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Research Article

Mechanisms and Clinical Evidence of the Pleiotropic Effects of the Hydroxy-Methyl-Glutaryl-CoA Reductase Inhibitors in Central Nervous System Disorders: A Comprehensive Review

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Pages 619-629 | Received 24 Mar 2012, Published online: 14 Aug 2012

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Lakshya U. Trivedi, Carlos A. Alvarez & Ishak A. Mansi. (2018) Association of Statin Therapy With Risk of Epilepsy in 2 Propensity Score–Matched Cohorts. Annals of Pharmacotherapy 52:6, pages 546-553.
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Clarissa Vasconcelos de Oliveira, Viviane Nogueira Zorzi, Michele Rechia Fighera, Luiz Fernando Freire Royes, Ana Flávia Furian & Mauro Schneider Oliveira. (2018) Subtle improvement of seizure susceptibility by atorvastatin treatment during epileptogenesis. Pharmacological Reports 70:2, pages 364-371.
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Catherine Buettner, Rony-Reuven Nir, Suzanne M. Bertisch, Carolyn Bernstein, Aaron Schain, Murray A. Mittleman & Rami Burstein. (2015) Simvastatin and vitamin D for migraine prevention: A randomized, controlled trial. Annals of Neurology 78:6, pages 970-981.
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C Potey, T Ouk, O Petrault, M Petrault, V Berezowski, J Salleron, R Bordet & S Gautier. (2015) Early treatment with atorvastatin exerts parenchymal and vascular protective effects in experimental cerebral ischaemia. British Journal of Pharmacology 172:21, pages 5188-5198.
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Matthew A Churchward & Kathryn G Todd. (2014) Statin treatment affects cytokine release and phagocytic activity in primary cultured microglia through two separable mechanisms. Molecular Brain 7:1.
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Christos G. Mihos, Andres M. Pineda & Orlando Santana. (2014) Cardiovascular effects of statins, beyond lipid-lowering properties. Pharmacological Research 88, pages 12-19.
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Rita Citraro, Serafina Chimirri, Rossana Aiello, Luca Gallelli, Francesca Trimboli, Domenico Britti, Giovambattista De Sarro & Emilio Russo. (2014) Protective effects of some statins on epileptogenesis and depressive‐like behavior in WAG /Rij rats, a genetic animal model of absence epilepsy . Epilepsia 55:8, pages 1284-1291.
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Majaz Moonis. (2014) The Current Status of Statins in Stroke Prevention. Journal of Neurology & Stroke 1:3.
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Giovanni Corrao, Buthaina Ibrahim, Federica Nicotra, Antonella Zambon, Luca Merlino, Thea Scognamiglio Pasini, Alberico L. Catapano & Giuseppe Mancia. (2013) Long-term use of statins reduces the risk of hospitalization for dementia. Atherosclerosis 230:2, pages 171-176.
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D. R. Tasat & J. S. Yakisich. (2012) Expanding the pleiotropic effects of statins: attenuation of air pollution-induced inflammatory response. American Journal of Physiology-Lung Cellular and Molecular Physiology 303:8, pages L640-L641.
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