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Original Article

Temporal discrimination in schizophrenic and affective disorders: Evidence for a dopamine-dependent internal clock

Pages 111-120 | Received 25 Jan 1990, Published online: 07 Jul 2009

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Rachel M. Msetfi, Robin A. Murphy & Diana E. Kornbrot. (2012) The effect of mild depression on time discrimination. The Quarterly Journal of Experimental Psychology 65:4, pages 632-645.
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ErnestH. Friedman & GaryG. Sanders. (1991) Speech Timing of Mood Disorders. Computers in Human Services 8:3-4, pages 121-142.
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Articles from other publishers (66)

Fran López‐Caballero, Mark Curtis, Brian A. Coffman & Dean F. Salisbury. (2023) Is source‐resolved magnetoencephalographic mismatch negativity a viable biomarker for early psychosis?. European Journal of Neuroscience.
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Morteza Izadifar. (2022) Three Clocks of the Brain. Neuroscience and Behavioral Physiology 53:3, pages 443-459.
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Zi H. Su, Salil Patel, Oliver Bredemeyer, James J. FitzGerald & Chrystalina A. Antoniades. (2022) Parkinson’s disease deficits in time perception to auditory as well as visual stimuli – A large online study. Frontiers in Neuroscience 16.
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Friederike Borngräber, Martina Hoffmann, Theresa Paulus, Johanna Junker, Tobias Bäumer, Eckart Altenmüller, Andrea A. Kühn & Alexander Schmidt. (2022) Characterizing the temporal discrimination threshold in musician’s dystonia. Scientific Reports 12:1.
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Anne‐Caroline Martel & Paul Apicella. (2020) Temporal processing in the striatum: Interplay between midbrain dopamine neurons and striatal cholinergic interneurons. European Journal of Neuroscience 53:7, pages 2090-2099.
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Nicholas A. Lusk. 2020. New Frontiers in Brain - Computer Interfaces. New Frontiers in Brain - Computer Interfaces.
Lena Klever, Dimitris Voudouris, Katja Fiehler & Jutta Billino. (2019) Age effects on sensorimotor predictions: What drives increased tactile suppression during reaching?. Journal of Vision 19:9, pages 9.
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Kyran T. Graham‐Schmidt, Mathew T. Martin‐Iverson & Flavie A.V. Waters. (2019) Setting the beat of an internal clock: Effects of dexamphetamine on different interval ranges of temporal processing in healthy volunteers. PsyCh Journal 8:1, pages 90-109.
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Sven Thoenes & Daniel Oberfeld. (2017) Meta-analysis of time perception and temporal processing in schizophrenia: Differential effects on precision and accuracy. Clinical Psychology Review 54, pages 44-64.
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Jan Lošák, Jitka Hüttlová, Petra Lipová, Radek Mareček, Martin Bareš, Pavel Filip, Jozef Žůbor, Libor Ustohal, Jiří Vaníček & Tomáš Kašpárek. (2016) Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study. Schizophrenia Bulletin 42:6, pages 1517-1527.
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Kyran T. Graham-Schmidt, Mathew T. Martin-Iverson, Nicholas P. Holmes & Flavie A.V. Waters. (2016) When one’s sense of agency goes wrong: Absent modulation of time perception by voluntary actions and reduction of perceived length of intervals in passivity symptoms in schizophrenia. Consciousness and Cognition 45, pages 9-23.
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Adam L. Halberstadt, Ivan S. Sindhunata, Kees Scheffers, Aaron D. Flynn, Richard F. Sharp, Mark A. Geyer & Jared W. Young. (2016) Effect of 5-HT 2A and 5-HT 2C receptors on temporal discrimination by mice. Neuropharmacology 107, pages 364-375.
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Giovanna Mioni, Franca Stablum, Elena Prunetti & Simon Grondin. (2016) Time perception in anxious and depressed patients: A comparison between time reproduction and time production tasks. Journal of Affective Disorders 196, pages 154-163.
