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Original Article

Absorbable Gelatin Sponge (Gelfoam) In Otosurgery: One Cause of Undesirable Postoperative Results?: An Experimental Study in the Rat

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Pages 269-275 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Naif Bawazeer, Sandra Zaouche, Stéphane Tringali & Maxime Fieux. (2021) Is gelfoam sealing necessary in stapes surgery?. Acta Oto-Laryngologica 141:3, pages 231-236.
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Dan Wang, Tongli Ren & Wuqing Wang. (2020) The outcomes of endoscopic myringoplasty: packing with gelatin sponge versus packing with nothing. Acta Oto-Laryngologica 140:4, pages 292-296.
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Cheol Hee Choi & Chul Ho Jang. (2015) Antiadhesive effect of polyurethane foam packing in the guinea pig middle ear. Acta Oto-Laryngologica 135:2, pages 130-134.
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J. Raúl Olmos-Zuñiga, Rosalva González-López, MD, Miguel Gaxiola-Gaxiola, MD, Lisette Cristerna-Sánchez, MD, Jaime Villalba-Caloca, PhD, Matilde Baltazares-Lipp, BS, Antonio Soda-Merhy, MD, Claudia Hernández-Jiménez & Rogelio Jasso-Victoria, MD. (2012) Effects of Middle Ear Packing with Collagen Polyvinylpyrrolidone and Hyaluronic Acid in Guinea Pigs. Journal of Investigative Surgery 25:6, pages 398-404.
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C. Laurent, S. Hellström, A. Tengblad, L.-E. Appelgren, J. Sehlin & K. Lilja. (1987) Hyaluronan in the Middle Ear of the Rat: The Normal Distribution of Hyaluronan and the Clearance of Exogenously Administered Hyaluronan from the Middle Ear. Acta Oto-Laryngologica 104:sup442, pages 36-40.
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Articles from other publishers (48)

Ebraheem Albazee, Ahmed Abu-Zaid, Bader Alshammari, Marzouqi Salamah, Ahmed Naif Alolaywi, Abdulaziz A. Almobarak & Abdulrahman Hagr. (2023) Efficacy of gelfoam middle ear packing in type-1 tympanoplasty: systematic review and meta-analysis. European Archives of Oto-Rhino-Laryngology 280:8, pages 3503-3514.
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S R Sahoo, J Tripathi, S Kumari & S Rastogi. (2021) Efficacy of middle-ear packing in success of type 1 tympanoplasty: a prospective randomised study. The Journal of Laryngology & Otology 135:10, pages 864-868.
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Adrian L James. (2021) Totally endoscopic tympanic membrane repairTotale endoskopische Trommelfellrekonstruktion. HNO 69:10, pages 791-796.
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Jae Sang Han, Jung Ju Han, Yahya Dhafer AlAhmari, Jung Mee Park, Jae-Hyun Seo, So Young Park & Shi Nae Park. (2021) Effect of middle ear gelfoam on hearing and healing process after tympanoplasty: A prospective randomized case-control study. American Journal of Otolaryngology 42:1, pages 102767.
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Mahtab Rabbani Anari, Amir Miratashi Yazdi, Elnaz Kazemi, Atie Moghtadaie, Abolfazl Farbod & Hamed Emami. (2020) Comparison of functional outcomes of cartilage tympanoplasty with silastic sheet versus Gelfoam packing in middle ear. American Journal of Otolaryngology 41:5, pages 102588.
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Barilin Dkhar, Abhijeet Bhatia, Pranjal Pratim Saikia & Haphidasara Pyngrope. (2020) Improved postauricular surgical approach to the round window of rats. Journal of Neuroscience Methods 330, pages 108481.
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Lumei Liu, Cole Rodman, Noah E. Worobetz, Jed Johnson, Charles Elmaraghy & Tendy Chiang. (2019) Topical biomaterials to prevent post-tonsillectomy hemorrhage. Journal of Otolaryngology - Head & Neck Surgery 48:1.
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Vijay Ramalingam, Muthukumar Ramanathan, Amarapathy Muraleedharan, Kandasamy Kamindan, Thalapathy Ramkumar, Mohankumar Venugopal & Murugesan Rajeswari. (2019) A Study on Outcome of Myringoplasty in Dry Ear (Quiescent/Inactive CSOM) Without Using Gelfoam in Middle Ear. Indian Journal of Otolaryngology and Head & Neck Surgery 71:S2, pages 1609-1614.
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Ji Eun Choi, Jae-Hun Lee, So-Young Chang, Min Young Lee & Jae Yun Jung. (2019) Clinical Implications of Poloxamer 407 as Packing Material in an Animal Model. Audiology and Neurotology 24:2, pages 100-108.
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Jingying Ma, Zhenxiao Huang & Bing Zhou. (2018) Transnasal Endoscopic Resection of Pediatric Orbital Cyst: “How I do it”. American Journal of Rhinology & Allergy 32:1, pages 71-73.
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Carol Nhan, Aren Bezdjian, Abdullah Alarfaj & Sam J. Daniel. (2017) Can floseal™ be applied safely during otologic surgery? Assessment of ototoxicity in a chinchilla animal model. Journal of Otolaryngology - Head & Neck Surgery 46:1.
