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Review

New approaches in the management of insomnia: weighing the advantages of prolonged-release melatonin and synthetic melatoninergic agonists

Pages 341-354 | Published online: 10 Jun 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Shohei Nishimon, Naoya Nishino & Seiji Nishino. (2021) Advances in the pharmacological management of non-24-h sleep-wake disorder. Expert Opinion on Pharmacotherapy 22:8, pages 1039-1049.
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Shohei Nishimon, Mari Nishimon & Seiji Nishino. (2019) Tasimelteon for treating non-24-h sleep-wake rhythm disorder. Expert Opinion on Pharmacotherapy 20:9, pages 1065-1073.
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Wendy Rydzkowski, Nicola Canale & Louisa Reynolds. (2016) A review of interventions for adolescents with insomnia and the role of the educational and child psychologist: when sleep does not come easily. Educational Psychology in Practice 32:1, pages 24-37.
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Eliza L Sutton. (2015) Profile of suvorexant in the management of insomnia. Drug Design, Development and Therapy 9, pages 6035-6042.
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Alessia Carocci, Alessia Catalano & Maria Stefania Sinicropi. (2014) Melatonergic drugs in development. Clinical Pharmacology: Advances and Applications 6, pages 127-137.
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Ludovit Paulis, Fedor Simko & Moshe Laudon. (2012) Cardiovascular effects of melatonin receptor agonists. Expert Opinion on Investigational Drugs 21:11, pages 1661-1678.
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Octavian C Ioachimescu & Ali A El-Solh. (2012) Pharmacotherapy of insomnia. Expert Opinion on Pharmacotherapy 13:9, pages 1243-1260.
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Dieter Kunz, Sébastien Bineau, Khaled Maman, Dominique Milea & Mondher Toumi. (2012) Benzodiazepine discontinuation with prolonged-release melatonin: hints from a German longitudinal prescription database. Expert Opinion on Pharmacotherapy 13:1, pages 9-16.
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D Alan Lankford. (2011) Tasimelteon for insomnia. Expert Opinion on Investigational Drugs 20:7, pages 987-993.
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Ben Green. (2011) Focus on agomelatine. Current Medical Research and Opinion 27:4, pages 745-749.
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Monique AJ Mets, Kenny R van Deventer, Berend Olivier & Joris C Verster. (2010) Critical appraisal of ramelteon in the treatment of insomnia. Nature and Science of Sleep 2, pages 257-266.
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Rüdiger Hardeland. (2010) Investigational melatonin receptor agonists. Expert Opinion on Investigational Drugs 19:6, pages 747-764.
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Christine Salahub, Peter E. Wu, Lisa D. Burry, Christine Soong, Kathleen A. Sheehan, Thomas E. MacMillan & Lauren Lapointe-Shaw. (2022) Melatonin for Insomnia in Medical Inpatients: A Narrative Review. Journal of Clinical Medicine 12:1, pages 256.
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Weiwei Chu, Shang Li, Xueying Geng, Dongshuang Wang, Junyu Zhai, Gang Lu, Wai-Yee Chan, Zi-Jiang Chen & Yanzhi Du. (2022) Long-term environmental exposure of darkness induces hyperandrogenism in PCOS via melatonin receptor 1A and aromatase reduction. Frontiers in Cell and Developmental Biology 10.
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Rüdiger Hardeland. (2022) Redox Biology of Melatonin: Discriminating Between Circadian and Noncircadian Functions. Antioxidants & Redox Signaling 37:10-12, pages 704-725.
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Ji Hoon Kim, Kyeongjin Kim & Hyo-Eon Jin. (2022) Three-Dimensional Printing for Oral Pharmaceutical Dosage Forms. Journal of Pharmaceutical Investigation 52:3, pages 293-317.
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Phillip T. Yuhas. (2022) Non-24-Hour Sleep–Wake Disorder and Tasimelteon: A Review for Practitioners Who Work With Blind People. Journal of Visual Impairment & Blindness 116:1, pages 70-84.
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M.S. Petronek, J.M. Stolwijk, S.D. Murray, E.J. Steinbach, Y. Zakharia, G.R. Buettner, D.R. Spitz & B.G. Allen. (2021) Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy. Redox Biology 42, pages 101864.
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Rüdiger Hardeland. (2021) Divergent Importance of Chronobiological Considerations in High- and Low-dose Melatonin Therapies. Diseases 9:1, pages 18.
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Rüdiger Hardeland. 2021. Sirtuin Biology in Medicine. Sirtuin Biology in Medicine 137 151 .
David Mantle, Marcel Smits, Myrthe Boss, Irene Miedema & Inge van Geijlswijk. (2020) Efficacy and safety of supplemental melatonin for delayed sleep–wake phase disorder in children: an overview. Sleep Medicine: X 2, pages 100022.
