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International Journal of Neuroscience Volume 27, 1985 - Issue 1-2
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Original Article

Neurochemical Aspects of Depression: The Past and the Future?

James A. Jesberger Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, S7NOWO, Canada
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J. Steven Richardson Department of Pharmacology and Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, S7NOWO, CanadaView further author information
Pages 19-47 | Received 08 Nov 1984, Published online: 07 Jul 2009

Citations (14)

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Read on this site (2)

Norma A Labra Ruiz, Daniel Santamaría del Ángel, Hugo Juárez Olguín & Miroslava Lindoro Silva. (2018) Neuroprogression: the hidden mechanism of depression. Neuropsychiatric Disease and Treatment 14, pages 2837-2845.
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James A. Jesberger & J. Steven Richardson. (1988) Brain Output Dysregulation Induced by Olfactory Bulbectomy: An Approximation in the Rat of Major Depressive Disorder in Humans?. International Journal of Neuroscience 38:3-4, pages 241-265.
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Articles from other publishers (12)

João Ronielly Campêlo Araújo, Cauê Barbosa Coelho, Adriana Rolim Campos, Renato de Azevedo Moreira & Ana Cristina de Oliveira Monteiro-Moreira. (2020) Animal Galectins and Plant Lectins as Tools for Studies in Neurosciences. Current Neuropharmacology 18:3, pages 202-215.
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M Kreilgaard, D G Smith, L T Brennum & C Sánchez. (2008) Prediction of clinical response based on pharmacokinetic/pharmacodynamic models of 5-hydroxytryptamine reuptake inhibitors in mice. British Journal of Pharmacology 155:2, pages 276-284.
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Christina P Lynn-Bullock, Kristy Welshhans, Sarah L Pallas & Paul S Katz. (2004) The effect of oral 5-HTP administration on 5-HTP and 5-HT immunoreactivity in monoaminergic brain regions of rats. Journal of Chemical Neuroanatomy 27:2, pages 129-138.
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Pablo Muriel & Jazmin M. Pérez-Rojas. (2003) Nitric oxide inhibits mitochondrial monoamine oxidase activity and decreases outer mitochondria membrane fluidity. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 136:3, pages 191-197.
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Haiyun Xu, J Steven Richardson & Xin-Min Li. (2003) Dose-Related Effects of Chronic Antidepressants on Neuroprotective Proteins BDNF, Bcl-2 and Cu/Zn-SOD in Rat Hippocampus. Neuropsychopharmacology 28:1, pages 53-62.
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Handan He & J. Steven Richardson. (2006) Nefazodone: A Review of Its Neurochemical Mechanisms, Pharmacokinetics, and Therapeutic Use in Major Depressive Disorder. CNS Drug Reviews 3:1, pages 34-48.
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JR Hibbeln & N SalemJrJr. (1995) Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy. The American Journal of Clinical Nutrition 62:1, pages 1-9.
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Joseph V. Martin, Emmeline Edwards, Joel O. Johnson & Fritz A. Henn. (2006) Monoamine Receptors in an Animal Model of Affective Disorder. Journal of Neurochemistry 55:4, pages 1142-1148.
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A.H.K. Tiong & J.S. Richardson. (1990) Differential effects of olfactory bulbectomy on β-adrenoceptors in rat amygdala, hippocampus and cerebral cortex. Brain Research 531:1-2, pages 269-275.
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P. Soubrie, P. Martin, S. El Mestikawy & M. Hamon. (1987) Delayed behavioral response to antidepressant drugs following selective damage to the hippocampal noradrenergic innervation in rats. Brain Research 437:2, pages 323-331.
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James A. Jesberger & J.Steven Richardson. (1986) Differential effects of antidepressant drugs on [3H]dihydroalprenolol and [3H]imipramine ligand recognition sites in olfactory bulbectomized and sham-lesioned rats. General Pharmacology: The Vascular System 17:3, pages 293-307.
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James A. Jesberger & J.Steven Richardson. (1985) Animal models of depression: Parallels and correlates to severe depression in humans. Biological Psychiatry 20:7, pages 764-784.
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