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Acta Oto-Laryngologica Volume 117, 1997 - Issue 6
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Original Article

Caroverine in Tinnitus Treatment

A Placebo-Controlled Blind Study

Doris-Maria Denk ENT Department and, University of Vienna, Austria
,
Harald Heinzl Department of Medical Computer Sciences, Section of Clinical Biometrics, University of Vienna, Austria
,
Peter Franz ENT Department and, University of Vienna, Austria
&
Klaus Ehrenberger ENT Department and, University of Vienna, Austria
Pages 825-830 | Received 11 Oct 1996, Accepted 19 Dec 1996, Published online: 08 Jul 2009

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Toru Ohashi, Hirohito Nishino, Yositane Nishimoto, Yoko Arai & Izumi Koizuka. (2014) The recovery from AP adaptation in sensorineural hearing loss. Acta Oto-Laryngologica 134:3, pages 275-279.
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Berthold Langguth & Ana Belén Elgoyhen. (2012) Current pharmacological treatments for tinnitus. Expert Opinion on Pharmacotherapy 13:17, pages 2495-2509.
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Berthold Langguth, Richard Salvi & Ana Belén Elgoyhen. (2009) Emerging pharmacotherapy of tinnitus. Expert Opinion on Emerging Drugs 14:4, pages 687-702.
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Ilmari Pyykkö, Jing Zou, Erna Kentala & Dafydd Stephens. (2008) Tinnitus treatment: Are drugs effective?. Audiological Medicine 6:1, pages 25-39.
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L. Salembier, D. De Ridder & P.H. Van de Heyning. (2006) The use of flupirtine in treatment of tinnitus. Acta Oto-Laryngologica 126:sup556, pages 93-95.
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Maoli Duan, Zhiqiang Chen, Jianxin Qiu, Mats Ulfendahl, Göran Laurell, Erik Borg & Runsheng Ruan. (2006) Low-dose, long-term caroverine administration attenuates impulse noise-induced hearing loss in the rat. Acta Oto-Laryngologica 126:11, pages 1140-1147.
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Elmar Oestreicher, Wolfgang Arnold, Klaus Ehrenberger, Dominik Felix. (1999) New Approaches for Inner Ear Therapy with Glutamate Antagonists. Acta Oto-Laryngologica 119:2, pages 174-178.
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Hannes Domeisen, Michel A. Hotz, Rudolf Häusler. (1998) Caroverine in Tinnitus Treatment. Acta Oto-Laryngologica 118:4, pages 606-607.
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RAMARAPPU SOWMYA & DASARI MAHESH. (2023) COCHLEAR SYNAPTIC TINNITUS – CAN IT BE CURED. Asian Journal of Pharmaceutical and Clinical Research, pages 132-134.
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Berthold Langguth. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 755 769 .
Sang Hoon Kim, Dokyoung Kim, Jae-Min Lee, Sun Kyu Lee, Hee Jin Kang & Seung Geun Yeo. (2021) Review of Pharmacotherapy for Tinnitus. Healthcare 9:6, pages 779.
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Marisa Zallocchi, Santanu Hati, Zhenhang Xu, William Hausman, Huizhan Liu, David Z. He & Jian Zuo. (2021) Characterization of quinoxaline derivatives for protection against iatrogenically induced hearing loss. JCI Insight 6:5.
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Jaime N Wertman, Nicole Melong, Matthew R Stoyek, Olivia Piccolo, Stewart Langley, Benno Orr, Shelby L Steele, Babak Razaghi & Jason N Berman. (2020) The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model. eLife 9.
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Tobias Kleinjung & Berthold Langguth. 2021. The Behavioral Neuroscience of Tinnitus. The Behavioral Neuroscience of Tinnitus 193 212 .
Rajeev Kumar Nishad, Anil Kumar Jain, Mangal Singh, Reetu Verma & Sanyogita Jain. (2019) Randomised Controlled Clinical Study of Injection Caroverine and Ginkgo Biloba Extract in Cochlear Synaptic Tinnitus. Indian Journal of Otolaryngology and Head & Neck Surgery 71:S2, pages 1523-1528.
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Berthold LangguthAna Belen Elgoyhen & Christopher R. Cederroth. (2019) Therapeutic Approaches to the Treatment of Tinnitus. Annual Review of Pharmacology and Toxicology 59:1, pages 291-313.
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Hannah Tetteh, Minseok Lee, C. Geoffrey Lau, Sunggu Yang & Sungchil Yang. (2017) Tinnitus: Prospects for Pharmacological Interventions With a Seesaw Model. The Neuroscientist 24:4, pages 353-367.
