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Research Article

Correlation between spasticity and quality of life in patients with multiple sclerosis: the CANDLE study

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Pages 850-858 | Received 22 Feb 2013, Accepted 01 Jun 2013, Published online: 15 Jul 2013

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Read on this site (8)

Maede Khalifeloo, Soofia Naghdi, Noureddin Nakhostin Ansari, Jan Dommerholt & Mohammad Ali Sahraian. (2022) Dry needling for the treatment of muscle spasticity in a patient with multiple sclerosis: a case report. Physiotherapy Theory and Practice 38:13, pages 3248-3254.
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Sven G Meuth, Thomas Henze, Ute Essner, Christiane Trompke & Carlos Vila Silván. (2020) Tetrahydrocannabinol and cannabidiol oromucosal spray in resistant multiple sclerosis spasticity: consistency of response across subgroups from the SAVANT randomized clinical trial. International Journal of Neuroscience 130:12, pages 1199-1205.
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Jolana Markovà, Ute Essner, Bülent Akmaz, Marcella Marinelli, Christiane Trompke, Arnd Lentschat & Carlos Vila. (2019) Sativex® as add-on therapy vs. further optimized first-line ANTispastics (SAVANT) in resistant multiple sclerosis spasticity: a double-blind, placebo-controlled randomised clinical trial. International Journal of Neuroscience 129:2, pages 119-128.
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Joan Vidal, John Slof, David Serrano, Teresa Marqués, Hatice Kumru & Jesús Benito-Penalva. (2017) Cost-effectiveness of Intrathecal Baclofen Therapy in severe refractory non-focal disabling spasticity: a Spanish hospital perspective. Expert Review of Pharmacoeconomics & Outcomes Research 17:1, pages 67-76.
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K. Milinis & C. A. Young. (2016) Systematic review of the influence of spasticity on quality of life in adults with chronic neurological conditions. Disability and Rehabilitation 38:15, pages 1431-1441.
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Sven G Meuth, Carlos Vila & Kerry L Dechant. (2015) Effect of Sativex on spasticity-associated symptoms in patients with multiple sclerosis. Expert Review of Neurotherapeutics 15:8, pages 909-918.
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John Slof, Leonardo Ruiz & Carlos Vila. (2015) Cost-effectiveness of Sativex in multiple sclerosis spasticity: new data and application to Italy. Expert Review of Pharmacoeconomics & Outcomes Research 15:3, pages 379-391.
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Articles from other publishers (37)

Katarzyna Leszczyńska & Juliusz Huber. (2023) Unveiling the Correlations between Clinical Assessment of Spasticity and Muscle Strength and Neurophysiological Testing of Muscle Activity in Incomplete Spinal Cord Injury Patients: The Importance of a Comprehensive Evaluation. Applied Sciences 13:13, pages 7609.
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Michael Guger, Robert Hatschenberger & Fritz Leutmezer. (2023) Non‐interventional, prospective, observational study on spasticity‐associated symptom control with nabiximols as add‐on therapy in patients with multiple sclerosis spasticity in Austria. Brain and Behavior 13:4.
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İlknur Özkan, Cansu Polat Dunya & Serkan Demir. (2022) Life Experiences of Patients With Multiple Sclerosis About Their Spasticity: A Phenomenological Study. Clinical Nursing Research 32:1, pages 49-59.
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Laleh Abadi Marand, Shohreh Noorizadeh Dehkordi, Mahtab Roohi-Azizi & Mehdi Dadgoo. (2022) Effect of dynamic neuromuscular stabilization on balance and trunk function in people with multiple sclerosis: protocol for a randomized control trial. Trials 23:1.
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Luis Andreu-Caravaca, Domingo J. Ramos-Campo, Linda H. Chung & Jacobo Á. Rubio-Arias. (2022) Can strength training modify voluntary activation, contractile properties and spasticity in Multiple Sclerosis?: A randomized controlled trial.. Physiology & Behavior 255, pages 113932.
