Advanced search
Publication Cover
International Journal of Neuroscience Volume 61, 1991 - Issue 3-4
Submit an article Journal homepage
16
Views
49
CrossRef citations to date
0
Altmetric
Original Article

Anti-Stress Role of the Melatonin-Immuno-Opioid Network: Evidence for a Physiological Mechanism Involving T Cell-Derived, Immuno-Reactive β-Endorphin and Met-Enkephalin Binding to Thymic Opioid Receptors

Georges J. M. Maestroni Laboratory for Experimental Pathology, Istituto Cantonale di Patologia, 6604, Locarno, Switzerland
&
Ario Conti Laboratory for Experimental Pathology, Istituto Cantonale di Patologia, 6604, Locarno, Switzerland
Pages 289-298 | Received 19 Feb 1991, Published online: 07 Jul 2009

Citations (49)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Shin-Jung Park & Hiromi Tokura. (1999) Bright Light Exposure During the Daytime Affects Circadian Rhythms of Urinary Melatonin and Salivary Immunoglobulin A. Chronobiology International 16:3, pages 359-371.
Read now
Zhen Zhang, Paula F. Inserra, Bailin Liang, Sussan K. Ardestani, Kerry K. Elliott, Mark Molitor & Ronald Ross Watson. (1997) Melatonin, Immune Modulation and Aging. Autoimmunity 26:1, pages 43-53.
Read now
Ronald R Watson, Henry R Matz & Ariana Call. (1996) Section Review Oncologic, Endocrine & Metabolic: Melatonin related to health promotion and biological function. Expert Opinion on Investigational Drugs 5:12, pages 1647-1656.
Read now

Articles from other publishers (46)

