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Special Report

Metabolic and cardiovascular effects of berberine: from preclinical evidences to clinical trial results

Pages 553-563 | Published online: 18 Jan 2017

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Antonio Cianci, Arrigo F. G. Cicero, Nicola Colacurci, Maria Grazia Matarazzo & Vincenzo De Leo. (2012) Activity of isoflavones and berberine on vasomotor symptoms and lipid profile in menopausal women. Gynecological Endocrinology 28:9, pages 699-702.
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Articles from other publishers (32)

Priya Chaudhary, Pracheta Janmeda, Anca Oana Docea, Balakyz Yeskaliyeva, Ahmad Faizal Abdull Razis, Babagana Modu, Daniela Calina & Javad Sharifi-Rad. (2023) Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases. Frontiers in Chemistry 11.
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Tapan Behl, Sukhbir Singh, Neelam Sharma, Ishrat Zahoor, Ali Albarrati, Mohammed Albratty, Abdulkarim M. Meraya, Asim Najmi & Simona Bungau. (2022) Expatiating the Pharmacological and Nanotechnological Aspects of the Alkaloidal Drug Berberine: Current and Future Trends. Molecules 27:12, pages 3705.
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Avinash Shenoy, Harpal S. Buttar, ParnikaDilip Dicholkar, Ginpreet Kaur & Meena Chintamaneni. 2022. Functional Foods and Nutraceuticals in Metabolic and Non-Communicable Diseases. Functional Foods and Nutraceuticals in Metabolic and Non-Communicable Diseases 583 601 .
Roberta D’Assante, Mariarosaria De Luca, Sergio Ferraro, Andrea Ferraro, Antonio Ruvolo, Francesco Natale, Pietro Sotgiu, Maurizio Petitto, Romolo Rizzo, Umberto De Maria, Luigi Liguori, Gianluigi Gentile, Paola Ragucci, Vittorio Donadio, Valeria Valente & Antonio Cittadini. (2021) Beneficial Metabolic Effect of a Nutraceuticals Combination (Monacolin K, Yeasted Red Rice, Polyphenolic Extract of Annurca Apple and Berberine) on Acquired Hypercholesterolemia: A Prospective Analysis. Metabolites 11:4, pages 223.
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Kalyan Hazra, Achintya Mitra, Ravindra Singh, Arjun Singh & Jayram Hazra. (2021) Rationalisation of extractive protocol by high-performance thin-layer chromatographic–densitometric quantification of berberine in multiple hydroalcoholic extract of Tinospora cordifolia stem. JPC – Journal of Planar Chromatography – Modern TLC 34:2, pages 157-163.
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Khaled AbouAitah & Witold Lojkowski. (2021) Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy. Pharmaceutics 13:2, pages 143.
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Rajeev Kumar, Nitin Sharma, Rajan Rolta, Uma Ranjan Lal, Anuradha Sourirajan, Kamal Dev & Vikas Kumar. (2020) Thalictrum foliolosum DC: An unexplored medicinal herb from north western Himalayas with potential against fungal pathogens and scavenger of reactive oxygen species. Biocatalysis and Agricultural Biotechnology 26, pages 101621.
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Ying Li & Chunyan Zhu. (2020) Development and In Vitro and In Vivo Evaluation of Microspheres Containing Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate for the Oral Delivery of Berberine Hydrochloride. Molecules 25:8, pages 1957.
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Roy Upton. 2020. Textbook of Natural Medicine. Textbook of Natural Medicine 648 657.e3 .
Yueh-Hsiang Huang, Szu-Tah Chen, Feng-Hsuan Liu, Sheng-Hwu Hsieh, Chia-Hung Lin, Miaw-Jene Liou, Chih-Ching Wang, Chung-Huei Huang, Geng-Hao Liu, Jr-Rung Lin, Lan-Yan Yang, Tzu-Yang Hsu, Ming-Chung Lee, Chun-Teng Huang & Yi-Hong Wu. (2019) The efficacy and safety of concentrated herbal extract granules, YH1, as an add-on medication in poorly controlled type 2 diabetes: A randomized, double-blind, placebo-controlled pilot trial. PLOS ONE 14:8, pages e0221199.
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Hui-Hui Guo, Chen-Lin Feng, Wen-Xuan Zhang, Zhi-Gang Luo, Hong-Juan Zhang, Ting-Ting Zhang, Chen Ma, Yun Zhan, Rui Li, Song Wu, Zeper Abliz, Cong Li, Xiao-Lin Li, Xiao-Lei Ma, Lu-Lu Wang, Wen-Sheng Zheng, Yan-Xing Han & Jian-Dong Jiang. (2019) Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases. Nature Communications 10:1.
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William Setzer. (2018) The Phytochemistry of Cherokee Aromatic Medicinal Plants. Medicines 5:4, pages 121.
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Graziano Riccioni, Maria Gammone, Walter Currenti & Nicolantonio D’Orazio. (2018) Effectiveness and Safety of Dietetic Supplementation of a New Nutraceutical on Lipid Profile and Serum Inflammation Biomarkers in Hypercholesterolemic Patients. Molecules 23:5, pages 1168.
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Giuseppe Marazzi, Giuseppe Campolongo, Francesco Pelliccia, Silvia Quattrino, Cristiana Vitale, Luca Cacciotti, Rosalba Massaro, Maurizio Volterrani & Giuseppe Rosano. (2017) Comparison of Low-Dose Statin Versus Low-Dose Statin + Armolipid Plus in High-Intensity Statin-Intolerant Patients With a Previous Coronary Event and Percutaneous Coronary Intervention (ADHERENCE Trial). The American Journal of Cardiology 120:6, pages 893-897.
