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Research Article

Association Between the MTHFR Gene and Alzheimer's Disease: A Meta-Analysis

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Pages 462-471 | Received 13 Jan 2011, Published online: 10 Jun 2011

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Laith N AL-Eitan, Islam M Al-Dalalah, Mohamed M Mustafa, Mansour A Alghamdi, Afrah K Elshammari, Wael H Khreisat & Hanan A Aljamal. (2019) Effects of MTHFR and ABCC2 gene polymorphisms on antiepileptic drug responsiveness in Jordanian epileptic patients. Pharmacogenomics and Personalized Medicine 12, pages 87-95.
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Innocenzo Rainero, Alessandro Vacca, Fausto Roveta, Flora Govone, Annalisa Gai & Elisa Rubino. (2019) Targeting MTHFR for the treatment of migraines. Expert Opinion on Therapeutic Targets 23:1, pages 29-37.
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Alaina M. Reagan, Kristen D. Onos, Sarah E. Heuer, Michael Sasner & Gareth R. Howell. 2022. Mouse Models of Development and Disease. Mouse Models of Development and Disease 79 113 .
Jadranka Miletić Vukajlović & Tanja Panić-Janković. 2021. Mass Spectrometry in Life Sciences and Clinical Laboratory. Mass Spectrometry in Life Sciences and Clinical Laboratory.
Isha NasaArminja N. Kettenbach. (2020) Effects of carboxyl-terminal methylation on holoenzyme function of the PP2A subfamily. Biochemical Society Transactions 48:5, pages 2015-2027.
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Thomas G. Guilliams. 2018. Integrative Medicine. Integrative Medicine 395 403.e2 .
Mona Hersi, Brittany Irvine, Pallavi Gupta, James Gomes, Nicholas Birkett & Daniel Krewski. (2017) Risk factors associated with the onset and progression of Alzheimer’s disease: A systematic review of the evidence. NeuroToxicology 61, pages 143-187.
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Kirsty Porter, Leane Hoey, Catherine Hughes, Mary Ward & Helene McNulty. (2016) Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing. Nutrients 8:11, pages 725.
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Qing Ye, Feng Bai & Zhijun Zhang. (2016) Shared Genetic Risk Factors for Late-Life Depression and Alzheimer’s Disease. Journal of Alzheimer's Disease 52:1, pages 1-15.
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Francesco Bonetti, Gloria Brombo & Giovanni Zuliani. (2016) The relationship between hyperhomocysteinemia and neurodegeneration. Neurodegenerative Disease Management 6:2, pages 133-145.
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Svetlana Ukraintseva, Anatoliy Yashin, Konstantin Arbeev, Alexander Kulminski, Igor Akushevich, Deqing Wu, Gaurang Joshi, Kenneth C. Land & Eric Stallard. (2015) Puzzling role of genetic risk factors in human longevity: “risk alleles” as pro-longevity variants. Biogerontology 17:1, pages 109-127.
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Thomas B. Shea & Ruth Remington. (2015) Nutritional supplementation for Alzheimerʼs disease?. Current Opinion in Psychiatry 28:2, pages 141-147.
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Luciano Belcavello, Daniela Camporez, Leila D. Almeida, Renato L. Morelato, Maria C. P. Batitucci & Flavia de Paula. (2014) Association of MTHFR and PICALM polymorphisms with Alzheimer’s disease. Molecular Biology Reports 42:3, pages 611-616.
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Ting Zou. (2015) Correlation of Homocysteine Metabolic Enzymes Gene Polymorphism and Mild Cognitive Impairment in the Xinjiang Uygur Population. Medical Science Monitor 21, pages 326-332.
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Qiliu Peng, Xianjun Lao, Xiuli Huang, Xue Qin, Shan Li & Zhiyu Zeng. (2015) The MTHFR C677T polymorphism contributes to increased risk of Alzheimer’s Disease: Evidence based on 40 case-control studies. Neuroscience Letters 586, pages 36-42.
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Siaw-Cheok Liew & Esha Das Gupta. (2015) Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Epidemiology, metabolism and the associated diseases. European Journal of Medical Genetics 58:1, pages 1-10.
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Vandana Rai, Upendra Yadav, Pradeep Kumar, Sushil Kumar Yadav & Om Prakesh Mishra. (2014) Maternal Methylenetetrahydrofolate Reductase C677T Polymorphism and Down Syndrome Risk: A Meta-Analysis from 34 Studies. PLoS ONE 9:9, pages e108552.
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Jean-Marie Sontag, Brandi Wasek, Goce Taleski, Josephine Smith, Erland Arning, Estelle Sontag & Teodoro Bottiglieri. (2014) Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice. Frontiers in Aging Neuroscience 6.
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Florence F. Roussotte, Madelaine Daianu, Neda Jahanshad, Cassandra D. Leonardo & Paul M. Thompson. (2013) Neuroimaging and genetic risk for Alzheimer’s disease and addiction-related degenerative brain disorders. Brain Imaging and Behavior 8:2, pages 217-233.
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Jean-Marie Sontag & Estelle Sontag. (2014) Protein phosphatase 2A dysfunction in Alzheimer’s disease. Frontiers in Molecular Neuroscience 7.
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Fabio Coppedè, Pierpaola Tannorella, Gloria Tognoni, Silvia Bagnoli, Paolo Bongioanni, Benedetta Nacmias, Gabriele Siciliano, Sandro Sorbi, Ubaldo Bonuccelli & Lucia Migliore. (2014) A Pilot Study Evaluating the Contribution of SLC19A1 ( RFC-1 ) 80G>A Polymorphism to Alzheimer’s Disease in Italian Caucasians . BioMed Research International 2014, pages 1-6.
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Fabio Coppedè, Enzo Grossi, Massimo Buscema & Lucia Migliore. (2013) Application of Artificial Neural Networks to Investigate One-Carbon Metabolism in Alzheimer’s Disease and Healthy Matched Individuals. PLoS ONE 8:8, pages e74012.
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Katherine S. Button, John P. A. Ioannidis, Claire Mokrysz, Brian A. Nosek, Jonathan Flint, Emma S. J. Robinson & Marcus R. Munafò. (2013) Power failure: why small sample size undermines the reliability of neuroscience. Nature Reviews Neuroscience 14:5, pages 365-376.
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Margareta Hinterberger & Peter Fischer. (2012) Folate and Alzheimer: when time matters. Journal of Neural Transmission 120:1, pages 211-224.
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Maritha J. Kotze & Susan J. van Rensburg. (2012) Pathology supported genetic testing and treatment of cardiovascular disease in middle age for prevention of Alzheimer’s disease. Metabolic Brain Disease 27:3, pages 255-266.
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