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Original Research

Cytotoxicity of prostaglandin analog eye drops preserved with benzalkonium chloride in multiple corneoconjunctival cell lines

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Pages 919-924 | Published online: 17 Aug 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Hyun Joo Lee, Roo Min Jun, Min Sun Cho & Kyu-Ryong Choi. (2015) Comparison of the ocular surface changes following the use of two different prostaglandin F2α analogues containing benzalkonium chloride or polyquad in rabbit eyes. Cutaneous and Ocular Toxicology 34:3, pages 195-202.
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Stephen C Pflugfelder & Christophe Baudouin. (2011) Challenges in the clinical measurement of ocular surface disease in glaucoma patients. Clinical Ophthalmology 5, pages 1575-1583.
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Articles from other publishers (18)

John Hovanesian, I Paul Singh, Aditi Bauskar, Srilatha Vantipalli, Rabia Gurses Ozden & Michael H. Goldstein. (2023) Identifying and addressing common contributors to nonadherence with ophthalmic medical therapy. Current Opinion in Ophthalmology 34:Supplement 1, pages S1-S13.
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Yuri Tsugeno, Tatsuya Sato, Megumi Watanabe, Masato Furuhashi, Araya Umetsu, Yosuke Ida, Fumihito Hikage & Hiroshi Ohguro. (2022) Benzalkonium Chloride, Even at Low Concentrations, Deteriorates Intracellular Metabolic Capacity in Human Conjunctival Fibroblasts. Biomedicines 10:9, pages 2315.
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Ching Yi Wu, Mengliang Wu, Xin Huang, Ben J. Gu, Carole Maldonado-Codina, Philip B. Morgan, Laura E. Downie & Holly R. Chinnery. (2022) Topographical Distribution and Phenotype of Resident Meibomian Gland Orifice Immune Cells (MOICs) in Mice and the Effects of Topical Benzalkonium Chloride (BAK). International Journal of Molecular Sciences 23:17, pages 9589.
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Josefine C. Freiberg, Anne Hedengran, Steffen Heegaard, Goran Petrovski, Jette Jacobsen, Barbara Cvenkel & Miriam Kolko. (2022) An Evaluation of the Physicochemical Properties of Preservative-Free 0.005% (w/v) Latanoprost Ophthalmic Solutions, and the Impact on In Vitro Human Conjunctival Goblet Cell Survival. Journal of Clinical Medicine 11:11, pages 3137.
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Chun-Huei LiaoChing-Li TsengShiun-Long LinChung-Ling LiangSuh-Hang H. Juo. (2022) MicroRNA Therapy for Dry Eye Disease. Journal of Ocular Pharmacology and Therapeutics 38:2, pages 125-132.
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Michael H. Goldstein, Fabiana Q. Silva, Nysha Blender, Trung Tran & Srilatha Vantipalli. (2021) Ocular benzalkonium chloride exposure: problems and solutions. Eye 36:2, pages 361-368.
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Katarzyna Barbara Wróblewska, Bartłomiej Milanowski, Małgorzata Kucińska, Szymon Plewa, Jolanta Długaszewska & Izabela Muszalska-Kolos. (2021) Novel Formulation of Eye Drops Containing Choline Salicylate and Hyaluronic Acid: Stability, Permeability, and Cytotoxicity Studies Using Alternative Ex Vivo and In Vitro Models. Pharmaceuticals 14:9, pages 849.
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Kamran Rahmatnejad, Christopher J. Rapuano, Parul Ichhpujani, Sheryl S. Wizov, Marlene R. Moster, Lisa A. Hark & L. Jay Katz. (2018) The Effects of Latanoprost With Benzalkonium Chloride Versus Travoprost With SofZia on the Ocular Surface. Eye & Contact Lens: Science & Clinical Practice 44:2, pages S93-S98.
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Yumi Hashimoto, Seiichi Yokoo, Tomohiko Usui, Yukiko Tsubota & Satoru Yamagami. (2017) High Permeability and Intercellular Space Widening With Brimonidine Tartrate Eye Drops in Cultured Stratified Human Corneal Epithelial Sheets. Cornea 37:2, pages 242-247.
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Gábor Holló, Andreas Katsanos, Kostas G. Boboridis, Murat Irkec & Anastasios G. P. Konstas. (2017) Preservative-Free Prostaglandin Analogs and Prostaglandin/Timolol Fixed Combinations in the Treatment of Glaucoma: Efficacy, Safety and Potential Advantages. Drugs 78:1, pages 39-64.
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H. Fernández Jiménez-Ortiz, N. Toledano Fernández, C.S. Fernández Escamez, S. Perucho Martinez & M.J. Crespo Carballés. (2013) The effects of ocular hypotensive drugs on the cornea: An in vivo analysis with confocal microscopy. Archivos de la Sociedad Española de Oftalmología (English Edition) 88:11, pages 423-432.
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H. Fernández Jiménez-Ortiz, N. Toledano Fernández, C.S. Fernández Escamez, S. Perucho Martinez & M.J. Crespo Carballés. (2013) Efectos corneales de hipotensores oculares que contienen cloruro de benzalconio: análisis in vivo con microscopia confocal. Archivos de la Sociedad Española de Oftalmología 88:11, pages 423-432.
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Hong Liang, Christophe Baudouin, Philippe Daull, Jean-Sébastien Garrigue, Ronald Buggage & Françoise Brignole-Baudouin. (2012) In Vitro and In Vivo Evaluation of a Preservative-Free Cationic Emulsion of Latanoprost in Corneal Wound Healing Models. Cornea 31:11, pages 1319-1329.
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MASAHIKO AYAKI, ATSUO IWASAWA & YOSHIMI NIWANO. (2012) Cell Viability Score as an Integrated Indicator for Cytotoxicity of Benzalkonium Chloride-Containing Antiglaucoma Eyedrops. Biocontrol Science 17:3, pages 121-128.
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Flavio Mantelli, Laura Tranchina, Alessandro Lambiase & Stefano Bonini. (2011) Ocular surface damage by ophthalmic compounds. Current Opinion in Allergy & Clinical Immunology 11:5, pages 464-470.
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Elad MoisseievDavid Varssano. (2011) Comparison of Ocular Tolerability Between Preserved and Preservative-Free Diclofenac Sodium Drops. Journal of Ocular Pharmacology and Therapeutics 27:4, pages 333-337.
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Masahiko Ayaki, Atsuo Iwasawa, Shigeo Yaguchi & Ryohei Koide. (2011) In Vitro Assessment of the Cytotoxicity of Anti-allergic Eye Drops Using 5 Cultured Corneal and Conjunctival Cell Lines. Journal of Oleo Science 60:3, pages 139-144.
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MASAHIKO AYAKI & ATSUO IWASAWA. (2011) Cell Viability of Four Corneoconjunctival Cell Lines Exposed to Five Preservatives and a Surfactant Used for Infection Control in Eyedrops. Biocontrol Science 16:3, pages 117-121.
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