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Original Article

Ototoxic Effects of the Interaction Between Kanamycin and Ethacrynic Acid: Cochlear infrastructure Correlated with Cochlear Potentials and Kanamycin Levels

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Pages 369-381 | Received 24 Nov 1978, Published online: 08 Jul 2009

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Read on this site (9)

Chia-Der Lin, Takeshi Oshima, Kiyoshi Oda, Daisuke Yamauchi, Ming-Hsui Tsai & Toshimitsu Kobayashi. (2008) Ototoxic interaction of kanamycin and 3-nitropropionic acid. Acta Oto-Laryngologica 128:12, pages 1280-1285.
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Michael Mulheran & Ernest S. Harpur. (1998) The Effect of Gentamicin and Furosemide Given in Combination on Cochlear Potentials in the Guinea Pig. British Journal of Audiology 32:1, pages 47-56.
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Douglas H. Johnson & Renee C. Tschumper. (1993) Ethacrynic acid: outflow effects and toxicity in human trabecular meshwork in perfusion organ culture. Current Eye Research 12:5, pages 385-396.
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Tetsuro Hayashida, Hakim Hiel, Didier Dulon, Jean-Paul Erre, Anne Guilhaume & Jean-Marie Aran. (1989) Dynamic Changes Following Combined Treatment with Gentamicin and Ethacrynic Acid with and without Acoustic Stimulation: Cellular Uptake and Functional Correlates. Acta Oto-Laryngologica 108:5-6, pages 404-413.
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J. P. Griffin. (1988) Drug-induced ototoxicity. British Journal of Audiology 22:3, pages 195-210.
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Hideo Yamane, Yoshiaki Nakai & Kazuo Konishi. (1988) Furosemide-induced Alteration of Drug Pathway to Cochlea. Acta Oto-Laryngologica 105:sup447, pages 28-35.
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Robert S. Kimura & Lisa B. Maynard. (1984) Histopathological Study of the Cochlea with Altered Perilymph Metabolism. Acta Oto-Laryngologica 97:5-6, pages 535-546.
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Beth A. Prieve & Jerry L. Yanz. (1984) Age-dependent Changes in Susceptibility to Ototoxic Hearing Loss. Acta Oto-Laryngologica 98:5-6, pages 428-438.
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Ernest S. Harpur. (1982) The Pharmacology of Ototoxic Drugs. British Journal of Audiology 16:2, pages 81-93.
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Articles from other publishers (39)

