Advanced search
Publication Cover
International Journal of Neuroscience Volume 61, 1991 - Issue 3-4
Submit an article Journal homepage
86
Views
52
CrossRef citations to date
0
Altmetric
Review Article

Relevance of the Habenular Complex to Neuropsychiatry: A Review and Hypothesis

Reuven Sandyk Department of Psychiatry, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, 10461, USA
Pages 189-219 | Received 10 Nov 1990, Published online: 07 Jul 2009

Citations (52)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Reuven Sandyk. (1995) Weak electromagnetic fields reverse visuospatial hemi-inattention in parkinson's disease. International Journal of Neuroscience 81:3-4, pages 47-65.
Read now
Reuven Sandyk & Kyriakos Derpapas. (1994) Successful Treatment of Respiratory Dyskinesia with Picotesla Range Magnetic Fields. International Journal of Neuroscience 75:1-2, pages 91-102.
Read now
Reuven Sandyk. (1994) Reversal of visuospatial hemi-inattention in patients with chronic progressive multiple sclerosis by treatment with weak electromagnetic fields. International Journal of Neuroscience 79:3-4, pages 169-184.
Read now
Reuven Sandyk, N. Tsagas, P. A. Anninos & K. Derpapas. (1992) Magnetic Fields Mimic the Behavioral Effects of rem Sleep Deprivation in Humans. International Journal of Neuroscience 65:1-4, pages 61-68.
Read now
Reuven Sandyk. (1992) Weak Magnetic Fields in the Treatment of Parkinson's Disease with the “on-off” Phenomenon. International Journal of Neuroscience 66:1-2, pages 97-106.
Read now

Articles from other publishers (47)

