarese, Rosaria Condurso, Eva Germanò, Clemente Cedro, Edoardo Spina & Rosalia Silvestri. (2011) Restless Leg Syndrome in ADHD children: Levetiracetam as a reasonable therapeutic option. Brain and Development 33:6, pages 480-486.
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Alessandro S. De NadaiEric A. StorchJoseph F. McguireAdam B. LewinTanya K. Murphy. (2011) Evidence-Based Pharmacotherapy for Pediatric Obsessive-Compulsive Disorder and Chronic Tic Disorders. Journal of Central Nervous System Disease 3, pages JCNSD.S6616.
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Emilio Russo, Rita Citraro, Francesca Scicchitano, Salvatore De Fazio, Eugenio D. Di Paola, Andrew Constanti & Giovambattista De Sarro. (2009) Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy. Epilepsia 51:8, pages 1560-1569.
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Joseph P. Vande Griend, Sunny A. Linnebur & Jacquelyn L. Bainbridge. (2009) Probable levetiracetam-associated depression in the elderly: Two case reports. The American Journal of Geriatric Pharmacotherapy 7:5, pages 281-284.
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