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Research Article

Pharmacokinetics In Baclofen Overdose

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Pages 11-20 | Published online: 25 Sep 2008

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Vincent R. Lee, Rachel M. Shively, Michael K. Connolly, Robert S. Hoffman & Joshua Nogar. (2021) Removal of baclofen with hemodialysis is negligible compared to intact kidney excretion in a pediatric overdose: a case report. Clinical Toxicology 59:3, pages 231-234.
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Cédric Cleophax, Antonio Goncalves, Céline Chasport, Eugénie de Beaugrenier, Laurence Labat, Xavier Declèves & Bruno Mégarbane. (2015) Usefulness of plasma drug monitoring in severe baclofen poisoning. Clinical Toxicology 53:9, pages 923-924.
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Yung-Chang Chen, Chin-Tung Chang, Ji-Tseng Fang & Chiu-Ching Huang. (2003) Baclofen Neurotoxicity in Uremic Patients: Is Continuous Ambulatory Peritoneal Dialysis Less Effective Than Intermittent Hemodialysis?. Renal Failure 25:2, pages 297-305.
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Sara Nugent, Michael D. Katz & Timothy E. Little. (1986) Baclofen Overdose with Cardiac Conduction Abnormalities: Case Report and Review of the Literature. Journal of Toxicology: Clinical Toxicology 24:4, pages 321-328.
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Articles from other publishers (29)