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Enrico Moretti, Gaia Favero, Luigi Fabrizio Rodella & Rita Rezzani. (2020) Melatonin’s Antineoplastic Potential Against Glioblastoma. Cells 9:3, pages 599.
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Marija Delaš Aždajić, Robert Likić, Stjepan Aždajić, Mirna Šitum, Ivana Lovrić & Danijela Štimac Grbić. (2019) Outpatient benzodiazepine utilization in Croatia: drug use or misuse. International Journal of Clinical Pharmacy 41:6, pages 1526-1535.
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Glenn Gunzelmann, Stephen M. James & Jo Lynn Caldwell. 2019. Sleep Deprivation and Cognition. Sleep Deprivation and Cognition 177 204 .
Rui Guan & Roneil G. Malkani. 2019. Allergy and Sleep. Allergy and Sleep 367 384 .
Ziqing Li, Yu Zhang, Yuanping Wang, Xia Yan & Pingchang Xie. (2018) Electroacupuncture for primary insomnia. Medicine 97:27, pages e11063.
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Rüdiger Hardeland. (2017) Melatonergic Sleep Promotion: Fundamental Chronobiological Issues Concerning Sleep Onset and Maintenance, Dose and Duration of Action. Sleep and Vigilance 2:1, pages 5-11.
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Gregory M. Brown, Roger S. McIntyre, Joshua Rosenblat & Rüdiger Hardeland. (2018) Depressive disorders: Processes leading to neurogeneration and potential novel treatments. Progress in Neuro-Psychopharmacology and Biological Psychiatry 80, pages 189-204.
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Rüdiger Hardeland. 2018. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Sung-Phil Kim, Joo-Hee Kim, Bo-Kyung Kim, Hyeong-Jun Kim, In Chul Jung, Jung Hyo Cho, Jung-Eun Kim, Mi-Kyung Kim, O-Jin Kwon, Ae-Ran Kim, Hyo-Ju Park & Bok-Nam Seo. (2017) Electroacupuncture for insomnia disorder: study protocol for a randomized controlled trial. Trials 18:1.
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Andrew C. Forrestel, Susanne U. Miedlich, Michael Yurcheshen, Steven D. Wittlin & Michael T. Sellix. (2016) Chronomedicine and type 2 diabetes: shining some light on melatonin. Diabetologia 60:5, pages 808-822.
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P. Pévet. 2017. Reference Module in Neuroscience and Biobehavioral Psychology. Reference Module in Neuroscience and Biobehavioral Psychology.
Rüdiger Hardeland. 2017. Hormones in Ageing and Longevity. Hormones in Ageing and Longevity 209 242 .
Jing Yang, Hui Juan Jin, Elisabeth Mocaër, Laure Seguin, Hua Zhao & Benjamin Rusak. (2016) Agomelatine affects rat suprachiasmatic nucleus neurons via melatonin and serotonin receptors. Life Sciences 155, pages 147-154.
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Huimin Zhao, Yifei Wang, Yi Jin, Shu Liu, Haiyan Xu & Xiumei Lu. (2016) Rapid and sensitive analysis of melatonin by LC-MS/MS and its application to pharmacokinetic study in dogs. Asian Journal of Pharmaceutical Sciences 11:2, pages 273-280.
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Rüdiger Hardeland. (2016) Melatonergic Treatment: Focus on Metabolism and Chronobiology. Focus on Sciences 2:1, pages 1-10.
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Sinan Canpolat, Nazife Ulker, Ahmet Yardimci, Ozgur Bulmus, Gokcen Ozdemir, Zafer Sahin, Zubeyde Ercan, Ihsan Serhatlioglu, Emine Kacar, Mete Ozcan, Gaffari Turk, Yusuf Ozkan, Murad Atmaca, Bayram Yilmaz & Haluk Kelestimur. (2016) Studies on the reproductive effects of chronic treatment with agomelatine in the rat. European Journal of Pharmacology 770, pages 33-39.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 65 76 .
Eva Ramos, Paloma Patiño, José Luis Marco-Contelles, Ramón Cacabelos & Alejandro Romero. 2016. Melatonin, Neuroprotective Agents and Antidepressant Therapy. Melatonin, Neuroprotective Agents and Antidepressant Therapy 91 99 .
Agata Carpentieri, Vanessa Areco, Gabriela Díaz de Barboza, María Angélica Rivoira, Solange Guizzardi & Nori Tolosa de Talamoni. 2016. Melatonin, Neuroprotective Agents and Antidepressant Therapy. Melatonin, Neuroprotective Agents and Antidepressant Therapy 55 64 .
Rüdiger Hardeland. 2016. Inflammation, Aging, and Oxidative Stress. Inflammation, Aging, and Oxidative Stress 345 376 .
