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International Journal of Neuroscience Volume 111, 2001 - Issue 3-4
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Original Article

Experimental Models of Partial Lesion of Rat Spinal Cord to Investigate Neurodegeneration, Glial Activation, and Behavior Impairments

G. Chadi Laboratory of Neuroregeneration Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo, BrazilCorrespondence[email protected]
,
M. S. R. Andrade Laboratory of Neuroregeneration Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo, Brazil
,
R. J. A. Leme Laboratory of Neuroregeneration Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo, Brazil
&
V. C. Gomide Laboratory of Neuroregeneration Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo, Brazil
Pages 137-165 | Received 21 Apr 2001, Published online: 07 Jul 2009

Citations (20)

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VÂNIA G. GOMIDE, THEO BIBANCOS, GERSON CHADI, VÂNIA G. GOMIDE, THEO BIBANCOS & GERSON CHADI. (2005) DOPAMINE CELL MORPHOLOGY AND GLIAL CELL HYPERTROPHY AND PROCESS BRANCHING IN THE NIGROSTRIATAL SYSTEM AFTER STRIATAL 6-OHDA ANALYZED BY SPECIFIC STEROLOGICAL TOOLS. International Journal of Neuroscience 115:4, pages 557-582.
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VÂNIA C. GOMIDE & GERSON CHADI. (2005) GLIAL bFGF AND S100 IMMUNOREACTIVITIES INCREASE IN ASCENDING DOPAMINE PATHWAYS FOLLOWING STRIATAL 6-OHDA-INDUCED PARTIAL LESION OF THE NIGROSTRIATAL SYSTEM: A STEROLOGICAL ANALYSIS. International Journal of Neuroscience 115:4, pages 537-555.
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V. C. GOMIDE, G. A. SILVEIRA & Gerson Chadi. (2005) Transient and Widespread Astroglial Activation in the Brain after a Striatal 6-Ohda-Induced Partial Lesion of the Nigrostriatal System. International Journal of Neuroscience 115:1, pages 99-117.
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R. W. P. RODRIGUES, V. C. GOMIDE & G. CHADI. (2004) ASTROGLIAL AND MICROGLIAL ACTIVATION IN THE WISTAR RAT VENTRAL TEGMENTAL AREA AFTER A SINGLE STRIATAL INJECTION OF 6-HYDROXYDOPAMINE. International Journal of Neuroscience 114:2, pages 197-216.
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Articles from other publishers (16)

