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Original Article

Free Radical Mechanisms in the Central Nervous System: An Overview

Pages 13-18 | Received 10 Jul 1987, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

C. Colton, J. Yao, Y. Grossman & D. Gilbert. (1991) The Effect of Xanthine/Xanthine Oxidase Generated Reactive Oxygen Species on Synaptic Transmission. Free Radical Research Communications 14:5-6, pages 385-393.
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James A. Jesberger & J. Steven Richardson. (1991) Oxygen Free Radicals and Brain Dysfunction. International Journal of Neuroscience 57:1-2, pages 1-17.
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Reuven Sandyk. (1990) Possible Role of Pineal Melatonin in the Mechanisms of Aging. International Journal of Neuroscience 52:1-2, pages 85-92.
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Jeffrey Thomas, Vernice Jackson-lewis, Stanley Fahn & Jean Lud Cadet. (1989) Methylprednisolone Treatments Alter Apomorphine-Induced Circling in the Rat Model of 6-Hydroxydopamine-Induced Striatal Denervation. International Journal of Neuroscience 44:1-2, pages 149-154.
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Articles from other publishers (44)

Sarita Das, Puneet K. Singh, Shaikh Ameeruddin, Birendra Kumar Bindhani, Wajdi J. Obaidullah, Ahmad J. Obaidullah, Snehasish Mishra & Ranjan K. Mohapatra. (2023) Ethnomedicinal values of Boerhaavia diffusa L. as a panacea against multiple human ailments: a state of art review. Frontiers in Chemistry 11.
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Glenda Daniela Martin Molinero, Gabriel Giezi Boldrini, María Verónica Pérez Chaca, Mario Franco Moyano, Samanta Armonelli Fiedler, María Sofía Giménez, Nidia Noemí Gómez, Pablo Héctor Horacio López & Silvina Mónica Álvarez. (2022) A soybean based-diet prevents Cadmium access to rat cerebellum, maintaining trace elements homeostasis and avoiding morphological alterations. BioMetals 36:1, pages 67-96.
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Gabriel Giezi Boldrini, Glenda Daniela Martin Molinero, María Verónica Pérez Chaca, Nidia Noemí Gómez & Silvina Mónica Alvarez. 2022. Legumes Research - Volume 2. Legumes Research - Volume 2.
Sarita Das, Biswa Mohan Sahoo & Subrat Kumar Bhattamisra. (2022) Multifunctional Role of Phytochemicals Derived from Boerhaavia diffusa L. in Human Health, Ailments, and Therapy. Current Nutrition & Food Science 18:6, pages 574-588.
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Verónica Bisagno & Jean Lud Cadet. 2022. Handbook of Neurotoxicity. Handbook of Neurotoxicity 563 585 .
Veronica Bisagno & Jean Lud Cadet. (2021) Histone Deacetylases and Immediate Early Genes: Key Players in Psychostimulant-Induced Neuronal Plasticity. Neurotoxicity Research 39:6, pages 2134-2140.
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Subramaniam Jayanthi, Atul P. Daiwile & Jean Lud Cadet. (2021) Neurotoxicity of methamphetamine: Main effects and mechanisms. Experimental Neurology 344, pages 113795.
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Lili Fan, Huayu Chen, Junhui Liang, Da Chen & Yuexiang Huang. (2021) Controllable synthesis of hydrogen bubbles via aeration method for efficient antioxidant process. Applied Nanoscience 11:3, pages 833-840.
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Vaibhav Walia, Sushil Kumar Chaudhary & Neeraj Kumar Sethiya. (2021) Therapeutic potential of mangiferin in the treatment of various neuropsychiatric and neurodegenerative disorders. Neurochemistry International 143, pages 104939.
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Verónica Bisagno & Jean Lud Cadet. 2021. Handbook of Neurotoxicity. Handbook of Neurotoxicity 1 24 .
Mehnaz Kamal, Mamuna Naz, Talha Jawaid & Muhammad Arif. (2019) Natural products and their active principles used in the treatment of neurodegenerative diseases: a review. Oriental Pharmacy and Experimental Medicine 19:4, pages 343-365.