Lukas Horvath, David B�chinger, Tim Honegger, Daniel Bodmer & Arianne Monge Naldi. (2019) Functional and morphological analysis of different aminoglycoside treatment regimens inducing hearing loss in mice. Experimental and Therapeutic Medicine.
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Jae-Hun Lee, Min Young Lee, Phil-Sang Chung & Jae Yun Jung. (2018) Secondary Degeneration of Auditory Neurons after Topical Aminoglycoside Administration in a Gerbil Model. BioMed Research International 2018, pages 1-10.
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Wenli Gao, Zheng Wu, Junyang Sun, Xianpu Ni & Huanzhang Xia. (2017) Modulation of kanamycin B and kanamycin A biosynthesis in Streptomyces kanamyceticus via metabolic engineering. PLOS ONE 12:7, pages e0181971.
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Yohei Takada, Tomoko Takada, Hiroshi Iwai, Koichi Tomoda & Yehoash Raphael. (2017) HSP70 gene transfer protects against ototoxicity in guinea pigs and study of HSP70 expression site. The Journal of Kansai Medical University 68:0, pages 1-7.
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Long Ma, Hai-jin Yi, Fen-qian Yuan, Wei-wei Guo & Shi-ming Yang. (2015) An efficient strategy for establishing a model of sensorineural deafness in rats. Neural Regeneration Research 10:10, pages 1683.
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Yohei Takada, Tomoko Takada, Min Young Lee, Donald L Swiderski, Lisa L Kabara, David F Dolan & Yehoash Raphael. (2015) Ototoxicity-induced loss of hearing and inner hair cells is attenuated by HSP70 gene transfer. Molecular Therapy - Methods & Clinical Development 2, pages 15019.
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Sarah Havenith, Sjaak F. L. Klis, Huib Versnel & Wilko Grolman. (2013) A Guinea Pig Model of Selective Severe High-Frequency Hearing Loss. Otology & Neurotology 34:8, pages 1510-1518.
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Hiroshi Kuse, Tatsuya Ogawa, Norihiko Nakamura, Yoshihiro Nakayama, Ayumi Nakakarumai, Chiaki Komori, Yuichi Tsuda, Keita Matsushima, Atsushi Nakamura & Kazutoshi Tamura. (2011) Changes in auditory brainstem response (ABR) in Kanamycin-induced auditory disturbance model rats. The Journal of Toxicological Sciences 36:6, pages 835-841.
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Dalian Ding, Haiyan Jiang & Richard J. Salvi. (2010) Mechanisms of rapid sensory hair-cell death following co-administration of gentamicin and ethacrynic acid. Hearing Research 259:1-2, pages 16-23.
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Elizabeth C. Oesterle & Sean Campbell. (2009) Supporting Cell Characteristics in Long-deafened Aged Mouse Ears. Journal of the Association for Research in Otolaryngology 10:4, pages 525-544.
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Ruth Rebecca Taylor, Graham Nevill & Andrew Forge. (2007) Rapid Hair Cell Loss: A Mouse Model for Cochlear Lesions. Journal of the Association for Research in Otolaryngology 9:1, pages 44-64.
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Huib Versnel, Martijn J.H. Agterberg, John C.M.J. de Groot, Guido F. Smoorenburg & Sjaak F.L. Klis. (2007) Time course of cochlear electrophysiology and morphology after combined administration of kanamycin and furosemide. Hearing Research 231:1-2, pages 1-12.
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Michael S. Hildebrand, Hans-Henrik M. Dahl, Jennifer Hardman, Bryony Coleman, Robert K. Shepherd & Michelle G. de Silva. (2005) Survival of Partially Differentiated Mouse Embryonic Stem Cells in the Scala Media of the Guinea Pig Cochlea. Journal of the Association for Research in Otolaryngology 6:4, pages 341-354.
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Kirill V. Nourski, Charles A. Miller, Ning Hu & Paul J. Abbas. (2004) Co-administration of kanamycin and ethacrynic acid as a deafening method for acute animal experiments. Hearing Research 187:1-2, pages 131-133.
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Dalian Ding, Sandra L. McFadden, Richard W. Browne & Richard J. Salvi. (2003) Late dosing with ethacrynic acid can reduce gentamicin concentration in perilymph and protect cochlear hair cells. Hearing Research 185:1-2, pages 90-96.
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W.P.L Hellier, S.A Wagstaff, S.J O’Leary & R.K Shepherd. (2002) Functional and morphological response of the stria vascularis following a sensorineural hearing loss. Hearing Research 172:1-2, pages 127-136.
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Anil K. Lalwani, Jay J. Han, Caley M. Castelein, Gerard J. Carvalho & Anand N. Mhatre. (2009) In Vitro and In Vivo Assessment of the Ability of Adeno‐Associated Virus–Brain‐Derived Neurotrophic Factor to Enhance Spiral Ganglion Cell Survival Following Ototoxic Insult. The Laryngoscope 112:8, pages 1325-1334.
