46
Views
83
CrossRef citations to date
0
Altmetric
Original Article

An Enquiry on the Morphological Characteristics and Possible Changes with Age in the Olfactory Region of Man

Pages 49-62 | Received 18 May 1970, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Takashi Kashiwagi, Yasuhiro Tsunemi, Makoto Akutsu, Itsuo Nakajima & Shinichi Haruna. (2019) Postoperative evaluation of olfactory dysfunction in eosinophilic chronic rhinosinusitis – comparison of histopathological and clinical findings. Acta Oto-Laryngologica 139:10, pages 881-889.
Read now
CharlesJ. Wysocki & MarciaL. Pelchat. (1993) The effects of aging on the human sense of smell and its relationship to food choice. Critical Reviews in Food Science and Nutrition 33:1, pages 63-82.
Read now
Tsunemasa Aiba & Yoshiaki Nakai. (1991) Influence of Experimental Rhino-sinusitis on Olfactory Epithelium. Acta Oto-Laryngologica 111:sup486, pages 184-192.
Read now

Articles from other publishers (80)

Kyle M. Roddick, Heather M. Schellinck & Richard E. Brown. (2023) Serial reversal learning in an olfactory discrimination task in 3xTg-AD mice. Learning & Memory 30:12, pages 310-319.
Crossref
Huart Caroline, Philippe Eloy & Philippe Rombaux. 2023. Nasal Physiology and Pathophysiology of Nasal Disorders. Nasal Physiology and Pathophysiology of Nasal Disorders 381 402 .
Mira Fitzek, Parthkumar K. Patel, Peter D. Solomon, Brian Lin, Thomas Hummel, James E. Schwob & Eric H. Holbrook. (2022) Integrated age‐related immunohistological changes occur in human olfactory epithelium and olfactory bulb. Journal of Comparative Neurology 530:12, pages 2154-2175.
Crossref
Walaa Abdelwahab Abdeghani Basha, Sameh Mohamed Farouk & Said Ahmed Mohamed Hassan. (2022) Anatomical, histochemical and surface ultrastructural characteristics of cavum nasi of the common quails ( Coturnix coturnix. Erlangeri ) . Anatomia, Histologia, Embryologia 51:4, pages 468-476.
Crossref
建三 都築. (2022) 加齢による感覚器・運動器障害と認知症―高齢者における嗅覚障害―. Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo) 125:2, pages 112-120.
Crossref
Xiaoguang Yan, Akshita Joshi, Yunpeng Zang, Francisca Assunção, Henrique M. Fernandes & Thomas Hummel. (2022) The Shape of the Olfactory Bulb Predicts Olfactory Function. Brain Sciences 12:2, pages 128.
Crossref
Eri Mori, Rumi Ueha, Kenji Kondo, Shotaro Funada, Hajime Shimmura, Kai Kanemoto, Hirotaka Tanaka, Hironobu Nishijima, Nobuyoshi Otori, Tatsuya Yamasoba & Hiromi Kojima. (2021) Squamous and Respiratory Metaplasia After Olfactory Mucosal Resection. Frontiers in Neuroscience 15.
Crossref
Shima T. Moein, Seyed MohammadReza Hashemian, Payam Tabarsi & Richard L. Doty. (2020) Prevalence and reversibility of smell dysfunction measured psychophysically in a cohort of COVID‐19 patients. International Forum of Allergy & Rhinology 10:10, pages 1127-1135.
Crossref
Sofia Håglin, Anna Berghard & Staffan Bohm. (2020) Increased Retinoic Acid Catabolism in Olfactory Sensory Neurons Activates Dormant Tissue-Specific Stem Cells and Accelerates Age-Related Metaplasia. The Journal of Neuroscience 40:21, pages 4116-4129.
Crossref
Thomas Hummel & Anna Oleszkiewicz. 2020. The Senses: A Comprehensive Reference. The Senses: A Comprehensive Reference 717 726 .