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Veronica Bisagno & Jean Lud Cadet. (2019) Expression of immediate early genes in brain reward circuitries: Differential regulation by psychostimulant and opioid drugs. Neurochemistry International 124, pages 10-18.
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Mohamed M. Amin. 2019. Handbook of Research on Critical Examinations of Neurodegenerative Disorders. Handbook of Research on Critical Examinations of Neurodegenerative Disorders 195 216 .
Tingting Ku, Yingying Zhang, Xiaotong Ji, Guangke Li & Nan Sang. (2017) PM2.5-bound metal metabolic distribution and coupled lipid abnormality at different developmental windows. Environmental Pollution 228, pages 354-362.
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Qingzhao Li, Huibin Liu, Mohamed Alattar, Shoufang Jiang, Jing Han, Yujiao Ma & Chunyang Jiang. (2015) The preferential accumulation of heavy metals in different tissues following frequent respiratory exposure to PM2.5 in rats. Scientific Reports 5:1.
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Chandan K. Sen. (2009) Wound healing essentials: Let there be oxygen. Wound Repair and Regeneration 17:1, pages 1-18.
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Serpil Ersan, Sevtap Bakir, E. Erdal Ersan & Orhan Dogan. (2006) Examination of free radical metabolism and antioxidant defence system elements in patients with obsessive–compulsive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry 30:6, pages 1039-1042.
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C. Groussard. (2006) Stress oxydatif et exercice anaérobie. Science & Sports 21:2, pages 62-67.
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Medaim Yanik, Ozcan Erel & Mahmut Kati. (2014) The relationship between potency of oxidative stress and severity of depression. Acta Neuropsychiatrica 16:4, pages 200-203.
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Pinkhas Sirota, Ronit Gavrieli & Baruch Wolach. (2003) Overproduction of neutrophil radical oxygen species correlates with negative symptoms in schizophrenic patients: parallel studies on neutrophil chemotaxis, superoxide production and bactericidal activity. Psychiatry Research 121:2, pages 123-132.
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Giorgio Marchese, Maria Antonietta Casu, Francesco Bartholini, Stefania Ruiu, Pierluigi Saba, Gian Luigi Gessa & Luca Pani. (2002) Sub-chronic treatment with classical but not atypical antipsychotics produces morphological changes in rat nigro-striatal dopaminergic neurons directly related to ‘early onset’ vacuous chewing. European Journal of Neuroscience 15:7, pages 1187-1196.
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W. B. Jolley & H. B. Cottam. 2001. Kirk-Othmer Encyclopedia of Chemical Technology. Kirk-Othmer Encyclopedia of Chemical Technology.
Irfan Altuntas, Hülya Aksoy, Irfan Coskun, Ali Çayköylü & Fatih Akçay. (2000) Erythrocyte Superoxide Dismutase and Glutathione Peroxidase Activities, and Malondialdehyde and Reduced Glutathione Levels in Schizophrenic Patients. Clinical Chemistry and Laboratory Medicine 38:12.
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Anthony J. Nappi & Emily Vass. (1998) Hydroxyl radical formation via iron-mediated Fenton chemistry is inhibited by methylated catechols. Biochimica et Biophysica Acta (BBA) - General Subjects 1425:1, pages 159-167.
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Richard Jed Wyatt, Farouk Karoum & Joseph Masserano. (1998) Effects of antipsychotics, vitamin E, and MK-801 on dopamine dynamics in the rat brain following discontinuation of cocaine. Psychiatry Research 80:3, pages 213-225.
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Servet Inci, Osman E. Özcan & Kamer Kilinç. (1998) Time-Level Relationship for Lipid Peroxidation and the Protective Effect of α-Tocopherol in Experimental Mild and Severe Brain Injury. Neurosurgery 43:2, pages 330-335.
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Yuval Melamed, Pinkhas Sirota, Dror R. Dicker & Pnina Fishman. (1998) Superoxide anion production by neutrophils derived from peripheral blood of schizophrenic patients. Psychiatry Research 77:1, pages 29-34.
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Hema Mann, Michael T McCoy, Jayanthi Subramaniam, Holly Van Remmen & Jean Lud Cadet. (1997) Overexpression of superoxide dismutase and catalase in immortalized neural cells: toxic effects of hydrogen peroxide. Brain Research 770:1-2, pages 163-168.
