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Review

Current and emerging therapies for the treatment of pancreatic cancer

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Pages 111-127 | Published online: 14 Jul 2010

Keep up to date with the latest research on this topic with citation updates for this article.

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Thinzar M. Lwin, Robert M. Hoffman & Michael Bouvet. (2018) The development of fluorescence guided surgery for pancreatic cancer: from bench to clinic. Expert Review of Anticancer Therapy 18:7, pages 651-662.
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Malyn M Asuncion Valenzuela, Imilce Castro, Amber Gonda, Carlos J Diaz Osterman, Jessica M Jutzy, Jonathan R Aspe, Salma Khan, Jonathan W Neidigh & Nathan R Wall. (2015) Cell death in response to antimetabolites directed at ribonucleotide reductase and thymidylate synthase. OncoTargets and Therapy 8, pages 495-507.
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Lishan Song, Chaojie Xu, Tong Zhang, Shengyang Chen, Zhigang Shi, Shuiquan Hu, Bingbing Cheng, Hao Tong, Guangkun Wei & Xiaoyong Li. (2022) Development and validation of a competing risk model for second primary pancreatic ductal adenocarcinoma: A population-based study. Frontiers in Surgery 9.
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Dan Wang, Chongshun Liu, Yuan Zhou, Tingyu Yan, Chenglong Li, Qionghui Yang, Yang Xu, Lilan Zhao, Qian Pei, Fengbo Tan, Cenap Güngör & Yuqiang Li. (2020) Effect of neoadjuvant radiotherapy on survival of non-metastatic pancreatic ductal adenocarcinoma: a SEER database analysis. Radiation Oncology 15:1.
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M W Steen, L B Rijssen, S Festen, O R Busch, B Groot Koerkamp, L G Geest, I H Hingh, H C Santvoort, M G Besselink & M F Gerhards. (2020) Impact of time interval between multidisciplinary team meeting and intended pancreatoduodenectomy on oncological outcomes. BJS Open 4:5, pages 884-892.
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Ryan Nicoletti, Ruthanne Chun, Kaitlin M. Curran, Louis-Philippe de Lorimier, Michelle A. Morges, Suzanne Rau, Courtney H. Zwehlen & Douglas H. Thamm. (2018) Postsurgical Outcome in Cats with Exocrine Pancreatic Carcinoma: Nine Cases (2007–2016). Journal of the American Animal Hospital Association 54:5, pages 291-295.
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Elisa Dalla Pozza, Marcello Manfredi, Jessica Brandi, Arianna Buzzi, Eleonora Conte, Raffaella Pacchiana, Daniela Cecconi, Emilio Marengo & Massimo Donadelli. (2017) Trichostatin A alters cytoskeleton and energy metabolism of pancreatic adenocarcinoma cells: An in depth proteomic study. Journal of Cellular Biochemistry 119:3, pages 2696-2707.
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Steffi J. E. Rombouts, Maarten W. Nijkamp, Willemijn P. M. van Dijck, Lodewijk A. A. Brosens, Maurits Konings, R. van Hillegersberg, Inne H. M. Borel Rinkes, Jeroen Hagendoorn, Fred H. Wittkampf & I. Quintus Molenaar. (2017) Irreversible Electroporation of the Pancreas Using Parallel Plate Electrodes in a Porcine Model: A Feasibility Study. PLOS ONE 12:1, pages e0169396.
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Vanessa L Beesley, Leesa F Wockner, Peter O’Rourke, Monika Janda, David Goldstein, Helen Gooden, Neil D Merrett, Dianne L O’Connell, Ingrid J Rowlands, David K Wyld & Rachel E Neale. (2016) Risk factors for current and future unmet supportive care needs of people with pancreatic cancer. A longitudinal study. Supportive Care in Cancer 24:8, pages 3589-3599.
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María-Victoria Alvarez-Sánchez & Bertrand Napoléon. (2016) Review of endoscopic radiofrequency in biliopancreatic tumours with emphasis on clinical benefits, controversies and safety. World Journal of Gastroenterology 22:37, pages 8257.
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H Sugimoto, M Nakamura, H Yoda, K Hiraoka, K Shinohara, M Sang, K Fujiwara, O Shimozato, H Nagase & T Ozaki. (2015) Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death. Cell Death & Disease 6:10, pages e1914-e1914.
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H Sugimoto, M Nakamura, H Yoda, K Hiraoka, K Shinohara, M Sang, K Fujiwara, O Shimozato, H Nagase & T Ozaki. (2015) Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death. Cell Death Discovery 1:1.
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Helga L. Weber, Manuel Gidekel, Santiago Werbajh, Edgardo Salvatierra, Cecilia Rotondaro, Leonardo Sganga, Gabriela Acosta Haab, David T. Curiel, Eduardo G. Cafferata & Osvaldo L. Podhajcer. (2015) A Novel CDC25B Promoter–Based Oncolytic Adenovirus Inhibited Growth of Orthotopic Human Pancreatic Tumors in Different Preclinical Models . Clinical Cancer Research 21:7, pages 1665-1674.