James E. Schwob, Richard M. Costanzo & Steven L. Youngentob. 2020. The Senses: A Comprehensive Reference. The Senses: A Comprehensive Reference 565 590 .
Jennifer J. Stamps. 2019. Cognitive Changes and the Aging Brain. Cognitive Changes and the Aging Brain 68 94 .
C. Huart, Ph Rombaux & T. Hummel. (2019) Neural plasticity in developing and adult olfactory pathways – focus on the human olfactory bulb. Journal of Bioenergetics and Biomembranes 51:1, pages 77-87.
Crossref
Emanuele Brai & Lavinia Alberi. 2018. Sensory Nervous System. Sensory Nervous System.
S. M. Farouk, S. A. Hassan & M. A. Emam. (2017) Histochemical and surface ultrastructural characteristics of the nasal cavity of laughing dove. Anatomia, Histologia, Embryologia 46:6, pages 592-599.
Crossref
James E. Schwob, Woochan Jang, Eric H. Holbrook, Brian Lin, Daniel B. Herrick, Jesse N. Peterson & Julie Hewitt Coleman. (2017) Stem and progenitor cells of the mammalian olfactory epithelium: Taking poietic license. Journal of Comparative Neurology 525:4, pages 1034-1054.
Crossref
Richard L. Doty. 2017. Springer Handbook of Odor. Springer Handbook of Odor 59 60 .
Philippe Rombaux, C. Huart, P. Levie, C. Cingi & T. Hummel. (2016) Olfaction in Chronic Rhinosinusitis. Current Allergy and Asthma Reports 16:5.
Crossref
Alan Mackay-Sim, James St John & James E. Schwob. 2015. Handbook of Olfaction and Gustation. Handbook of Olfaction and Gustation 133 156 .
Kelly Hale & Kay StanneyDavid Jones, Sara Dechmerowski, Razia Oden, Valerie Lugo, Jingjing Wang-Costello & William Pike. 2014. Handbook of Virtual Environments. Handbook of Virtual Environments 131 161 .
Richard L. Doty, Austin H. Berman, Mohammad Izhar, Hugh B. Hamilton, Danylko Villano, Britney E. Vazquez, Maja N. Warrum & Mariam Mahbob. (2014) Influenza Vaccinations and Chemosensory Function. American Journal of Rhinology & Allergy 28:1, pages 50-53.
Crossref
Takao OGAWA. (2014) Age-related olfactory dysfunction and congenital anosmia老年性嗅覚障害と先天性嗅覚障害. Journal of Japan Association on Odor Environment 45:4, pages 287-297.
Crossref
Caroline Huart, Philippe Rombaux & Thomas Hummel. (2013) Plasticity of the Human Olfactory System: The Olfactory Bulb. Molecules 18:9, pages 11586-11600.
Crossref
Caroline Huart, Philippe Eloy & Philippe Rombaux. 2013. Nasal Physiology and Pathophysiology of Nasal Disorders. Nasal Physiology and Pathophysiology of Nasal Disorders 113 137 .
Richard C. Krolewski, Woochan Jang & James E. Schwob. (2011) The generation of olfactory epithelial neurospheres in vitro predicts engraftment capacity following transplantation in vivo. Experimental Neurology 229:2, pages 308-323.
Crossref
David Tsui & Derek van der Kooy. (2008) Serotonin mediates a learned increase in attraction to high concentrations of benzaldehyde in aged C. elegans . Learning & Memory 15:11, pages 844-855.
Crossref
Salvatore Caruso, Agostino Serra, Calogero Grillo, Luigi Maiolino, Carmela Agnello, Lucia Di Mari & Antonio Cianci. (2008) Characteristics of nasal epithelial cells in naturally postmenopausal women receiving hormone therapy with 1 mg 17β-estradiol and 2 mg drospirenone. Menopause 15:5, pages 963-966.
Crossref
G. Demarquay, P. Ryvlin & J.P. Royet. (2007) Olfaction et pathologies neurologiques : revue de la littérature. Revue Neurologique 163:2, pages 155-167.