Marc Ghannoum, Ingrid Berling, Valéry Lavergne, Darren M. Roberts, Tais Galvao, Robert S. Hoffman, Thomas D. Nolin, Andrew Lewington, Kent Doi, Sophie Gosselin, Badria Alhatali, Kurt Anseeuw, Steven Bird, Josée Bouchard, Timothy E. Bunchman, Diane P. Calello, Paul K. Chin, David S. Goldfarb, Hossein Hassanian-Moghaddam, Lotte C. Hoegberg, Siba Kallab, Sofia Kebede, Jan T. Kielstein, Joshua D. King, Yi Li, Etienne M. Macedo, Rob MacLaren, Bruno Megarbane, James B. Mowry, Marlies E. Ostermann, Ai Peng, Jean-Philippe Roy, Greene Shepherd, Anitha Vijayan, Steven J. Walsh, Anselm Wong, David M. Wood & Christopher Yates. (2021) Recommendations from the EXTRIP workgroup on extracorporeal treatment for baclofen poisoning. Kidney International 100:4, pages 720-736.
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Lauren Murphy, Hannah Wolfer & Robert G. Hendrickson. (2020) Toxicologic Confounders of Brain Death Determination: A Narrative Review. Neurocritical Care 34:3, pages 1072-1089.
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Abhishek Sachan, Varun Kumar Singh, Jayantee Kalita & Usha Kant Misra. (2020) Baclofen encephalopathy: uncommon side effect of a common drug. Postgraduate Medical Journal 96:1142, pages 780-781.
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G. Drevin, M. Briet, S. Ghamrawi, F. Beloncle & C. Abbara. (2020) Baclofen overdose following recreational use in adolescents and young adults: A case report and review of the literature. Forensic Science International 316, pages 110541.
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Caitlin N. Kent, Charlotte Park & Craig W. Lindsley. (2020) Classics in Chemical Neuroscience: Baclofen. ACS Chemical Neuroscience 11:12, pages 1740-1755.
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Sahar Farhat, Tarek El Halabi, Achraf Makki, Samir F. Atweh, Wassim Nasreddine & Ahmad Beydoun. (2020) Coma With Absent Brainstem Reflexes and a Burst Suppression on EEG Secondary to Baclofen Toxicity. Frontiers in Neurology 11.
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Ram A. Mishaal, Nancy E. Lanphear, Erez Armarnik, Esias R. van Rensburg & Douglas G. Matsell. (2020) Baclofen Toxicity in Children With Acute Kidney Injury: Case Reports and Review of the Literature. Child Neurology Open 7, pages 2329048X2093711.
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James D. Triplett, Nicholas D. Lawn & John W. Dunne. (2019) Baclofen Neurotoxicity. Journal of Clinical Neurophysiology 36:3, pages 209-212.
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Abdelhamid Hachimi, Saad ElBahja, Soleimane Rachda, Mohamed Fajri, Zakaria Abjaw, Naila Boukoub & Mina ElKhayari. (2019) Oral baclofen poisoning with normal renal function: A new case and review of the literature. Toxicologie Analytique et Clinique 31:2, pages 119-124.
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Laurence Labat, Antonio Goncalves, Cédric Cleophax, Bruno Megarbane & Xavier Decleves. (2016) Dosage du baclofène dans le plasma en chromatographie phase liquide couplée à de la spectrométrie de masse en tandem : à propos d’un cas de surdosage. Toxicologie Analytique et Clinique 28:3, pages 211-217.
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Louise Bendix Kiel, Lotte Christine Groth Hoegberg, Tejs Jansen, John Asger Petersen & Kim Peder Dalhoff. (2015) A Nationwide Register-Based Survey of Baclofen Toxicity. Basic & Clinical Pharmacology & Toxicology 116:5, pages 452-456.
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Didier Meulendijks, Saheed Khan, Cornelis H. W. Koks, Alwin D. R. Huitema, Jan H. M. Schellens & Jos H. Beijnen. (2015) Baclofen overdose treated with continuous venovenous hemofiltration. European Journal of Clinical Pharmacology 71:3, pages 357-361.
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T.J.R. Beveridge, H.R. Smith & L.J. Porrino. (2013) Differential development of tolerance to the functional and behavioral effects of repeated baclofen treatment in rats. Pharmacology Biochemistry and Behavior 106, pages 27-32.
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Roxanna Khorzad, Justine A. Lee, Megan Whelan, Ahna G. Brutlag, Elizabeth P. Martin, Lee T. Miyahara & Lynn R. Hovda. (2012) Baclofen toxicosis in dogs and cats: 145 cases (2004–2010). Journal of the American Veterinary Medical Association 241:8, pages 1059-1064.
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Ming-Ju Hsieh, Shyr-Chyr Chen, Te-I Weng, Cheng-Chung Fang & Tun-Jun Tsai. (2012) Treating baclofen overdose by hemodialysis. The American Journal of Emergency Medicine 30:8, pages 1654.e5-1654.e7.
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Guido F. Weißhaar, Marc Hoemberg, Katja Bender, Ursula Bangen, Peter Herkenrath, Frank Eifinger, Markus Rothschild, Bernhard Roth & André Oberthuer. (2012) Baclofen intoxication: a “fun drug” causing deep coma and nonconvulsive status epilepticus—a case report and review of the literature. European Journal of Pediatrics 171:10, pages 1541-1547.
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Geoffrey C. WallAmy WasiakGreg A. Hicklin. (2006) An Initially Unsuspected Case of Baclofen Overdose. American Journal of Critical Care 15:6, pages 611-613.
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Nicola Y Leung, Ian M Whyte & Geoffrey K Isbister. (2006) Baclofen overdose: Defining the spectrum of toxicity. Emergency Medicine Australasia 18:1, pages 77-82.
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Angela F. Slaughter, Sarah M. Roddy, Barbara A. Holshouser & Shamel A. Abd-Allah. (2006) Magnetic Resonance Spectroscopy and Electroencephalography in Baclofen Coma. Pediatric Neurology 34:2, pages 151-155.
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V.-C. Wu, S.-L. Lin, S.-M. Lin & C.-C. Fang. (2004) Treatment of baclofen overdose by haemodialysis: a pharmacokinetic study. Nephrology Dialysis Transplantation 20:2, pages 441-443.
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H. E. Wiersma, C. J. van Boxtel, J. J. Butter, W. M. C. van Aalderen, T. Omari & M. A. Benninga. (2003) Pharmacokinetics of a Single Oral Dose of Baclofen in Pediatric Patients With Gastroesophageal Reflux Disease. Therapeutic Drug Monitoring 25:1, pages 93-98.
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DENISE CHAPPLE, DAVID JOHNSON & RUTH CONNORS. (2001) Baclofen overdose in two siblings. Pediatric Emergency Care 17:2, pages 110-112.
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