Diana Schaufler, Maria Eleni Manthou, Paschalis Theotokis, Svenja Rink-Notzon & Doychin N. Angelov. (2023) Effects of Whole-Body Vibration and Manually Assisted Locomotor Therapy on Neurotrophin-3 Expression and Microglia/Macrophage Mobilization Following Thoracic Spinal Cord Injury in Rats. Current Issues in Molecular Biology 45:4, pages 3238-3254.
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Zahra Khodabandeh, Davood Mehrabani, Farzaneh Dehghani, Nooshin Gashmardi, Mahboobeh Erfanizadeh, Shahrokh Zare & Farzaneh Bozorg-Ghalati. (2021) Spinal cord injury repair using mesenchymal stem cells derived from bone marrow in mice: A stereological study. Acta Histochemica 123:5, pages 151720.
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MayaraFerraz de Menezes, Fabrício Nicola, IvyReichert Vital da Silva, Adriana Vizuete, VivianeRostirola Elsner, LéderLeal Xavier, CarlosAlberto Saraiva Gonçalves, CarlosAlexandre Netto & RégisGemerasca Mestriner. (2018) Glial fibrillary acidic protein levels are associated with global histone H4 acetylation after spinal cord injury in rats. Neural Regeneration Research 13:11, pages 1945.
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Chary Marquez Batista, Leonardo Luis Torres Bianqui, Bruno Bonganha Zanon, Mauricio Menezes Aben Athar Ivo, Gabriela Pintar de Oliveira, Jessica Ruivo Maximino & Gerson Chadi. (2014) Behavioral Improvement and Regulation of Molecules Related to Neuroplasticity in Ischemic Rat Spinal Cord Treated with PEDF. Neural Plasticity 2014, pages 1-16.
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Elham Saghaei, Fatemeh Abbaszadeh, Kobra Naseri, Samar Ghorbanpoor, Mina Afhami, Ali Haeri, Farzaneh Rahimi & Masoumeh Jorjani. (2013) Estradiol attenuates spinal cord injury-induced pain by suppressing microglial activation in thalamic VPL nuclei of rats. Neuroscience Research 75:4, pages 316-323.
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Fatih Bayrakli, Hatice Balaban, Unal Ozum, Cevdet Duger, Suat Topaktas & Hamit Zafer Kars. (2012) Etanercept treatment enhances clinical and neuroelectrophysiological recovery in partial spinal cord injury. European Spine Journal 21:12, pages 2588-2593.
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André Luis Bombeiro, Lígia Antunes Gonçalves, Carlos Penha-Gonçalves, Claudio Romero Farias Marinho, Maria Regina D’Império Lima, Gerson Chadi & José Maria Álvarez. (2012) IL-12p40 Deficiency Leads to Uncontrolled Trypanosoma cruzi Dissemination in the Spinal Cord Resulting in Neuronal Death and Motor Dysfunction. PLoS ONE 7:11, pages e49022.
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Young S. Gwak, Jonghoon Kang, Geda C. Unabia & Claire E. Hulsebosch. (2012) Spatial and temporal activation of spinal glial cells: Role of gliopathy in central neuropathic pain following spinal cord injury in rats. Experimental Neurology 234:2, pages 362-372.
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Chrystian Junqueira Alves, Luana Pereira de Santana, Angélica Janaína Dias dos Santos, Gabriela Pintar de Oliveira, Tatiana Duobles, Juliana Milani Scorisa, Roberto Sérgio Martins, Jessica Ruivo Maximino & Gerson Chadi. (2011) Early motor and electrophysiological changes in transgenic mouse model of amyotrophic lateral sclerosis and gender differences on clinical outcome. Brain Research 1394, pages 90-104.
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Araceli Diaz-Ruiz, Hermelinda Salgado-Ceballos, Sergio Montes, Gabriel Guizar-Sahagún, Noemi Gelista-Herrera, Marisela Mendez-Armenta, Sofia Diaz-Cintra & Camilo Ríos. (2011) Delayed administration of dapsone protects from tissue damage and improves recovery after spinal cord injury. Journal of Neuroscience Research 89:3, pages 373-380.
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Gabriela Pintar de Oliveira, Tatiana Duobles, Patrícia Castelucci & Gerson Chadi. (2010) Differential regulation of FGF-2 in neurons and reactive astrocytes of axotomized rat hypoglossal nucleus. A possible therapeutic target for neuroprotection in peripheral nerve pathology. Acta Histochemica 112:6, pages 604-617.
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Michele Schultz Ramos Andrade, Lúcio Mário Mendonça & Gerson Chadi. (2010) Treadmill running protects spinal cord contusion from secondary degeneration. Brain Research 1346, pages 266-278.
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M.S.R. Andrade, F.R. Hanania, K. Daci, R.J.A. Leme & G. Chadi. (2008) Contuse lesion of the rat spinal cord of moderate intensity leads to a higher time-dependent secondary neurodegeneration than severe one. Tissue and Cell 40:2, pages 143-156.
Crossref
Jinger do Carmo Cunha, Beatriz de Freitas Azevedo Levy, Bianca Aparecida de Luca, Michele Schultz Ramos de Andrade, Vânia Canterucci Gomide & Gerson Chadi. (2007) Responses of reactive astrocytes containing S100? protein and fibroblast growth factor-2 in the border and in the adjacent preserved tissue after a contusion injury of the spinal cord in rats: implications for wound repair and neuroregeneration. Wound Repair and Regeneration 15:1, pages 134-146.
Crossref
M Myers, K L Britt, N G M Wreford, F J P Ebling & J B Kerr. (2004) Methods for quantifying follicular numbers within the mouse ovary. Reproduction 127:5, pages 569-580.
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Teresa P Silva, Gilcélio A Silveira, Débora R Fior-Chadi & Gerson Chadi. (2004) Effects of ethanol consumption on vasopressin and neuropeptide Y immunoreactivity and mRNA expression in peripheral and central areas related to cardiovascular regulation. Alcohol 32:3, pages 213-222.
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