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SD Newsome, B Thrower, B Hendin, S Danese, J Patterson & R Chinnapongse. (2022) Symptom Burden, Management and Treatment Goals of People with MS Spasticity: Results from SEEN-MSS, a Large-scale, Self-reported Survey. Multiple Sclerosis and Related Disorders, pages 104376.
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Francesco Patti, Clara Grazia Chisari, Óscar Fernández, Jorge Sarroca, Elena Ferrer‐Picón, Francisco Hernández Vicente & Carlos Vila Silván. (2022) A real‐world evidence study of nabiximols in multiple sclerosis patients with resistant spasticity: Analysis in relation to the newly described ‘spasticity‐plus syndrome’. European Journal of Neurology 29:9, pages 2744-2753.
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Armando Creta, Luana Gilio, Diego Centonze & Roberta Fantozzi. (2022) Usability of an application device for nabiximols oromucosal spray in patients with upper limb impaired multiple sclerosis. Neurodegenerative Disease Management 12:4, pages 195-201.
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Bruno Kusznir Vitturi, Alborz Rahmani, Guglielmo Dini, Alfredo Montecucco, Nicoletta Debarbieri, Paolo Bandiera, Mario Alberto Battaglia, Tommaso Manacorda, Benedetta Persechino, Giuliana Buresti, Michela Ponzio, Matilde Inglese & Paolo Durando. (2022) Spatial and temporal distribution of the prevalence of unemployment and early retirement in people with multiple sclerosis: A systematic review with meta-analysis. PLOS ONE 17:7, pages e0272156.
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Andrew Chan & Carlos Vila Silván. (2022) Evidence-based management of multiple sclerosis spasticity with nabiximols oromucosal spray in clinical practice: a 10-year recap. Neurodegenerative Disease Management 12:3, pages 141-154.
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Fatemeh Pashazadeh Kan, Zahra Hoseinipalangi, Niloofar Ahmadi, Hossein Hosseinifard, Afsaneh Dehnad, Batool Sadat Hoseini, Mahsa Tohidi Asl & Ahmad Ghashghaee. (2022) Global, regional and national quality of life in patients with multiple sclerosis: a global systematic review and meta-analysis. BMJ Supportive & Palliative Care 12:2, pages 158-166.
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Yehuda Weizman, Oren Tirosh, Franz Konstantin Fuss, Adin Ming Tan & Erich Rutz. (2022) Recent State of Wearable IMU Sensors Use in People Living with Spasticity: A Systematic Review. Sensors 22:5, pages 1791.
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Bobbette J Miller, Thubi HA Kolobe, Rebecca D Larson, Brian A Pribble, Gabriel Pardo & Shirley A James. (2022) Functional intermuscular reduction in spasticity for people with multiple sclerosis. Multiple Sclerosis Journal - Experimental, Translational and Clinical 8:1, pages 205521732110615.
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Marie D’hooghe, Barbara Willekens, Valerie Delvaux, Miguel D’haeseleer, Daniel Guillaume, Guy Laureys, Guy Nagels, Patrick Vanderdonckt, Vincent Van Pesch & Veronica Popescu. (2021) Sativex® (nabiximols) cannabinoid oromucosal spray in patients with resistant multiple sclerosis spasticity: the Belgian experience. BMC Neurology 21:1.
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Arianna Sartori, Alessandro Dinoto, Lara Stragapede, Giulia Mazzon, Maria Elisa Morelli, Fulvio Pasquin, Alessio Bratina, Antonio Bosco & Paolo Manganotti. (2021) Nabiximols and botulinum toxin injections for patients with multiple sclerosis: efficacy on spasticity and spasms in a single-centre experience. Neurological Sciences 42:12, pages 5037-5043.
