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Original Article

Increased Radiosensitivity is Associated with p53 Mutations in Cell Lines Derived from Oral Cavity Carcinoma

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Pages 341-344 | Published online: 08 Jul 2009

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Eva Henriksson, Bo Baldetorp, Åke Borg, Elisabeth Kjellen, Jan Åkervall, Johan Wennerberg & Peter Wahlberg. (2006) p53 mutation and cyclin D1 amplification correlate with cisplatin sensitivity in xenografted human squamous cell carcinomas from head and neck. Acta Oncologica 45:3, pages 300-305.
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Kaarina Sundelin, Karin Roberg, Reidar Grénman & Leif Håkansson. (2005) Effects of cytokines on matrix metalloproteinase expression in oral squamous cell carcinoma in vitro. Acta Oto-Laryngologica 125:7, pages 765-773.
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Anne Kiuru, Kristina Servomaa, Reidar Grénman, Jaakko Pulkkinen & Tapio Rytömaa. (1997) p53 Mutations in Human Head and Neck Cancer Cell Lines. Acta Oto-Laryngologica 117:sup529, pages 237-240.
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Aki Salo, Kristina Servomaa, Anne Kiuru, Jaakko Pulkkinen, Reidar Grénman, Kirsi Pekkola-Heino & Tapio Rytömaa. (1997) The bcl-2 Gene Status of Human Head and Neck Cancer Cell Lines. Acta Oto-Laryngologica 117:sup529, pages 233-236.
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Articles from other publishers (23)