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Hans-Peter Zenner, Wolfgang Delb, Birgit Kröner-Herwig, Burkhard Jäger, Ingrid Peroz, Gerhard Hesse, Birgit Mazurek, Gerhard Goebel, Christian Gerloff, Regina Trollmann, Eberhard Biesinger, Harald Seidler & Berthold Langguth. (2016) A multidisciplinary systematic review of the treatment for chronic idiopathic tinnitus. European Archives of Oto-Rhino-Laryngology 274:5, pages 2079-2091.
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Thanarath Imsuwansri, Derek J Hoare, Wanasri Phaisaltuntiwongs, Attasit Srisubat & Kornkiat Snidvongs. (2016) Glutamate receptor antagonists for tinnitus. Cochrane Database of Systematic Reviews.
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So Young Park. (2016) Pharmacological Treatments for Tinnitus. Hanyang Medical Reviews 36:2, pages 113.
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Brian L. Allman, Ashley L. Schormans, Marei Typlt & Edward Lobarinas. 2016. Translational Research in Audiology, Neurotology, and the Hearing Sciences. Translational Research in Audiology, Neurotology, and the Hearing Sciences 165 195 .
Georg Haymerle, Dietmar Thurnher, Lorenz Kadletz, Isabella Stanisz, Markus Brunner, Ulana Kotowski, Elisabeth Enzenhofer & Gregor Heiduschka. (2014) Assessment of caroverine as a potential chemotherapeutical agent in HNSCC cell lines. European Archives of Oto-Rhino-Laryngology 272:11, pages 3451-3456.
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Kartik Parelkar, Vandana Thorawade, Mohan Jagade, Smita Nagle, Rajanala Nataraj, Madhavi Pandare, Reshma Hanwate, Bandu Nagrale, Kiran Kulsange, Devkumar Rangaraja & Arpita Singhal. (2015) Intratympanic Injections: An Unsolved Mystery. International Journal of Otolaryngology and Head & Neck Surgery 04:02, pages 124-132.
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Konrad Skotnicki, Julio De la Fuente, Alvaro Cañete & Krzysztof Bobrowski. (2014) Spectral and Kinetic Properties of Radicals Derived from Oxidation of Quinoxalin-2-One and Its Methyl Derivative. Molecules 19:11, pages 19152-19171.
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Iwona Niedziałek, Izabela Sarnicka, Monika Lewandowska, Rafał Milner, Małgorzata Ganc, Małgorzata Fludra, Karina Karendys, Agata Szkiełkowska & Henryk Skarżyński. (2020) Pathomechanisms of tinnitus – a review of selected hypotheses. Nowa Audiofonologia 3:1, pages 15-19.
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Tony L. Sahley, Michael D. Hammonds & Frank E. Musiek. (2013) Endogenous dynorphins, glutamate and N-methyl-d-aspartate (NMDA) receptors may participate in a stress-mediated Type-I auditory neural exacerbation of tinnitus. Brain Research 1499, pages 80-108.
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David Baguley, Gerhard Andersson, Don McFerran & Laurence McKenna. 2013. Tinnitus: A Multidisciplinary Approach. Tinnitus: A Multidisciplinary Approach 243 301 .
Berthold Langguth, Ana Belén Elgoyhen, Dirk De Ridder & Richard J. Salvi. 2013. Disorders of Peripheral and Central Auditory Processing. Disorders of Peripheral and Central Auditory Processing 345 381 .
Hasan Belli, Seyda Belli, Mehmet Faruk Oktay & Cenk Ural. (2012) Psychopathological dimensions of tinnitus and psychopharmacologic approaches in its treatment. General Hospital Psychiatry 34:3, pages 282-289.
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Berthold Langguth, Dirk De Ridder, Tobias Kleinjung & Ana Belén Elgoyhen. 2012. Tinnitus. Tinnitus 255 289 .
James A. Kaltenbach & Ryan Manz. 2012. Noise-Induced Hearing Loss. Noise-Induced Hearing Loss 151 175 .
Calvin Wu, Kamakshi Gopal, Guenter W. Gross, Thomas J. Lukas & Ernest J. Moore. (2011) An in vitro model for testing drugs to treat tinnitus. European Journal of Pharmacology 667:1-3, pages 188-194.
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Ana Belén Elgoyhen & Berthold Langguth. 2011. Textbook of Tinnitus. Textbook of Tinnitus 625 637 .
Avril Genene Holt, David Bissig, Najab Mirza, Gary Rajah & Bruce Berkowitz. (2010) Evidence of Key Tinnitus-Related Brain Regions Documented by a Unique Combination of Manganese-Enhanced MRI and Acoustic Startle Reflex Testing. PLoS ONE 5:12, pages e14260.
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Gentiana Ioana Wenzel, Athanasia Warnecke, Timo Stöver & Thomas Lenarz. (2009) Effects of extracochlear gacyclidine perfusion on tinnitus in humans: a case series. European Archives of Oto-Rhino-Laryngology 267:5, pages 691-699.