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Andrea SANTAMATO, Salvatore FACCIORUSSO, Stefania SPINA, Nicoletta CINONE, Christian AVVANTAGGIATO, Luigi SANTORO, Chiara CIRITELLA, Nicola SMANIA, Alessandro PICELLI, Giulio GASPERINI, Franco MOLTENI, Alessio BARICICH & Pietro FIORE. (2021) Discontinuation of botulinum neurotoxin type-A treatment during COVID-19 pandemic: an Italian survey in post stroke and traumatic brain injury patients living with spasticity. European Journal of Physical and Rehabilitation Medicine 57:3.
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Justin R Abbatemarco, Austin Griffin, Noble G Jones, Jennifer Hartman, Keith McKee, Zhini Wang, Sean J Nagel, Andre G Machado & Francois Bethoux. (2020) Long-term outcomes of intrathecal baclofen in ambulatory multiple sclerosis patients: A single-center experience. Multiple Sclerosis Journal 27:6, pages 933-941.
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Omid Motamedzadeh, Noureddin Nakhostin Ansari, Soofia Naghdi, Amirreza Azimi, Ashraf Mahmoudzadeh, Sandra Calvo & Pablo Herrero. (2021) A Study on the Effects of Dry Needling in Multiple Sclerosis Patients with Spasticity: Protocol of a Randomized Waitlist-Controlled Trial. Journal of Acupuncture and Meridian Studies 14:2, pages 82-88.
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Friedemann Paul & Carlos Vila Silván. (2021) Effect of nabiximols on Goal Attainment Scale scores in patients with treatment-resistant multiple sclerosis spasticity. Neurodegenerative Disease Management 11:2, pages 143-153.
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Antonella Conte & Carlos Vila Silván. (2021) Review of Available Data for the Efficacy and Effectiveness of Nabiximols Oromucosal Spray (Sativex®) in Multiple Sclerosis Patients with Moderate to Severe Spasticity. Neurodegenerative Diseases 21:3-4, pages 55-62.
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Francesco Patti, Clara Grazia Chisari, Claudio Solaro, Maria Donata Benedetti, Eliana Berra, Assunta Bianco, Roberto Bruno Bossio, Fabio Buttari, Letizia Castelli, Paola Cavalla, Raffaella Cerqua, Gianfranco Costantino, Claudio Gasperini, Angelica Guareschi, Domenico Ippolito, Roberta Lanzillo, Giorgia Teresa Maniscalco, Manuela Matta, Damiano Paolicelli, Loredana Petrucci, Simona Pontecorvo, Isabella Righini, Margherita Russo, Francesco Saccà, Giovanna Salamone, Elisabetta Signoriello, Gabriella Spinicci, Daniele Spitaleri, Eleonora Tavazzi, Maria Trotta, Mauro Zaffaroni & Mario Zappia. (2020) Effects of THC/CBD oromucosal spray on spasticity-related symptoms in people with multiple sclerosis: results from a retrospective multicenter study. Neurological Sciences 41:10, pages 2905-2913.
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Lorenzo G. Mantovani, Paolo Cozzolino, Paolo A. Cortesi & Francesco Patti. (2020) Cost-Effectiveness Analysis of Cannabinoid Oromucosal Spray Use for the Management of Spasticity in Subjects with Multiple Sclerosis. Clinical Drug Investigation 40:4, pages 319-326.
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Anja Davis Norbye, Rune Midgard & Gyrd Thrane. (2019) Spasticity, gait, and balance in patients with multiple sclerosis: A cross‐sectional study. Physiotherapy Research International 25:1.
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Joanna Dymecka & Mariola Bidzan. (2018) Biomedical Variables and Adaptation to Disease and Health-Related Quality of Life in Polish Patients with MS. International Journal of Environmental Research and Public Health 15:12, pages 2678.