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Deepak Awasthi, Daniel F. Church, Dan Torbati, Michael E. Carey & William A. Pryor. (1997) Oxidative stress following traumatic brain injury in rats. Surgical Neurology 47:6, pages 575-581.
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Hakan Caner, Kamer Kilinc, Ayse Ayhan, Kemal Benli, Suleyman Saglam & Mehmet Haberal. (1996) Preliminary report: Effect of cobaltous ion on cerebral vasospasm in a rabbit subarachnoid hemorrhage model. International Journal of Angiology 5:1, pages 45-48.
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Manuchair Ebadi, Shashi K. Srinivasan & Mayur D. Baxi. (1996) Oxidative stress and antioxidant therapy in Parkinson's disease. Progress in Neurobiology 48:1, pages 1-19.
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Gregory I. Elmer, Jennifer L. Evans, Bruce Ladenheim, Charles J. Epstein & Jean Lud Cadet. (1995) Transgenic superoxide dismutase mice differ in opioid-induced analgesia. European Journal of Pharmacology 283:1-3, pages 227-232.
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Jean L. Cadet & Linda A. Kahler. (1994) Free radical mechanisms in schizophrenia and tardive dyskinesia. Neuroscience & Biobehavioral Reviews 18:4, pages 457-467.
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E. Reimund. (1994) The free radical flux theory of sleep. Medical Hypotheses 43:4, pages 231-233.
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Kayoko Kujirai, Elaine Carlson, Charles J. Epstein & Jean Lud Cadet. (2004) Autoradiographic distribution of Mu opioid receptors in the brains of Cu/Zn‐superoxide dismutase mice. Synapse 17:2, pages 76-83.
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Jean Lud Cadet, Kayoko Kujirai, Elaine Carlson & Charles J. Epstein. (2004) Autoradiographic distribution of [ 3 H]neurotensin receptors in the brains of superoxide dismutase transgenic mice . Synapse 14:1, pages 24-33.
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Hakan Caner, Sasan Senaati, Hayrunnisa Bolay, Kamer Kilinc & Kemal Benli. (2016) Protective Effect of the Iron Chelator Deferoxamine on Cerebral Vasospasm. Vascular Surgery 26:8, pages 665-671.
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W. Freas, R. Llave, J.L. Hart, Y. Kobayashi, J. Nagel & S.M. Muldoon. (1992) Neurovascular effects of reactive oxygen intermediates produced by photoradiation. Neuropharmacology 31:8, pages 809-815.
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S. Przedborski, V. Jackson‐Lewis, V. Kostic, E. Carlson, C. J. Epstein & J. L. Cadet. (2006) Superoxide Dismutase, Catalase, and Glutathione Peroxidase Activities in Copper/Zinc‐Superoxide Dismutase Transgenic Mice. Journal of Neurochemistry 58:5, pages 1760-1767.
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Michael J. Caron, David A. Hovda & Donald P. Becker. (1991) Changes in the Treatment of Head Injury. Neurosurgery Clinics of North America 2:2, pages 483-491.
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Karin Berger, Serge Przedborski & Jean Lud Cadet. (1991) Retrograde degeneration of nigrostriatal neurons induced by intrastriatal 6-hydroxydopamine injection in rats. Brain Research Bulletin 26:2, pages 301-307.
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Vernice Jackson-Lewis, Serge Przedborski, Vladimir Kostic, Freeman Suber, Stanley Fahn & Jean Lud Cadet. (1991) Partial attenuation of chronic fluphenazine-induced changes in regional monoamine metabolism by D-α-tocopherol in rat brain. Brain Research Bulletin 26:2, pages 251-258.
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Michael Markefski & Gerald Wolf. (1991) Influence of ammonia, octanoate, quinolinate and hypoxic conditions on NAD(P)H fluorescence of hippocampal slices. Neurochemistry International 18:3, pages 323-329.
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Jean Lud Cadet, Serge Przedborski, Vladimir Kostic, Vernice Jackson-Lewis, Elaine Carlson & Charles J. Epstein. (1990) Quantitative autoradiographic distribution of [3H]mazindol-labeled dopamine uptake sites in the brains of superoxide dismutase transgenic mice. Brain Research Bulletin 25:1, pages 187-192.
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