Crossref
Bum Sun Kwon, Min Kyu Kim, Woo Ho Kim, Jung-Soo Pyo, Young Hee Cheon, Choong Ik Cha, Seon Young Nam, Tai-Kyoung Baik & Byung Lan Lee. (2005) Age-related changes in microvillar cells of rat olfactory epithelium. Neuroscience Letters 378:2, pages 65-69.
Crossref
R C. Kern, D B. Conley, G K. HainesIIIIII & A M. Robinson. (2004) Treatment of Olfactory Dysfunction, II: Studies With Minocycline. The Laryngoscope 114:12, pages 2200-2204.
Crossref
Salvatore Caruso, Calogero Grillo, Carmela Agnello, Lucia Di Mari, Marco Farina & Agostino Serra. (2004) Olfactometric and rhinomanometric outcomes in post-menopausal women treated with hormone therapy: a prospective study. Human Reproduction 19:12, pages 2959-2964.
Crossref
Kristin A. Seiberling & David B. Conley. (2004) Aging and olfactory and taste function. Otolaryngologic Clinics of North America 37:6, pages 1209-1228.
Crossref
N Giannetti, E Moyse, A Ducray, J.-R Bondier, F Jourdan, A Propper & A Kastner. (2004) Accumulation of Ym1/2 protein in the mouse olfactory epithelium during regeneration and aging. Neuroscience 123:4, pages 907-917.
Crossref
David B. Conley, Alan M. Robinson, Michael J. Shinners & Robert C. Kern. (2018) Age-Related Olfactory Dysfunction: Cellular and Molecular Characterization in the Rat. American Journal of Rhinology 17:3, pages 169-175.
Crossref
Edward Morrison & Bert Menco. 2003. Handbook of Olfaction and Gustation. Handbook of Olfaction and Gustation.
Dean Clerico, Wyatt To & Donald Lanza. 2003. Handbook of Olfaction and Gustation. Handbook of Olfaction and Gustation.
Salvatore Caruso, Lucia Roccasalva, Enza Di Fazio, Gloria Sapienza, Carmela Agnello, Simona Ficarra, Lucia Di Mari & Agostino Serra. (2003) Cytologic aspects of the nasal respiratory epithelium in postmenopausal women treated with hormone therapy. Fertility and Sterility 79:3, pages 543-549.
Crossref
Thomas Hummel, Stefan Heilmann & Claire Murphy. 2009. Olfaction, Taste, and Cognition. Olfaction, Taste, and Cognition 441 456 .
Catherine Rouby, Benoist Schaal, Danièle Dubois, Rémi Gervais & A. Holley. 2009. Olfaction, Taste, and Cognition. Olfaction, Taste, and Cognition 389 390 .
Mario F. Dulay & Claire Murphy. (2002) Olfactory acuity and cognitive function converge in older adulthood: Support for the common cause hypothesis.. Psychology and Aging 17:3, pages 392-404.
Crossref
Alan M. Robinson, D. B. Conley, M. J. Shinners & Robert C. Kern. (2009) Apoptosis in the Aging Olfactory Epithelium. The Laryngoscope 112:8, pages 1431-1435.
Crossref
Susan S Schiffman & Jennifer Zervakis. 2002. 247 346 .
Chihiro Nakayasu, Fukujyu Kanemura, Yoshiyuki Hirano, Yasutake Shimizu & Keiichi Tonosaki. (2000) Sensitivity of the olfactory sense declines with the aging in senescence-accelerated mouse (SAM-P1). Physiology & Behavior 70:1-2, pages 135-139.
Crossref
Edward W. Johnson. (2000) Immunocytochemical characteristics of cells and fibers in the nasal mucosa of young and adult macaques. The Anatomical Record 259:2, pages 215-228.
Crossref
Robert C. Kern. (2009) Candidate's Thesis: Chronic Sinusitis and Anosmia: Pathologic Changes in the Olfactory Mucosa. The Laryngoscope 110:7, pages 1071-1077.