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Valentina Ciullo, Gianfranco Spalletta, Carlo Caltagirone, Ricardo E Jorge & Federica Piras. (2016) Explicit Time Deficit in Schizophrenia: Systematic Review and Meta-Analysis Indicate It Is Primary and Not Domain Specific. Schizophrenia Bulletin 42:2, pages 505-518.
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Sylvie Droit-Volet & John Wearden. (2016) Passage of Time Judgments Are Not Duration Judgments: Evidence from a Study Using Experience Sampling Methodology. Frontiers in Psychology 7.
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Brendan Keane, Morgan Spence, Kielan Yarrow & Derek Arnold. (2015) Perceptual confidence demonstrates trial-by-trial insight into the precision of audio–visual timing encoding. Consciousness and Cognition 38, pages 107-117.
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Sophie Fayolle, Sandrine Gil & Sylvie Droit-Volet. (2015) Fear and time: Fear speeds up the internal clock. Behavioural Processes 120, pages 135-140.
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Sven Thönes & Daniel Oberfeld. (2015) Time perception in depression: A meta-analysis. Journal of Affective Disorders 175, pages 359-372.
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Phil Reed & Jordan Randell. (2014) Altered time-perception performance in individuals with high schizotypy levels. Psychiatry Research 220:1-2, pages 211-216.
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Carla Merino-Rajme. (2014) A Quantum Theory of Felt Duration. Analytic Philosophy 55:3, pages 239-275.
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Daniel Oberfeld, Sven Thönes, Benyne J. Palayoor & Heiko Hecht. (2014) Depression does not affect time perception and time-to-contact estimation. Frontiers in Psychology 5.
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Adam L. Halberstadt & Mark A. Geyer. (2013) Serotonergic hallucinogens as translational models relevant to schizophrenia. International Journal of Neuropsychopharmacology 16:10, pages 2165-2180.
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Sylvie Droit-Volet. (2013) Time perception, emotions and mood disorders. Journal of Physiology-Paris 107:4, pages 255-264.
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Irene Preuschoff, Helge H. Müller, Wolfgang Sperling, Teresa Biermann, Matthias Bergner, Johannes Kornhuber & Teja W. Groemer. (2013) iPad-Assisted Measurements of Duration Estimation in Psychiatric Patients and Healthy Control Subjects. PLoS ONE 8:5, pages e61295.
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J.W. Moore, V.C. Cambridge, H. Morgan, F. Giorlando, R. Adapa & P.C. Fletcher. (2013) Time, action and psychosis: Using subjective time to investigate the effects of ketamine on sense of agency. Neuropsychologia 51:2, pages 377-384.
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Martin Roy, Simon Grondin & Marc-André Roy. (2012) Time perception disorders are related to working memory impairment in schizophrenia. Psychiatry Research 200:2-3, pages 159-166.
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I. G. Sil’kis. (2012) Possible mechanisms for the effects of neuromodulators on the perception of time intervals. Neurochemical Journal 6:2, pages 144-152.
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Warren H. Meck, Ruey-Kuang Cheng, Christopher J. MacDonald, Raul R. Gainetdinov, Marc G. Caron & Münire Özlem Çevik. (2012) Gene-dose dependent effects of methamphetamine on interval timing in dopamine-transporter knockout mice. Neuropharmacology 62:3, pages 1221-1229.
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Thomas H. Rammsayer. (2012) Developing a Psychophysical Measure to Assess Duration Discrimination in the Millisecond Range. European Journal of Psychological Assessment 28:3, pages 172-180.
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Olivier Bonnot, Marie de Montalembert, Solenn Kermarrec, Michel Botbol, Michel Walter & Nathalie Coulon. (2011) Are impairments of time perception in schizophrenia a neglected phenomenon?. Journal of Physiology-Paris 105:4-6, pages 164-169.
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Patrick D. Skosnik. 2011. Marijuana and Madness. Marijuana and Madness 144 159 .
