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Review

Miltefosine in the treatment of leishmaniasis: Clinical evidence for informed clinical risk management

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Pages 733-740 | Published online: 24 Dec 2022

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Andrea Naranjo, Jaime D. Martinez, Darlene Miller, Rahul Tonk & Guillermo Amescua. (2021) Systemic Miltefosine as an Adjunct Treatment of Progressive Acanthamoeba Keratitis. Ocular Immunology and Inflammation 29:7-8, pages 1576-1584.
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Sibgha Batool, Fatima Zahid, Fakhar- Ud-Din, Syeda Sohaila Naz, Muhammad Junaid Dar, Muhammad Waseem Khan, Alam Zeb & Gul Majid Khan. (2021) Macrophage targeting with the novel carbopol-based miltefosine-loaded transfersomal gel for the treatment of cutaneous leishmaniasis: in vitro and in vivo analyses. Drug Development and Industrial Pharmacy 47:3, pages 440-453.
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Ema Avdagic, Hall F. Chew, Peter Veldman, Elmer Y. Tu, Mansab Jafri, Rutvi Doshi, Andrea K. Boggild, James J. Reidy & Asim V. Farooq. (2021) Resolution of Acanthamoeba Keratitis with Adjunctive Use of Oral Miltefosine. Ocular Immunology and Inflammation 29:2, pages 278-281.
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Juliana Q. Reimão, Débora P. Pita Pedro & Adriano C. Coelho. (2020) The preclinical discovery and development of oral miltefosine for the treatment of visceral leishmaniasis: a case history. Expert Opinion on Drug Discovery 15:6, pages 647-658.
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Vanessa Ortega, Selma Giorgio & Eneida de Paula. (2017) Liposomal formulations in the pharmacological treatment of leishmaniasis: a review. Journal of Liposome Research 27:3, pages 234-248.
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Manu Vanaerschot, Franck Dumetz, Syamal Roy, Alicia Ponte-Sucre, Jorge Arevalo & Jean-Claude Dujardin. (2014) Treatment failure in leishmaniasis: drug-resistance or another (epi-) phenotype?. Expert Review of Anti-infective Therapy 12:8, pages 937-946.
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Maha M. Eissa, Eglal I. Amer, Shereen F. Mossallam, Maha M. Gomaa & Nahed M. Baddour. (2012) Miltefosine for Old World cutaneous leishmaniasis: An experimental study on Leishmania major infected mice. Alexandria Journal of Medicine 48:3, pages 261-271.
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E Sinkala, M Katubulushi, S Sianongo, A Obwaller & P Kelly. (2011) In a trial of the use of miltefosine to treat HIV‐related cryptosporidiosis in Zambian adults, extreme metabolic disturbances contribute to high mortality. Annals of Tropical Medicine & Parasitology 105:2, pages 129-134.
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Smriti Mondal, Pradyot Bhattacharya & Nahid Ali. (2010) Current diagnosis and treatment of visceral leishmaniasis. Expert Review of Anti-infective Therapy 8:8, pages 919-944.
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Sheila J Thornton & Kishor M Wasan. (2009) The reformulation of Amphotericin B for oral administration to treat systemic fungal infections and visceral leishmaniasis. Expert Opinion on Drug Delivery 6:3, pages 271-284.
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