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Adrian L. James. (2017) Endoscope or microscope-guided pediatric tympanoplasty? Comparison of grafting technique and outcome. The Laryngoscope 127:11, pages 2659-2664.
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Gaurav Khandelwal. (2016) TYMPANOPLASTY: BLOOD-SOAKED GELFOAM VERSES ANTIBIOTIC-SOAKED GELFOAM AS EAR CANAL PACKING. Journal of Evolution of Medical and Dental Sciences 5:53, pages 3560-3562.
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Enrique Perez, Ralph Abi Hachem, Daniel Carlton, Isabel Bueno, Stephen Vernon, Thomas R. Van De Water & Simon I. Angeli. (2016) Comparison of packing material in an animal model of middle ear trauma. American Journal of Otolaryngology 37:4, pages 323-329.
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Selin Ünsaler, Bora Başaran, Şule Öztürk Sarı, Eyüp Kara, Kemal Değer & Peter John Wormald. (2016) Safety and Efficacy of Chitosan-Dextran Hydrogel in the Middle Ear in an Animal Model. Audiology and Neurotology 21:4, pages 254-260.
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Erdem Eren, Mehmet Sinan Başoğlu, Erkan Kulduk, Fatma Şimsek & Sevinç İnan. (2014) Mucosal trauma induced apoptosis in guinea pig middle ear: Comparision of hemostatic agents. International Journal of Pediatric Otorhinolaryngology 78:12, pages 2222-2228.
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E Kulduk, E Eren, FK Soy, R Dundar, M Aslan, MS Basoglu, F Simsek & H Katilmis. (2014) Histological analysis of the effects of anti-adhesive haemostatic agents on the middle ear of the guinea pig. The Journal of Laryngology & Otology 128:10, pages 885-891.
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Débora Lopes Bunzen, Nathalia Lins, Mariana de Carvalho Leal, Mariana Montenegro de Melo Lira & Silvio da Silva Caldas Neto. (2014) Middle ear packing materials: comparison between absorbable hemostatic gelatine sponge and sugarcane biopolymer sponge in rats. Brazilian Journal of Otorhinolaryngology 80:3, pages 237-244.
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Yi Shen, Sharon L Redmond, John M Papadimitriou, Bing M Teh, Sheng Yan, Yan Wang, Marcus D Atlas, Robert J Marano, Minghao Zheng & Rodney J Dilley. (2014) The biocompatibility of silk fibroin and acellular collagen scaffolds for tissue engineering in the ear. Biomedical Materials 9:1, pages 015015.
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Yi ShenSharon Leanne RedmondBing Mei TehSheng YanYan WangLin ZhouCharley A. BudgeonRobert Henry EikelboomMarcus David AtlasRodney James DilleyMinghao ZhengRobert Jeffery Marano. (2013) Scaffolds for Tympanic Membrane Regeneration in Rats. Tissue Engineering Part A 19:5-6, pages 657-668.
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Chul Ho Jang, Yong Beom Cho, Cheol Hee Choi, Jun Sik Lee & Sung In Kang. (2013) Effect of anti-adhesion barrier solution containing ciprofloxacin-hydrocortisone on abraded mucosa with otitis media. International Journal of Pediatric Otorhinolaryngology 77:1, pages 19-24.
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J. Tahar Aissa & M. Hultcrantz. (2012) Healing of laser-induced tympanic membrane perforations in rats: No contribution of granulocyte colony-stimulating factor or Gelfoam®. International Journal of Pediatric Otorhinolaryngology 76:7, pages 963-968.
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Joong Ho Ahn, Hyun Woo Lim & Hye‐Ran Hong. (2012) The clinical application and efficacy of sodium hyaluronate–carboxymethylcellulose during tympanomastoid surgery. The Laryngoscope 122:4, pages 912-915.
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Guiliang Huang, Xihui Chen & Hongyan Jiang. (2011) Effects of NasoPore Packing in the Middle Ear Cavity of the Guinea Pig. Otolaryngology–Head and Neck Surgery 145:1, pages 131-136.
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Michael Julian Lipan, Ibrahim Alava, Ralph Abi‐Hachem, Stephen Vernon, Thomas R. Van De Water & Simon I. Angeli. (2011) Middle Ear Packing. Otolaryngology–Head and Neck Surgery 144:5, pages 763-769.
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Yi Shen, Bing Mei Teh, Peter L. Friedland, Robert Henry Eikelboom & Marcus David Atlas. (2011) To pack or not to pack? A contemporary review of middle ear packing agents. The Laryngoscope 121:5, pages 1040-1048.
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Anders Niklasson & Krister Tano. (2011) The Gelfoam® plug: An alternative treatment for small eardrum perforations. The Laryngoscope 121:4, pages 782-784.
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Patrick J. Antonelli, Edith M. Sampson & Dustin M. Lang. (2010) Safety and efficacy of carbomethylcellulose foam in guinea pig middle ear surgery. Otolaryngology–Head and Neck Surgery 142:3, pages 405-408.