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Laura Barin, Anke Salmen, Giulio Disanto, Haris Babačić, Pasquale Calabrese, Andrew Chan, Christian P. Kamm, Jürg Kesselring, Jens Kuhle, Claudio Gobbi, Caroline Pot, Milo A. Puhan & Viktor von Wyl. (2018) The disease burden of Multiple Sclerosis from the individual and population perspective: Which symptoms matter most?. Multiple Sclerosis and Related Disorders 25, pages 112-121.
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Javier Mallada Frechín. (2018) Effect of tetrahydrocannabinol:cannabidiol oromucosal spray on activities of daily living in multiple sclerosis patients with resistant spasticity: a retrospective, observational study. Neurodegenerative Disease Management 8:3, pages 151-159.
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Giacomo Lus, Roberto Cantello, Maura Chiara Danni, Agusto Rini, Paola Sarchielli, Tiziana Tassinari & Elisabetta Signoriello. (2018) Palatability and oral cavity tolerability of THC:CBD oromucosal spray and possible improvement measures in multiple sclerosis patients with resistant spasticity: a pilot study. Neurodegenerative Disease Management 8:2, pages 105-113.
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Sean J. Nagel, Saul Wilson, Michael D. Johnson, Andre Machado, Leonardo Frizon, Matthieu K. Chardon, Chandan G. Reddy, George T. Gillies & Matthew A. HowardIIIIII. (2017) Spinal Cord Stimulation for Spasticity: Historical Approaches, Current Status, and Future Directions. Neuromodulation: Technology at the Neural Interface 20:4, pages 307-321.
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G. Illomei, G. Spinicci, E. Locci & M. G. Marrosu. (2016) Muscle elastography: a new imaging technique for multiple sclerosis spasticity measurement. Neurological Sciences 38:3, pages 433-439.
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J. Ofori, J. Freeman, A. Logan, R. Rapson, J. Zajieck, J. Hobart & J. Marsden. (2016) An investigation of commonly prescribed stretches of the ankle plantarflexors in people with Multiple Sclerosis. Clinical Biomechanics 37, pages 22-26.
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K. Milinis, A. Tennant & C.A. Young. (2016) Spasticity in multiple sclerosis: Associations with impairments and overall quality of life. Multiple Sclerosis and Related Disorders 5, pages 34-39.
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Mar Tintoré. (2015) Advances in the management of multiple sclerosis symptoms: pathophysiology and assessment of spasticity in multiple sclerosis. Neurodegenerative Disease Management 5:6s, pages 15-17.
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Jose Eustasio Meca‐Lallana, Rocío Hernández‐Clares & Ester Carreón‐Guarnizo. (2015) Spasticity in multiple sclerosis and role of glatiramer acetate treatment. Brain and Behavior 5:9.
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Wenli Zhao, Chao Wang, Zhongzheng Li, Lei Chen, Jianbo Li, Weidong Cui, Shasha Ding, Qiang Xi, Fan Wang, Fei Jia, Shuhua Xiao, Yi Guo & Ye Zhao. (2015) Efficacy and Safety of Transcutaneous Electrical Acupoint Stimulation to Treat Muscle Spasticity following Brain Injury: A Double-Blinded, Multicenter, Randomized Controlled Trial. PLOS ONE 10:2, pages e0116976.
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Patrick Vermersch. (2014) MObility ImproVEment with spasticity in multiple sclerosis in Europe: the MOVE 1 EU study. Neurodegenerative Disease Management 4:6, pages 407-415.
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Rafael Arroyo, Carlos Vila & Kerry L Dechant. (2014) Impact of Sativex ® on quality of life and activities of daily living in patients with multiple sclerosis spasticity . Journal of Comparative Effectiveness Research 3:4, pages 435-444.
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Maria Trojano, Elisabeth G. Celius, Cecile Donzé, Guillermo Izquierdo, Francesco Patti & Dieter Pöhlau. (2014) Clinical Case Reviews and Poster Sessions in Multiple Sclerosis Spasticity: Main Outcomes and Highlights. European Neurology 72:Suppl. 1, pages 15-19.
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