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Acta Oto-Laryngologica Volume 93, 1982 - Issue 1-6
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Original Article

Effects of the Parasympathomimetic Drug Methacholine and Its Antagonist Atropine on Mucociliary Activity

Jan-Christer Hybbinette Department of Otorhinolaryngology, University Hospital, Lund, Sweden
&
Ulf Mercke Department of Otorhinolaryngology, University Hospital, Lund, Sweden
Pages 465-473 | Received 19 May 1981, Published online: 08 Jul 2009

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Muhammad Quadir, Hossein Zia & Thomas E. Needham. (1999) Toxicological Implications of Nasal Formulations. Drug Delivery 6:4, pages 227-242.
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Anders Cervin, Sven Lindberg, Ulf Mercke & Rolf Uddman. (1992) Neuropeptide Y in the Rabbit Maxillary Sinus Modulates Cholinergic Acceleration of Mucociliary Activity. Acta Oto-Laryngologica 112:5, pages 872-881.
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Kazuhiko Takeuchi, Eri Suzumura, Yuichi Majima & Yasuo Sakakura. (1990) Effect of Atropine on Nasal Mucociliary Clearance. Acta Oto-Laryngologica 110:1-2, pages 120-123.
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Sven Lindberg, Ulf Mercke & Rolf Uddman. (1986) The Morphological Basis for the Effect of Substance P on Mucociliary Activity in Rabbit Maxillary Sinus. Acta Oto-Laryngologica 101:3-4, pages 314-319.
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Sven Lindberg & Ulf Mercke. (1986) Antidromic Nerve Stimulation Accelerates Mucociliary Activity in Rabbit Maxillary Sinus. Acta Oto-Laryngologica 101:5-6, pages 484-493.
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Sven Lindberg & Ulf Mercke. (1986) Bradykinin Accelerates Mucociliary Activity in Rabbit Maxillary Sinus. Acta Oto-Laryngologica 101:1-2, pages 114-121.
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Articles from other publishers (32)