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Zhihong DengJunjie WuJianhua QiuJinling WangYongsheng TianYuan LiYan Jin. (2009) Comparison of Porcine Acellular Dermis and Dura Mater as Natural Scaffolds for Bioengineering Tympanic Membranes. Tissue Engineering Part A 15:12, pages 3729-3739.
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Salim Dogru, Abdulah Haholu, Atila Gungor, Zafer Kucukodaci, Hakan Cincik, Taner Ozdemir & Huseyin Sen. (2009) Histologic analysis of the effects of three different support materials within rat middle ear. Otolaryngology–Head and Neck Surgery 140:2, pages 177-182.
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Chul Ho Jang, Haekyun Park, Yong Bum Cho & Cheol Hee Choi. (2008) The effect of anti-adhesive packing agents in the middle ear of guinea pig. International Journal of Pediatric Otorhinolaryngology 72:11, pages 1603-1608.
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Chul Ho Jang, Haekyun Park, Yong Bum Cho & Chel Hee Choi. (2008) The effect of Interceed for reducing adhesion as a middle ear packing agent: An experimental study. International Journal of Pediatric Otorhinolaryngology 72:10, pages 1517-1521.
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Simon Angeli, Sarah Connell, Brian Gibson, Ali Ozdek, John T. McElveenJrJr & Thomas R. Van De Water. (2016) Injectable Form of Cross-Linked Hyaluronan is Effective for Middle Ear Wound Healing. Annals of Otology, Rhinology & Laryngology 116:9, pages 667-673.
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Albert H. Park, Adrienne Jackson, Lisa Hunter, Lawrence McGill, Sara Ellis Simonsen, Stephen C. Alder, Xiao Zheng Shu & Glenn Prestwich. (2006) Cross-Linked Hydrogels for Middle Ear Packing. Otology & Neurotology 27:8, pages 1170-1175.
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Albert H. Park, Casey W. Hughes, Adrienne Jackson, Lisa Hunter, Lawrence McGill, Sara Ellis Simonsen, Stephen C. Alder, Xiao Zheng Shu & Glenn D. Prestwich. (2016) Crosslinked hydrogels for tympanic membrane repair. Otolaryngology–Head and Neck Surgery 135:6, pages 877-883.
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Marc Puterman & Alberto Leiberman. (2005) Gelfoam plug tympanoplasty concomitant with removal of retained ventilation tubes. International Journal of Pediatric Otorhinolaryngology 69:1, pages 57-60.
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Jason Smith, Edward Gardner & John L. Dornhoffer. (2009) Hearing Results With a Hydroxylapatite/Titanium Bell Partial Ossicular Replacement Prosthesis. The Laryngoscope 112:10, pages 1796-1799.
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Rainer Weber, Rainer Keerl, Friedrich Hochapfel, Wolfgang Draf & Paul H. Toffel. (2001) Packing in endonasal surgery. American Journal of Otolaryngology 22:5, pages 306-320.
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John L. Dornhoffer. (2016) Retrograde Mastoidectomy with Canal Wall Reconstruction: A Single-Stage Technique for Cholesteatoma Removal. Annals of Otology, Rhinology & Laryngology 109:11, pages 1033-1039.
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Richard A. Chole & Douglas J. Skarada. (1999) MIDDLE EAR RECONSTRUCTIVE TECHNIQUES. Otolaryngologic Clinics of North America 32:3, pages 489-503.
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Douglas A. Liening, Larry Lundy, Boris Silberberg & Kenn Finstuen. (2016) A Comparison of the Biocompatibility of three Absorbable Hemostatic Agents in the Rat Middle Ear. Otolaryngology–Head and Neck Surgery 116:4, pages 454-457.
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Michael J Hawes. (1988) GELFOAM DACRYOCYSTORHINOSTOMY STENT: ONE CAUSE OF SURGICAL FAILURE?. Pediatric Annals 17:11, pages 824-825.
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PATRICIA A. SCHACHERN, MICHAEL M. PAPARELLA & MARCOS V. GOYCOOLEA. (1987) EXPERIMENTAL GRAFTING OF THE ROUND WINDOW MEMBRANE. The Laryngoscope 97:7, pages 790???796.
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Claude Laurent, Sten Hellström, Lars-Erik Appelgren, Janove Sehlin & Karin Lilja. (1986) Fate of exogenous hyaluronic acid in the middle ear. American Journal of Otolaryngology 7:5, pages 334-340.
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Claude Laurent, Sten Hellstöm & Lars-Eric Stenfords. (1986) Hyaluronic acid reduces connective tissue formation in middle ears filled with absorbable gelatin sponge. American Journal of Otolaryngology 7:3, pages 181-186.
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Frank DeLustro, Richard A. Condell, Mai Anh Nguyen & John M. McPherson. (2004) A comparative study of the biologic and immunologic response to medical devices derived from dermal collagen. Journal of Biomedical Materials Research 20:1, pages 109-120.
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Jerome O. Klein. (2016) Otitis Media with Effusion and Development of Speech and Language. Annals of Otology, Rhinology & Laryngology 94:5_suppl2, pages 53-60.
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