Geoffroy Laumet, Jules D. Edralin, Robert Dantzer, Cobi J. Heijnen & Annemieke Kavelaars. (2020) CD3+ T cells are critical for the resolution of comorbid inflammatory pain and depression-like behavior. Neurobiology of Pain 7, pages 100043.
Crossref
Len WisneskiLen Wisneski. 2017. The Scientific Basis of Integrative Health. The Scientific Basis of Integrative Health 439 482 .
Shu-Yu Tai, Shu-Pin Huang, Bo-Ying Bao & Ming-Tsang Wu. (2016) Urinary melatonin-sulfate/cortisol ratio and the presence of prostate cancer: A case-control study. Scientific Reports 6:1.
Crossref
Antonio Muñoz-Hoyos, Antonio Molina-Carballo, MaríadelCarmen Augustin-Morales, Francisco Contreras-Chova, Ana Naranjo-Gómez, Fuensanta Justicia-Martínez & José Uberos. (2011) Psychosocial dwarfism: Psychopathological aspects and putative neuroendocrine markers. Psychiatry Research 188:1, pages 96-101.
Crossref
Marcello Iriti & Franco Faoro. (2009) Bioactivity of Grape Chemicals for Human Health. Natural Product Communications 4:5, pages 1934578X0900400.
Crossref
Marcello Iriti & Franco Faoro. 2009. Complementary and Alternative Therapies and the Aging Population. Complementary and Alternative Therapies and the Aging Population 445 474 .
Alice Che-Ha Chen, Nigel A. J. McMillan & Annika Antonsson. (2008) Human papillomavirus type spectrum in normal skin of individuals with or without a history of frequent sun exposure. Journal of General Virology 89:11, pages 2891-2897.
Crossref
Hajime Kimata. (2007) Laughter elevates the levels of breast-milk melatonin. Journal of Psychosomatic Research 62:6, pages 699-702.
Crossref
Shiv Shankar Singh, Chandana Haldar & Seema Rai. (2006) Melatonin and differential effect of l-thyroxine on immune system of Indian tropical bird Perdicula asiatica. General and Comparative Endocrinology 145:3, pages 215-221.
Crossref
V Srinivasan, GJM Maestroni, DP Cardinali, AI Esquifino, SR Pandi Perumal & SC Miller. (2005) Melatonin, immune function and aging. Immunity & Ageing 2:1.
Crossref
C.B. Moore & T.D. Siopes. (2005) Enhancement of cellular and humoral immunity following embryonic exposure to melatonin in turkeys (Meleagris gallopavo). General and Comparative Endocrinology 143:2, pages 178-183.
Crossref
CB Moore & TD Siopes. (2002) Effect of melatonin supplementation on the ontogeny of immunity in the Large White turkey poult. Poultry Science 81:12, pages 1898-1903.
Crossref
Qun Chen & Wei Wei. (2002) Effects and mechanisms of melatonin on inflammatory and immune responses of adjuvant arthritis rat. International Immunopharmacology 2:10, pages 1443-1449.
Crossref
VijayalaxmiCharles R. ThomasJrJrRussel J. ReiterTerence S. Herman. (2002) Melatonin: From Basic Research to Cancer Treatment Clinics. Journal of Clinical Oncology 20:10, pages 2575-2601.
Crossref
C.B Moore, T.D Siopes, C.T Steele & H Underwood. (2002) Pineal melatonin secretion, but not ocular melatonin secretion, is sufficient to maintain normal immune responses in Japanese quail (Coturnix coturnix japonica). General and Comparative Endocrinology 126:3, pages 352-358.
Crossref
Georges J. M. Maestroni. 2002. Melatonin After Four Decades. Melatonin After Four Decades 395 405 .
Dominika Kanikowska, Yukiko Hirata, Ki-ja Hyun & Hiromi Tokura. (2001) Acute Phase Proteins, Body Temperature and Urinary Melatonin under the Influence of Bright and Dim Light Intensities during the Daytime.. Journal of PHYSIOLOGICAL ANTHROPOLOGY and Applied Human Science 20:6, pages 333-338.
Crossref
Ario Conti & Georges J. M. Maestroni. 2001. The Pineal Gland and Cancer. The Pineal Gland and Cancer 395 407 .
Georges J. M. Maestroni. 2001. The Pineal Gland and Cancer. The Pineal Gland and Cancer 384 394 .
Peter M. Liebmann, Albert Wölfler & Konrad Schauenstein. 2001. The Pineal Gland and Cancer. The Pineal Gland and Cancer 371 383 .
Wilson Savino & Mireille Dardenne. (2000) Neuroendocrine Control of Thymus Physiology*. Endocrine Reviews 21:4, pages 412-443.
Crossref
C.B. Moore & T.D. Siopes. (2000) Effects of Lighting Conditions and Melatonin Supplementation on the Cellular and Humoral Immune Responses in Japanese Quail Coturnix coturnix japonica. General and Comparative Endocrinology 119:1, pages 95-104.
Crossref