Kristy D. Bruse. 2016. Drug Discovery and Evaluation: Pharmacological Assays. Drug Discovery and Evaluation: Pharmacological Assays 1011 1028 .
Kristy D. Bruse. 2014. Drug Discovery and Evaluation: Pharmacological Assays. Drug Discovery and Evaluation: Pharmacological Assays 1 19 .
Stanislas Grassin-Delyle, Amparo Buenestado, Emmanuel Naline, Christophe Faisy, Sabine Blouquit-Laye, Louis-Jean Couderc, Morgan Le Guen, Marc Fischler & Philippe Devillier. (2012) Intranasal drug delivery: An efficient and non-invasive route for systemic administration. Pharmacology & Therapeutics 134:3, pages 366-379.
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Staffan Edsbäcker, Per Wollmer, Olof Selroos, Lars Borgström, Bo Olsson & Jarl Ingelf. (2008) Do airway clearance mechanisms influence the local and systemic effects of inhaled corticosteroids?. Pulmonary Pharmacology & Therapeutics 21:2, pages 247-258.
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Hans Gerhard Vogel. 2008. Drug Discovery and Evaluation. Drug Discovery and Evaluation 511 564 .
Jonathan Rutland, Lucy Morgan & Robb de Iongh. 2004. Therapy for Mucus-Clearance Disorders. Therapy for Mucus-Clearance Disorders 225 306 .
Muneo Nakaya, Takafumi Yuasa & Nobuo Usui. (2016) Immunohistochemical Localization of Subtypes of Muscarinic Receptors in Human Inferior Turbinate Mucosa. Annals of Otology, Rhinology & Laryngology 111:7, pages 593-597.
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H. Gerhard Vogel, Wolfgang H. Vogel, Bernward A. Schölkens, Jürgen Sandow, Günter Müller & Wolfgang F. Vogel. 2002. Drug Discovery and Evaluation. Drug Discovery and Evaluation 351 383 .
Chikako Kishioka, Kosuke Okamoto, Jungsoo Kim & Bruce K Rubin. (2001) Regulation of secretion from mucous and serous cells in the excised ferret trachea. Respiration Physiology 126:2, pages 163-171.
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Gurpreet S. Padda, Chikako Kishioka & Bruce K. Rubin. (2001) Propofol and methohexital have no significant effect on mucus secretion or clearance in the anesthetized dog. Critical Care Medicine 29:5, pages 1045-1048.
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Thomas Runer, Anders Cervin, Sven Lindberg & Rolf Uddman. (2016) Nitric Oxide is a Regulator of Mucociliary Activity in the Upper Respiratory Tract. Otolaryngology–Head and Neck Surgery 119:3, pages 278-287.
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Scott M. Gayner & Thomas V. McCaffrey. (2018) Muscarinic Ciliostimulation Requires Endogenous Prostaglandin Production. American Journal of Rhinology 12:3, pages 203-208.
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Thomas Runer & Sven Lindberg. (2016) Effects of Nitric Oxide on Blood Flow and Mucociliary Activity in the Human Nose. Annals of Otology, Rhinology & Laryngology 107:1, pages 40-46.
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Emmeline Marttin, Nicolaas G.M Schipper, J.Coos Verhoef & Frans W.H.M Merkus. (1998) Nasal mucociliary clearance as a factor in nasal drug delivery. Advanced Drug Delivery Reviews 29:1-2, pages 13-38.
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Chikako Kishioka, Pi‐Wan Cheng, Richard E. B. Seftor, Paul A. Lartey & Bruce K. Rubin. (2016) Regulation of Mucin Secretion in the Ferret Trachea. Otolaryngology–Head and Neck Surgery 117:5, pages 480-486.
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Bin Yang, Rodney J. Schlosser & Thomas V. McCaffrey. (2016) Signal Transduction Pathways in Modulation of Ciliary Beat Frequency by Methacholine. Annals of Otology, Rhinology & Laryngology 106:3, pages 230-236.
Crossref
H. Gerhard Vogel & Wolfgang H. Vogel. 1997. Drug Discovery and Evaluation. Drug Discovery and Evaluation 183 203 .
Sven Lindberg, Thomas Runer, Anders Cervin & Lars Thomasson. (2016) Recordings of Mucociliary Activity in Vivo: Benefit of Fast Fourier Transformation of the Photoelectric Signal. Annals of Otology, Rhinology & Laryngology 105:9, pages 734-745.
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Thomas Runer, Sven Lindberg, Ulf Mercke & Peter Olsson. (2018) Effects of Substance P and Methacholine on Mucosal Blood Flow in the Upper Airways. American Journal of Rhinology 9:6, pages 335-348.
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Sven Lindberg & Jan Dolata. (1993) NK1 receptors mediate the increase in mucociliary activity produced by tachykinins. European Journal of Pharmacology 231:3, pages 375-380.
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Paul A. Staskowski & Thomas V. McCaffrey. (1992) Effect of Substance P on Ciliary Beat Frequency in Human Adenoid Explants. Otolaryngology–Head and Neck Surgery 107:4, pages 553-557.
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A. CERVIN, S. LINDBERG & U. MERCKE. (2008) Sympathetic nerve stimulation influences mucociliary activity in the rabbit maxillary sinus. Acta Physiologica Scandinavica 143:4, pages 405-412.
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Sven Lindberg & Rolf Uddman. (2018) The Rabbit Maxillary Sinus: A Review of the Effects of Innervation on Mucociliary Activity. American Journal of Rhinology 4:6, pages 225-233.
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Jan Dolata, Sven Lindberg & Ulf Mercke. (2016) Histamine Stimulation of Mucociliary Activity in the Rabbit Maxillary Sinus. Annals of Otology, Rhinology & Laryngology 99:8, pages 666-671.
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Sven Lindberg, Jan Dolata & Ulf Mercke. (1990) Mucociliary activity and the diving reflex. American Journal of Otolaryngology 11:3, pages 182-187.
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Michael J. Sanderson & Ellen R. Dirksen. (1989) Mechanosensitive and Beta-Adrenergic Control of the Ciliary Beat Frequency of Mammalian Respiratory Tract Cells in Culture. American Review of Respiratory Disease 139:2, pages 432-440.
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Sven Lindberg, Anders Cervin, Ulf Mercke & Rolf Uddman. (1988) VIP Potentiates Cholinergic Effects on the Mucociliary System in the Maxillary Sinus. Otolaryngology–Head and Neck Surgery 99:4, pages 401-407.
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Adam Wanner. (1987) Autonomic Control and Mucociliary Functions. Chest 91:5, pages 49S-51S.
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S. Lindberg, J. Dalta & U. Mercke. 1987. Substance P and Neurokinins. Substance P and Neurokinins 276 278 .
Sven Lindberg, Jan Dolata & Ulf Mercke. (1986) Effects of neurokinin A and calcitonin gene-related peptide on mucociliary activity in rabbit maxillary sinus. Regulatory Peptides 16:1, pages 15-25.
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Sven Lindberg, Jan-Christer Hybbinette & Ulf Mercke. (2016) Effects of Neuropeptides on Mucociliary Activity. Annals of Otology, Rhinology & Laryngology 95:1, pages 94-100.
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Sven Lindberg & Ulf Mercke. (1985) Substance P antagonists and mucociliary activity in rabbit. Naunyn-Schmiedeberg's Archives of Pharmacology 329:4, pages 376-381.
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