Valentina Vengeliene, Hamid R Noori & Rainer Spanagel. (2015) Activation of Melatonin Receptors Reduces Relapse-Like Alcohol Consumption. Neuropsychopharmacology 40:13, pages 2897-2906.
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Maria Bonmati-Carrion, Raquel Arguelles-Prieto, Maria Martinez-Madrid, Russel Reiter, Ruediger Hardeland, Maria Rol & Juan Madrid. (2014) Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure. International Journal of Molecular Sciences 15:12, pages 23448-23500.
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Jessica D. Johnsa & Michael W. Neville. (2014) Tasimelteon. Annals of Pharmacotherapy 48:12, pages 1636-1641.
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Rüdiger Hardeland. 2014. Melatonin. Melatonin 11 18 .
Moshe Laudon & Anat Frydman-Marom. (2014) Therapeutic Effects of Melatonin Receptor Agonists on Sleep and Comorbid Disorders. International Journal of Molecular Sciences 15:9, pages 15924-15950.
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Darius. P. Zlotos, Ralf Jockers, Erika Cecon, Silvia Rivara & Paula A. Witt-Enderby. (2013) MT 1 and MT 2 Melatonin Receptors: Ligands, Models, Oligomers, and Therapeutic Potential . Journal of Medicinal Chemistry 57:8, pages 3161-3185.
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Darius P. Zlotos. 2014. Melatonin and Melatonergic Drugs in Clinical Practice. Melatonin and Melatonergic Drugs in Clinical Practice 97 116 .
Lindsay T. Fourman & B. Robert Meyer. (2013) Autoimmune Hepatitis in Association With Ramelteon. Journal of Clinical Gastroenterology 47:7, pages 651-654.
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Katherine A. Lyseng-Williamson. (2013) Melatonin prolonged release: a guide to its use in the treatment of insomnia in patients aged ≥55 years. Drugs & Therapy Perspectives 29:5, pages 125-129.
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Stefano Comai, Rafael Ochoa-Sanchez & Gabriella Gobbi. (2013) Sleep–wake characterization of double MT1/MT2 receptor knockout mice and comparison with MT1 and MT2 receptor knockout mice. Behavioural Brain Research 243, pages 231-238.
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Emilie Clay, Bruno Falissard, Nicholas Moore & Mondher Toumi. (2012) Contribution of prolonged-release melatonin and anti-benzodiazepine campaigns to the reduction of benzodiazepine and z-drugs consumption in nine European countries. European Journal of Clinical Pharmacology 69:4, pages 1-10.
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Rüdiger Hardeland. (2013) Chronobiology of Melatonin beyond the Feedback to the Suprachiasmatic Nucleus—Consequences to Melatonin Dysfunction. International Journal of Molecular Sciences 14:3, pages 5817-5841.
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Hee Yeon ChoiWeon-Jeong Lim. (2013) Current Clinical Practice of Insomnia. The Ewha Medical Journal 36:2, pages 84.
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P. Pévet. 2013. Encyclopedia of Sleep. Encyclopedia of Sleep 442 445 .
Katherine A. Lyseng-Williamson. (2012) Melatonin Prolonged Release. Drugs & Aging 29:11, pages 911-923.
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A. Carpentieri, G. Díaz de Barboza, V. Areco, M. Peralta López & N. Tolosa de Talamoni. (2012) New perspectives in melatonin uses. Pharmacological Research 65:4, pages 437-444.
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Rüdiger Hardeland, Juan Antonio Madrid, Dun-Xian Tan & Russel J. Reiter. (2012) Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling. Journal of Pineal Research 52:2, pages 139-166.
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Mohamed Ettaoussi, Ahmed Sabaouni, Marouan Rami, Jean A. Boutin, Philippe Delagrange, Pierre Renard, Michael Spedding, Daniel-Henri Caignard, Pascal Berthelot & Saïd Yous. (2012) Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I). European Journal of Medicinal Chemistry 49, pages 310-323.
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M.A. Quera SalvaS. Hartley. (2012) Mood Disorders, Circadian Rhythms, Melatonin and Melatonin Agonists. Journal of Central Nervous System Disease 4, pages JCNSD.S4103.
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David N. Neubauer. 2012. Therapy in Sleep Medicine. Therapy in Sleep Medicine 172 180 .
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Lucia Sukys-Claudino, Walter André dos Santos Moraes, Sergio Tufik & Dalva Poyares. (2010) Novos sedativos hipnóticos. Revista Brasileira de Psiquiatria 32:3, pages 288-293.
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Marta Garaulet & Juan Antonio Madrid. (2010) Chronobiological aspects of nutrition, metabolic syndrome and obesity. Advanced Drug Delivery Reviews 62:9-10, pages 967-978.
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Rüdiger Hardeland. (2009) Neuroprotection by Radical Avoidance: Search for Suitable Agents. Molecules 14:12, pages 5054-5102.
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