Deana B. Davalos, Donald C. Rojas & Jason R. Tregellas. (2011) Temporal processing in schizophrenia: Effects of task-difficulty on behavioral discrimination and neuronal responses. Schizophrenia Research 127:1-3, pages 123-130.
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A. Ameller, Y. Delevoye-Turrell, H. Wilquin & P. Thomas. (2011) Production de rythmes dans la schizophrénie : rôle central de l’attention. L'Encéphale 37:2, pages 86-93.
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Hélène Wilquin, Yvonne Delevoye-Turrell, Aurély Ameller, Alan M. Wing & Pierre Thomas. (2011) Production de rythmes dans la schizophrénie : un déficit de l’alternance de temps. L’Année psychologique 110:04, pages 517.
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Hélène Wilquin, Yvonne Delevoye-Turrell, Aurély Ameller, Alan M. Wing & Pierre Thomas. (2010) Production de rythmes dans la schizophrénie : un déficit de l’alternance de temps. L’Année psychologique Vol. 110:4, pages 517-539.
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Olga V. Sysoeva, Alexander G. Tonevitsky & Jiří Wackermann. (2010) Genetic Determinants of Time Perception Mediated by the Serotonergic System. PLoS ONE 5:9, pages e12650.
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Kwang-Hyuk Lee, Rajinder S. Bhaker, Ashok Mysore, Randolph W. Parks, Paul B.L. Birkett & Peter W.R. Woodruff. (2009) Time perception and its neuropsychological correlates in patients with schizophrenia and in healthy volunteers. Psychiatry Research 166:2-3, pages 174-183.
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Catherine R. G. Jones & Marjan Jahanshahi. 2009. Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra. Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra 161 171 .
Vladimir Orduña, Ana García, Marina Menez, Enrique Hong & Arturo Bouzas. (2008) Performance of spontaneously hypertensive rats in a peak-interval procedure with gaps. Behavioural Brain Research 191:1, pages 72-76.
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Nadine Helmbold, Stefan Troche & Thomas Rammsayer. (2007) Processing of Temporal and Nontemporal Information as Predictors of Psychometric Intelligence: A Structural-Equation-Modeling Approach. Journal of Personality 75:5, pages 985-1006.
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Ruey-Kuang Cheng, Yusuf M. Ali & Warren H. Meck. (2007) Ketamine “unlocks” the reduced clock-speed effects of cocaine following extended training: Evidence for dopamine–glutamate interactions in timing and time perception. Neurobiology of Learning and Memory 88:2, pages 149-159.
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Natasha Matthews, Juanita Todd, Timothy W. Budd, Gavin Cooper & Patricia T. Michie. (2007) Auditory lateralization in schizophrenia – Mismatch negativity and behavioral evidence of a selective impairment in encoding interaural time cues. Clinical Neurophysiology 118:4, pages 833-844.
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Vladimir Orduña, Enrique Hong & Arturo Bouzas. (2007) Interval bisection in spontaneously hypertensive rats. Behavioural Processes 74:1, pages 107-111.
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Simon Grondin, Viviane Pouthas, Séverine Samson & Martin Roy. (2006) Mécanismes et désordres liés à l'adaptation au temps.. Canadian Psychology / Psychologie canadienne 47:3, pages 170-183.
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Kwang-Hyuk Lee, Joanna K. Dixon, Sean A. Spence & Peter W.R. Woodruff. (2006) Time perception dysfunction in psychometric schizotypy. Personality and Individual Differences 40:7, pages 1363-1373.
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Jiří Wackermann & Werner Ehm. (2006) The dual klepsydra model of internal time representation and time reproduction. Journal of Theoretical Biology 239:4, pages 482-493.
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Thomas H. Rammsayer. (2006) Effects of pharmacologically induced changes in NMDA receptor activity on human timing and sensorimotor performance. Brain Research 1073-1074, pages 407-416.