Xin Feng, Tan Zhang, Jeff Chou, Liang Liu, Lance D. Miller, Christopher A. Sullivan & James D. Browne. (2021) Comprehensive gene cluster analysis of head and neck squamous cell carcinoma TCGA RNA‐seq data defines B cell immunity‐related genes as a robust survival predictor . Head & Neck 44:2, pages 443-452.
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Corinna Haist, Elena Schulte, Nina Bartels, Arthur Bister, Zoe Poschinski, Tabea C. Ibach, Katja Geipel, Constanze Wiek, Martin Wagenmann, Cornelia Monzel, Kathrin Scheckenbach & Helmut Hanenberg. (2021) CD44v6-targeted CAR T-cells specifically eliminate CD44 isoform 6 expressing head/neck squamous cell carcinoma cells. Oral Oncology 116, pages 105259.
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David M. Vossen, Caroline V. M. Verhagen, Reidar Grénman, Roelof J. C. Kluin, Marcel Verheij, Michiel W. M. van den Brekel, Lodewyk F. A. Wessels & Conchita Vens. (2018) Role of variant allele fraction and rare SNP filtering to improve cellular DNA repair endpoint association. PLOS ONE 13:11, pages e0206632.
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Amy J.C. Dohmen, Xiaohang Qiao, Anja Duursma, Ruud H. Wijdeven, Cor Lieftink, Floor Hageman, Ben Morris, Pasi Halonen, Conchita Vens, Michiel W.M. van den Brekel, Huib Ovaa, Jacques Neefjes & Charlotte L. Zuur. (2017) Identification of a novel ATM inhibitor with cancer cell specific radiosensitization activity. Oncotarget 8:43, pages 73925-73937.
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Dong Pan, Yarong Du, Zhenxin Ren, Yaxiong Chen, Xiaoman Li, Jufang Wang & Burong Hu. (2016) Radiation induces premature chromatid separation via the miR-142-3p/Bod1 pathway in carcinoma cells. Oncotarget 7:37, pages 60432-60445.
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RAN ZHU, WEI LI, YAN XU, JIANMEI WAN & ZENGLI ZHANG. (2015) Upregulation of BTG1 enhances the radiation sensitivity of human breast cancer in vitro and in vivo. Oncology Reports 34:6, pages 3017-3024.
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Xin Wu, Nan Ding, Wentao Hu, Jinpeng He, Shuai Xu, Hailong Pei, Junrui Hua, Guangming Zhou & Jufang Wang. (2014) Down-regulation of BTG1 by miR-454-3p enhances cellular radiosensitivity in renal carcinoma cells. Radiation Oncology 9:1.
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George D. Wilson, Brian Marples, Sandra Galoforo, Timothy J. Geddes, Bryan J. Thibodeau, Reidar Grénman & Jan Akervall. (2013) Isolation and genomic characterization of stem cells in head and neck cancer. Head & Neck 35:11, pages 1573-1582.
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David Eriksson, Katrine Riklund, Lennart Johansson & Torgny Stigbrand. 2008. Targeted Radionuclide Tumor Therapy. Targeted Radionuclide Tumor Therapy 215 248 .
Karin Roberg, Ann‐Charlotte Jonsson, Reidar Grénman & Lena Norberg‐Spaak. (2006) Radiotherapy response in oral squamous carcinoma cell lines: Evaluation of apoptotic proteins as prognostic factors. Head & Neck 29:4, pages 325-334.
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Kaarina Sundelin, Karin Roberg, Reidar Grénman & Leif Håkansson. (2007) Effects of cisplatin, α-interferon, and 13-cis retinoic acid on the expression of Fas (CD95), intercellular adhesion molecule-1 (ICAM-1), and epidermal growth factor receptor (EGFR) in oral cancer cell lines. Journal of Oral Pathology & Medicine 36:3, pages 177-183.
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Jesper Grau Eriksen, Jan Alsner, Torben Steiniche & Jens Overgaard. (2005) The possible role of TP53 mutation status in the treatment of squamous cell carcinomas of the head and neck (HNSCC) with radiotherapy with different overall treatment times. Radiotherapy and Oncology 76:2, pages 135-142.
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O Bettendorf, J Piffkò & A Bànkfalvi. (2004) Prognostic and predictive factors in oral squamous cell cancer: important tools for planning individual therapy?. Oral Oncology 40:2, pages 110-119.
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Johanna Haikonen, Virpi Rantanen, Kirsi Pekkola, Jarmo Kulmala & Reidar Grénman. (2003) Does skin fibroblast radiosensitivity predict squamous cancer cell radiosensitivity of the same individual?. International Journal of Cancer 103:6, pages 784-788.
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A. Pérez-carro ríos, A. Clemente garcía, A. Lozano ramírez, T. García caballero & T. Labella caballero. (2003) Proteína p53 mediante inmunohistoquímica en el carcinoma epidermoide de laringe. Acta Otorrinolaringológica Española 54:4, pages 263-268.
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Christopher D. Lansford, Reidar Grenman, Henning Bier, Kenneth D. Somers, Sang Yoon Kim, Theresa L. Whiteside, Gary L. Clayman, Hans-J. Welkoborsky & Thomas E. Carey. 2002. Human Cell Culture. Human Cell Culture 185 255 .
Gerhard G Grabenbauer, Christine Mühlfriedel, Franz Rödel, Gerald Niedobitek, Joachim Hornung, Claus Rödel, Peter Martus, Heiner Iro, Thomas Kirchner, Helmuth Steininger, Rolf Sauer, Manfred Weidenbecher & Luitpold Distel. (2000) Squamous cell carcinoma of the oropharynx: Ki-67 and p53 can identify patients at high risk for local recurrence after surgery and postoperative radiotherapy. International Journal of Radiation Oncology*Biology*Physics 48:4, pages 1041-1050.
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C. Scully, J.K. Field & H. Tanzawa. (2000) Genetic aberrations in oral or head and neck squamous cell carcinoma 3: clinico-pathological applications. Oral Oncology 36:5, pages 404-413.
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Kathleen F Pirollo, Kerrie B Bouker & Esther H Chang. (2000) Does p53 status influence tumor response to anticancer therapies?. Anti-Cancer Drugs 11:6, pages 419-432.
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T Björk-Eriksson, C M L West, E Cvetskovska, M Svensson, E Karlsson, B Magnusson, N J Slevin, S Edström & C Mercke. (1999) The lack of correlation between proliferation (Ki-67, PCNA, LI, Tpot), p53 expression and radiosensitivity for head and neck cancers. British Journal of Cancer 80:9, pages 1400-1404.
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H Hiranuma, A Jikko, T Maeda, S Matumura, S Murakami, Y Fukuda, S Furukawa, T Ishida & H Fuchihata. (1998) An analysis of the prognostic significance of p53 status for squamous cell carcinoma of the oral cavity treated by radiotherapy. Oral Oncology 34:6, pages 513-518.
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Kirsi Pekkola-Heino, Kristina Servomaa, Anne Kiuru & Reidar Grenman. (1998) Sublethal damage repair capacity in carcinoma cell lines with p53 mutations. Head & Neck 20:4, pages 298-303.
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Wilfried Budach. (1997) Erhöhte Strahlensensitivität beim Nachweis von p53-Mutationen bei Mundhöhlenkarzinom-Zellinien. Strahlentherapie und Onkologie 173:5, pages 290-292.
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