Crossref
STEVEN E. ARNOLD, GREGORY S. SMUTZER, JOHN Q. TROJANOWSKI & PAUL J. MOBERG. (1998) Cellular and Molecular Neuropathology of the Olfactory Epithelium and Central Olfactory Pathways in Alzheimer's Disease and Schizophreniaa. Annals of the New York Academy of Sciences 855:1 OLFACTION AND, pages 762-775.
Crossref
ESMAIL MEISAMI, LAURA MIKHAIL, DARRIN BAIM & KUNWAR P. BHATNAGAR. (1998) Human Olfactory Bulb: Aging of Glomeruli and Mitral Cells and a Search for the Accessory Olfactory Bulba. Annals of the New York Academy of Sciences 855:1 OLFACTION AND, pages 708-715.
Crossref
Wen-Hui Feng, John S. Kauer, Lester Adelman & Barbara R. Talamo. (1997) New structure, the ?olfactory pit,? in human olfactory mucosa. The Journal of Comparative Neurology 378:4, pages 443-453.
Crossref
T. Hirai, S. Kojima, A. Shimada, T. Umemura, M. Sakai & C. Itakurat. (2008) Age‐related changes in the olfactory system of dogs. Neuropathology and Applied Neurobiology 22:6, pages 531-539.
Crossref
Alice T. Loo, Steven L. Youngentob, Paul F. Kent & James E. Schwob. (1996) The aging olfactory epithelium: Neurogenesis, response to damage, and odorant-induced activity. International Journal of Developmental Neuroscience 14:7-8, pages 881-900.
Crossref
N. Thüraüf, M. Gjuric, G. Kobal & H. Hatt. (2006) Cyclic Nucleotide‐gated Channels in Identified Human Olfactory Receptor Neurons. European Journal of Neuroscience 8:10, pages 2080-2089.
Crossref
David R. Edelstein. (1996) Aging of the Normal Nose in Adults. The Laryngoscope 106:S81, pages 1-25.
Crossref
Edward E. Morrison & Richard M. Contanzo. (1995) Regeneration of olfactory sensory neurons and reconnection in the aging hamster central nervous system. Neuroscience Letters 198:3, pages 213-217.
Crossref
W. James Evans, Liying Cui & Arnold Starr. (1995) Olfactory event-related potentials in normal human subjects: effects of age and gender. Electroencephalography and Clinical Neurophysiology 95:4, pages 293-301.
Crossref
James E. Schwob, Steven L. Youngentob & Renee C. Mezza. (2004) Reconstitution of the rat olfactory epithelium after methyl bromide‐induced lesion. Journal of Comparative Neurology 359:1, pages 15-37.
Crossref
Nancy L. Segal, Tari D. Topolski, Steven M. Wilson, Kathleen W. Brown & Linda Araki. (1995) Twin analysis of odor identification and perception. Physiology & Behavior 57:3, pages 605-609.
Crossref
L. Vallés San Leandro, I. Arcas Martínez-Salas, M.P. Villegas Pérez, J. García González, A.M. Gómez Ramírez, M. Redondo Manuel, A.R. Gutiérrez Ortega, J.B. López Lloret & J. Miralles De Imperial. (2018) Esthesioneuroblastoma: An Atypical Form of Manifestation. European Journal of Ophthalmology 4:2, pages 118-122.
Crossref
James E. Schwob, Steven L. Youngentob & Karina F. Meiri. (2004) On the formation of neuromata in the primtary olfactory projection. Journal of Comparative Neurology 340:3, pages 361-380.
Crossref
D.C. Davies, J.W. Brooks & D.A. Lewis. (1993) Axonal loss from the olfactory tracts in alzheimer's disease. Neurobiology of Aging 14:4, pages 353-357.
Crossref
Meng Inn Chuah & Da Ren Zheng. (2005) The human primary olfactory pathway: Fine structural and cytochemical aspects during development and in adults. Microscopy Research and Technique 23:1, pages 76-85.