Vasudeva Raghavendra, Javed N Agrewala & Shrinivas K Kulkarni. (2000) Melatonin reversal of lipopolysacharides-induced thermal and behavioral hyperalgesia in mice. European Journal of Pharmacology 395:1, pages 15-21.
Crossref
Sofía García-Mauriño, David Pozo, Antonio Carrillo-Vico, Juan R. Calvo & Juan M. Guerrero. (1999) Melatonin activates Th1 lymphocytes by increasing IL-12 production. Life Sciences 65:20, pages 2143-2150.
Crossref
George C. Brainard, Robert Kavet & Leeka I. Kheifets. (2007) The relationship between electromagnetic field and light exposures to melatonin and breast cancer risk: A review of the relevant literature. Journal of Pineal Research 26:2, pages 65-100.
Crossref
George J. M. Maestroni. 1999. Tryptophan, Serotonin, and Melatonin. Tryptophan, Serotonin, and Melatonin 217 226 .
F Saravia, M.R Padros, A Ase, R Aloyz, S Duran & O Vindrola. (1998) Differential response to a stress stimulus of proenkephalin peptide content in immune cells of naive and chronically stressed rats. Neuropeptides 32:4, pages 351-359.
Crossref
ARIO CONTI & GEORGES J. M. MAESTRONI. (1998) Melatonin Rhythms in Mice: Role in Autoimmune and Lymphoproliferative Diseases. Annals of the New York Academy of Sciences 840:1, pages 395-410.
Crossref
M Boranić, L Krizanac-Bengez, J Gabrilovac, T Marotti & D Breijak. (1997) Enkephalins in hematopoiesis. Biomedicine & Pharmacotherapy 51:1, pages 29-37.
Crossref
R. Hardeland. 1997. Skin Cancer and UV Radiation. Skin Cancer and UV Radiation 186 198 .
LeGrande C. Ellis. (2007) Melatonin reduces mortality from Aleutian disease in mink ( Mustela vison ) . Journal of Pineal Research 21:4, pages 214-217.
Crossref
Peter M. Liebmann, Dietmar Hofer, Peter Felsner, Albert Wölfler & Konrad Schauenstein. (1996) Beta-blockade enhances adrenergic immunosuppression in rats via inhibition of melatonin release. Journal of Neuroimmunology 67:2, pages 137-142.
Crossref
Georges J. M. Maestroni. (2007) Melatonin as a therapeutic agent in experimental endotoxic shock. Journal of Pineal Research 20:2, pages 84-89.
Crossref
L.J. Krizanac-Bengez, D Breijak & M Boranic. (1996) Suppressive effect of met-enkephalin on bone marrow cell proliferation in vitro shows circadian pattern and depends on the presence of adherent accessory cells. Biomedicine & Pharmacotherapy 50:2, pages 85-91.
Crossref
Georges J. M. Maestroni. 1996. Molecular Biology of Hematopoiesis 5. Molecular Biology of Hematopoiesis 5 619 626 .
Ario Conti & Georges J.M. Maestroni. (2007) The clinical neuroimmunotherapeutic role of melatonin in oncology. Journal of Pineal Research 19:3, pages 103-110.
Crossref
Darfo Acufla‐Castroviejo, Germaine Escames, Manuel Macks, Antono Muñóz Hoyos, Antonio Molina Carballo, Mariano Arauzo, Rosa Montes & Francisco Vives. (2007) Minireview: Cell protective role of melatonin in the brain. Journal of Pineal Research 19:2, pages 57-63.
Crossref
Joan E. Roberts. (1995) Visible light induced changes in the immune response through an eye-brain mechanism (photoneuroimmunology). Journal of Photochemistry and Photobiology B: Biology 29:1, pages 3-15.
Crossref
Georges J.M. Maestroni. (2007) T‐Helper‐2 lymphocytes as a peripheral target of melatonin*. Journal of Pineal Research 18:2, pages 84-89.
Crossref
A.O. Massion, J. Teas, J.R. Hebert, M.D. Wertheimer & J. Kabat-Zinn. (1995) Meditation, melatonin and breast/prostate cancer: Hypothesis and preliminary data. Medical Hypotheses 44:1, pages 39-46.
Crossref
HORST-W. KORF. (1994) The Pineal Organ as a Component of the Biological Clock.. Annals of the New York Academy of Sciences 719:1 The Aging Clo, pages 13-42.
Crossref
N. Müller. (1993) Psychoimmunologie und Onkologie. Archives of Gynecology and Obstetrics 254:1-4, pages 654-660.
Crossref
Georges J. M. Maestroni. (2007) The immunoneuroendocrine role of melatonin. Journal of Pineal Research 14:1, pages 1-10.
Crossref
N. Müller. 1993. Gynäkologie und Geburtshilfe 1992. Gynäkologie und Geburtshilfe 1992 654 660 .
Gayle A. Olson, Richard D. Olson & Abba J. Kastin. (1992) Endogenous opiates: 1991. Peptides 13:6, pages 1247-1287.
Crossref
Ario Conti, Nechama Haran-Ghera & Georges J. M. Maestroni. (1992) Role of pineal melatonin and melatonin-induced-immuno-opioids in murine leukemogenesis. Medical Oncology and Tumor Pharmacotherapy 9:2, pages 87-92.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.