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Original Article

Gentamicin Uptake by Cochlear Hair Cells Precedes Hearing Impairment during Chronic Treatment

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Pages 78-87 | Received 03 Mar 1992, Accepted 27 Mar 1992, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Mitsuya Suzuki, Mitsuya Suzuki, Munetaka Ushio & Tatsuya Yamasoba. (2008) Time course of apoptotic cell death in guinea pig cochlea following intratympanic gentamicin application. Acta Oto-Laryngologica 128:7, pages 724-731.
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Joshua G Yorgason, Jose N Fayad & Federico Kalinec. (2006) Understanding drug ototoxicity: molecular insights for prevention and clinical management. Expert Opinion on Drug Safety 5:3, pages 383-399.
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Deise Lima da Costa, Jean-Paul Erre & Jean-Marie Aran. (1998) Aminoglycoside Ototoxicity and the Medial Efferent System: I. Comparison of Acute and Chronic Gentamicin Treatments. Audiology 37:3, pages 151-161.
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SHUICHIROH HOTTA, MITSUAKI TAKAHASHI, TOSHIHIRO ITOH, KOHTAROH YAMAMURA. (1998) Experimental Study on the Effects of Gentamicin Injection on the Guinea-pig: Electrophysiological Studies. Acta Oto-Laryngologica 118:3, pages 362-368.
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Jean-Marie Aran, Jean-Paul Erre & Paul Avan. (1994) Contralateral suppression of transient evoked otoacoustic emissions in guinea-pigs: effects of gentamicin. British Journal of Audiology 28:4-5, pages 267-271.
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Articles from other publishers (48)