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Vivencio Barrios, Carlos Escobar, Arrigo Francesco Giuseppe Cicero, David Burke, Peter Fasching, Maciej Banach & Eric Bruckert. (2017) A nutraceutical approach (Armolipid Plus) to reduce total and LDL cholesterol in individuals with mild to moderate dyslipidemia: Review of the clinical evidence. Atherosclerosis Supplements 24, pages 1-15.
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Shengyao Li, Ming Guo, Huimin Mao, Zhuye Gao, Hao Xu & Dazhuo Shi. (2016) Qing-Xin-Jie-Yu Granules in addition to conventional treatment for patients with stable coronary artery disease (QUEST Trial): study protocol for a randomized controlled trial. Trials 17:1.
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Xiaopeng Zhu, Hua Bian & Xin Gao. (2016) The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease. Molecules 21:10, pages 1336.
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Arrigo F.G. Cicero & Alessandro Colletti. (2016) Role of phytochemicals in the management of metabolic syndrome. Phytomedicine 23:11, pages 1134-1144.
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Arrigo F.G. Cicero & Alessandro Colletti. (2016) Combinations of phytomedicines with different lipid lowering activity for dyslipidemia management: The available clinical data. Phytomedicine 23:11, pages 1113-1118.
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Jesus Millán, Arrigo F.G. Cicero, Francisco Torres & Anna Anguera. (2016) Effects of a nutraceutical combination containing berberine (BRB), policosanol, and red yeast rice (RYR), on lipid profile in hypercholesterolemic patients: A meta-analysis of randomised controlled trials. Clínica e Investigación en Arteriosclerosis 28:4, pages 178-187.
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Arrigo FG Cicero, Martina Rosticci, Angelo Parini, Martino Morbini, Riccardo Urso, Elisa Grandi & Claudio Borghi. (2015) Short-term effects of a combined nutraceutical of insulin-sensitivity, lipid level and indexes of liver steatosis: a double-blind, randomized, cross-over clinical trial. Nutrition Journal 14:1.
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Stefano Gonnelli, Carla Caffarelli, Kostantinos Stolakis, Claudia Cuda, Nicola Giordano & Ranuccio Nuti. (2015) Efficacy and Tolerability of a Nutraceutical Combination (Red Yeast Rice, Policosanols, and Berberine) in Patients with Low-Moderate Risk Hypercholesterolemia: A Double-Blind, Placebo-Controlled Study. Current Therapeutic Research 77, pages 1-6.
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Xin-Pei Wang, Fan Lei, Feng Du, Yu-Shuang Chai, Jing-Fei Jiang, Yu-Gang Wang, Xuan Yu, Xiao-Jin Yan, Dong-Ming Xing & Li-Jun Du. (2015) Protection of Gastrointestinal Mucosa from Acute Heavy Alcohol Consumption: The Effect of Berberine and Its Correlation with TLR2, 4/IL1β-TNFα Signaling. PLOS ONE 10:7, pages e0134044.
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Arrigo F.G. Cicero, Angelo Parini & Martina Rosticci. (2015) Nutraceuticals and cholesterol-lowering action. IJC Metabolic & Endocrine 6, pages 1-4.
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Arrigo F. G. Cicero & Alessandro Colletti. 2015. Combination Therapy In Dyslipidemia. Combination Therapy In Dyslipidemia 127 142 .
Han-Ming Cui, Qiu-Yan Zhang, Jia-Long Wang, Jian-Long Chen, Yu-Ling Zhang & Xiao-Lin Tong. (2014) In vitro studies of berberine metabolism and its effect of enzyme induction on HepG2 cells. Journal of Ethnopharmacology 158, pages 388-396.
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Arrigo F.G. CiceroElisa TartagniAlienor FerroniValeria De SandoElisa GrandiClaudio Borghi. (2013) Combined Nutraceutical Approach to Postmenopausal Syndrome and Vascular Remodeling Biomarkers. The Journal of Alternative and Complementary Medicine 19:6, pages 582-587.
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Arrigo F. G. Cicero, Valeria De Sando, Danilo Benedetto, Matteo Cevenini, Elisa Grandi & Claudio Borghi. (2012) Long-term efficacy and tolerability of a multicomponent lipid-lowering nutraceutical in overweight and normoweight patients. Nutrafoods 11:2, pages 55-61.
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Yi-Hong Wu, Yi-Chia Wei, Yu-Shan Tai, Kuan-Jen Chen & Hsueh-Yu Li. (2012) Clinical Outcomes of Traditional Chinese Medicine Compound Formula in Treating Sleep-Disordered Breathing Patients. The American Journal of Chinese Medicine 40:01, pages 11-24.
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Ting Wang, Ning Wang, Hui Song, Xiaonan Xi, JianAn Wang, Aijun Hao & Tiefu Li. (2011) Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine. European Journal of Pharmaceutical Sciences 44:1-2, pages 127-135.
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Bruno Trimarco, Claudio Benvenuti, Francesco Rozza, Claudia Sara Cimmino, Renata Giudice & Salvatore Crispo. (2011) Clinical evidence of efficacy of red yeast rice and berberine in a large controlled study versus diet. Mediterranean Journal of Nutrition and Metabolism 4:2, pages 133-139.
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Satin Salehi & Theresa M. Filtz. (2011) Berberine possesses muscarinic agonist-like properties in cultured rodent cardiomyocytes. Pharmacological Research 63:4, pages 335-340.
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