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Mao-li Duan & Chen Zhi-qiang. (2009) Permeability of round window membrane and its role for drug delivery: our own findings and literature review. Journal of Otology 4:1, pages 34-43.
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Ricardo Rodrigues Figueiredo, Berthold Langguth, Patricia Mello de Oliveira & Andréia Aparecida de Azevedo. (2008) Tinnitus treatment with memantine. Otolaryngology–Head and Neck Surgery 138:4, pages 492-496.
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Wei Sun, Jianzhong Lu & Erin Laundrie. (2007) Neurotransmitter Modulation Relates with Tinnitus Signal Generation and Management. Journal of Otology 2:2, pages 63-69.
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B. Mazurek, T. Stöver, H. Haupt, J. Gross & A. Szczepek. (2007) Die Rolle der kochleären Neurotransmitter in Bezug auf TinnitusThe role of cochlear neurotransmitters in tinnitus. HNO 55:12, pages 964-971.
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Andréia A. Azevedo & Ricardo R. Figueiredo. (2005) Uso do acamprosato no tratamento do zumbido: um estudo duplo-cego. Revista Brasileira de Otorrinolaringologia 71:5, pages 618-623.
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Andréia A. Azevedo & Ricardo R. Figueiredo. (2005) Tinnitus treatment with acamprosate: double-blind study. Brazilian Journal of Otorhinolaryngology 71:5, pages 618-623.
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G. Halmos, Z. Doleviczényi, G. Répássy, Á. Kittel, E.S. Vizi, B. Lendvai & T. Zelles. (2005) D2 autoreceptor inhibition reveals oxygen-glucose deprivation-induced release of dopamine in guinea-pig cochlea. Neuroscience 132:3, pages 801-809.
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C. Herraiz. (2005) Mecanismos fisiopatológicos en la génesis y cronificación del acúfeno. Acta Otorrinolaringológica Española 56:8, pages 335-342.
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B. Mazurek, H. Haupt & J. Gross. 2005. Tinnitus. Tinnitus 43 51 .
Zhiqiang Chen, Mats Ulfendahl, Runsheng Ruan, Luke Tan & Maoli Duan. (2004) Protection of auditory function against noise trauma with local caroverine administration in guinea pigs. Hearing Research 197:1-2, pages 131-136.
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Michael D. Seidman & Prashant Vivek. (2004) Intratympanic treatment of hearing loss with novel and traditional agents. Otolaryngologic Clinics of North America 37:5, pages 973-990.
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Kamakshi V. Gopal & Guenter W. Gross. (2004) Unique responses of auditory cortex networks in vitro to low concentrations of quinine. Hearing Research 192:1-2, pages 10-22.
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Elisabeth Formann, Rudolf Stauber, Doris-Maria Denk, Wolfgang Jessner, Gernot Zollner, Petra Munda-Steindl, Alfred Gangl & Peter Ferenci. (2004) Sudden Hearing Loss in Patients with Chronic Hepatitis C Treated with Pegylated Interferon/Ribavirin. The American Journal of Gastroenterology 99:5, pages 873-877.
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Michael D. SeidmanThomas R. Van De Water. (2003) Pharmacologic Manipulation of the Labyrinth with Novel and Traditional Agents Delivered to the Inner Ear. Ear, Nose & Throat Journal 82:4, pages 276-300.
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Natalia Udilova, Andrey V. Kozlov, Werner Bieberschulte, Klemens Frei, Klaus Ehrenberger & Hans Nohl. (2003) The antioxidant activity of caroverine. Biochemical Pharmacology 65:1, pages 59-65.
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Tony L. Sahley & Richard H. Nodar. (2001) Tinnitus: present and future. Current Opinion in Otolaryngology & Head and Neck Surgery 9:5, pages 323-328.
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Tony L Sahley & Richard H Nodar. (2001) A biochemical model of peripheral tinnitus. Hearing Research 152:1-2, pages 43-54.
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Gordon J. Lees. (2000) Pharmacology of AMPA/Kainate Receptor Ligands and Their Therapeutic Potential in Neurological and Psychiatric Disorders. Drugs 59:1, pages 33-78.
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Robert A. Dobie. (1999) A Review of Randomized Clinical Trials in Tinnitus. The Laryngoscope 109:8, pages 1202-1211.
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Julie J. Simpson & W.Ewart Davies. (1999) Recent advances in the pharmacological treatment of tinnitus. Trends in Pharmacological Sciences 20:1, pages 12-18.
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Christian Geretsegger & Reinhold Fartacek. (1998) Infusional high-dose application of the calcium-channel-blocking and antiglutamatergic agent caroverine in the treatment of alcohol withdrawal (DSM-III-R 291.80). European Neuropsychopharmacology 8:3, pages 191-194.
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