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S. Fegrachi, I.Q. Molenaar, J.H. Klaessens, M.G. Besselink, J.A. Offerhaus & R. van Hillegersberg. (2014) Radiofrequency ablation of the pancreas: Two-week follow-up in a porcine model. European Journal of Surgical Oncology (EJSO) 40:8, pages 1000-1007.
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Samira Fegrachi, Marc G. Besselink, Hjalmar C. van Santvoort, Richard van Hillegersberg & Izaak Quintus Molenaar. (2014) Radiofrequency ablation for unresectable locally advanced pancreatic cancer: a systematic review. HPB 16:2, pages 119-123.
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Samira Fegrachi, I. Quintus Molenaar, John H. Klaessens, Marc G. Besselink, Johan A. Offerhaus & Richard van Hillegersberg. (2013) Radiofrequency ablation of the pancreas with and without intraluminal duodenal cooling in a porcine model. Journal of Surgical Research 184:2, pages 867-872.
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J. R. E. Rees, R. C. Macefield, N. S. Blencowe, D. Alderson, M. D. Finch-Jones & J. M. Blazeby. (2013) A Prospective Study of Patient Reported Outcomes in Pancreatic and Peri-ampullary Malignancy. World Journal of Surgery 37:10, pages 2443-2453.
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M. J. Linderman, E. M. Brodsky, L.-P. de Lorimier, C. A. Clifford & G. S. Post. (2013) Feline exocrine pancreatic carcinoma: a retrospective study of 34 cases. Veterinary and Comparative Oncology 11:3, pages 208-218.
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WEI LI, LIN PING XU, LING DI ZHAO, LI WANG, YONG ZHANG, QUAN LI GAO & LING MAI. (2013) Cytokine-induced killer cell therapy for advanced pancreatic adenocarcinoma: A case report and review of the literature. Oncology Letters 5:4, pages 1427-1429.
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E R Camp, C Wang, E C Little, P M Watson, K F Pirollo, A Rait, D J Cole, E H Chang & D K Watson. (2013) Transferrin receptor targeting nanomedicine delivering wild-type p53 gene sensitizes pancreatic cancer to gemcitabine therapy. Cancer Gene Therapy 20:4, pages 222-228.
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Marie Lafitte, Benoit Rousseau, Isabelle Moranvillier, Miguel Taillepierre, Evelyne Peuchant, Véronique Guyonnet-Dupérat, Aurélie Bedel, Pierre Dubus, Hubert de Verneuil, François Moreau-Gaudry & Sandrine Dabernat. (2012) In vivo gene transfer targeting in pancreatic adenocarcinoma with cell surface antigens. Molecular Cancer 11:1.
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Lesley A. Mathews, Jonathan M. Keller, Bonnie L. Goodwin, Rajarshi Guha, Paul Shinn, Rebecca Mull, Craig J. Thomas, Rachel L. de Kluyver, Thomas J. Sayers & Marc Ferrer. (2012) A 1536-Well Quantitative High-Throughput Screen to Identify Compounds Targeting Cancer Stem Cells. SLAS Discovery 17:9, pages 1231-1242.
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Simon W. Nienhuijs, Sanne A. van den Akker, Esther de Vries, Ignace H. de Hingh, Otto Visser & Valery E. Lemmens. (2012) Nationwide Improvement of Only Short-Term Survival After Resection for Pancreatic Cancer in The Netherlands. Pancreas 41:7, pages 1063-1066.
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Elizabeth C. Little, Cindy Wang, Patricia M. Watson, Dennis K. Watson, David J. Cole & E. Ramsay Camp. (2012) Novel Immunocompetent Murine Models Representing Advanced Local and Metastatic Pancreatic Cancer. Journal of Surgical Research 176:2, pages 359-366.
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Sonal Gupta, Dipankar Pramanik, Radha Mukherjee, Nathaniel R. Campbell, Sathyanarayanan Elumalai, Roeland F. de Wilde, Seung-Mo Hong, Michael G. Goggins, Ana De Jesus-Acosta, Daniel Laheru & Anirban Maitra. (2012) Molecular Determinants of Retinoic Acid Sensitivity in Pancreatic Cancer. Clinical Cancer Research 18:1, pages 280-289.
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Lesley A. Mathews, Stephanie M. Cabarcas, Elaine M. Hurt, Xiaohu Zhang, Elizabeth M. Jaffee & William L. Farrar. (2011) Increased Expression of DNA Repair Genes in Invasive Human Pancreatic Cancer Cells. Pancreas 40:5, pages 730-739.
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Lesley A. Mathews, Stephanie M. Cabarcas & William L. Farrar. (2011) DNA repair: the culprit for tumor-initiating cell survival?. Cancer and Metastasis Reviews 30:2, pages 185-197.
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