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Meredith M. Garcia, Ryan Edwards, G.Brooks Brennan & Richard E. Harlan. (2000) Deafferentation-induced changes in protein kinase C expression in the rat cochlear nucleus. Hearing Research 147:1-2, pages 113-124.
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Keiji Matsuda, Shizuo Komune, Tetsuya Tono, Masayuki Yamasaki, Atsushi Haruta & Eiji Kato. (2000) A role of glutamate in drug-induced ototoxicity: in vivo microdialysis study combined with on-line enzyme fluorometric detection of glutamate in the guinea pig cochlea. Brain Research 852:2, pages 492-495.
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Gregory I Frolenkov, Inna A Belyantseva, Mauricio Kurc, Mary Ann Mastroianni & Bechara Kachar. (1998) Cochlear outer hair cell electromotility can provide force for both low and high intensity distortion product otoacoustic emissions. Hearing Research 126:1-2, pages 67-74.
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Brendan J. Conlon, S. David McSwain & David W. Smith. (1998) Topical gentamicin and ethacrynic acid: Effects on cochlear function. The Laryngoscope 108:7, pages 1087-1089.
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Stephen J. O'Leary & David R. Moore. (2016) Development of Cochlear Sensitivity to Aminoglycoside Antibiotics. Annals of Otology, Rhinology & Laryngology 107:3, pages 220-226.
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Shaheen Ara Alam, Katsuhisa Ikeda, Tetsuaki Kawase, Toshihiko Kikuchi, Yukio Katori, Ken-ichi Watanabe & Tomonori Takasaka. (1998) Acute Effects of Combined Administration of Kanamycin and Furosemide on the Stria Vascularis Studied by Distortion Product Otoacoustic Emission and Transmission Electron Microscopy.. The Tohoku Journal of Experimental Medicine 186:2, pages 79-86.
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Yuji UZUKA, Tomohiro FURUTA, Mayumi YAMAOKA, Takafumi OHNISHI, Hirokazu TSUBONE & Shigeru SUGANO. (1996) Threshold Changes in Auditory Brainstem Response(ABR) Due to the Administration of Kanamycin in Dogs.. Experimental Animals 45:4, pages 325-331.
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Martin L. Whitehead, Brenda L. Lonsbury-Martin, Glen K. Martin & Marcy J. McCoy. 1996. Clinical Aspects of Hearing. Clinical Aspects of Hearing 199 257 .
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Shi-Ang Xu, Robert K. Shepherd, Yin Chen & Graeme M. Clark. (1993) Profound hearing loss in the cat following the single co-administration of kanamycin and ethacrynic acid. Hearing Research 70:2, pages 205-215.
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Sylvain Bartolami, Myriam Planche & Rémy Pujol. (1993) Inhibition of the carbachol-evoked synthesis of inositol phosphates by ototoxic drugs in the rat cochlea. Hearing Research 67:1-2, pages 203-210.
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K.M.M. Nicol, C.M. Hackney, U.F. Evans & S.R. Pratt. (1992) Behavioural evidence for recovery of auditory function in guinea pigs following kanamycin administration. Hearing Research 61:1-2, pages 117-131.
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J. Syka. 1989. Progress in Sensory Physiology 9. Progress in Sensory Physiology 9 97 170 .
Douglas W. Hoffman, Kitty L. Jones-King, Craig A. Whitworth & Leonard P. Rybak. (2016) Potentiation of Ototoxicity by Glutathione Depletion. Annals of Otology, Rhinology & Laryngology 97:1, pages 36-41.
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Kaye E. Fox & Nancy J. Russell. (1987) Pharmacokinetics of kanamycin in the bullfrog, Rana catesbeiana. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 87:2, pages 245-250.
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Takehiko Harada, Yoshitaka Nagai, Masao Iwamori & Yasuya Nomura. (2016) Ototoxicity of Neomycin and its Penetration through the round Window Membrane into the Perilymph. Annals of Otology, Rhinology & Laryngology 95:4, pages 404-408.
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Simon J. Lee & Ernest S. Harpur. (1985) Abolition of the negative endocochlear potential as a consequence of the gentamicin—furosemide interaction. Hearing Research 20:1, pages 37-43.
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P.Tran Ba Huy, C. Manuel, A. Meulemans, O. Sterkers, M. Wassef & C. Amiel. (1983) Ethacrynic acid facilitates gentamicin entry into endolymph of the rat. Hearing Research 11:2, pages 191-202.
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P.A. Santi, M.A. Ruggero, D.A. Nelson & C.W. Turner. (1982) Kanamycin and bumetanide ototoxicity: Anatomical, physiological and behavioral correlates. Hearing Research 7:3, pages 261-279.
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ROBERT E. BRUMMETT, T. BENDRICK & D. HIMES. (2013) Comparative Ototoxicity of Bumetanide and Furosemide when Used in Combination with Kanamycin. The Journal of Clinical Pharmacology 21:11, pages 628-636.
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