Crossref
Tomonori Nagurok & Kazuto Iwashita. (2005) Olfactory epithelium in young adult and aging rats as seen with high‐resolution scanning electron microscopy. Microscopy Research and Technique 23:1, pages 62-75.
Crossref
Edward E. Morrison & Richard M. Costanzo. (2005) Morphology of olfactory epithelium in humans and other vertebrates. Microscopy Research and Technique 23:1, pages 49-61.
Crossref
Frank Schieber. 1992. Handbook of Mental Health and Aging. Handbook of Mental Health and Aging 251 306 .
James E. Schwob. 1992. Science of Olfaction. Science of Olfaction 80 125 .
Susan S. Schiffman. 1992. Science of Olfaction. Science of Olfaction 500 525 .
RICHARD L. DOTY. (1991) Olfactory Capacities in Aging and Alzheimer's Diseasea. Annals of the New York Academy of Sciences 640:1, pages 20-27.
Crossref
John Q. Trojanowski, Paul D. Newman, William D. Hill & Virginia M.‐Y. Lee. (2004) Human olfactory epithelium in normal aging, alzheimer's disease, and other neurodegenerative disorders. Journal of Comparative Neurology 310:3, pages 365-376.
Crossref
Richard L Doty. 1991. The Human Sense of Smell. The Human Sense of Smell 181 195 .
Edward E. Morrison & Richard M. Costanzo. (2004) Morphology of the human olfactory epithelium. Journal of Comparative Neurology 297:1, pages 1-13.
Crossref
S. J. Massicotte, P. S. Hersh, G. R. Dickersin, J. L. Craft & D. M. Albert. (1987) Olfactory neuroblastoma metastatic to the eye. Graefes Archive for Clinical and Experimental Ophthalmology 225:4, pages 285-290.
Crossref
Eugene Roberts. (1986) Alzheimer's disease may begin in the nose and may be caused by aluminosilicates. Neurobiology of Aging 7:6, pages 561-567.
Crossref
Richard L. Doty, Paul Shaman, Steven L. Applebaum, Ronita Giberson, Lenore Siksorski & Lysa Rosenberg. (1984) Smell Identification Ability: Changes with Age. Science 226:4681, pages 1441-1443.
Crossref
C. Beck. 1984. Geriatrics 3. Geriatrics 3 270 296 .
Bruce W. Jafek. (2009) Ultrastructure of human nasal mucosa. The Laryngoscope 93:12, pages 1576-1599.
Crossref
Elvio G. Silva, James J. Butler, Bruce MacKay & Helmuth Goepfert. (1982) Neuroblastomas and neuroendocrine carcinomas of the nasal cavity. A proposed new classification. Cancer 50:11, pages 2388-2405.
Crossref
David T. Moran, J. Carter RowleyIIIIII, Bruce W. Jafek & Mark A. Lovell. (1982) The fine structure of the olfactory mucosa in man. Journal of Neurocytology 11:5, pages 721-746.
Crossref
Anand P. Chaudhry, Jean G. Haar, Ashok Koul & Peter A. Nickerson. (2006) Olfactory neuroblastoma (esthesioneuroblastoma). A light and ultrastructural study of two cases . Cancer 44:2, pages 564-579.
Crossref
Jerome B. Taxy & Denise F. Hidvegi. (1977) Olfactory neuroblastoma.An ultrastructural study. Cancer 39:1, pages 131-138.
Crossref
C. Herberhold. (1975) Funktionspr�fungen und St�rungen des GeruchssinnesOlfactometry and the diseases of the sense of smell. Archives of Oto-Rhino-Laryngology 210:1, pages 67-164.
Crossref
Robert S. Redman. (1974) Nasopalatine duct cyst with pigmented lining suggestive of olfactory epithelium. Oral Surgery, Oral Medicine, Oral Pathology 37:3, pages 421-428.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.