Kristen Janky & Peter S. Steyger. (2023) Mechanisms and Impact of Aminoglycoside-Induced Vestibular Deficits. American Journal of Audiology 32:3S, pages 746-760.
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Joseph A. Bellairs, Van A. Redila, Patricia Wu, Ling Tong, Alyssa Webster, Julian A. Simon, Edwin W. Rubel & David W. Raible. (2022) An in vivo Biomarker to Characterize Ototoxic Compounds and Novel Protective Therapeutics. Frontiers in Molecular Neuroscience 15.
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Enid Owusu, Benjamin T. Amartey, Emmanuel Afutu & Neal Boafo. (2022) Aminoglycoside Therapy for Tuberculosis: Evidence for Ototoxicity among Tuberculosis Patients in Ghana. Diseases 10:1, pages 10.
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Peter S. Steyger. (2021) Mechanisms of Ototoxicity and Otoprotection. Otolaryngologic Clinics of North America 54:6, pages 1101-1115.
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Peter S. Steyger. (2021) Mechanisms of Aminoglycoside- and Cisplatin-Induced Ototoxicity. American Journal of Audiology 30:3S, pages 887-900.
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Allison B. Coffin, Robert Boney, Jordan Hill, Cong Tian & Peter S. Steyger. (2021) Detecting Novel Ototoxins and Potentiation of Ototoxicity by Disease Settings. Frontiers in Neurology 12.
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Xiaoqing Qian, Ziyu He, Yanmei Wang, Binjun Chen, Alisa Hetrick, Chunfu Dai, Fanglu Chi, Hongzhe Li & Dongdong Ren. (2020) Hair cell uptake of gentamicin in the developing mouse utricle. Journal of Cellular Physiology 236:7, pages 5235-5252.
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Shasha Guo, Nana Xu, Peng Chen, Ying Liu, Xiaofei Qi, Sheng Liu, Cuixian Li & Jie Tang. (2019) Rapamycin Protects Spiral Ganglion Neurons from Gentamicin-Induced Degeneration In Vitro. Journal of the Association for Research in Otolaryngology 20:5, pages 475-487.
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Meiyan Jiang, Hongzhe Li, Anastasiya Johnson, Takatoshi KarasawaYuan ZhangWilliam B. Meier, Farshid Taghizadeh, Allan KachelmeierPeter S. Steyger. (2019) Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss. Science Advances 5:7.
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Peter S. Steyger. 2018. Inflammatory Mechanisms in Mediating Hearing Loss. Inflammatory Mechanisms in Mediating Hearing Loss 133 147 .
Meiyan Jiang, Farshid Taghizadeh & Peter S. Steyger. (2017) Potential Mechanisms Underlying Inflammation-Enhanced Aminoglycoside-Induced Cochleotoxicity. Frontiers in Cellular Neuroscience 11.
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Meiyan Jiang, Takatoshi Karasawa & Peter S. Steyger. (2017) Aminoglycoside-Induced Cochleotoxicity: A Review. Frontiers in Cellular Neuroscience 11.
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Hongzhe Li, Allan Kachelmeier, David N. Furness & Peter S. Steyger. (2015) Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells. Frontiers in Cellular Neuroscience 9.
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Lyandysha V. Zholudeva, Kristina G. Ward, Michael G. Nichols & Heather Jensen Smith. (2015) Gentamicin differentially alters cellular metabolism of cochlear hair cells as revealed by NAD(P)H fluorescence lifetime imaging. Journal of Biomedical Optics 20:5, pages 051032.
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Min Li & Peter R. Byron. (2013) Tobramycin Disposition in the Rat Lung Following Airway Administration. Journal of Pharmacology and Experimental Therapeutics 347:2, pages 318-324.
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D. Dulon, I. Mosnier & D. Bouccara. (2013) Ototoxicidad farmacológica. EMC - Otorrinolaringología 42:1, pages 1-13.
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D. Dulon, I. Mosnier & D. Bouccara. (2012) Ototoxicité médicamenteuse. EMC - Oto-rhino-laryngologie 7:4, pages 1-12.
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Ruben S. Stepanyan, Artur A. Indzhykulian, A. Catalina Vélez-Ortega, Erich T. Boger, Peter S. Steyger, Thomas B. Friedman & Gregory I. Frolenkov. (2011) TRPA1-Mediated Accumulation of Aminoglycosides in Mouse Cochlear Outer Hair Cells. Journal of the Association for Research in Otolaryngology 12:6, pages 729-740.
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Andrew Forge, Ruth Taylor & Brad Bolon. 2011. Fundamental Neuropathology for Pathologists and Toxicologists. Fundamental Neuropathology for Pathologists and Toxicologists 413 428 .
Hongzhe Li, Qi Wang & Peter S. Steyger. (2011) Acoustic Trauma Increases Cochlear and Hair Cell Uptake of Gentamicin. PLoS ONE 6:4, pages e19130.
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Michael G. Leitner, Christian R. Halaszovich & Dominik Oliver. (2011) Aminoglycosides Inhibit KCNQ4 Channels in Cochlear Outer Hair Cells via Depletion of Phosphatidylinositol(4,5)bisphosphate. Molecular Pharmacology 79:1, pages 51-60.
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Dalian Ding, Haiyan Jiang & Richard J. Salvi. (2010) Mechanisms of rapid sensory hair-cell death following co-administration of gentamicin and ethacrynic acid. Hearing Research 259:1-2, pages 16-23.
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G. Russo, D. Calzi, L. Gioglio, L. Botta, M.R. Polimeni, G. Zucca, M. Martini, D. Contini, R. Fesce, M.L. Rossi & I. Prigioni. (2009) Analysis of pre- and postsynaptic activity in the frog semicircular canal following ototoxic insult: differential recovery of background and evoked afferent activity. Neuroscience 163:4, pages 1327-1339.
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Andrew Forge, Ruth Taylor & Ernest S. Harpur. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Y.H. Choung, A. Taura, K. Pak, S.J. Choi, M. Masuda & A.F. Ryan. (2009) Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of corti treated with gentamicin. Neuroscience 161:1, pages 214-226.
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Qi Wang & Peter S. Steyger. (2009) Trafficking of Systemic Fluorescent Gentamicin into the Cochlea and Hair Cells. Journal of the Association for Research in Otolaryngology 10:2, pages 205-219.
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K. Faucher, Ø. Aas-Hansen, B. Damsgård & N.C. Stenklev. (2008) Effects of systemic versus local gentamicin on the inner ear in the Atlantic cod, Gadus morhua (L.), relevance for fish hearing investigations. Hearing Research 240:1-2, pages 12-21.
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M. Riga, S. Korres, M. Varvutsi, H. Kosmidis, D. Douniadakis, I. Psarommatis, I. Yiotakis & E. Ferekidis. (2007) Long-term effects of chemotherapy for acute lymphoblastic leukemia on the medial olivocochlear bundle: Effects of different cumulative doses of gentamicin. International Journal of Pediatric Otorhinolaryngology 71:11, pages 1767-1773.
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Kelly N. Owens, Dale E. Cunningham, Glen Macdonald, Edwin W. Rubel, David W. Raible & Remy Pujol. (2007) Ultrastructural analysis of aminoglycoside‐induced hair cell death in the zebrafish lateral line reveals an early mitochondrial response. Journal of Comparative Neurology 502:4, pages 522-543.
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Walter Marcotti, Sietse M. Van Netten & Corné J. Kros. (2005) The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano 
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Jonathan I. Matsui, Jonathan E. Gale & Mark E. Warchol. (2004) Critical signaling events during the aminoglycoside‐induced death of sensory hair cells in vitro . Journal of Neurobiology 61:2, pages 250-266.
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Dalian Ding, Alfred Stracher & Richard J Salvi. (2002) Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity. Hearing Research 164:1-2, pages 115-126.
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M. Mulheran, C. Degg, S. Burr, D. W. Morgan & D. E. Stableforth. (2001) Occurrence and Risk of Cochleotoxicity in Cystic Fibrosis Patients Receiving Repeated High-Dose Aminoglycoside Therapy. Antimicrobial Agents and Chemotherapy 45:9, pages 2502-2509.
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Michael E. Hoffer, Keith Allen, Richard D. Kopke, Peter Weisskopf, Kim Gottshall & Derin Wester. (2009) Transtympanic Versus Sustained‐Release Administration of Gentamicin: Kinetics, Morphology, and Function. The Laryngoscope 111:8, pages 1343-1357.
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Eri Hashino, Marlene Shero & Richard J. Salvi. (2000) Lysosomal augmentation during aminoglycoside uptake in cochlear hair cells. Brain Research 887:1, pages 90-97.
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R. Dauman & D. Dulon. (2000) Ototoxicidad medicamentosa. EMC - Otorrinolaringología 29:1, pages 1-12.
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JEAN‐MARIE ARAN, JEAN‐PAUL ERRE, DEISE LIMA DA COSTA, IKRAM DEBBARH & DIDIER DULON. (2006) Acute and Chronic Effects of Aminoglycosides on Cochlear Hair Cells. Annals of the New York Academy of Sciences 884:1, pages 60-68.
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