V. N. Nikolenko, N. A. Rizaeva, M. V. Oganesyan, K. A. Vekhova, N. A. F. Alyautdinova, S. I. Balan, T. A. Karashaeva & A. A. Bolotskaya. (2022) Brain commissures and related pathologies. Neurology, Neuropsychiatry, Psychosomatics 14:6, pages 73-79.
Crossref
Guo‐Tzau WangHe‐Yen PanWei‐Han LangYuan‐Ding YuChang‐Huain HsiehYung‐Shu Kuan. (2021) Three‐dimensional multi‐gene expression maps reveal cell fate changes associated with laterality reversal of zebrafish habenula. Journal of Neuroscience Research 99:6, pages 1632-1645.
Crossref
Chuan-Chie Chang, Hsiao-Ying Kuo, Shih-Yun Chen, Wan-Ting Lin, Kuan-Ming Lu, Tetsuichiro Saito & Fu-Chin Liu. (2021) Developmental Characterization of Schizophrenia-Associated Gene Zswim6 in Mouse Forebrain. Frontiers in Neuroanatomy 15.
Crossref
Vladimir N. Nikolenko, Leonid A. Gridin, Marine V. Oganesyan, Negoriya A. Rizaeva, Yury S. Podolskiy, Valentina A. Kudryashova, Ekaterina V. Kochurova, Roman K. Kostin, Ekaterina E. Tyagunova, Liudmila M. Mikhaleva, Marco Avila-Rodriguez, Siva G. Somasundaram, Cecil E. Kirkland & Gjumrakch Aliev. (2020) The Posterior Perforated Substance: A Brain Mystery Wrapped in an Enigma. Current Topics in Medicinal Chemistry 19:32, pages 2991-2998.
Crossref
Hidenori Aizawa & Meina Zhu. (2019) Toward an understanding of the habenula's various roles in human depression. Psychiatry and Clinical Neurosciences 73:10, pages 607-612.
Crossref
Marc Fakhoury. (2017) The habenula in psychiatric disorders: More than three decades of translational investigation. Neuroscience & Biobehavioral Reviews 83, pages 721-735.
Crossref
Edgar Soria-Gómez, Arnau Busquets-Garcia, Fei Hu, Amine Mehidi, Astrid Cannich, Liza Roux, Ines Louit, Lucille Alonso, Theresa Wiesner, Francois Georges, Danièle Verrier, Peggy Vincent, Guillaume Ferreira, Minmin Luo & Giovanni Marsicano. (2015) Habenular CB1 Receptors Control the Expression of Aversive Memories. Neuron 88:2, pages 306-313.
Crossref
Eugenia Díaz, Daniela Bravo, Ximena Rojas & Miguel L. Concha. (2011) Morphologic and immunohistochemical organization of the human habenular complex. Journal of Comparative Neurology 519:18, pages 3727-3747.
Crossref
Cristian Gutiérrez-Ibáñez, Adam R. Reddon, Michael B. Kreuzer, Douglas R. Wylie & Peter L. Hurd. (2011) Variation in asymmetry of the habenular nucleus correlates with behavioural asymmetry in a cichlid fish. Behavioural Brain Research 221:1, pages 189-196.
Crossref
Jing Ren, Chang Qin, Fei Hu, Jie Tan, Li Qiu, Shengli Zhao, Guoping Feng & Minmin Luo. (2011) Habenula “Cholinergic” Neurons Corelease Glutamate and Acetylcholine and Activate Postsynaptic Neurons via Distinct Transmission Modes. Neuron 69:3, pages 445-452.
Crossref
Ikuo Matsuda, Masahiro Fukaya, Harumi Nakao, Kazuki Nakao, Hideyuki Matsumoto, Kensaku Mori, Masahiko Watanabe & Atsu Aiba. (2010) Development of the somatosensory cortex, the cerebellum, and the main olfactory system in Semaphorin 3F knockout mice. Neuroscience Research 66:3, pages 321-329.
Crossref
Marco Dadda, Alice Domenichini, Laura Piffer, Francesco Argenton & Angelo Bisazza. (2010) Early differences in epithalamic left–right asymmetry influence lateralization and personality of adult zebrafish. Behavioural Brain Research 206:2, pages 208-215.
Crossref
C. Qin & M. Luo. (2009) Neurochemical phenotypes of the afferent and efferent projections of the mouse medial habenula. Neuroscience 161:3, pages 827-837.
Crossref
Adam R. Reddon, Cristián Gutiérrez-Ibáñez, Douglas R. Wylie & Peter L. Hurd. (2009) The relationship between growth, brain asymmetry and behavioural lateralization in a cichlid fish. Behavioural Brain Research 201:1, pages 223-228.
Crossref
Iskra A Signore, Néstor Guerrero, Felix Loosli, Alicia Colombo, Aldo Villalón, Joachim Wittbrodt & Miguel L Concha. (2008) Zebrafish and medaka: model organisms for a comparative developmental approach of brain asymmetry. Philosophical Transactions of the Royal Society B: Biological Sciences 364:1519, pages 991-1003.
Crossref
Okihide Hikosaka, Susan R. Sesack, Lucas Lecourtier & Paul D. Shepard. (2008) Habenula: Crossroad between the Basal Ganglia and the Limbic System. The Journal of Neuroscience 28:46, pages 11825-11829.
Crossref
Shuei Sugama & Bruno Conti. (2008) Interleukin-18 and stress. Brain Research Reviews 58:1, pages 85-95.
Crossref
Niina Aaltonen, Ville A.B. Palomäki, Anne Lecklin & Jarmo T. Laitinen. (2008) Neuroanatomical mapping of juvenile rat brain regions with prominent basal signal in [35S]GTPγS autoradiography. Journal of Chemical Neuroanatomy 35:2, pages 233-241.
Crossref
John E. Mendoza & Anne L. Foundas. 2008. Clinical Neuroanatomy: A Neurobehavioral Approach. Clinical Neuroanatomy: A Neurobehavioral Approach 195 211 .
Masayuki Matsumoto & Okihide Hikosaka. (2007) Lateral habenula as a source of negative reward signals in dopamine neurons. Nature 447:7148, pages 1111-1115.
Crossref
Lucas Lecourtier & Peter H. Kelly. (2007) A conductor hidden in the orchestra? Role of the habenular complex in monoamine transmission and cognition. Neuroscience & Biobehavioral Reviews 31:5, pages 658-672.
Crossref
Vittorio Guglielmotti & Luigia Cristino. (2006) The interplay between the pineal complex and the habenular nuclei in lower vertebrates in the context of the evolution of cerebral asymmetry. Brain Research Bulletin 69:5, pages 475-488.