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Catalin V. Buhusi & Warren H. Meck. (2005) What makes us tick? Functional and neural mechanisms of interval timing. Nature Reviews Neuroscience 6:10, pages 755-765.
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Christopher J. MacDonald & Warren H. Meck. (2005) Differential effects of clozapine and haloperidol on interval timing in the supraseconds range. Psychopharmacology 182:2, pages 232-244.
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Daniel Umbricht & Sanya Krljes. (2005) Mismatch negativity in schizophrenia: a meta-analysis. Schizophrenia Research 76:1, pages 1-23.
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Trevor B. Penney, Warren H. Meck, Simone A. Roberts, John Gibbon & L. Erlenmeyer-Kimling. (2005) Interval-timing deficits in individuals at high risk for schizophrenia. Brain and Cognition 58:1, pages 109-118.
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S.M. Brown, P.D. Kieffaber, C.A. Carroll, J.L. Vohs, J.A. Tracy, A. Shekhar, B.F. O’Donnell, J.E. Steinmetz & W.P. Hetrick. (2005) Eyeblink conditioning deficits indicate timing and cerebellar abnormalities in schizophrenia. Brain and Cognition 58:1, pages 94-108.
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Warren H. Meck. (2005) Neuropsychology of timing and time perception. Brain and Cognition 58:1, pages 1-8.
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Brita Elvevåg, Gordon D. A. Brown, Teresa McCormack, Janet I. Vousden & Terry E. Goldberg. (2004) Identification of Tone Duration, Line Length, and Letter Position: An Experimental Approach to Timing and Working Memory Deficits in Schizophrenia.. Journal of Abnormal Psychology 113:4, pages 509-521.
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Amy L. Odum & Ryan D. Ward. (2004) THE EFFECTS OF MORPHINE ON THE PRODUCTION AND DISCRIMINATION OF INTERRESPONSE TIMES. Journal of the Experimental Analysis of Behavior 82:2, pages 197-212.
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Juanita Todd, P.T Michie & A.V Jablensky. (2003) Association between reduced duration mismatch negativity (MMN) and raised temporal discrimination thresholds in schizophrenia. Clinical Neurophysiology 114:11, pages 2061-2070.
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Trevor Penney. 2003. Functional and Neural Mechanisms of Interval Timing. Functional and Neural Mechanisms of Interval Timing.
Patricia T. Michie. (2001) What has MMN revealed about the auditory system in schizophrenia?. International Journal of Psychophysiology 42:2, pages 177-194.
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Hans-Peter Volz, Igor Nenadic, Christian Gaser, Thomas Rammsayer, Frank Häger & Heinrich Sauer. (2001) Time estimation in schizophrenia: an fMRI study at adjusted levels of difficulty. Neuroreport 12:2, pages 313-316.
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Juanita Todd, Patricia T. Michie, T.William Budd, Danny Rock & Assen V. Jablensky. (2000) Auditory sensory memory in schizophrenia: inadequate trace formation?. Psychiatry Research 96:2, pages 99-115.
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Parto Farjampour & Åke Hellström. (2016) Discrimination of Tone Durations across the Menstrual Cycle. Perceptual and Motor Skills 90:3_suppl, pages 1059-1070.
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P.T Michie, T.W Budd, J Todd, D Rock, H Wichmann, J Box & A.V Jablensky. (2000) Duration and frequency mismatch negativity in schizophrenia. Clinical Neurophysiology 111:6, pages 1054-1065.
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Sean C. Hinton & Warren H. Meck. (1997) The ‘internal clocks’ of circadian and interval timing ( erratum ). Endeavour 21:2, pages 82-87.
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Sean C. Hinton & Warren H. Meck. (1997) The ‘internal clocks’ of circadian and interval timing. Endeavour 21:1, pages 3-8.
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Thomas H. Rammsayer. (1994) Effects of practice and signal energy on duration discrimination of brief auditory intervals. Perception & Psychophysics 55:4, pages 454-464.
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