Crossref
Masaru USUI, Hitoshi AOSHIMA, Yoshimi YAMAMOTO, Claudius LUZIGA & Koichi MAMBA. (2006) Characterization and Distribution of an Arginine Vasotocin Receptor in Mouse. Journal of Veterinary Medical Science 68:7, pages 655-661.
Crossref
L. Lecourtier, O. Deschaux, C. Arnaud, A. Chessel, P.H. Kelly & R. Garcia. (2006) Habenula lesions alter synaptic plasticity within the fimbria–accumbens pathway in the rat. Neuroscience 141:2, pages 1025-1032.
Crossref
David C. Osmon & Jessica M. Smerz. (2016) Neuropsychological Evaluation in the Diagnosis and Treatment of Tourette’s Syndrome. Behavior Modification 29:5, pages 746-783.
Crossref
Heike Endepols, Katja Roden & Wolfgang Walkowiak. (2005) Hodological characterization of the septum in anuran amphibians: II. Efferent connections. Journal of Comparative Neurology 483:4, pages 437-457.
Crossref
Lucas Lecourtier & Peter H Kelly. (2004) Bilateral Lesions of the Habenula Induce Attentional Disturbances in Rats. Neuropsychopharmacology 30:3, pages 484-496.
Crossref
Miguel L. Concha. (2004) The dorsal diencephalic conduction system of zebrafish as a model of vertebrate brain lateralisation. NeuroReport 15:12, pages 1843-1846.
Crossref
Atanas Ignatov, Irm Hermans-Borgmeyer & H.Chica Schaller. (2004) Cloning and characterization of a novel G-protein-coupled receptor with homology to galanin receptors. Neuropharmacology 46:8, pages 1114-1120.
Crossref
Lucas Lecourtier, Hans C. Neijt & Peter H. Kelly. (2004) Habenula lesions cause impaired cognitive performance in rats: implications for schizophrenia. European Journal of Neuroscience 19:9, pages 2551-2560.
Crossref
Vittorio Guglielmotti, Luigia Cristino, Errico Sada & Marina Bentivoglio. (2004) The epithalamus of the developing and adult frog: calretinin expression and habenular asymmetry in Rana esculenta. Brain Research 999:1, pages 9-19.
Crossref
J. Shumake & F. Gonzalez-Lima. (2016) Brain Systems Underlying Susceptibility to Helplessness and Depression. Behavioral and Cognitive Neuroscience Reviews 2:3, pages 198-221.
Crossref
J. Shumake, E. Edwards & F. Gonzalez-Lima. (2003) Opposite metabolic changes in the habenula and ventral tegmental area of a genetic model of helpless behavior. Brain Research 963:1-2, pages 274-281.
Crossref
Shuei Sugama, Byung Pil Cho, Harriet Baker, Tong H Joh, Jacinta Lucero & Bruno Conti. (2002) Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS. Brain Research 958:1, pages 1-9.
Crossref
J. Amat, P.D. Sparks, P. Matus-Amat, J. Griggs, L.R. Watkins & S.F. Maier. (2001) The role of the habenular complex in the elevation of dorsal raphe nucleus serotonin and the changes in the behavioral responses produced by uncontrollable stress. Brain Research 917:1, pages 118-126.
Crossref
MIGUEL L. CONCHA & STEPHEN W. WILSON. (2001) Asymmetry in the epithalamus of vertebrates. Journal of Anatomy 199:1-2, pages 63-84.
Crossref
X. Zhuang, A.-J. Silverman & R. Silver. (1999) Distribution and local differentiation of mast cells in the parenchyma of the forebrain. The Journal of Comparative Neurology 408:4, pages 477-488.
Crossref
Hiroaki KawasakiGregory M. SpringettNaoki MochizukiShinichiro TokiMie NakayaMichiyuki MatsudaDavid E. HousmanAnn M. Graybiel. (1998) A Family of cAMP-Binding Proteins That Directly Activate Rap1. Science 282:5397, pages 2275-2279.
Crossref
B Sperlágh, Zs Maglóczky, E.S Vizi & T.F Freund. (1998) The triangular septal nucleus as the major source of ATP release in the rat habenula: A combined neurochemical and morphological study. Neuroscience 86:4, pages 1195-1207.
Crossref
X Zhuang, A.-J Silverman & R Silver. (1997) Mast cell number and maturation in the central nervous system: influence of tissue type, location and exposure to steroid hormones. Neuroscience 80:4, pages 1237-1245.
Crossref
A. Vale-Martı́nez, M. Martı́-Nicolovius, G. Guillazo-Blanch, M. Coll-Andreu & I. Morgado-Bernal. (1997) Effects of Habenular Lesions upon Two-Way Active Avoidance Conditioning in Rats. Neurobiology of Learning and Memory 68:1, pages 68-74.
Crossref
X. Zhuang, A.-J. Silverman & R. Silver. (1996) Brain mast cell degranulation regulates blood-brain barrier. Journal of Neurobiology 31:4, pages 393-403.
Crossref
Blesilda S. Reinoso, Aurea F. Pimenta & Pat Levitt. (1998) Expression of the mRNAs encoding the limbic system‐associated membrane protein (LAMP): I. Adult rat brain. Journal of Comparative Neurology 375:2, pages 274-288.
Crossref
J.P. Herman, C.M. Dolgas, D. Rucker & M.C. Langub. (1996) Localization of natriuretic peptide-activated guanylate cyclase mRNAs in the rat brain. The Journal of Comparative Neurology 369:2, pages 165-187.
Crossref
Keith P. Corodimas, Jay S. Rosenblatt, Tracy R. Matthews-Felton & Joan I. Morrell. (2016) Role of Neurons in the Lateral Habenula for the Expression of Maternal Behavior. Current Directions in Psychological Science 4:4, pages 127-129.
Crossref
Will P. J. M. Spooren, Suzanne N. Haber, Jan G. Veening & Alexander R. Cools. (1995) Descending efferent connections of the sub-pallidal areas in the cat: projections to the lateral habenula. NeuroReport 6:7, pages 977-980.
Crossref
Gaylord Ellison. (1994) Stimulant-induced psychosis, the dopamine theory of schizophrenia, and the habenula. Brain Research Reviews 19:2, pages 223-239.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.